Bearers of Memory: Georges Senga’s Assani’s ‘Cette maison n’est pas a vendre et a vendre
- Authors: Mukendi, Jean-Sylvain Tshilumba
- Date: 2017
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/147182 , vital:38600 , https://artthrob.co.za/2017/06/06/bearers-of-memory-georges-senga-assanis-cette-maison-nest-pas-a-vendre-et-a-vendre/
- Description: Dedicated to the work of emerging international photographers, the upper gallery of the new Market Photo Workshop relocated building is showcasing Georges Senga Assani’s latest series ‘Cette maison n’est pas à vendre et à vendre’ which translates as ‘This house is not for sale, and for sale’. The Lubumbashi-based photographer has been wandering his surroundings, alert to the passage of time and history. Immutable concepts like history and time leave traces. Time enforces memory, history bequeaths and infuses collective memory.
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- Date Issued: 2017
Development of Bioinformatics Infrastructure for Genomics Research:
- Authors: Mulder, Nicola J , Adebiyi, Ezekiel , Adebiyi, Marion , Adeyemi, Seun , Ahmed, Azza , Ahmed, Rehab , Akanle, Bola , Alibi, Mohamed , Armstrong, Don L , Aron, Shaun , Ashano, Efejiro , Baichoo, Shakuntala , Benkahla, Alia , Brown, David K , Chimusa, Emile Rugamika , Fadlelmola, Faisal M , Falola, Dare , Fatumo, Segun , Ghedira, Kais , Ghouila, Amel , Hazelhurst, Scott , Itunuoluwa Isewon , Segun Jung , Kassim, Samar Kamal , Kayondo, Jonathan K , Mbiyavanga, Mamana , Meintjes, Ayton , Mohammed, Somia , Mosaku, Abayomi , Moussa, Ahmed , Muhammd, Mustafa , Mungloo-Dilmohamud, Zahra , Nashiru, Oyekanmi , Odia, Trust , Okafor, Adaobi , Oladipo, Olaleye , Osamor, Victor , Oyelade, Jellili , Sadki, Khalid , Salifu, Samson Pandam , Soyemi, Jumoke , Panji, Sumir , Radouani, Fouzia , Souiai, Oussama , Tastan Bishop, Özlem
- Date: 2017
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/148239 , vital:38722 , DOI: 10.1016/j.gheart.2017.01.005
- Description: Although pockets of bioinformatics excellence have developed in Africa, generally, large-scale genomic data analysis has been limited by the availability of expertise and infrastructure. H3ABioNet, a pan-African bioinformatics network, was established to build capacity specifically to enable H3Africa (Human Heredity and Health in Africa) researchers to analyze their data in Africa. Since the inception of the H3Africa initiative, H3ABioNet's role has evolved in response to changing needs from the consortium and the African bioinformatics community.
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- Date Issued: 2017
Listening and the ambiguities of voice in South African journalism:
- Authors: Garman, Anthea , Malila, Vanessa
- Date: 2017
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/158394 , vital:40180 , https://doi.org/10.1080/02500167.2016.1226914
- Description: Political theorists like Bickford (1996) and media theorists like Couldry (2006) have introduced the concept of listening as a complement to long-standing discussions about voice in democracies and in the media which serve the democratic project. This enhanced understanding of voice goes beyond just hearing into giving serious attention to, in particular, marginalised voices. This article reports on an investigation into the ways in which mainstream and community media in the Eastern Cape, South Africa, understand listening as an important part of their role as journalists. Interviews probed the attitudes of journalists and editors towards listening, and also interrogated their own understandings of their role in South Africa, particularly in relation to young people who are finding their political “voice”.
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- Date Issued: 2017
Structure-based analysis of single nucleotide variants in the renin-angiotensinogen complex:
- Authors: Brown, David K , Olivier, Sheik Amamuddy , Tastan Bishop, Özlem
- Date: 2017
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/147994 , vital:38700 , https://doi.org/10.1016/j.gheart.2017.01.006
- Description: The renin-angiotensin system (RAS) plays an important role in regulating blood pressure and controlling sodium levels in the blood. Hyperactivity of this system has been linked to numerous conditions including hypertension, kidney disease, and congestive heart failure. Three classes of drugs have been developed to inhibit RAS. In this study, we provide a structure-based analysis of the effect of single nucleotide variants (SNVs) on the interaction between renin and angiotensinogen with the aim of revealing important residues and potentially damaging variants for further inhibitor design purposes.
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- Date Issued: 2017
The evaluation and validation of copper (II) force field parameters of the Auxiliary Activity family 9 enzymes:
- Authors: Moses, Vuyani , Tastan Bishop, Özlem , Lobb, Kevin A
- Date: 2017
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/148206 , vital:38719 , DOI: 10.1016/j.cplett.2017.04.022
- Description: The Auxiliary Activity family 9 (AA9) proteins are Cu2+ coordinating enzymes which are crucial for the early stages of cellulose degradation. In this study, the force field parameters for copper-containing bonds in the Type 1 AA9 protein active site were established and used in a molecular dynamics simulation on a solvated, neutralized system containing an AA9 protein, Cu2+ and a β-cellulose surface. The copper to cellulose interaction was evident during the dynamics, which could also be accelerated by the use of high Cu O van der Waals parameters. The interaction of AA9, Cu2+ and cellulose is described in detail.
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- Date Issued: 2017
The role of structural bioinformatics in drug discovery via computational SNP analysis–a proposed protocol for analyzing variation at the protein level:
- Authors: Brown, David K , Tastan Bishop, Özlem
- Date: 2017
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/162914 , vital:40996 , doi: 10.1016/j.gheart.2017.01.009
- Description: With the completion of the human genome project at the beginning of the 21st century, the biological sciences entered an unprecedented age of data generation, and made its first steps towards an era of personalized medicine. This abundance of sequence data has led to the proliferation of numerous sequence-based techniques for associating variation with disease, such as Genome-Wide Association Studies (GWAS) and Candidate Gene Association Studies (CGAS). However, these statistical methods do not provide an understanding of the functional effects of variation. Structure-based drug discovery and design is increasingly incorporating structural bioinformatics techniques to model and analyze protein targets, perform large scale virtual screening to identify hit to lead compounds, and simulate molecular interactions. These techniques are fast, cost-effective, and complement existing experimental techniques such as High Throughput Sequencing (HTS).
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- Date Issued: 2017