Identification of Novel Potential Inhibitors of Pteridine Reductase 1 in Trypanosoma brucei via Computational Structure-Based Approaches and in Vitro Inhibition Assays
- Kimuda, Magambo Phillip, Laming, Dustin, Hoppe, Heinrich C, Tastan Bishop, Özlem
- Authors: Kimuda, Magambo Phillip , Laming, Dustin , Hoppe, Heinrich C , Tastan Bishop, Özlem
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/124675 , vital:35647 , https://doi:10.3390/molecules24010142
- Description: Pteridine reductase 1 (PTR1) is a trypanosomatid multifunctional enzyme that provides a mechanism for escape of dihydrofolate reductase (DHFR) inhibition. This is because PTR1 can reduce pterins and folates. Trypanosomes require folates and pterins for survival and are unable to synthesize them de novo. Currently there are no anti-folate based Human African Trypanosomiasis (HAT) chemotherapeutics in use. Thus, successful dual inhibition of Trypanosoma brucei dihydrofolate reductase (TbDHFR) and Trypanosoma brucei pteridine reductase 1 (TbPTR1) has implications in the exploitation of anti-folates. We carried out molecular docking of a ligand library of 5742 compounds against TbPTR1 and identified 18 compounds showing promising binding modes. The protein-ligand complexes were subjected to molecular dynamics to characterize their molecular interactions and energetics, followed by in vitro testing. In this study, we identified five compounds which showed low micromolar Trypanosome growth inhibition in in vitro experiments that might be acting by inhibition of TbPTR1. Compounds RUBi004, RUBi007, RUBi014, and RUBi018 displayed moderate to strong antagonism (mutual reduction in potency) when used in combination with the known TbDHFR inhibitor, WR99210. This gave an indication that the compounds might inhibit both TbPTR1 and TbDHFR. RUBi016 showed an additive effect in the isobologram assay. Overall, our results provide a basis for scaffold optimization for further studies in the development of HAT anti-folates.
- Full Text:
- Date Issued: 2019
- Authors: Kimuda, Magambo Phillip , Laming, Dustin , Hoppe, Heinrich C , Tastan Bishop, Özlem
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/124675 , vital:35647 , https://doi:10.3390/molecules24010142
- Description: Pteridine reductase 1 (PTR1) is a trypanosomatid multifunctional enzyme that provides a mechanism for escape of dihydrofolate reductase (DHFR) inhibition. This is because PTR1 can reduce pterins and folates. Trypanosomes require folates and pterins for survival and are unable to synthesize them de novo. Currently there are no anti-folate based Human African Trypanosomiasis (HAT) chemotherapeutics in use. Thus, successful dual inhibition of Trypanosoma brucei dihydrofolate reductase (TbDHFR) and Trypanosoma brucei pteridine reductase 1 (TbPTR1) has implications in the exploitation of anti-folates. We carried out molecular docking of a ligand library of 5742 compounds against TbPTR1 and identified 18 compounds showing promising binding modes. The protein-ligand complexes were subjected to molecular dynamics to characterize their molecular interactions and energetics, followed by in vitro testing. In this study, we identified five compounds which showed low micromolar Trypanosome growth inhibition in in vitro experiments that might be acting by inhibition of TbPTR1. Compounds RUBi004, RUBi007, RUBi014, and RUBi018 displayed moderate to strong antagonism (mutual reduction in potency) when used in combination with the known TbDHFR inhibitor, WR99210. This gave an indication that the compounds might inhibit both TbPTR1 and TbDHFR. RUBi016 showed an additive effect in the isobologram assay. Overall, our results provide a basis for scaffold optimization for further studies in the development of HAT anti-folates.
- Full Text:
- Date Issued: 2019
Impacts of gum-resin harvest and Lantana camara invasion on the population structure and dynamics of Boswellia serrata in the Western Ghats, India
- Soumya, Kori V, Shackleton, Charlie M, Setty, Siddappa R
- Authors: Soumya, Kori V , Shackleton, Charlie M , Setty, Siddappa R
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/177549 , vital:42832 , https://doi.org/10.1016/j.foreco.2019.117618
- Description: Assessing the effects of harvesting on the population dynamics of important non-timber forest products (NTFPs) species is important for informing species conservation options, guiding sustainable harvesting practices and offtake and supporting local livelihoods. However, harvesting is rarely the only pressure on NTFP populations, and it is vital that the effects of interactive pressures be considered. This applies to Boswellia serrata, an NTFP tree species which is widely harvested for gum-resin used in religious practices. However, in many settings populations are in decline, presumably due to heavy harvesting, but other factors may play a role, such as altered fire regimes and invasive species. Here we report on the effects of harvesting and invasion by Lantana camara on B. serrata populations in three protected areas in the Western Ghats biodiversity hotspot in southern India. We considered tree and juvenile density, size class distribution, and growth, mortality, and recruitment rates in harvested and unharvested populations over two years.
- Full Text:
- Date Issued: 2019
- Authors: Soumya, Kori V , Shackleton, Charlie M , Setty, Siddappa R
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/177549 , vital:42832 , https://doi.org/10.1016/j.foreco.2019.117618
- Description: Assessing the effects of harvesting on the population dynamics of important non-timber forest products (NTFPs) species is important for informing species conservation options, guiding sustainable harvesting practices and offtake and supporting local livelihoods. However, harvesting is rarely the only pressure on NTFP populations, and it is vital that the effects of interactive pressures be considered. This applies to Boswellia serrata, an NTFP tree species which is widely harvested for gum-resin used in religious practices. However, in many settings populations are in decline, presumably due to heavy harvesting, but other factors may play a role, such as altered fire regimes and invasive species. Here we report on the effects of harvesting and invasion by Lantana camara on B. serrata populations in three protected areas in the Western Ghats biodiversity hotspot in southern India. We considered tree and juvenile density, size class distribution, and growth, mortality, and recruitment rates in harvested and unharvested populations over two years.
