- Title
- Dynamic mitochondrial localisation of STAT3 in the cellular adipogenesis model 3T3-L1:
- Creator
- Kramer, Adam H, Edkins, Adrienne L, Hoppe, Heinrich C, Prinsloo, Earl
- Date
- 2015
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/164885
- Identifier
- vital:41181
- Identifier
- DOI: 10.1002/jcb.25076
- Description
- A mechanistic relationship exists between protein localisation, activity and cellular differentiation. Understanding the contribution of these molecular mechanisms is required for elucidation of conditions that drive development. Literature suggests non‐canonical translocation of the Signal Transducer and Activator of Transcription 3 (STAT3) to the mitochondria contributes to the regulation of the electron transport chain, cellular respiration and reactive oxygen species production. Based on this we investigated the role of mitochondrial STAT3, specifically the serine 727 phosphorylated form, in cellular differentiation using the well‐defined mouse adipogenic model 3T3-L1.
- Format
- 9 pages, pdf
- Language
- English
- Relation
- Journal of Cellular Biochemistry, Kramer, A.H., Edkins, A.L., Hoppe, H.C. and Prinsloo, E., 2015. Dynamic mitochondrial localisation of STAT3 in the cellular adipogenesis model 3T3‐L1. Journal of Cellular Biochemistry, 116(7), pp.1232-1240, Journal of Cellular Biochemistry volume 116 number 7 1232 1240 January 2015 1097-4644
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Wiley Library Online Terms of Use Statement (https://onlinelibrary.wiley.com/terms-and-conditions)
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Collections
Prinsloo, Earl (Dr)
RU DST/NRF SARChI for Molecular and Cellular Biology of the Eukaryotic Stress Response
Edkins, Adrienne Lesley (Associate Prof)
RU DST/NRF SARChI for Biotechnology Innovation and Engagement
Hoppe, Heinrich C (Prof)
SDG 03. Good Health and Well-Being
RU Department of Biochemistry, Microbiology and Bioinformatics
SDG 09. Industry, Innovation and Infrastructure
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