- Title
- Un-functionalized gold nanoparticles as a simple colorimetric probe for sensitive and selective detection of dopamine
- Creator
- Khanyile, Nokuthula, Krause, Rui W M, Vilakazi, Sibulelo, Torto, Nelson
- Subject
- To be catalogued
- Date
- 2019
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/195048
- Identifier
- vital:45522
- Identifier
- xlink:href="http://dx.doi.org/10.17159/0379-4350/2019/v72a27"
- Description
- A dopamine (DA) colorimetric probe based on the growth and aggregation of un-functionalized gold nanoparticles (AuNPs) is reported. Upon addition of AuNPs to dopamine at various concentrations, the shape, size and colour change of the nanoparticles results in spectral shifts to higher wavelengths and hence colour change is the mode of detection. The colour change can be easily observed by the naked eye from as low as 5.0 nM DA, even under sub-optimal conditions. Under optimal pH conditions the calculated limit of detection was 2.5 nM (3σ). The probe was successfully applied to whole blood sample and showed good selectivity and sensitivity towards DA. The simple, sensitive and selective probe could be an excellent alternative for on-site and immediate detection of DA without the use of instrumentation and would thus be useful for rapid diagnostic applications.
- Format
- computer, online resource, application/pdf, 1 online resource (10 pages), pdf
- Publisher
- Sabinet
- Language
- English
- Relation
- South African Journal of Chemistry, Khanyile, N., Krause, R., Vilakazi, S. and Torto, N., 2019. Un-functionalized gold nanoparticles as a simple colorimetric probe for sensitive and selective detection of dopamine. South African Journal of Chemistry, 72, pp.207-214, South African Journal of Chemistry volume 72 p. 207 2019 1996-840X
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Sabinet Terms and Conditions Statement (https://www.sabinet.co.za/terms-conditions)
- Rights
- Open Access
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Collections
Torto, Nelson (Prof)
Krause, Rui Werner Maçedo (Prof)
RU Department of Chemistry
SDG 03. Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details | SOURCE1 | Un-functionalized gold nanoparticles as a simple colorimetric probe.pdf | 2 MB | Adobe Acrobat PDF | View Details |