Designing writing groups to support postgraduate students’ academic writing: a case study from a South African university
- Authors: Wilmot, Kirstin
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/66267 , vital:28926 , https://doi.org/10.1080/14703297.2016.1238775
- Description: publisher version , This paper reports on a writing group pilot programme implemented at a South African university. Drawing on literature, anonymous student evaluations and facilitator observations, it discusses the use of writing groups for supporting postgraduate academic writing practices. Developed within a broader postgraduate academic writing support programme, the paper discusses a case study of two pilot writing groups: a multidisciplinary long-term group and a disciplinary short-term ‘writing-intensive’ group. The findings indicate that the overall experience of the writing group was a positive one, with each group presenting varied ‘success’ aspects as well as challenges. Insights gleaned may contribute to our understanding of how these groups can be utilised to support postgraduate students and how different kinds of groups can be developed to serve particular student needs. The paper concludes with a discussion of the inclusion of a disciplinary expert, which proved particularly useful in this pilot.
- Full Text: false
- Date Issued: 2018
- Authors: Wilmot, Kirstin
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/66267 , vital:28926 , https://doi.org/10.1080/14703297.2016.1238775
- Description: publisher version , This paper reports on a writing group pilot programme implemented at a South African university. Drawing on literature, anonymous student evaluations and facilitator observations, it discusses the use of writing groups for supporting postgraduate academic writing practices. Developed within a broader postgraduate academic writing support programme, the paper discusses a case study of two pilot writing groups: a multidisciplinary long-term group and a disciplinary short-term ‘writing-intensive’ group. The findings indicate that the overall experience of the writing group was a positive one, with each group presenting varied ‘success’ aspects as well as challenges. Insights gleaned may contribute to our understanding of how these groups can be utilised to support postgraduate students and how different kinds of groups can be developed to serve particular student needs. The paper concludes with a discussion of the inclusion of a disciplinary expert, which proved particularly useful in this pilot.
- Full Text: false
- Date Issued: 2018
HOP expression is regulated by p53 and RAS and characteristic of a cancer gene signature
- Mattison, Stacey A, Blatch, Gregory L, Edkins, Adrienne L
- Authors: Mattison, Stacey A , Blatch, Gregory L , Edkins, Adrienne L
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/66278 , vital:28928 , https://doi.org/10.1007/s12192-016-0755-8
- Description: publisher version , The Hsp70/Hsp90 organising protein (HOP) is a co-chaperone essential for client protein transfer from Hsp70 to Hsp90 within the Hsp90 chaperone machine. Although HOP is upregulated in various cancers, there is limited information from in vitro studies on how HOP expression is regulated in cancer. The main objective of this study was to identify the HOP promoter and investigate its activity in cancerous cells. Bioinformatic analysis of the -2500 to +16 bp region of the HOP gene identified a large CpG island and a range of putative cis-elements. Many of the cis-elements were potentially bound by transcription factors which are activated by oncogenic pathways. Luciferase reporter assays demonstrated that the upstream region of the HOP gene contains an active promoter in vitro. Truncation of this region suggested that the core HOP promoter region was -855 to +16 bp. HOP promoter activity was highest in Hs578T, HEK293T and SV40- transformed MEF1 cell lines which expressed mutant or inactive p53. In a mutant p53 background, expression of wild-type p53 led to a reduction in promoter activity, while inhibition of wild-type p53 in HeLa cells increased HOP promoter activity. Additionally, in Hs578T and HEK293T cell lines containing inactive p53, expression of HRAS increased HOP promoter activity. However, HRAS activation of the HOP promoter was inhibited by p53 overexpression. These findings suggest for the first time that HOP expression in cancer may be regulated by both RAS activation and p53 inhibition. Taken together, these data suggest that HOP may be part of the cancer gene signature induced by a combination of mutant p53 and mutated RAS that is associated with cellular transformation.