- Full Text:
- Date Issued: 2019
Improving intravenous fluid prescribing in the Eastern Cape in South Africa
- Luce, Cate, Soffair,Rosie, Parrish, Andy
- Authors: Luce, Cate , Soffair,Rosie , Parrish, Andy
- Date: 2019
- Subjects: South Africa Intravenous fluids Computer File
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/5120 , vital:44351 , https://doi:10.1136/bmjoq-2018-000406
- Description: Intravenous fluids are an essential component of patient care, but a 2013 National Institute for Health and Care Excellence (NICE) guideline noted that inappropriate prescribing or administration may lead to actual or potential patient harm in up to 20% of patients.1 This project aimed to improve prescribing documentation and communication between nurses and doctors regarding intravenous fluid management. This was done through the introduction of a fluid chart, in combination with teaching on appropriate fluid management. It was initiated within the medical department of Cecelia Makiwane Hospital in East London, South Africa. 309 patients were included and data were analysed over a 6-month period. The outcome measures were the standards of intravenous fluid prescribing set by the NICE guidelines. The process measure was the use of the new chart. Baseline data highlighted that there was no standardised location for fluid prescriptions within the bedside notes. Following the intervention, 81% of fluid prescriptions were on a fluid chart. The percentage of fluid scripts with a 24-hour fluid prescription, a recorded indication and recorded input increased after the intervention. Seventy six per cent of patients received more than 50% of the fluids prescribed following the intervention compared with 22% at baseline. These results indicated an increase in the doctor’s awareness of appropriate fluid prescribing and an improvement in the communication between doctors and nurses regarding the patient’s fluid management. The engagement of local stakeholders and staff was fundamental to the success of the project and allowed for this change in practice. Fluid management is a vital part of care in many specialties; therefore, a toolkit has been created to allow similar quality improvement projects to be implemented across other hospitals around the Eastern Cape.
- Full Text:
- Date Issued: 2019
- Authors: Luce, Cate , Soffair,Rosie , Parrish, Andy
- Date: 2019
- Subjects: South Africa Intravenous fluids Computer File
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/5120 , vital:44351 , https://doi:10.1136/bmjoq-2018-000406
- Description: Intravenous fluids are an essential component of patient care, but a 2013 National Institute for Health and Care Excellence (NICE) guideline noted that inappropriate prescribing or administration may lead to actual or potential patient harm in up to 20% of patients.1 This project aimed to improve prescribing documentation and communication between nurses and doctors regarding intravenous fluid management. This was done through the introduction of a fluid chart, in combination with teaching on appropriate fluid management. It was initiated within the medical department of Cecelia Makiwane Hospital in East London, South Africa. 309 patients were included and data were analysed over a 6-month period. The outcome measures were the standards of intravenous fluid prescribing set by the NICE guidelines. The process measure was the use of the new chart. Baseline data highlighted that there was no standardised location for fluid prescriptions within the bedside notes. Following the intervention, 81% of fluid prescriptions were on a fluid chart. The percentage of fluid scripts with a 24-hour fluid prescription, a recorded indication and recorded input increased after the intervention. Seventy six per cent of patients received more than 50% of the fluids prescribed following the intervention compared with 22% at baseline. These results indicated an increase in the doctor’s awareness of appropriate fluid prescribing and an improvement in the communication between doctors and nurses regarding the patient’s fluid management. The engagement of local stakeholders and staff was fundamental to the success of the project and allowed for this change in practice. Fluid management is a vital part of care in many specialties; therefore, a toolkit has been created to allow similar quality improvement projects to be implemented across other hospitals around the Eastern Cape.
- Full Text:
- Date Issued: 2019
Improving TB infection control in a regional hospital in the Eastern Cape, South Africa
- Haeusler, Ilsa Louisa, Knights, Felicity, George, Vishaal, Parrish, Andy
- Authors: Haeusler, Ilsa Louisa , Knights, Felicity , George, Vishaal , Parrish, Andy
- Date: 2019
- Subjects: Quality circles Tuberculosis--Prevention Computer File
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/6399 , vital:45465 , https://doi.org/10.4102/hts.v77i2.6828
- Description: This quality improvement (QI) work was carried out in Cecilia Makiwane Hospital (CMH), a regional public hospital in the Eastern Cape, South Africa (SA). SA has among the highest incidence of tuberculosis (TB) in the world and this is a leading cause of death in SA. Nosocomial infection is an important source of TB transmission. Adherence to TB infection prevention control (IPC) measures in the medical inpatient department was suboptimal at CMH. The overall aim of this QI project was to make sustainable improvements in TB IPC. A multidisciplinary team was formed to undertake a root cause analysis and develop a strategy for change. The main barriers to adherence to IPC measures were limited knowledge of IPC methods and stigma associated with TB. Specifically, the project aimed to increase the number of: ‘airborne precaution’ signs placed above patients’ beds, patients correctly isolated and patients wearing surgical face masks. Four Plan Do-Study-Act cycles were used. The strategy for change involved education and awareness-raising in different formats, including formal in-service training delivered to nurses and doctors, a hospital-wide TB awareness week with engaging activities and competitions, and a World TB Day provincial solidarity march. Data on adherence to the three IPC measures were collected over an 8-month period. Pre-intervention (October 2016), a mean of 2 percent of patients wore face masks, 22 percent were correctly isolated and 12 percent had an airborne precaution sign. Postintervention (May 2017), the compliance improved to 17 percent, 50 percent and 25 percent, respectively. There was a large variation in compliance to each measure. Improvement was greatest in the number of patients correctly isolated. We learnt it is important to work with, not in parallel to, existing teams or structures during QI work. On-the-ground training of nurses and clinicians should be undertaken alongside engagement of senior staff members and managers. This improves the chance of change being adopted into hospital policy.
