- Title
- Synthesis and anti-parasitic activity of C-benzylated (N-arylcarbamoyl) alkylphosphonate esters
- Creator
- Adeyemi, Christiana Modupe, Isaacs, Michelle, Mnkandhla, Dumisani, Krause, Rui W M, Klein, Rosalyn, Hoppe, Heinrich C, Lobb, Kevin A, Kaye, Perry T
- Date
- 2017
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/125641
- Identifier
- vital:35803
- Identifier
- https://doi.org/10.1016/j.tet.2017.01.045
- Description
- Unexpected substituent-dependent regioselectivty challenges in the synthesis of C-benzylated (N-arylcarbamoyl)phosphonate esters have been resolved. The C-benzylated N-furfurylcarbamoyl derivative showed low micromolar PfLDH inhibition, while one of the C-benzylated N-arylcarbamoyl analogues was active against Nagana Trypanosoma brucei parasites which are responsible for African trypanosomiasis in cattle.
- Format
- 7 pages, pdf
- Language
- English
- Relation
- Tetrahedron, Adeyemi, C.M., Isaacs, M., Mnkandhla, D., Klein, R., Hoppe, H.C., Krause, R.W., Lobb, K.A. and Kaye, P.T., 2017. Synthesis and anti-parasitic activity of C-benzylated (N-arylcarbamoyl) alkylphosphonate esters. Tetrahedron, 73(13), pp.1661-1667., Tetrahedron number 73 number 13 1661 1667 2017 0040-4020
- Rights
- Tetrahedron
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
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