Anti-HIV-1 integrase potency of methylgallate from Alchornea cordifolia using in vitro and in silico approaches:
- Noundou, Xavier S, Musyoka, Thommas M, Moses, Vuyani, Ndinteh, Derek T, Mnkandhla, Dumisani, Hoppe, Heinrich C, Tastan Bishop, Özlem, Krause, Rui W M
- Authors: Noundou, Xavier S , Musyoka, Thommas M , Moses, Vuyani , Ndinteh, Derek T , Mnkandhla, Dumisani , Hoppe, Heinrich C , Tastan Bishop, Özlem , Krause, Rui W M
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/162975 , vital:41001 , https://0-doi.org.wam.seals.ac.za/10.1038/s41598-019-41403-x
- Description: According to the 2018 report of the United Nations Programme on HIV/AIDS (UNAIDS), acquired immune deficiency syndrome (AIDS), a disease caused by the human immunodeficiency virus (HIV), remains a significant public health problem. The non-existence of a cure or effective vaccine for the disease and the associated emergence of resistant viral strains imply an urgent need for the discovery of novel anti-HIV drug candidates. The current study aimed to identify potential anti-retroviral compounds from Alchornea cordifolia.
- Full Text:
- Date Issued: 2019
- Authors: Noundou, Xavier S , Musyoka, Thommas M , Moses, Vuyani , Ndinteh, Derek T , Mnkandhla, Dumisani , Hoppe, Heinrich C , Tastan Bishop, Özlem , Krause, Rui W M
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/162975 , vital:41001 , https://0-doi.org.wam.seals.ac.za/10.1038/s41598-019-41403-x
- Description: According to the 2018 report of the United Nations Programme on HIV/AIDS (UNAIDS), acquired immune deficiency syndrome (AIDS), a disease caused by the human immunodeficiency virus (HIV), remains a significant public health problem. The non-existence of a cure or effective vaccine for the disease and the associated emergence of resistant viral strains imply an urgent need for the discovery of novel anti-HIV drug candidates. The current study aimed to identify potential anti-retroviral compounds from Alchornea cordifolia.
- Full Text:
- Date Issued: 2019
Out of Africa?: a dated molecular phylogeny of the cicada tribe Platypleurini Schmidt (Hemiptera: Cicadidae), with a focus on African genera and the genus Platypleura Amyot and Audinet‐Serville
- Price, Benjamin W, Marshall, David C, Barker, Nigel P, Simon, Chris, Villet, Martin H
- Authors: Price, Benjamin W , Marshall, David C , Barker, Nigel P , Simon, Chris , Villet, Martin H
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/140704 , vital:37911 , DOI: 10.1111/syen.12360
- Description: The Platypleurini is a large group of charismatic cicadas distributed from Cape Agulhas in South Africa, through tropical Africa, Madagascar, India and eastern Asia to Japan, with generic diversity concentrated in equatorial and southern Africa. This distribution suggests the possibility of a Gondwanan origin and dispersal to eastern Asia from Africa or India. We used a four-gene (three mitochondrial) molecular dataset, fossil calibrations and molecular clock information to explore the phylogenetic relationships of the platypleurine cicadas and the timing and geography of their diversification. The earliest splits in the tribe were found to separate forest genera in Madagascar and equatorial Africa from the main radiation, and all of the Asian/Indian species sampled formed a younger clade nested well within the African taxa.
- Full Text:
- Date Issued: 2019
- Authors: Price, Benjamin W , Marshall, David C , Barker, Nigel P , Simon, Chris , Villet, Martin H
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/140704 , vital:37911 , DOI: 10.1111/syen.12360
- Description: The Platypleurini is a large group of charismatic cicadas distributed from Cape Agulhas in South Africa, through tropical Africa, Madagascar, India and eastern Asia to Japan, with generic diversity concentrated in equatorial and southern Africa. This distribution suggests the possibility of a Gondwanan origin and dispersal to eastern Asia from Africa or India. We used a four-gene (three mitochondrial) molecular dataset, fossil calibrations and molecular clock information to explore the phylogenetic relationships of the platypleurine cicadas and the timing and geography of their diversification. The earliest splits in the tribe were found to separate forest genera in Madagascar and equatorial Africa from the main radiation, and all of the Asian/Indian species sampled formed a younger clade nested well within the African taxa.
- Full Text:
- Date Issued: 2019
Speaking to power through newspaper editorials in Zimbabwe:
- Nyaungwa, Mathew, Garman, Anthea
- Authors: Nyaungwa, Mathew , Garman, Anthea
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/158438 , vital:40186 , https://0-doi.org.wam.seals.ac.za/10.1386/jams.11.1.51_1
- Description: This article seeks to provide an insight into the complex role that editorials – a newspaper’s institutional voice – play in highly polarised political contexts. It focuses on how the editorials of two Zimbabwean daily newspapers – The Herald, a progovernment newspaper, and NewsDay, a perceived pro-opposition newspaper – spoke to those in power at a time of transition from a government of national unity to majoritarian rule in 2013. The study also sets out to understand how both the newspapers’ editorials over this time responded to a contested political domain. Qualitative content analysis, rhetorical analysis and in-depth interviews were used to consider the tactics employed in the editorials to question and challenge the decisions and behaviours of those in positions of authority. The research findings contradict the common view in Zimbabwe that the privately–owned media blindly support the opposition while the state-owned media do the same with ZANU-PF. The findings show that in the period in question both newspapers exploited the editorial as a space to urge politicians to think of the national common good.
- Full Text:
- Date Issued: 2019
- Authors: Nyaungwa, Mathew , Garman, Anthea
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/158438 , vital:40186 , https://0-doi.org.wam.seals.ac.za/10.1386/jams.11.1.51_1
- Description: This article seeks to provide an insight into the complex role that editorials – a newspaper’s institutional voice – play in highly polarised political contexts. It focuses on how the editorials of two Zimbabwean daily newspapers – The Herald, a progovernment newspaper, and NewsDay, a perceived pro-opposition newspaper – spoke to those in power at a time of transition from a government of national unity to majoritarian rule in 2013. The study also sets out to understand how both the newspapers’ editorials over this time responded to a contested political domain. Qualitative content analysis, rhetorical analysis and in-depth interviews were used to consider the tactics employed in the editorials to question and challenge the decisions and behaviours of those in positions of authority. The research findings contradict the common view in Zimbabwe that the privately–owned media blindly support the opposition while the state-owned media do the same with ZANU-PF. The findings show that in the period in question both newspapers exploited the editorial as a space to urge politicians to think of the national common good.
- Full Text:
- Date Issued: 2019
- «
- ‹
- 1
- ›
- »