- Full Text:
- Date Issued: 2019
- Authors: Haeusler, Ilsa Louisa , Knights, Felicity , George, Vishaal , Parrish, Andy
- Date: 2019
- Subjects: Quality circles Tuberculosis--Prevention Computer File
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/6399 , vital:45465 , https://doi.org/10.4102/hts.v77i2.6828
- Description: This quality improvement (QI) work was carried out in Cecilia Makiwane Hospital (CMH), a regional public hospital in the Eastern Cape, South Africa (SA). SA has among the highest incidence of tuberculosis (TB) in the world and this is a leading cause of death in SA. Nosocomial infection is an important source of TB transmission. Adherence to TB infection prevention control (IPC) measures in the medical inpatient department was suboptimal at CMH. The overall aim of this QI project was to make sustainable improvements in TB IPC. A multidisciplinary team was formed to undertake a root cause analysis and develop a strategy for change. The main barriers to adherence to IPC measures were limited knowledge of IPC methods and stigma associated with TB. Specifically, the project aimed to increase the number of: ‘airborne precaution’ signs placed above patients’ beds, patients correctly isolated and patients wearing surgical face masks. Four Plan Do-Study-Act cycles were used. The strategy for change involved education and awareness-raising in different formats, including formal in-service training delivered to nurses and doctors, a hospital-wide TB awareness week with engaging activities and competitions, and a World TB Day provincial solidarity march. Data on adherence to the three IPC measures were collected over an 8-month period. Pre-intervention (October 2016), a mean of 2 percent of patients wore face masks, 22 percent were correctly isolated and 12 percent had an airborne precaution sign. Postintervention (May 2017), the compliance improved to 17 percent, 50 percent and 25 percent, respectively. There was a large variation in compliance to each measure. Improvement was greatest in the number of patients correctly isolated. We learnt it is important to work with, not in parallel to, existing teams or structures during QI work. On-the-ground training of nurses and clinicians should be undertaken alongside engagement of senior staff members and managers. This improves the chance of change being adopted into hospital policy.
- Full Text:
- Date Issued: 2019
In conversation with South African artist Viwe Madinda: after her performance “Kwathi Kaloku Ngatsomi” during the National Arts Festival
- Authors: Muvhuti, Barnabas
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/146948 , vital:38579 , https://africanah.org/viwe-madinda/
- Description: Focusing on Viwe Madinda’s Kwathi Kaloku Ngatsomi, a live art performance staged under the Arts Lounge Program, during South Africa’s 2019 National Arts Festival in Makhanda, this conversation dwells on the significance of the performance. It explores the key symbolic gestures the artist and her mother employed to convey the underlying message. In the aftermath of the performance, Barnabas Ticha Muvhuti sat down with Viwe Madinda to discuss and unpack some of the key moments in the work. What follows is an edited transcript of the conversation which took place at the Arts Lounge at the Arts of Africa and Global Souths Research Program at Rhodes University.
- Full Text:
- Date Issued: 2019
- Authors: Muvhuti, Barnabas
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/146948 , vital:38579 , https://africanah.org/viwe-madinda/
- Description: Focusing on Viwe Madinda’s Kwathi Kaloku Ngatsomi, a live art performance staged under the Arts Lounge Program, during South Africa’s 2019 National Arts Festival in Makhanda, this conversation dwells on the significance of the performance. It explores the key symbolic gestures the artist and her mother employed to convey the underlying message. In the aftermath of the performance, Barnabas Ticha Muvhuti sat down with Viwe Madinda to discuss and unpack some of the key moments in the work. What follows is an edited transcript of the conversation which took place at the Arts Lounge at the Arts of Africa and Global Souths Research Program at Rhodes University.
- Full Text:
- Date Issued: 2019
In conversation with Zimbabwean artist Kresiah Mukwazhi:
- Authors: Muvhuti, Barnabas
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/146959 , vital:38580 , https://africanah.org/in-conversation-with-kresiah-mukwazhi/
- Description: Kresiah Mukwazhi is a Harare-based multidisciplinary artist who is a Fellow of the “Arts of Africa and Global Souths” Residencies for Artists and Writers (RAW) programme in the Fine Art Department at Rhodes University in Makhanda, South Africa. During the 2019 National Arts Festival, she performed Summoned from Luzari as part of the Arts Lounge festival programme. Her two-months residency resulted in the Although I am Young, I am the Mother of this House open studio session in which the audience was invited to engage with the artist and the ideas she has been, is and will be working on. The persona Hes Keresiya, which came to life on that day, is one of the ideas. In this conversation, Barnabas Ticha Muvhuti asks Mukwazhi about her work during the residency and her artistic practice in general.
- Full Text:
- Date Issued: 2019
- Authors: Muvhuti, Barnabas
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/146959 , vital:38580 , https://africanah.org/in-conversation-with-kresiah-mukwazhi/
- Description: Kresiah Mukwazhi is a Harare-based multidisciplinary artist who is a Fellow of the “Arts of Africa and Global Souths” Residencies for Artists and Writers (RAW) programme in the Fine Art Department at Rhodes University in Makhanda, South Africa. During the 2019 National Arts Festival, she performed Summoned from Luzari as part of the Arts Lounge festival programme. Her two-months residency resulted in the Although I am Young, I am the Mother of this House open studio session in which the audience was invited to engage with the artist and the ideas she has been, is and will be working on. The persona Hes Keresiya, which came to life on that day, is one of the ideas. In this conversation, Barnabas Ticha Muvhuti asks Mukwazhi about her work during the residency and her artistic practice in general.
- Full Text:
- Date Issued: 2019
In Parenthesis:
- Authors: de Jager, Maureen
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/147880 , vital:38681 , DOI: 10.1080/02560046.2019.1684966
- Description: IN PARENTHESIS is a practice-based essay which takes shape, parasitically, amidst the “found text” of an existing book, British author Thomas Pakenham's The Boer War (1979, Johannesburg: Jonathan Ball). The “author-reader” interjects into the found text of this authoritative history book, inserting her words amongst those of Pakenham's. What becomes apparent, however, is that the text into which she interjects is not The Boer War verbatim, but a dramatically abridged version. The book's primary content has been edited out. What remains is The Boer War whittled down to a litany of Pakenham's parentheses (the history book distilled into an essence of the seemingly non-essential). Into this stream of bracketed matter, the author-reader writes, ruminating on the parenthesis as ethos (as prison and portal, barricade and breach, enclave and embrace). In turn, her ruminations invite reflection on the conundrum of writing history, of writing this history (and, indeed, of writing per se).
