Heterodimer formation by Oct4 and Smad3 differentially regulates epithelial-to-mesenchymal transition-associated factors in breast cancer progression:

- Mandal, Gunjan, Biswas, Subir, Chowdhury, Sougata R, Chatterjee, Annesha, Purohit, Suman, Khamaru, Poulomi, Chakraborty, Sayan, Mandal, Palash K, Gupta, Arnab, de la Mare, Jo-Anne, Edkins, Adrienne L, Bhattacharyya, Arindam

Title
Heterodimer formation by Oct4 and Smad3 differentially regulates epithelial-to-mesenchymal transition-associated factors in breast cancer progression:
Creator
Mandal, Gunjan, Biswas, Subir, Chowdhury, Sougata R, Chatterjee, Annesha, Purohit, Suman, Khamaru, Poulomi, Chakraborty, Sayan, Mandal, Palash K, Gupta, Arnab, de la Mare, Jo-Anne, Edkins, Adrienne L, Bhattacharyya, Arindam
Date
2018
Type
text
Type
article
Identifier
http://hdl.handle.net/10962/164907
Identifier
vital:41183
Identifier
DOI: 10.1016/j.bbadis.2018.03.010
Description
The multifunctional cytokine TGF-β crucially participates in breast cancer (BCa) metastasis and works differently in the disease stages, thus contributing in BCa progression. We address connections between TGF-β and the stem cell-related transcription factor (TF) Oct4 in BCa. In 147 BCa patients with infiltrating duct carcinoma, we identified a significantly higher number of cases with both moderate/high Oct4 expression and high TGF-β in late stages compared to early stages of the disease.
Format
14 pages, pdf
Language
English
Relation
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, Mandal, G., Biswas, S., Chowdhury, S.R., Chatterjee, A., Purohit, S., Khamaru, P., Chakraborty, S., Mandal, P.K., Gupta, A., de la Mare, J.A. and Edkins, A.L., 2018. Heterodimer formation by Oct4 and Smad3 differentially regulates epithelial-to-mesenchymal transition-associated factors in breast cancer progression. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1864(6), pp.2053-2066, Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease volume 1864 number 6 2053 2066 2018 0925-4439
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Publisher
Rights
Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
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RU DST/NRF SARChI for Molecular and Cellular Biology of the Eukaryotic Stress Response
De la Mare, Jo-Anne (Dr)
Edkins, Adrienne Lesley (Associate Prof)
RU Department of Biochemistry, Microbiology and Bioinformatics
SDG 03. Good Health and Well-Being
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