Compounds isolation and biological activities of Piptadeniastrum africanum (hook. f.) Brennan (Fabaceae) roots:
- Teinkela, Jean E M, Noundou, Xavier S, Mimba, Jeanne E Z, Meyer, Franck, Tabouguia, Octavie M, Nguedia, Jules C A, Hoppe, Heinrich C, Krause, Rui W M, Wintjens, René, Azebaze, Anatole G B
- Authors: Teinkela, Jean E M , Noundou, Xavier S , Mimba, Jeanne E Z , Meyer, Franck , Tabouguia, Octavie M , Nguedia, Jules C A , Hoppe, Heinrich C , Krause, Rui W M , Wintjens, René , Azebaze, Anatole G B
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/150084 , vital:38938 , https://doi.org/10.1016/j.jep.2020.112716
- Description: The dicotyledonous plant Piptadeniastrum africanum (hook.f.) Brennan (Fabaceae) is used in traditional medicine to treat various human complaints including bronchitis, coughing, urino-genital ailments, meningitis, abdominal pain, treatment of wounds, malaria and gastrointestinal ailments, and is used as a purgative and worm expeller. The present study describes the phytochemical investigation and the determination of the antimicrobial, antiplasmodial and antitrypanosomal activities of crude extract, fractions and compounds extracted from Piptadeniastrum africanum roots.
- Full Text:
- Authors: Teinkela, Jean E M , Noundou, Xavier S , Mimba, Jeanne E Z , Meyer, Franck , Tabouguia, Octavie M , Nguedia, Jules C A , Hoppe, Heinrich C , Krause, Rui W M , Wintjens, René , Azebaze, Anatole G B
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/150084 , vital:38938 , https://doi.org/10.1016/j.jep.2020.112716
- Description: The dicotyledonous plant Piptadeniastrum africanum (hook.f.) Brennan (Fabaceae) is used in traditional medicine to treat various human complaints including bronchitis, coughing, urino-genital ailments, meningitis, abdominal pain, treatment of wounds, malaria and gastrointestinal ailments, and is used as a purgative and worm expeller. The present study describes the phytochemical investigation and the determination of the antimicrobial, antiplasmodial and antitrypanosomal activities of crude extract, fractions and compounds extracted from Piptadeniastrum africanum roots.
- Full Text:
Biological activities of plant extracts from Ficus elastica and Selaginella vogelli: an antimalarial, antitrypanosomal and cytotoxity evaluation
- Meyer, Franck, Isaacs, Michelle, Noundou, Xavier S, Krause, Rui W M, Teinkela, J E M, Hoppe, Heinrich C, Mpondo, Albert E M, Azebaze, Anatole G B, Nguemfo, Edwige L, Wintjens, Rene
- Authors: Meyer, Franck , Isaacs, Michelle , Noundou, Xavier S , Krause, Rui W M , Teinkela, J E M , Hoppe, Heinrich C , Mpondo, Albert E M , Azebaze, Anatole G B , Nguemfo, Edwige L , Wintjens, Rene
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/126142 , vital:35853 , https://doi.org/10.1016/j.sjbs.2017.07.002
- Description: The cytotoxic, antiplasmodial, and antitrypanosomal activities of two medicinal plants traditionally used in Cameroon were evaluated. Wood of Ficus elastica Roxb. ex Hornem. aerial roots (Moraceae) and Selaginella vogelii Spring (Selaginellaceae) leaves were collected from two different sites in Cameroon. In vitro cell-growth inhibition activities were assessed on methanol extract of plant materials against Plasmodium falciparum strain 3D7 and Trypanosoma brucei brucei, as well as against HeLa human cervical carcinoma cells. Criteria for activity were an IC50 value 10 μg/mL. The extract of S. vogelii did not significantly reduce the viability of P. falciparum at a concentration of 25 μg/mL but dramatically affected the trypanosome growth with an IC50 of 2.4 μg/mL. In contrast, at the same concentration, the extract of F. elastica exhibited plasmodiacidal activity (IC50 value of 9.5 μg/mL) and trypanocidal (IC50 value of 0.9 μg/mL) activity. Both extracts presented low cytotoxic effects on HeLa cancer cell line. These results indicate that the selected medicinal plants could be further investigated for identifying compounds that may be responsible for the observed activities and that may represent new leads in parasitical drug discovery.
