- Title
- Cytotoxicity of lapachol, β-lapachone and related synthetic 1, 4-naphthoquinones against oesophageal cancer cells:
- Creator
- Sunassee, Suthananda N, Veale, Clinton G L, Shunmoogam-Gounden, Nelusha, Osoniyi, Omalaja, Hendricks, Denver T, Caira, Mino R, de la Mare, Jo-Anne, Edkins, Adrienne L, Pinto, Antônio V, da Silva Junior, Eufrânio N, Davies-Coleman, Michael T
- Date
- 2013
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/165207
- Identifier
- vital:41218
- Identifier
- DOI: 10.1016/j.ejmech.2012.12.048
- Description
- Naphthoquinones have been found to have a wide range of biological activities, including cytotoxicity to cancer cells. The secondary metabolites lapachol, α- and β-lapachone and a series of 25 related synthetic 1,4-naphthoquinones were screened against the oesophageal cancer cell line (WHCO1). Most of the compounds exhibited enhanced cytotoxicity (IC50 1.6–11.7 μM) compared to the current drug of choice cisplatin (IC50 = 16.5 μM).
- Format
- 13 pages, pdf
- Language
- English
- Relation
- European journal of medicinal chemistry, Sunassee, S.N., Veale, C.G., Shunmoogam-Gounden, N., Osoniyi, O., Hendricks, D.T., Caira, M.R., de la Mare, J.A., Edkins, A.L., Pinto, A.V., da Silva Junior, E.N. and Davies-Coleman, M.T., 2013. Cytotoxicity of lapachol, β-lapachone and related synthetic 1, 4-naphthoquinones against oesophageal cancer cells. European journal of medicinal chemistry, 62, pp.98-110, European journal of medicinal chemistry volume 62 number 98 110 April 2013 1768-3254
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
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Sunassee, Suthananda N (Dr)
De la Mare, Jo-Anne (Dr)
Edkins, Adrienne Lesley (Associate Prof)
Veale, Clinton G L (Dr)
Davies-Coleman, Michael Trevor (Prof)
RU Department of Chemistry
RU Department of Biochemistry, Microbiology and Bioinformatics
SDG 03. Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details | SOURCE1 | Cytotoxicity of lapachol, β-lapachone and related synthetic 1, 4-naphthoquinones against oesophageal cancer cells.pdf | 681 KB | Adobe Acrobat PDF | View Details |