- Full Text: false
- Date Issued: 2018
- Authors: Mattison, Stacey A , Blatch, Gregory L , Edkins, Adrienne L
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/66278 , vital:28928 , https://doi.org/10.1007/s12192-016-0755-8
- Description: publisher version , The Hsp70/Hsp90 organising protein (HOP) is a co-chaperone essential for client protein transfer from Hsp70 to Hsp90 within the Hsp90 chaperone machine. Although HOP is upregulated in various cancers, there is limited information from in vitro studies on how HOP expression is regulated in cancer. The main objective of this study was to identify the HOP promoter and investigate its activity in cancerous cells. Bioinformatic analysis of the -2500 to +16 bp region of the HOP gene identified a large CpG island and a range of putative cis-elements. Many of the cis-elements were potentially bound by transcription factors which are activated by oncogenic pathways. Luciferase reporter assays demonstrated that the upstream region of the HOP gene contains an active promoter in vitro. Truncation of this region suggested that the core HOP promoter region was -855 to +16 bp. HOP promoter activity was highest in Hs578T, HEK293T and SV40- transformed MEF1 cell lines which expressed mutant or inactive p53. In a mutant p53 background, expression of wild-type p53 led to a reduction in promoter activity, while inhibition of wild-type p53 in HeLa cells increased HOP promoter activity. Additionally, in Hs578T and HEK293T cell lines containing inactive p53, expression of HRAS increased HOP promoter activity. However, HRAS activation of the HOP promoter was inhibited by p53 overexpression. These findings suggest for the first time that HOP expression in cancer may be regulated by both RAS activation and p53 inhibition. Taken together, these data suggest that HOP may be part of the cancer gene signature induced by a combination of mutant p53 and mutated RAS that is associated with cellular transformation.
- Full Text: false
- Date Issued: 2018
The National Wellbeing Index in the isiXhosa translation: focus group discussions on how South Africans view the quality of their society
- Moller, Valerie, Roberts, Benjamin J, Zani, Dalindyebo
- Authors: Moller, Valerie , Roberts, Benjamin J , Zani, Dalindyebo
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/67135 , vital:29035 , https://doi.org/10.1007/s11205-016-1481-4
- Description: publisher version , The International Wellbeing Index covers two complementary measures, the Personal Wellbeing Index (PWI) and the National Wellbeing Index (NWI). The focus group study reported here tested the understanding of the NWI when translated into isiXhosa, a language spoken by 6 million South Africans, or 16% of the country’s population. A challenge for the NWI in measuring national well-being is the tendency for meaning to get ‘lost in translation’ in the wording of the instrument, owing to the disparities that exist between levels of living in developed and developing nations. The focussed discussions with native isiXhosa speakers conveyed the different shades of meaning associated with the six domains that make up the NWI. The isiXhosa keywords for the domains of social conditions, the natural environment, national security, and management of the country’s affairs (government) were readily understood, but discussants asked for further clarification of keywords for the domains relating to the economy and business. Conversations showed up the close link between personal and national well-being: discussants drew upon their personal and parochial life experiences along with their knowledge of current affairs to evaluate the nation’s quality of life. They described the social contract between citizens and their government to create a ‘caring society’ that promotes well-being across key domains of national life. Many of the reference standards used to evaluate national well-being were ones postulated to influence personal well-being (Michalos A.C, Social Indicators Research 16(4): 347–413 1985 ). The study also pointed to a potential problem for longitudinal studies if the bipolar satisfaction scale, formerly used to measure the International Wellbeing Index’s PWI and NWI, is changed to a unipolar one. Findings from this pilot study confirm the potential of the NWI as a tool for measuring national well-being cross-culturally.
- Full Text: false
- Date Issued: 2018
- Authors: Moller, Valerie , Roberts, Benjamin J , Zani, Dalindyebo
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/67135 , vital:29035 , https://doi.org/10.1007/s11205-016-1481-4
- Description: publisher version , The International Wellbeing Index covers two complementary measures, the Personal Wellbeing Index (PWI) and the National Wellbeing Index (NWI). The focus group study reported here tested the understanding of the NWI when translated into isiXhosa, a language spoken by 6 million South Africans, or 16% of the country’s population. A challenge for the NWI in measuring national well-being is the tendency for meaning to get ‘lost in translation’ in the wording of the instrument, owing to the disparities that exist between levels of living in developed and developing nations. The focussed discussions with native isiXhosa speakers conveyed the different shades of meaning associated with the six domains that make up the NWI. The isiXhosa keywords for the domains of social conditions, the natural environment, national security, and management of the country’s affairs (government) were readily understood, but discussants asked for further clarification of keywords for the domains relating to the economy and business. Conversations showed up the close link between personal and national well-being: discussants drew upon their personal and parochial life experiences along with their knowledge of current affairs to evaluate the nation’s quality of life. They described the social contract between citizens and their government to create a ‘caring society’ that promotes well-being across key domains of national life. Many of the reference standards used to evaluate national well-being were ones postulated to influence personal well-being (Michalos A.C, Social Indicators Research 16(4): 347–413 1985 ). The study also pointed to a potential problem for longitudinal studies if the bipolar satisfaction scale, formerly used to measure the International Wellbeing Index’s PWI and NWI, is changed to a unipolar one. Findings from this pilot study confirm the potential of the NWI as a tool for measuring national well-being cross-culturally.
- Full Text: false
- Date Issued: 2018
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