Detection of pharmaceutical residues in surface waters of the Eastern Cape Province:
- Vumazonke, Sesethu, Khamanga, Sandile M, Ngqwala, Nosiphiwe P
- Authors: Vumazonke, Sesethu , Khamanga, Sandile M , Ngqwala, Nosiphiwe P
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/149693 , vital:38875 , https://doi.org/10.3390/ijerph17114067
- Description: Pharmaceuticals are emerging contaminants in the aquatic environments. Their presence poses toxicological effects in humans and animals even at trace concentrations. This study investigated the presence of antibiotics, anti-epilepsy and anti-inflammatory drugs in river water of selected rivers in the Eastern Cape Province in South Africa. Enzyme-linked immunosorbent assay was used for screening of sulfamethoxazole and fluoroquinolones antibiotics. The samples were collected in upper-stream, middle-stream and lower-stream regions of the rivers and effluent of selected wastewater treatment plants. Pre-concentration of the samples was conducted using lyophilisation and extraction was conducted using solid phase extraction (SPE) on Waters Oasis hydrophilic-lipophilic-balanced cartridge.
- Full Text:
- Authors: Vumazonke, Sesethu , Khamanga, Sandile M , Ngqwala, Nosiphiwe P
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/149693 , vital:38875 , https://doi.org/10.3390/ijerph17114067
- Description: Pharmaceuticals are emerging contaminants in the aquatic environments. Their presence poses toxicological effects in humans and animals even at trace concentrations. This study investigated the presence of antibiotics, anti-epilepsy and anti-inflammatory drugs in river water of selected rivers in the Eastern Cape Province in South Africa. Enzyme-linked immunosorbent assay was used for screening of sulfamethoxazole and fluoroquinolones antibiotics. The samples were collected in upper-stream, middle-stream and lower-stream regions of the rivers and effluent of selected wastewater treatment plants. Pre-concentration of the samples was conducted using lyophilisation and extraction was conducted using solid phase extraction (SPE) on Waters Oasis hydrophilic-lipophilic-balanced cartridge.
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Occurrence of pharmaceuticals in aquatic environments: A review and potential impacts in South Africa
- Ngqwala, Nosiphiwe P, Muchesa, Petrus
- Authors: Ngqwala, Nosiphiwe P , Muchesa, Petrus
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/480551 , vital:78454 , https://hdl.handle.net/10520/EJC-1f60074845
- Description: The carbon footprint of pharmaceuticals through manufacturing, distribution, the incineration of unwanted pharmaceuticals as well as the packaging of pharmaceutical waste is an emerging and enormous challenge. Pharmaceuticals are major contributors to water pollution in aquatic environments that include surface water and groundwater. These pollutants arise not only from waste products but also from pharmaceutical products that have not been properly disposed of. The continuous exposure to unspecified sub-therapeutic doses of antibiotics presents risks to humans and other animals. Due to their extensive use and incomplete elimination, antibiotics have been detected in various environmental waters. The persistence of antibiotics in the environment and chronic exposure of organisms to these chemical stressors has also proven to have ecotoxicological effects. The prevailing emergence of antimicrobial resistance amongst bacteria is an area of primary concern, especially with regard to the release of antibiotics into the environment. Resistance is the acquired ability of bacterial populations to render an antibiotic ineffective as a result of a change in bacterial DNA which occurs when bacteria are subjected to an antibiotic concentration that will not kill them. A sub-lethal concentration possibly exerts a selective pressure that can result in the development of antimicrobial resistance in bacteria. It is clear that there is a need for extensive research to improve regulations and guidance on pharmaceutical waste management, pharmaceutical take-back programmes and consumer awareness.
- Full Text:
- Authors: Ngqwala, Nosiphiwe P , Muchesa, Petrus
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/480551 , vital:78454 , https://hdl.handle.net/10520/EJC-1f60074845
- Description: The carbon footprint of pharmaceuticals through manufacturing, distribution, the incineration of unwanted pharmaceuticals as well as the packaging of pharmaceutical waste is an emerging and enormous challenge. Pharmaceuticals are major contributors to water pollution in aquatic environments that include surface water and groundwater. These pollutants arise not only from waste products but also from pharmaceutical products that have not been properly disposed of. The continuous exposure to unspecified sub-therapeutic doses of antibiotics presents risks to humans and other animals. Due to their extensive use and incomplete elimination, antibiotics have been detected in various environmental waters. The persistence of antibiotics in the environment and chronic exposure of organisms to these chemical stressors has also proven to have ecotoxicological effects. The prevailing emergence of antimicrobial resistance amongst bacteria is an area of primary concern, especially with regard to the release of antibiotics into the environment. Resistance is the acquired ability of bacterial populations to render an antibiotic ineffective as a result of a change in bacterial DNA which occurs when bacteria are subjected to an antibiotic concentration that will not kill them. A sub-lethal concentration possibly exerts a selective pressure that can result in the development of antimicrobial resistance in bacteria. It is clear that there is a need for extensive research to improve regulations and guidance on pharmaceutical waste management, pharmaceutical take-back programmes and consumer awareness.