- Full Text:
- Date Issued: 2019
- Authors: de Jager, Maureen
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/147880 , vital:38681 , DOI: 10.1080/02560046.2019.1684966
- Description: IN PARENTHESIS is a practice-based essay which takes shape, parasitically, amidst the “found text” of an existing book, British author Thomas Pakenham's The Boer War (1979, Johannesburg: Jonathan Ball). The “author-reader” interjects into the found text of this authoritative history book, inserting her words amongst those of Pakenham's. What becomes apparent, however, is that the text into which she interjects is not The Boer War verbatim, but a dramatically abridged version. The book's primary content has been edited out. What remains is The Boer War whittled down to a litany of Pakenham's parentheses (the history book distilled into an essence of the seemingly non-essential). Into this stream of bracketed matter, the author-reader writes, ruminating on the parenthesis as ethos (as prison and portal, barricade and breach, enclave and embrace). In turn, her ruminations invite reflection on the conundrum of writing history, of writing this history (and, indeed, of writing per se).
- Full Text:
- Date Issued: 2019
In Search of the “Goodlife": Border Crossing and Agency in Luis Alberto Urrea's Into the Beautiful North and Graciela Limón's The River Flows North
- Authors: Naidu, Samantha
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/158046 , vital:40142 , https://doi.org/10.1080/18125441.2019.16474490
- Description: This article explores representations of complex diasporic subjectivities that resist, or attempt to resist, obsolete nationalist notions of citizenship and identity by crossing the US– Mexico border (and, in so doing, crossing other intangible borders) in search of a better life. Two examples of border literature, Luis Alberto Urrea's Into the Beautiful North (2009) and Graciela Limón's The River Flows North (2009), have been selected for analysis. These texts, in describing various diaspora spaces—to enlist Avtar Brah's term (Cartographies of Diaspora. London: Routledge, 1996)—also examine how those who do not migrate are affected by migration. In Writing the Goodlife: Mexican American Literature and the Environment (Tucson: University of Arizona Press, 2016), Priscilla Solis Ybarra reveals how the past century and a half's Mexican-American literature contains valuable new approaches to creating and sustaining new forms of transnational relations between humans, and ecologically sound relationships between humans and nature.
- Full Text:
- Date Issued: 2019
- Authors: Naidu, Samantha
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/158046 , vital:40142 , https://doi.org/10.1080/18125441.2019.16474490
- Description: This article explores representations of complex diasporic subjectivities that resist, or attempt to resist, obsolete nationalist notions of citizenship and identity by crossing the US– Mexico border (and, in so doing, crossing other intangible borders) in search of a better life. Two examples of border literature, Luis Alberto Urrea's Into the Beautiful North (2009) and Graciela Limón's The River Flows North (2009), have been selected for analysis. These texts, in describing various diaspora spaces—to enlist Avtar Brah's term (Cartographies of Diaspora. London: Routledge, 1996)—also examine how those who do not migrate are affected by migration. In Writing the Goodlife: Mexican American Literature and the Environment (Tucson: University of Arizona Press, 2016), Priscilla Solis Ybarra reveals how the past century and a half's Mexican-American literature contains valuable new approaches to creating and sustaining new forms of transnational relations between humans, and ecologically sound relationships between humans and nature.
- Full Text:
- Date Issued: 2019
In silico study of Plasmodium 1-deoxy-d-xylulose 5-phosphate reductoisomerase (DXR) for identification of novel inhibitors from SANCDB:
- Diallo, Bakary N, Lobb, Kevin A, Tastan Bishop, Özlem
- Authors: Diallo, Bakary N , Lobb, Kevin A , Tastan Bishop, Özlem
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/162687 , vital:40973 , https://doi.org/10.21955/aasopenres.1114960.1
- Description: In this study, we intended to find potential 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) inhibitors as antimalarial drugs from the South African National Compound Database (SANCDB; https://sancdb.rubi.ru.ac.za) using computational tools.
- Full Text:
- Date Issued: 2019
- Authors: Diallo, Bakary N , Lobb, Kevin A , Tastan Bishop, Özlem
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/162687 , vital:40973 , https://doi.org/10.21955/aasopenres.1114960.1
- Description: In this study, we intended to find potential 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) inhibitors as antimalarial drugs from the South African National Compound Database (SANCDB; https://sancdb.rubi.ru.ac.za) using computational tools.
- Full Text:
- Date Issued: 2019
In vitro and in vivo toxicity assessment of biologically synthesized silver nanoparticles from Elaeodendron croceum:
- Odeyemi, S W, de la Mare, Jo-Anne, Edkins, Adrienne L, Afolayan, A J
- Authors: Odeyemi, S W , de la Mare, Jo-Anne , Edkins, Adrienne L , Afolayan, A J
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/163488 , vital:41042 , DOI: 10.1515/jcim-2018-0184
- Description: The cytotoxic properties of nanoparticles have attracted a great deal of attention in the field of nanoscience and nanotechnology due to their small size and ability to penetrate cellular membranes.
- Full Text:
- Date Issued: 2019
- Authors: Odeyemi, S W , de la Mare, Jo-Anne , Edkins, Adrienne L , Afolayan, A J
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/163488 , vital:41042 , DOI: 10.1515/jcim-2018-0184
- Description: The cytotoxic properties of nanoparticles have attracted a great deal of attention in the field of nanoscience and nanotechnology due to their small size and ability to penetrate cellular membranes.
