The modulation of the photophysical and photodynamic therapy activities of a phthalocyanine by detonation nanodiamonds: Comparison with graphene quantum dots and carbon nanodots
- Matshitse, Refilwe, Managa, Muthumuni, Nyokong, Tebello
- Authors: Matshitse, Refilwe , Managa, Muthumuni , Nyokong, Tebello
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/186690 , vital:44525 , xlink:href="https://doi.org/10.1016/j.diamond.2019.107617"
- Description: A positively charged phthalocyanine (2,9,16,23-tetrakis[4-(N-methylpyridyloxy)]-phthalocyanine (ZnTPPcQ)) was non-covalently linked to carbon based nanoparticles: detonation nanodiamonds (DNDs), carbon dots (CDs) and graphene quantum dots (GQDs) to form nanosembles of DNDs-ZnTPPcQ, GQDs-ZnTPPcQ and CDs-ZnTPPcQ, respectively. Irrespective of its small size and the least number of Pcs (41.67 μg loading per milligram of DNDs), DNDs-ZnTPPcQ gave the highest singlet oxygen quantum yield (0.62) in dimethyl sulfoxide compared to the rest of the conjugates. This resulted in superior PDT activity against MCF7 breast cancer lines, with the lowest cell viability of 28% compared to ZnTPPcQ-CDs and ZnTPPcQ-GQDs at 30.1 ± 0.02% and 31.4 ± 0.23%, respectively.
- Full Text:
- Authors: Matshitse, Refilwe , Managa, Muthumuni , Nyokong, Tebello
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/186690 , vital:44525 , xlink:href="https://doi.org/10.1016/j.diamond.2019.107617"
- Description: A positively charged phthalocyanine (2,9,16,23-tetrakis[4-(N-methylpyridyloxy)]-phthalocyanine (ZnTPPcQ)) was non-covalently linked to carbon based nanoparticles: detonation nanodiamonds (DNDs), carbon dots (CDs) and graphene quantum dots (GQDs) to form nanosembles of DNDs-ZnTPPcQ, GQDs-ZnTPPcQ and CDs-ZnTPPcQ, respectively. Irrespective of its small size and the least number of Pcs (41.67 μg loading per milligram of DNDs), DNDs-ZnTPPcQ gave the highest singlet oxygen quantum yield (0.62) in dimethyl sulfoxide compared to the rest of the conjugates. This resulted in superior PDT activity against MCF7 breast cancer lines, with the lowest cell viability of 28% compared to ZnTPPcQ-CDs and ZnTPPcQ-GQDs at 30.1 ± 0.02% and 31.4 ± 0.23%, respectively.
- Full Text:
Theoretical and photodynamic therapy characteristics of heteroatom doped detonation nanodiamonds linked to asymmetrical phthalocyanine for eradication of breast cancer cells
- Matshitse, Refilwe, Tshiwawa, Tendamudzimu, Managa, Muthumuni, Nwaji, Njemuwa, Lobb, Kevin A, Nyokong, Tebello
- Authors: Matshitse, Refilwe , Tshiwawa, Tendamudzimu , Managa, Muthumuni , Nwaji, Njemuwa , Lobb, Kevin A , Nyokong, Tebello
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/186089 , vital:44462 , xlink:href="https://doi.org/10.1016/j.jlumin.2020.117465"
- Description: An amide mono substituted benzothiozole phthalocyanine: zinc(II) 3-(4-((3,17,23-tris(4-(benzo [d]thiazol-2-yl)phenoxy)-9-yl)oxy) phenyl)amide phthalocyanine (NH2BzPc) was covalently linked to undoped and heteroatom doped detonation nanodiamonds (DNDs): B@DNDs, P@DNDs, S@DNDs, N@DNDs, and SandN@DNDs There is a drastic decrease in highest occupied molecular orbital (HOMO) – lowest unoccupied molecular orbital (LUMO) energy gaps for nanoconjugates compared to DNDs alone. B@DNDs-NH2BzPc, SandN@DNDs-NH2BzPc, and P@DNDs-NH2BzPc showed superior photodynamic therapy (PDT) effects. DNDs-NH2BzPc also had a small HOMO-LUMO gap, but did not show improved PDT activity compared to the Pc alone, suggesting doping of DNDs is important. This study shows improved PDT effect on Michigan Cancer Foundation-7 breast cancer lines at 7.63%, 7.62% and 6.5% cell viability for P@DNDs-NH2BzPc, SandN@DNDs-NH2BzPc and B@DNDs-NH2BzPc, respectively.
- Full Text:
- Authors: Matshitse, Refilwe , Tshiwawa, Tendamudzimu , Managa, Muthumuni , Nwaji, Njemuwa , Lobb, Kevin A , Nyokong, Tebello
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/186089 , vital:44462 , xlink:href="https://doi.org/10.1016/j.jlumin.2020.117465"
- Description: An amide mono substituted benzothiozole phthalocyanine: zinc(II) 3-(4-((3,17,23-tris(4-(benzo [d]thiazol-2-yl)phenoxy)-9-yl)oxy) phenyl)amide phthalocyanine (NH2BzPc) was covalently linked to undoped and heteroatom doped detonation nanodiamonds (DNDs): B@DNDs, P@DNDs, S@DNDs, N@DNDs, and SandN@DNDs There is a drastic decrease in highest occupied molecular orbital (HOMO) – lowest unoccupied molecular orbital (LUMO) energy gaps for nanoconjugates compared to DNDs alone. B@DNDs-NH2BzPc, SandN@DNDs-NH2BzPc, and P@DNDs-NH2BzPc showed superior photodynamic therapy (PDT) effects. DNDs-NH2BzPc also had a small HOMO-LUMO gap, but did not show improved PDT activity compared to the Pc alone, suggesting doping of DNDs is important. This study shows improved PDT effect on Michigan Cancer Foundation-7 breast cancer lines at 7.63%, 7.62% and 6.5% cell viability for P@DNDs-NH2BzPc, SandN@DNDs-NH2BzPc and B@DNDs-NH2BzPc, respectively.
- Full Text:
- «
- ‹
- 1
- ›
- »