- Title
- Inhibitory effects of selected cannabinoids against dipeptidyl peptidase IV, an enzyme linked to type 2 diabetes
- Creator
- Mkabayi, Lithalethu, Viljoen, Zenobia, Krause, Rui W M, Lobb, Kevin A, Pletschke, Brett I, Frost, Carminita L
- Subject
- To be catalogued
- Date
- 2024
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/452760
- Identifier
- vital:75168
- Identifier
- xlink:href="https://doi.org/10.1016/j.heliyon.2023.e23289"
- Description
- Ethnopharmacological relevance: In recent times the decriminalisation of cannabis globally has increased its use as an alternative medication. Where it has been used in modern medicinal practises since the 1800s, there is limited scientific investigation to understand the biological activities of this plant. Aim of the study: Dipeptidyl peptidase IV (DPP-IV) plays a key role in regulating glucose homeostasis, and inhibition of this enzyme has been used as a therapeutic approach to treat type 2 diabetes. However, some of the synthetic inhibitors for this enzyme available on the market may cause undesirable side effects. Therefore, it is important to identify new inhibitors of DPP-IV and to understand their interaction with this enzyme.
- Format
- computer, online resource, application/pdf, 1 online resource (15 pages), pdf
- Publisher
- Elsevier
- Language
- English
- Relation
- Heliyon, Mkabayi, L., Viljoen, Z., Krause, R.W., Lobb, K.A., Pletschke, B.I. and Frost, C.L., 2024. Inhibitory effects of selected cannabinoids against dipeptidyl peptidase IV, an enzyme linked to type 2 diabetes. Heliyon, 10(1), Heliyon volume 10 number 1 2024 2405-8440
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
- Rights
- Open Access
- Hits: 109
- Visitors: 104
- Downloads: 2
Collections
Krause, Rui Werner Maçedo (Prof)
Lobb, Kevin Allan (Assoc Prof)
Pletschke, Brett (Prof)
RU Department of Chemistry
RU Department of Biochemistry, Microbiology and Bioinformatics
SDG 03. Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Inhibitory effects of selected cannabinoids against dipeptidyl.pdf | 6 MB | Adobe Acrobat PDF | View Details Download |