- Full Text:
- Date Issued: 2019
In vitro Anti-trypanosomal activities of indanone-based chalcones:
- Beteck, Richard M, Legoabe, Lesetje J, Isaacs, Michelle, Hoppe, Heinrich C
- Authors: Beteck, Richard M , Legoabe, Lesetje J , Isaacs, Michelle , Hoppe, Heinrich C
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/158280 , vital:40169 , https://doi.org/10.3354/meps12953
- Description: Human African trypanosomiasis is a neglected infectious disease that affects mostly people living in the rural areas of Africa. Current treatment options are limited to just four drugs that have been in use of four to nine decades. The life-threatening toxic side-effects associated with the use of these drugs are disconcerting. Poor efficacy, low oral bioavailability, and high cost are other shortcomings of current HAT treatments. Evaluating the potentials of known hits for other therapeutic areas may be a fast and convenient method to discover new hit compounds against alternative targets. A library of 34 known indanone based chalcones was screened against T.b. brucei and nine potent hits, having IC50 values between 0.5–8.9 µM, were found. The SAR studies of this series could provide useful information in guiding future exploration of this class of compounds in search of more potent, safe, and low cost anti-trypanosomal agents.
- Full Text:
- Date Issued: 2019
- Authors: Beteck, Richard M , Legoabe, Lesetje J , Isaacs, Michelle , Hoppe, Heinrich C
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/158280 , vital:40169 , https://doi.org/10.3354/meps12953
- Description: Human African trypanosomiasis is a neglected infectious disease that affects mostly people living in the rural areas of Africa. Current treatment options are limited to just four drugs that have been in use of four to nine decades. The life-threatening toxic side-effects associated with the use of these drugs are disconcerting. Poor efficacy, low oral bioavailability, and high cost are other shortcomings of current HAT treatments. Evaluating the potentials of known hits for other therapeutic areas may be a fast and convenient method to discover new hit compounds against alternative targets. A library of 34 known indanone based chalcones was screened against T.b. brucei and nine potent hits, having IC50 values between 0.5–8.9 µM, were found. The SAR studies of this series could provide useful information in guiding future exploration of this class of compounds in search of more potent, safe, and low cost anti-trypanosomal agents.
- Full Text:
- Date Issued: 2019
In vitro antimalarial, antitrypanosomal and HIV-1 integrase inhibitory activities of two Cameroonian medicinal plants
- Fouokeng, Yannick, Feumo Feusso, H M, Mbosso Teinkela, Jean E, Siwe-Noundou, Xavier, Wintjens, René T, Isaacs, Michelle, Hoppe, Heinrich, Krause, Rui W M, Azébazé, Anatole G B, Vardamides, Juliette C
- Authors: Fouokeng, Yannick , Feumo Feusso, H M , Mbosso Teinkela, Jean E , Siwe-Noundou, Xavier , Wintjens, René T , Isaacs, Michelle , Hoppe, Heinrich , Krause, Rui W M , Azébazé, Anatole G B , Vardamides, Juliette C
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/195014 , vital:45519 , xlink:href="https://doi.org/10.1016/j.sajb.2018.10.008"
- Description: Antiplasmodial, antitrypanosomal and anti-HIV-1 activities of crude extracts, fractions and some isolated compounds from two Cameroonian medicinal plants: Antrocaryon klaineanum Pierre (Anacardiaceae) and Diospyros conocarpa Gürke ex K. Schum. (Ebenaceae) were assessed. The phytochemical studies led to the isolation of eight compounds (1–8) from Diospyros conocarpa and six compounds (6, 9–13) from Antrocaryon klaineanum. These compounds were identified as mangiferolic acid (1), 3β, 22(S)-dihydroxycycloart-24E-en-26-oic acid (2), lupeol (3), aridanin (4), betulin (5), betulinic acid (6), bergenin (7), D-quercitol(8), entilin C(9), entilin A(10), antrocarine A(11), 7R,20(S)-dihydroxy-4,24(28)-ergostadien-3-one(12) and stigmasterol glucoside (13). The criteria for activity were set as follows: an IC50 value more than 10 μg/mL for crude extracts and more than 1 μg/mL for pure compounds. The hexane/ethyl acetate (1:1) fraction of A.klaineanum root bark (AKERF1) and the hexane/ethyl acetate (1:1) fraction of A.klaineanum trunk bark (AKETF1) presented the strongest antiplasmodial activities with IC50 values of 0.4 and 4.4 μg/mL, respectively. Aridanin (4) and antrocarine A(11), as well as the crude extract of D.conocarpa roots (EDCR), AKERF1 and AKETF1 showed moderate trypanocidal effects. The crude extract of A.klaineanum root bark (AKER) and AKETF1 exhibited attractive activities on HIV-1 integrase with IC50 values of 1.96 and 24.04 μg/mL, respectively. The results provide baseline information on the use of A.klaineanum and D.conocarpa extracts, as well as certain components, as sources of new antiplasmodial, antitrypanosomal and anti-HIV drugs.
- Full Text:
- Date Issued: 2019
- Authors: Fouokeng, Yannick , Feumo Feusso, H M , Mbosso Teinkela, Jean E , Siwe-Noundou, Xavier , Wintjens, René T , Isaacs, Michelle , Hoppe, Heinrich , Krause, Rui W M , Azébazé, Anatole G B , Vardamides, Juliette C
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/195014 , vital:45519 , xlink:href="https://doi.org/10.1016/j.sajb.2018.10.008"
- Description: Antiplasmodial, antitrypanosomal and anti-HIV-1 activities of crude extracts, fractions and some isolated compounds from two Cameroonian medicinal plants: Antrocaryon klaineanum Pierre (Anacardiaceae) and Diospyros conocarpa Gürke ex K. Schum. (Ebenaceae) were assessed. The phytochemical studies led to the isolation of eight compounds (1–8) from Diospyros conocarpa and six compounds (6, 9–13) from Antrocaryon klaineanum. These compounds were identified as mangiferolic acid (1), 3β, 22(S)-dihydroxycycloart-24E-en-26-oic acid (2), lupeol (3), aridanin (4), betulin (5), betulinic acid (6), bergenin (7), D-quercitol(8), entilin C(9), entilin A(10), antrocarine A(11), 7R,20(S)-dihydroxy-4,24(28)-ergostadien-3-one(12) and stigmasterol glucoside (13). The criteria for activity were set as follows: an IC50 value more than 10 μg/mL for crude extracts and more than 1 μg/mL for pure compounds. The hexane/ethyl acetate (1:1) fraction of A.klaineanum root bark (AKERF1) and the hexane/ethyl acetate (1:1) fraction of A.klaineanum trunk bark (AKETF1) presented the strongest antiplasmodial activities with IC50 values of 0.4 and 4.4 μg/mL, respectively. Aridanin (4) and antrocarine A(11), as well as the crude extract of D.conocarpa roots (EDCR), AKERF1 and AKETF1 showed moderate trypanocidal effects. The crude extract of A.klaineanum root bark (AKER) and AKETF1 exhibited attractive activities on HIV-1 integrase with IC50 values of 1.96 and 24.04 μg/mL, respectively. The results provide baseline information on the use of A.klaineanum and D.conocarpa extracts, as well as certain components, as sources of new antiplasmodial, antitrypanosomal and anti-HIV drugs.