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Occurrence of selected endocrine disrupting compounds in the Eastern Cape province of South Africa:
- Farounbi, Adebayo I, Ngqwala, Nosiphiwe P
- Authors: Farounbi, Adebayo I , Ngqwala, Nosiphiwe P
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/148447 , vital:38740 , DOI: 10.1007/s11356-020-08082-y
- Description: Endocrine-disrupting compounds are attracting attention worldwide because of their effects on living things in the environment. Ten endocrine disrupting compounds: 4-nonylphenol, 2,4-dichlorophenol, estrone, 17β-estradiol, bisphenol A, 4-tertoctylphenol, triclosan, atrazine, imidazole and 1,2,4-triazole were investigated in four rivers and wastewater treatment plants in this study. Rivers were sampled at upstream, midstream and downstream reaches, while the influent and effluent samples of wastewater were collected from treatment plants near the receiving rivers. Sample waters were freeze-dried followed by extraction of the organic content and purification by solid-phase extraction. Concentrations of the compounds in the samples were determined with ultra-high performance liquid chromatography-tandem mass spectrometry. The instrument was operated in the positive electrospray ionization (ESI) mode.
- Full Text:
- Authors: Farounbi, Adebayo I , Ngqwala, Nosiphiwe P
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/148447 , vital:38740 , DOI: 10.1007/s11356-020-08082-y
- Description: Endocrine-disrupting compounds are attracting attention worldwide because of their effects on living things in the environment. Ten endocrine disrupting compounds: 4-nonylphenol, 2,4-dichlorophenol, estrone, 17β-estradiol, bisphenol A, 4-tertoctylphenol, triclosan, atrazine, imidazole and 1,2,4-triazole were investigated in four rivers and wastewater treatment plants in this study. Rivers were sampled at upstream, midstream and downstream reaches, while the influent and effluent samples of wastewater were collected from treatment plants near the receiving rivers. Sample waters were freeze-dried followed by extraction of the organic content and purification by solid-phase extraction. Concentrations of the compounds in the samples were determined with ultra-high performance liquid chromatography-tandem mass spectrometry. The instrument was operated in the positive electrospray ionization (ESI) mode.
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Preliminary study on the potential use of Fly Ash as a Ventilated Improved Pit Latrine Additive:
- Collings, Dylan, Tandlich, Roman, Dube, Cyril S, Madikizela, Phindile, Ngqwala, Nosiphiwe P, Ahmed, Mustaque
- Authors: Collings, Dylan , Tandlich, Roman , Dube, Cyril S , Madikizela, Phindile , Ngqwala, Nosiphiwe P , Ahmed, Mustaque
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/160334 , vital:40436 , https://0-doi.org.wam.seals.ac.za/10.5276/JSWTM/2019.395
- Description: This study describes the results of a series of laboratory experiments on aimed at developing of a protocol for the use of fly ash as a pit additive in the ventilated improved pit latrines (VIPs) in South Africa. Model VIP vaults were prepared in the laboratory and filled with synthetic faecal sludge; and dosed with fly ash in amounts ranging from 5 to 20 % (w/w).
- Full Text:
- Authors: Collings, Dylan , Tandlich, Roman , Dube, Cyril S , Madikizela, Phindile , Ngqwala, Nosiphiwe P , Ahmed, Mustaque
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/160334 , vital:40436 , https://0-doi.org.wam.seals.ac.za/10.5276/JSWTM/2019.395
- Description: This study describes the results of a series of laboratory experiments on aimed at developing of a protocol for the use of fly ash as a pit additive in the ventilated improved pit latrines (VIPs) in South Africa. Model VIP vaults were prepared in the laboratory and filled with synthetic faecal sludge; and dosed with fly ash in amounts ranging from 5 to 20 % (w/w).
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