The use of response surface methodology and artificial neural networks for the establishment of a design space for a sustained release salbutamol sulphate formulation
- Authors: Chaibva, Faith Anesu
- Date: 2010
- Subjects: Salbutamol sulphate Artificial intelligence -- Medical applications Neural networks (Computer science) Response surfaces (Statistics) Pharmaceutical biotechnology -- Quality contro Drugs -- Design Pharmacokinetics Drugs -- Dosage forms Drugs -- Controlled release
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:3845 , http://hdl.handle.net/10962/d1010432
- Description: Quality by Design (QbD) is a systematic approach that has been recommended as suitable for the development of quality pharmaceutical products. The QbD approach commences with the definition of a quality target drug profile and predetermined objectives that are then used to direct the formulation development process with an emphasis on understanding the pharmaceutical science and manufacturing principles that apply to a product. The design space is directly linked to the use of QbD for formulation development and is a multidimensional combination and interaction of input variables and process parameters that have been demonstrated to provide an assurance of quality. The objective of these studies was to apply the principles of QbD as a framework for the optimisation of a sustained release (SR) formulation of salbutamol sulphate (SBS), and for the establishment of a design space using Response Surface Methodology (RSM) and Artificial Neural Networks (ANN). SBS is a short-acting ♭₂ agonist that is used for the management of asthma and chronic obstructive pulmonary disease (COPD). The use of a SR formulation of SBS may provide clinical benefits in the management of these respiratory disorders. Ashtalin®8 ER (Cipla Ltd., Mumbai, Maharashtra, India) was selected as a reference formulation for use in these studies. An Ishikawa or Cause and Effect diagram was used to determine the impact of formulation and process factors that have the potential to affect product quality. Key areas of concern that must be monitored include the raw materials, the manufacturing equipment and processes, and the analytical and assessment methods employed. The conditions in the laboratory and manufacturing processes were carefully monitored and recorded for any deviation from protocol, and equipment for assessment of dosage form performance, including dissolution equipment, balances and hardness testers, underwent regular maintenance. Preliminary studies to assess the potential utility of Methocel® Kl OOM, alone and in combination with other matrix forming polymers, revealed that the combination of this polymer with xanthan gum and Carbopol® has the potential to modulate the release of SBS at a specific rate, for a period of 12 hr. A central composite design using Methocel® KlOOM, xanthan gum, Carbopol® 974P and Surelease® as the granulating fluid was constructed to fully evaluate the impact of these formulation variables on the rate and extent of SBS release from manufactured formulations. The results revealed that although Methocel® KlOOM and xanthan gum had the greatest retardant effect on drug release, interactions between the polymers used in the study were also important determinants of the measureable responses. An ANN model was trained for optimisation using the data generated from a central composite study. The efficiency of the network was optimised by assessing the impact of the number of nodes in the hidden layer using a three layer Multi Layer Perceptron (MLP). The results revealed that a network with nine nodes in the hidden layer had the best predictive ability, suitable for application to formulation optimisation studies. Pharmaceutical optimisation was conducted using both the RSM and the trained ANN models. The results from the two optimisation procedures yielded two different formulation compositions that were subjected to in vitro dissolution testing using USP Apparatus 3. The results revealed that, although the formulation compositions that were derived from the optimisation procedures were different, both solutions gave reproducible results for which the dissolution profiles were indeed similar to that of the reference formulation. RSM and ANN were further investigated as possible means of establishing a design space for formulation compositions that would result in dosage forms that have similar in vitro release test profiles comparable to the reference product. Constraint plots were used to determine the bounds of the formulation variables that would result in the manufacture of dosage forms with the desired release profile. ANN simulations with hypothetical formulations that were generated within a small region of the experimental domain were investigated as a means of understanding the impact of varying the composition of the formulation on resultant dissolution profiles. Although both methods were suitable for the establishment of a design space, the use of ANN may be better suited for this purpose because of the manner in which ANN handles data. As more information about the behaviour of a formulation and its processes is generated during the product Iifecycle, ANN may be used to evaluate the impact of formulation and process variables on measureable responses. It is recommended that ANN may be suitable for the optimisation of pharmaceutical formulations and establishment of a design space in line with ICH Pharmaceutical Development [1], Quality Risk Management [2] and Pharmaceutical Quality Systems [3]
- Full Text:
- Authors: Chaibva, Faith Anesu
- Date: 2010
- Subjects: Salbutamol sulphate Artificial intelligence -- Medical applications Neural networks (Computer science) Response surfaces (Statistics) Pharmaceutical biotechnology -- Quality contro Drugs -- Design Pharmacokinetics Drugs -- Dosage forms Drugs -- Controlled release
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:3845 , http://hdl.handle.net/10962/d1010432