- Full Text:
- Date Issued: 2019
Inhibition of aluminium corrosion using benzothiazole and its phthalocyanine derivative
- Nnaji, Nnaemeka, Nwaji, Njemuwa, Fomo, Gertrude, Mack, John, Nyokong, Tebello
- Authors: Nnaji, Nnaemeka , Nwaji, Njemuwa , Fomo, Gertrude , Mack, John , Nyokong, Tebello
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/186949 , vital:44550 , xlink:href="https://doi.org/10.1007/s12678-019-00538-1"
- Description: Cyclic voltammetry and potentiodynamic polarization techniques were used to study the effects of 4-[4-(1,3-benzothiazol2yl)phenoxy] phthalonitrile (BT) and tetrakis[(benzo[d]thiazol-2ylphenoxy) phthalocyaninato] gallium(III)chloride (ClGaBTPc) as aluminium corrosion inhibitors in 1.0 M hydrochloric acid. The presence of the inhibitors in the concentration range of 2 to 10 μM was found to retard the aluminium corrosion process such that the inhibition efficiency was found to range from 28.2 to 76.1% for BT and from 71.5 to 82.7% for ClGaBTPc. The latter was a better inhibitor. Scanning electron microscopy and energy-dispersive X-ray measurements reveal effective metal surface protection by the inhibitors, most probably by shielding it from the corrosion attacks of Cl− from the acid. The calculated quantum chemical parameters agreed with experimental results.
- Full Text:
- Date Issued: 2019
- Authors: Nnaji, Nnaemeka , Nwaji, Njemuwa , Fomo, Gertrude , Mack, John , Nyokong, Tebello
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/186949 , vital:44550 , xlink:href="https://doi.org/10.1007/s12678-019-00538-1"
- Description: Cyclic voltammetry and potentiodynamic polarization techniques were used to study the effects of 4-[4-(1,3-benzothiazol2yl)phenoxy] phthalonitrile (BT) and tetrakis[(benzo[d]thiazol-2ylphenoxy) phthalocyaninato] gallium(III)chloride (ClGaBTPc) as aluminium corrosion inhibitors in 1.0 M hydrochloric acid. The presence of the inhibitors in the concentration range of 2 to 10 μM was found to retard the aluminium corrosion process such that the inhibition efficiency was found to range from 28.2 to 76.1% for BT and from 71.5 to 82.7% for ClGaBTPc. The latter was a better inhibitor. Scanning electron microscopy and energy-dispersive X-ray measurements reveal effective metal surface protection by the inhibitors, most probably by shielding it from the corrosion attacks of Cl− from the acid. The calculated quantum chemical parameters agreed with experimental results.
- Full Text:
- Date Issued: 2019
Interactions between two biological control agents and their target weed: a beetle, a bug and a cactus weed
- Mnqeta, Zezethu, Paterson, Iain D
- Authors: Mnqeta, Zezethu , Paterson, Iain D
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/417475 , vital:71456 , xlink:href="https://doi.org/10.1080/09583157.2019.1631960"
- Description: Pereskia aculeata Miller (Cactaceae) is an invasive alien shrub introduced into South Africa from Brazil. The leaf-feeding beetle, Phenrica guerini Bechyne (Chrysomelidae), was released as a biological control agent in South Africa in 1991 followed by the stem-wilting bug, Catorhintha schaffneri Brailovsky and Garcia (Coreidae), in 2014. This study investigated the interactions between the two agents under laboratory conditions. Potted plants were exposed to one of four treatments: control (no agents), P. guerini only, C. schaffneri only and both species together. Four densities, ranging from 2 to 12 insects per plant were used. Cathorhitha schaffneri alone at low to moderate densities resulted in the same reduction in number of leaves and shoot length as when combine with P. guerini. At the highest density, C. schaffneri reduced the number of leaves significantly more than any treatment. Mortality of P. guerini was significantly higher than C. schaffneri at the highest density when in combination. The antagonistic interaction between P. guerini and C. schaffneri suggests that these agents should not be released together because this would impact negatively on the overall biocontrol programme against P. aculeata. It is recommended that C. schaffneri should be released at sites where P. guerini is not present. Extrapolation of laboratory-based studies into the field is often challenging, so mass-rearing and releases of P. guerini should continue until there is convincing proof that C. schaffneri alone is more effective than P. guerini in the field.