- Full Text:
- Authors: Meyer, Franck , Isaacs, Michelle , Noundou, Xavier S , Krause, Rui W M , Teinkela, J E M , Hoppe, Heinrich C , Mpondo, Albert E M , Azebaze, Anatole G B , Nguemfo, Edwige L , Wintjens, Rene
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/126142 , vital:35853 , https://doi.org/10.1016/j.sjbs.2017.07.002
- Description: The cytotoxic, antiplasmodial, and antitrypanosomal activities of two medicinal plants traditionally used in Cameroon were evaluated. Wood of Ficus elastica Roxb. ex Hornem. aerial roots (Moraceae) and Selaginella vogelii Spring (Selaginellaceae) leaves were collected from two different sites in Cameroon. In vitro cell-growth inhibition activities were assessed on methanol extract of plant materials against Plasmodium falciparum strain 3D7 and Trypanosoma brucei brucei, as well as against HeLa human cervical carcinoma cells. Criteria for activity were an IC50 value 10 μg/mL. The extract of S. vogelii did not significantly reduce the viability of P. falciparum at a concentration of 25 μg/mL but dramatically affected the trypanosome growth with an IC50 of 2.4 μg/mL. In contrast, at the same concentration, the extract of F. elastica exhibited plasmodiacidal activity (IC50 value of 9.5 μg/mL) and trypanocidal (IC50 value of 0.9 μg/mL) activity. Both extracts presented low cytotoxic effects on HeLa cancer cell line. These results indicate that the selected medicinal plants could be further investigated for identifying compounds that may be responsible for the observed activities and that may represent new leads in parasitical drug discovery.
- Full Text:
In vitro antimicrobial activity of the methanol extract and compounds from the wood of Ficus elastica Roxb. ex Hornem. aerial roots
- Meyer, Franck, Fannang, Simone Véronique, Noundou, Xavier Siwe, Krause, Rui W M, Teinkela, Jean Emmanuel Mbosso, Vardamides, Juliette Cathérine, Mpondo, Albert Emmanuel Mpondo, Azebaze, Anatole Guy Blaise, Nguedia, Jules Clément Assob
- Authors: Meyer, Franck , Fannang, Simone Véronique , Noundou, Xavier Siwe , Krause, Rui W M , Teinkela, Jean Emmanuel Mbosso , Vardamides, Juliette Cathérine , Mpondo, Albert Emmanuel Mpondo , Azebaze, Anatole Guy Blaise , Nguedia, Jules Clément Assob
- Date: 2017
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/126154 , vital:35854 , https://doi.org/10.1016/j.sajb.2017.03.026
- Description: Ficus elastica Roxb. ex Hornem., an edible plant belonging to the family of Moraceae, is traditionally used against skin infections and allergies besides having diuretic properties. This study aimed at investigating the antimicrobial activity of the wood of F. elastica aerial roots against a set of bacteria (Staphylococcus aureus; Escherichia coli, Proteus vulgaris, Providencia stuartii and Pseudomonas aeruginosa) and a yeast (Candida albicans). A mixture of linear aliphatic alkanes with n-hexacosane as major compound, β-sitosterol, biochanin A, sitosteryl 3-O-β-D-glucopyranoside (1), elasticamide (2), elastiquinone (3) and ficusoside B (4) were purified and characterized. Antimicrobial activities, expressed as minimum inhibitory concentration (MIC), indicated that the methanol extract showed MIC of 39.1 μg/mL; the lowest values were obtained for 3 and 4, with MIC as low as 4.9 μg/mL, smaller than the values of reference antibiotics (25 μg/mL). Furthermore, as most of the studied samples exhibited Minimum Microbicidal Concentration/Minimum Inhibitory Concentration (MMC/MIC) ratios lower than 4, a microbicidal effect was clearly exhibited. The overall results provided evidence that the wood of F. elastica aerial roots, as well as some of its isolated components might be potential sources of new antimicrobial drugs.
- Full Text:
- Authors: Meyer, Franck , Fannang, Simone Véronique , Noundou, Xavier Siwe , Krause, Rui W M , Teinkela, Jean Emmanuel Mbosso , Vardamides, Juliette Cathérine , Mpondo, Albert Emmanuel Mpondo , Azebaze, Anatole Guy Blaise , Nguedia, Jules Clément Assob
- Date: 2017
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/126154 , vital:35854 , https://doi.org/10.1016/j.sajb.2017.03.026
- Description: Ficus elastica Roxb. ex Hornem., an edible plant belonging to the family of Moraceae, is traditionally used against skin infections and allergies besides having diuretic properties. This study aimed at investigating the antimicrobial activity of the wood of F. elastica aerial roots against a set of bacteria (Staphylococcus aureus; Escherichia coli, Proteus vulgaris, Providencia stuartii and Pseudomonas aeruginosa) and a yeast (Candida albicans). A mixture of linear aliphatic alkanes with n-hexacosane as major compound, β-sitosterol, biochanin A, sitosteryl 3-O-β-D-glucopyranoside (1), elasticamide (2), elastiquinone (3) and ficusoside B (4) were purified and characterized. Antimicrobial activities, expressed as minimum inhibitory concentration (MIC), indicated that the methanol extract showed MIC of 39.1 μg/mL; the lowest values were obtained for 3 and 4, with MIC as low as 4.9 μg/mL, smaller than the values of reference antibiotics (25 μg/mL). Furthermore, as most of the studied samples exhibited Minimum Microbicidal Concentration/Minimum Inhibitory Concentration (MMC/MIC) ratios lower than 4, a microbicidal effect was clearly exhibited. The overall results provided evidence that the wood of F. elastica aerial roots, as well as some of its isolated components might be potential sources of new antimicrobial drugs.
- Full Text:
- «
- ‹
- 1
- ›
- »