- Description: Quality by Design (QbD) is a systematic approach that has been recommended as suitable for the development of quality pharmaceutical products. The QbD approach commences with the definition of a quality target drug profile and predetermined objectives that are then used to direct the formulation development process with an emphasis on understanding the pharmaceutical science and manufacturing principles that apply to a product. The design space is directly linked to the use of QbD for formulation development and is a multidimensional combination and interaction of input variables and process parameters that have been demonstrated to provide an assurance of quality. The objective of these studies was to apply the principles of QbD as a framework for the optimisation of a sustained release (SR) formulation of salbutamol sulphate (SBS), and for the establishment of a design space using Response Surface Methodology (RSM) and Artificial Neural Networks (ANN). SBS is a short-acting ♭₂ agonist that is used for the management of asthma and chronic obstructive pulmonary disease (COPD). The use of a SR formulation of SBS may provide clinical benefits in the management of these respiratory disorders. Ashtalin®8 ER (Cipla Ltd., Mumbai, Maharashtra, India) was selected as a reference formulation for use in these studies. An Ishikawa or Cause and Effect diagram was used to determine the impact of formulation and process factors that have the potential to affect product quality. Key areas of concern that must be monitored include the raw materials, the manufacturing equipment and processes, and the analytical and assessment methods employed. The conditions in the laboratory and manufacturing processes were carefully monitored and recorded for any deviation from protocol, and equipment for assessment of dosage form performance, including dissolution equipment, balances and hardness testers, underwent regular maintenance. Preliminary studies to assess the potential utility of Methocel® Kl OOM, alone and in combination with other matrix forming polymers, revealed that the combination of this polymer with xanthan gum and Carbopol® has the potential to modulate the release of SBS at a specific rate, for a period of 12 hr. A central composite design using Methocel® KlOOM, xanthan gum, Carbopol® 974P and Surelease® as the granulating fluid was constructed to fully evaluate the impact of these formulation variables on the rate and extent of SBS release from manufactured formulations. The results revealed that although Methocel® KlOOM and xanthan gum had the greatest retardant effect on drug release, interactions between the polymers used in the study were also important determinants of the measureable responses. An ANN model was trained for optimisation using the data generated from a central composite study. The efficiency of the network was optimised by assessing the impact of the number of nodes in the hidden layer using a three layer Multi Layer Perceptron (MLP). The results revealed that a network with nine nodes in the hidden layer had the best predictive ability, suitable for application to formulation optimisation studies. Pharmaceutical optimisation was conducted using both the RSM and the trained ANN models. The results from the two optimisation procedures yielded two different formulation compositions that were subjected to in vitro dissolution testing using USP Apparatus 3. The results revealed that, although the formulation compositions that were derived from the optimisation procedures were different, both solutions gave reproducible results for which the dissolution profiles were indeed similar to that of the reference formulation. RSM and ANN were further investigated as possible means of establishing a design space for formulation compositions that would result in dosage forms that have similar in vitro release test profiles comparable to the reference product. Constraint plots were used to determine the bounds of the formulation variables that would result in the manufacture of dosage forms with the desired release profile. ANN simulations with hypothetical formulations that were generated within a small region of the experimental domain were investigated as a means of understanding the impact of varying the composition of the formulation on resultant dissolution profiles. Although both methods were suitable for the establishment of a design space, the use of ANN may be better suited for this purpose because of the manner in which ANN handles data. As more information about the behaviour of a formulation and its processes is generated during the product Iifecycle, ANN may be used to evaluate the impact of formulation and process variables on measureable responses. It is recommended that ANN may be suitable for the optimisation of pharmaceutical formulations and establishment of a design space in line with ICH Pharmaceutical Development [1], Quality Risk Management [2] and Pharmaceutical Quality Systems [3]
- Full Text:
The utility of Coleoptera in forensic investigations
- Midgley, John M, Richards, Cameron S, Villet, Martin H
- Authors: Midgley, John M , Richards, Cameron S , Villet, Martin H
- Date: 2010
- Subjects: To be catalogued
- Language: English
- Type: text , book chapter
- Identifier: http://hdl.handle.net/10962/442783 , vital:74033 , ISBN 978-1-4020-9684-6 , https://doi.org/10.1007/978-1-4020-9684-6_4
- Description: Forensic entomology is a developing field of forensic science, so there are many avenues to investigate. These avenues include novel directions that have never been addressed, as well as more critical and rigorous research into areas which have already been explored. Most research in forensic entomology has focused on flies, and beetles (Coleoptera) have been at best under-emphasized. A good example of this is the review by Smith (1986), where 70 pages are dedicated to Diptera and only 12 to Coleoptera; this situation has changed little in the subsequent 20 years. To contextualize the neglect, throughout the world there are at least as many species of Coleoptera that may visit a particular carcass as Diptera (Braack 1986; Louw and van der Linde 1993; Bourel et al. 1999; Lopes de Carvalho et al. 2000; Pérez et al. 2005; Shea 2005; Watson and Carlton 2005a; Salazar 2006; Martinez et al. 2007). A common assumption underlying the neglect of Coleoptera is that Diptera locate corpses faster, and thus give a more accurate estimate of minimum Post Mortem Interval (PMImin). Recent observations (Midgley and Villet 2009b) have shown that Thanatophilus micans (Silphidae) can locate corpses and start breeding within 24 h of death, and thus the potential utility of estimates based on this species is equal to that of those based on flies.
