Cytotoxicity of lapachol, β-lapachone and related synthetic 1, 4-naphthoquinones against oesophageal cancer cells:
- Authors: Sunassee, Suthananda N , Veale, Clinton G L , Shunmoogam-Gounden, Nelusha , Osoniyi, Omalaja , Hendricks, Denver T , Caira, Mino R , De la Mare, Jo-Anne , Edkins, Adrienne L , Pinto, Antônio V , Da Silva Junior, Eufrânio N , Davies-Coleman, Michael T
- Date: 2013
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/165207 , vital:41218 , DOI: 10.1016/j.ejmech.2012.12.048
- Description: Naphthoquinones have been found to have a wide range of biological activities, including cytotoxicity to cancer cells. The secondary metabolites lapachol, α- and β-lapachone and a series of 25 related synthetic 1,4-naphthoquinones were screened against the oesophageal cancer cell line (WHCO1). Most of the compounds exhibited enhanced cytotoxicity (IC50 1.6–11.7 μM) compared to the current drug of choice cisplatin (IC50 = 16.5 μM).
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- Date Issued: 2013
Anti-oesophageal cancer activity in extracts of deep-water Marion Island sponges
- Authors: Davies-Coleman, Michael T , Froneman, P William , Keyzers, Robert A , Whibley, Catherine , Hendricks, Denver T , Samaai, Toufiek , McQuaid, Christopher D
- Date: 2005
- Language: English
- Type: Article
- Identifier: vital:6569 , http://hdl.handle.net/10962/d1004132
- Description: Oesophageal cancer is one of the most common causes of cancer-related deaths in South African black males. The limited efficacy of chemotherapeutic agents to treat this disease has prompted a search for potential new chemical entities with anticancer properties. We report here on the evidence for anti-oesophageal cancer activity in the methanolic extracts of five species of sponges dredged from a depth of approximately 100 m in the vicinity of Marion Island in the Southern Ocean during the autumn of 2004.
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- Date Issued: 2005