Heterodimer formation by Oct4 and Smad3 differentially regulates epithelial-to-mesenchymal transition-associated factors in breast cancer progression:

Mandal, Gunjan; Biswas, Subir; Chowdhury, Sougata R; Chatterjee, Annesha; Purohit, Suman; Khamaru, Poulomi; Chakraborty, Sayan; Mandal, Palash K; Gupta, Arnab; de la Mare, Jo-Anne; Edkins, Adrienne L; Bhattacharyya, Arindam

Title: Heterodimer formation by Oct4 and Smad3 differentially regulates epithelial-to-mesenchymal transition-associated factors in breast cancer progression:
Creator: Mandal, Gunjan, Biswas, Subir, Chowdhury, Sougata R, Chatterjee, Annesha, Purohit, Suman, Khamaru, Poulomi, Chakraborty, Sayan, Mandal, Palash K, Gupta, Arnab, de la Mare, Jo-Anne, Edkins, Adrienne L, Bhattacharyya, Arindam
Date: 2018
Type: text
Type: article
Identifier: http://hdl.handle.net/10962/164907
Identifier: vital:41183
Identifier: DOI: 10.1016/j.bbadis.2018.03.010
Description: The multifunctional cytokine TGF-β crucially participates in breast cancer (BCa) metastasis and works differently in the disease stages, thus contributing in BCa progression. We address connections between TGF-β and the stem cell-related transcription factor (TF) Oct4 in BCa. In 147 BCa patients with infiltrating duct carcinoma, we identified a significantly higher number of cases with both moderate/high Oct4 expression and high TGF-β in late stages compared to early stages of the disease.
Format: 14 pages, pdf
Language: English
Relation: Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, Mandal, G., Biswas, S., Chowdhury, S.R., Chatterjee, A., Purohit, S., Khamaru, P., Chakraborty, S., Mandal, P.K., Gupta, A., de la Mare, J.A. and Edkins, A.L., 2018. Heterodimer formation by Oct4 and Smad3 differentially regulates epithelial-to-mesenchymal transition-associated factors in breast cancer progression. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1864(6), pp.2053-2066, Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease volume 1864 number 6 2053 2066 2018 0925-4439
Rights: Publisher
Rights: Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)

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RU DST/NRF SARChI for Molecular and Cellular Biology of the Eukaryotic Stress Response

De la Mare, Jo-Anne (Dr)

Edkins, Adrienne Lesley (Associate Prof)

RU Department of Biochemistry, Microbiology and Bioinformatics

SDG 03. Good Health and Well-Being

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