- Full Text:
- Authors: Midgley, John M , Richards, Cameron S , Villet, Martin H
- Date: 2010
- Subjects: To be catalogued
- Language: English
- Type: text , book chapter
- Identifier: http://hdl.handle.net/10962/442783 , vital:74033 , ISBN 978-1-4020-9684-6 , https://doi.org/10.1007/978-1-4020-9684-6_4
- Description: Forensic entomology is a developing field of forensic science, so there are many avenues to investigate. These avenues include novel directions that have never been addressed, as well as more critical and rigorous research into areas which have already been explored. Most research in forensic entomology has focused on flies, and beetles (Coleoptera) have been at best under-emphasized. A good example of this is the review by Smith (1986), where 70 pages are dedicated to Diptera and only 12 to Coleoptera; this situation has changed little in the subsequent 20 years. To contextualize the neglect, throughout the world there are at least as many species of Coleoptera that may visit a particular carcass as Diptera (Braack 1986; Louw and van der Linde 1993; Bourel et al. 1999; Lopes de Carvalho et al. 2000; Pérez et al. 2005; Shea 2005; Watson and Carlton 2005a; Salazar 2006; Martinez et al. 2007). A common assumption underlying the neglect of Coleoptera is that Diptera locate corpses faster, and thus give a more accurate estimate of minimum Post Mortem Interval (PMImin). Recent observations (Midgley and Villet 2009b) have shown that Thanatophilus micans (Silphidae) can locate corpses and start breeding within 24 h of death, and thus the potential utility of estimates based on this species is equal to that of those based on flies.
- Full Text:
The valuation of campus built heritage from the student perspective: comparative analysis of Rhodes University in South Africa and St. Mary’s College of Maryland in the United States
- Poor, Joan P, Snowball, Jeanette D
- Authors: Poor, Joan P , Snowball, Jeanette D
- Date: 2010
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/67488 , vital:29102 , https://doi.org/10.1016/j.culher.2009.05.002
- Description: Pre-print , Many universities and colleges around the world have done extensive surveys of their campus built heritage resources. A detailed description and accounting of a campus's built heritage, landscape heritage and archaeology, are often used for historic preservation planning, and sustaining built culture is also an important aspect of campus master planning of future buildings. Such institutions of higher education have deep historical roots, in Europe it is not uncommon for buildings to be dated prior to the sixteenth century. In countries where European colonies were established, institutions of higher education often date to the eighteenth and early nineteenth centuries. Once students have arrived at their chosen campus, however, except for perhaps the first week orientation rituals, do the students actually develop ties to their campus built heritage? This research investigates the knowledge students possess of their respective campus built heritage and the importance of built heritage as a legacy to them. Two institutions are included in this study in an effort of draw comparative assessments. A student questionnaire was administered at Rhodes University in South Africa and St. Mary's College of Maryland in the United States during April 2008. Results indicate students on both campuses place positive intrinsic value on their respective campus built heritage. Just over half (52%) of Rhodes students and about 68% of St. Mary's students were willing to pay some positive amount to protect campus built heritage. Empirical probit model results combining the data from both institutions found that current student knowledge of their respective campus built heritage did not positively relate to the value they place on preservation, even though the visual identity was significant for students and influenced their decision to attend the particular institution. The lack of significance regarding a racial variable coefficient estimate suggests that the use of an institution's visual identity in terms of built heritage may have important marketing implications, particularly in cases where universities or colleges are trying to attract students from more diverse backgrounds. We found no significant relationships between willingness to pay to preserve an institution's built heritage and the demographic variables included in our empirical model. Fundraising data analysis includes positive willingness to pay for conserving built heritage, yet funding for new construction was not significant.