- Full Text:
- Date Issued: 2019
- Authors: Mnqeta, Zezethu , Paterson, Iain D
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/417475 , vital:71456 , xlink:href="https://doi.org/10.1080/09583157.2019.1631960"
- Description: Pereskia aculeata Miller (Cactaceae) is an invasive alien shrub introduced into South Africa from Brazil. The leaf-feeding beetle, Phenrica guerini Bechyne (Chrysomelidae), was released as a biological control agent in South Africa in 1991 followed by the stem-wilting bug, Catorhintha schaffneri Brailovsky and Garcia (Coreidae), in 2014. This study investigated the interactions between the two agents under laboratory conditions. Potted plants were exposed to one of four treatments: control (no agents), P. guerini only, C. schaffneri only and both species together. Four densities, ranging from 2 to 12 insects per plant were used. Cathorhitha schaffneri alone at low to moderate densities resulted in the same reduction in number of leaves and shoot length as when combine with P. guerini. At the highest density, C. schaffneri reduced the number of leaves significantly more than any treatment. Mortality of P. guerini was significantly higher than C. schaffneri at the highest density when in combination. The antagonistic interaction between P. guerini and C. schaffneri suggests that these agents should not be released together because this would impact negatively on the overall biocontrol programme against P. aculeata. It is recommended that C. schaffneri should be released at sites where P. guerini is not present. Extrapolation of laboratory-based studies into the field is often challenging, so mass-rearing and releases of P. guerini should continue until there is convincing proof that C. schaffneri alone is more effective than P. guerini in the field.
- Full Text:
- Date Issued: 2019
International book donors and public libraries as partners in primary school literacy development in Kenya:
- Mose, Peter, Kaschula, Russell H
- Authors: Mose, Peter , Kaschula, Russell H
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/174783 , vital:42509 , https://doi.org/10.1108/LM-05-2018-0046
- Description: The purpose of this paper is to explore the impact of international library materials aid in primary schools and to outline obstacles to effective utilization for maximum literacy benefits among primary school children. Data were gathered via interviews, observation, focus group discussions and document analyses.
- Full Text:
- Date Issued: 2019
- Authors: Mose, Peter , Kaschula, Russell H
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/174783 , vital:42509 , https://doi.org/10.1108/LM-05-2018-0046
- Description: The purpose of this paper is to explore the impact of international library materials aid in primary schools and to outline obstacles to effective utilization for maximum literacy benefits among primary school children. Data were gathered via interviews, observation, focus group discussions and document analyses.
- Full Text:
- Date Issued: 2019
Intersecting Diasporas:
- Authors: Naidu, Samantha
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/158034 , vital:40141 , DOI: 10.1080/18125441.2019.1661597
- Description: With increased mobility enabled by evolving technology, the world experiences higher rates of migration and globalisation than ever before. This phenomenon has led, in recent years, to a high volume of literature about migration and diaspora, i.e. literature which deals with the general theme of transnationalism. The term transnational, in its simplest guise, refers to the relations between citizens of different nation states and the networks which link them. It also refers to the complex subjectivity of those who migrate. Scholars emphasise that transnationalism, because of heterogeneity and diversity, gives rise to a site for dynamic social and cultural change. At the same time, continuity is a necessary feature of this site. The co-existence of change and continuity (a focused process of adaptation and assimilation which simultaneously considers the role of memory, the past, and ties to homeland) then is also a defining element of transnationalism.
- Full Text:
- Date Issued: 2019
- Authors: Naidu, Samantha
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/158034 , vital:40141 , DOI: 10.1080/18125441.2019.1661597
- Description: With increased mobility enabled by evolving technology, the world experiences higher rates of migration and globalisation than ever before. This phenomenon has led, in recent years, to a high volume of literature about migration and diaspora, i.e. literature which deals with the general theme of transnationalism. The term transnational, in its simplest guise, refers to the relations between citizens of different nation states and the networks which link them. It also refers to the complex subjectivity of those who migrate. Scholars emphasise that transnationalism, because of heterogeneity and diversity, gives rise to a site for dynamic social and cultural change. At the same time, continuity is a necessary feature of this site. The co-existence of change and continuity (a focused process of adaptation and assimilation which simultaneously considers the role of memory, the past, and ties to homeland) then is also a defining element of transnationalism.
- Full Text:
- Date Issued: 2019
Investigation of novel substituted zinc and aluminium phthalocyanines for photodynamic therapy of epithelial breast cancer
- Mohammed, Imadalulla, Oluwole, David O, Nemakal, Majunatha, Sannegowda, Lokesh K, Nyokong, Tebello
- Authors: Mohammed, Imadalulla , Oluwole, David O , Nemakal, Majunatha , Sannegowda, Lokesh K , Nyokong, Tebello
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/186824 , vital:44537 , xlink:href="https://doi.org/10.1016/j.dyepig.2019.107592"
- Description: A series of phthalonitrile ligands were synthesized by nucleophilic substitution reaction using the hydroxyl or sulfanyl group precursors and the nitro moiety of the nitrophthalonitrile to yield corresponding oxy or sulfanyl bridged ligands. These ligands were subsequently subjected to cyclocondensation reaction with diamagnetic metal ions like zinc and aluminium to afford symmetrically substituted zinc and aluminium phthalocyanine (Pc) complexes and polymers. The ligands and Pc complexes were characterized by 1 H nuclear magnetic resonance, fourier transform infrared, ultraviolet visible and mass spectrometric techniques. Additionally, thermal gravimetric, and elemental analyzer were used for characterization of the Pc complexes. The photophysical and photochemical behaviour of the Pc complexes were investigated in dimethyl sulfoxide. Additionally, the complexes were tested against epithelial breast cancer cells for photodynamic therapy (PDT) effect. The substituted ZnPc complexes afforded higher singlet oxygen quantum yields as compared to the AlPc analogue. All the complexes showed innocuous invitro dark cytotoxicity and moderate PDT effect.
