- Title
- Characterization and computational studies of 2-(benzamido) thiazol-5-yl benzoate
- Creator
- Odame, Felix, Hosten, Eric C, Betz, Richard, Lobb, Kevin A, Tshentu, Zenixole R
- Subject
- To be catalogued
- Date
- 2019
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/447003
- Identifier
- vital:74576
- Identifier
- xlink:href="https://doi.org/10.1134/S0022476619010190"
- Description
- Thiazoles have shown a broad range of biological activities and are found in many potent biologically active molecules such as Sulfathiazol (antimicrobial drug), Ritonavir (antiretroviral drug), Abafungin (antifungal drug), and Tiazofurin (antineoplastic drug) [1]. They have exhibited some degree of plant growth regulatory and antifungal activities [2], whilst some thiazoles have shown anti-infective [3] as well as antibacterial activities [4]. The regio-controlled synthesis of 2,5-disubstituted and 2,4,5-trisubstituted thiazoles from ethyl-2-bromo-5-chloro-4-thiazolecarboxylates using sequential palladium-catalyzed coupling reactions has been reported [5]. An efficient general method for the preparation of 2,4-di- and trisubsituted thiazoles is via P–TsOH. H2O-Catalyzed cyclization of trisubstituted propargylic alcohols with thioamides has been accomplished with moderate to excellent product yields under mild and standard conditions [6]. In the presence of triethylamine, (Z)-(2-acetoxyl-1-alkenyl) phenyl-λ3 iodanes reacts with thioureas or thioamides in methanol to afford 2,4- disubstituted thiazoles in good yields. The reaction is thought to proceed by the generation of highly reactive α-λ3 iodanyl ketones through ester exchange of the β-acetoxy group with liberation of methyl acetate, followed by nucleophilic substitutions with thioureas or thioamides [7].
- Format
- computer, online resource, application/pdf, 1 online resource (7 pages), pdf
- Publisher
- Springer
- Language
- English
- Relation
- Journal of Structural Chemistry, Odame, F., Hosten, E., Betz, R., Lobb, K. and Tshentu, Z., 2019. Characterization and computational studies of 2-(benzamido) thiazol-5-yl benzoate. Journal of Structural Chemistry, 60, pp.136-142, Journal of Structural Chemistry volume 60 p. 136 2019 1573-8779
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the SpringerLink Terms of Use Statement ( https://link.springer.com/termsandconditions)
- Rights
- Closed Access
- Hits: 155
- Visitors: 152
- Downloads: 5
Collections
Lobb, Kevin Allan (Assoc Prof)
RU Department of Chemistry
SDG 03. Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Characterization and computational studies of 2-(benzamido) thiazol-5-yl benzoate.pdf | 634 KB | Adobe Acrobat PDF | View Details Download |