- Full Text:
- Date Issued: 2019
- Authors: Mohammed, Imadalulla , Oluwole, David O , Nemakal, Majunatha , Sannegowda, Lokesh K , Nyokong, Tebello
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/186824 , vital:44537 , xlink:href="https://doi.org/10.1016/j.dyepig.2019.107592"
- Description: A series of phthalonitrile ligands were synthesized by nucleophilic substitution reaction using the hydroxyl or sulfanyl group precursors and the nitro moiety of the nitrophthalonitrile to yield corresponding oxy or sulfanyl bridged ligands. These ligands were subsequently subjected to cyclocondensation reaction with diamagnetic metal ions like zinc and aluminium to afford symmetrically substituted zinc and aluminium phthalocyanine (Pc) complexes and polymers. The ligands and Pc complexes were characterized by 1 H nuclear magnetic resonance, fourier transform infrared, ultraviolet visible and mass spectrometric techniques. Additionally, thermal gravimetric, and elemental analyzer were used for characterization of the Pc complexes. The photophysical and photochemical behaviour of the Pc complexes were investigated in dimethyl sulfoxide. Additionally, the complexes were tested against epithelial breast cancer cells for photodynamic therapy (PDT) effect. The substituted ZnPc complexes afforded higher singlet oxygen quantum yields as compared to the AlPc analogue. All the complexes showed innocuous invitro dark cytotoxicity and moderate PDT effect.
- Full Text:
- Date Issued: 2019
Knowledge and knowledge sources on the importance of fruits for nutritional security are unaffected by deforestation status in Cameroon
- Ijang, T N P, Shackleton, Charlie M, Degrande, A
- Authors: Ijang, T N P , Shackleton, Charlie M , Degrande, A
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/177454 , vital:42823 , DOI: 10.17660/th2019/74.6.2
- Description: The Congo basin forest is experiencing increasing rate of deforestation, and is prone to inconsistent food supply and sporadic food shortages with corresponding high levels of malnutrition. Maintenance or planting of fruit trees can help mitigate deforestation while supplying fruits for home consumption. However, data on rates of fruit consumption are lacking for many developing countries, including Cameroon.
- Full Text:
- Date Issued: 2019
- Authors: Ijang, T N P , Shackleton, Charlie M , Degrande, A
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/177454 , vital:42823 , DOI: 10.17660/th2019/74.6.2
- Description: The Congo basin forest is experiencing increasing rate of deforestation, and is prone to inconsistent food supply and sporadic food shortages with corresponding high levels of malnutrition. Maintenance or planting of fruit trees can help mitigate deforestation while supplying fruits for home consumption. However, data on rates of fruit consumption are lacking for many developing countries, including Cameroon.
- Full Text:
- Date Issued: 2019
Landscape, memory and learning to change in changing worlds: Contemplating intergenerational learning and traditional knowledge practices within social-ecological landscapes of change
- O'Donoghue, Rob B, Sandoval-Rivera, Juan Carlos, Payyappallimana, Unnikrishnan
- Authors: O'Donoghue, Rob B , Sandoval-Rivera, Juan Carlos , Payyappallimana, Unnikrishnan
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/388061 , vital:68304 , xlink:href="https://www.ajol.info/index.php/sajee/article/view/187218"
- Description: The core paper and collection of short papers from Mexico, Africa, India and Sweden that make up this study on social-ecological landscapes developed as a South–South collaboration that was extended to include a case in the North. Our concern was to explore how situated, intergenerational knowledge commonly takes a back seat to the conceptual propositions that the environmental sciences have developed around matters of concern like biodiversity loss. In this way, scientific propositions have become the conceptual capital for informing future sustainability through Education for Sustainable Development (ESD). In response to this, a more situated turn has developed to engage both intergenerational practices and the institutional sciences, but the playing fields are seldom level and deliberations are often rife with misunderstandings.
- Full Text:
- Date Issued: 2019
- Authors: O'Donoghue, Rob B , Sandoval-Rivera, Juan Carlos , Payyappallimana, Unnikrishnan
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/388061 , vital:68304 , xlink:href="https://www.ajol.info/index.php/sajee/article/view/187218"
- Description: The core paper and collection of short papers from Mexico, Africa, India and Sweden that make up this study on social-ecological landscapes developed as a South–South collaboration that was extended to include a case in the North. Our concern was to explore how situated, intergenerational knowledge commonly takes a back seat to the conceptual propositions that the environmental sciences have developed around matters of concern like biodiversity loss. In this way, scientific propositions have become the conceptual capital for informing future sustainability through Education for Sustainable Development (ESD). In response to this, a more situated turn has developed to engage both intergenerational practices and the institutional sciences, but the playing fields are seldom level and deliberations are often rife with misunderstandings.
- Full Text:
- Date Issued: 2019
Language policy and linguistic landscapes at schools in South Africa:
- Kaschula, Russell H, Kretzer, Michael M
- Authors: Kaschula, Russell H , Kretzer, Michael M
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/174635 , vital:42496 , https://doi.org/10.1080/14790718.2019.1666849
- Description: Language policy and Linguistic Landscapes (LL) are a highly contested area in South Africa. Due to Apartheid, the education system constitutes the core of such contestation. In Post-Apartheid South Africa the new Constitution of 1996, the South African Schools Act (SASA) and recent political initiatives such as the Use of Official Languages Act of 2012 form the foundation of language policy at schools. The Constitution declares 11 official languages on a macro-level. Nevertheless, English dominates the LL in South Africa. African Languages are significantly underrepresented in the public sphere. The vast majority of research emphasises the urban or semi-urban areas. This research tries to close the existing research gap with a broad comparative study in three research provinces.
- Full Text:
- Date Issued: 2019
- Authors: Kaschula, Russell H , Kretzer, Michael M
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/174635 , vital:42496 , https://doi.org/10.1080/14790718.2019.1666849
- Description: Language policy and Linguistic Landscapes (LL) are a highly contested area in South Africa. Due to Apartheid, the education system constitutes the core of such contestation. In Post-Apartheid South Africa the new Constitution of 1996, the South African Schools Act (SASA) and recent political initiatives such as the Use of Official Languages Act of 2012 form the foundation of language policy at schools. The Constitution declares 11 official languages on a macro-level. Nevertheless, English dominates the LL in South Africa. African Languages are significantly underrepresented in the public sphere. The vast majority of research emphasises the urban or semi-urban areas. This research tries to close the existing research gap with a broad comparative study in three research provinces.
- Full Text:
- Date Issued: 2019