- Full Text:
- Authors: Poor, Joan P , Snowball, Jeanette D
- Date: 2010
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/67488 , vital:29102 , https://doi.org/10.1016/j.culher.2009.05.002
- Description: Pre-print , Many universities and colleges around the world have done extensive surveys of their campus built heritage resources. A detailed description and accounting of a campus's built heritage, landscape heritage and archaeology, are often used for historic preservation planning, and sustaining built culture is also an important aspect of campus master planning of future buildings. Such institutions of higher education have deep historical roots, in Europe it is not uncommon for buildings to be dated prior to the sixteenth century. In countries where European colonies were established, institutions of higher education often date to the eighteenth and early nineteenth centuries. Once students have arrived at their chosen campus, however, except for perhaps the first week orientation rituals, do the students actually develop ties to their campus built heritage? This research investigates the knowledge students possess of their respective campus built heritage and the importance of built heritage as a legacy to them. Two institutions are included in this study in an effort of draw comparative assessments. A student questionnaire was administered at Rhodes University in South Africa and St. Mary's College of Maryland in the United States during April 2008. Results indicate students on both campuses place positive intrinsic value on their respective campus built heritage. Just over half (52%) of Rhodes students and about 68% of St. Mary's students were willing to pay some positive amount to protect campus built heritage. Empirical probit model results combining the data from both institutions found that current student knowledge of their respective campus built heritage did not positively relate to the value they place on preservation, even though the visual identity was significant for students and influenced their decision to attend the particular institution. The lack of significance regarding a racial variable coefficient estimate suggests that the use of an institution's visual identity in terms of built heritage may have important marketing implications, particularly in cases where universities or colleges are trying to attract students from more diverse backgrounds. We found no significant relationships between willingness to pay to preserve an institution's built heritage and the demographic variables included in our empirical model. Fundraising data analysis includes positive willingness to pay for conserving built heritage, yet funding for new construction was not significant.
- Full Text:
The value of a Rhodes University degree and securing employment
- Authors: Chambers, Tracy Laura
- Date: 2010
- Subjects: Rhodes University -- Graduate students -- Employment Education, Higher -- South Africa Graduate students -- Employment -- South Africa Labor supply -- Effect of education on -- South Africa Economic development -- Effect of education on -- South Africa Labor market -- South Africa
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: vital:769 , http://hdl.handle.net/10962/d1003890
- Description: In South Africa, reform policies and frameworks introduced since the 1994 democratic election have sought to bring about change to a highly ineffective and unfair system. In spite of all the changes which have occurred, however, there is evidence to suggest that the system is still not functioning as effectively as it might, given that a relatively large number of graduates remain unemployed in a country with a high skills shortage. This thesis aims to explore the experiences of graduates from one university, Rhodes University in the Eastern Cape, as they enter the job market. It does this through the administration of a first job destination survey administered at the 2009 Graduation Ceremonies held in Grahamstown. Analysis of the survey takes into account the idea that it is not a degree per se, or even a degree from a prestigious university which brings employment, but also the social, cultural and human capital that graduates can bring to their job search.
- Full Text:
- Authors: Chambers, Tracy Laura
- Date: 2010
- Subjects: Rhodes University -- Graduate students -- Employment Education, Higher -- South Africa Graduate students -- Employment -- South Africa Labor supply -- Effect of education on -- South Africa Economic development -- Effect of education on -- South Africa Labor market -- South Africa
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: vital:769 , http://hdl.handle.net/10962/d1003890
- Description: In South Africa, reform policies and frameworks introduced since the 1994 democratic election have sought to bring about change to a highly ineffective and unfair system. In spite of all the changes which have occurred, however, there is evidence to suggest that the system is still not functioning as effectively as it might, given that a relatively large number of graduates remain unemployed in a country with a high skills shortage. This thesis aims to explore the experiences of graduates from one university, Rhodes University in the Eastern Cape, as they enter the job market. It does this through the administration of a first job destination survey administered at the 2009 Graduation Ceremonies held in Grahamstown. Analysis of the survey takes into account the idea that it is not a degree per se, or even a degree from a prestigious university which brings employment, but also the social, cultural and human capital that graduates can bring to their job search.
- Full Text:
Thermoregulation under seminatural conditions in two species of African barbets (Piciformes Lybiidae)
- McKechnie, Andrew E, Smit, Ben
- Authors: McKechnie, Andrew E , Smit, Ben
- Date: 2010
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/448413 , vital:74728 , https://doi.org/10.2989/00306525.2010.488384
- Description: Torpor has been documented in a number of avian orders, but our understanding of the phylogenetic distribution of this phenomenon is far from complete, and several groups have yet to be investigated. We examined patterns of rest- and active-phase thermoregulation in Acacia Pied Barbets Lybius leucomelas and Crested Barbets Trachyphonus vaillantii held in outdoor aviaries, using surgically-implanted miniature data loggers to record body temperature (Tb). Both species exhibited large circadian rhythms of Tb, with maximum active-phase and minimum rest-phase Tb (ρTbmin) values of 42.3 ± 0.1 °C and 37.7 ± 0.6 °C, respectively, in Acacia Pied Barbets (n = 3) and 42.5 ± 0.4 °C and 37.0 ± 0.6 °C, respectively, in Crested Barbets (n = 5).
- Full Text:
- Authors: McKechnie, Andrew E , Smit, Ben
- Date: 2010
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/448413 , vital:74728 , https://doi.org/10.2989/00306525.2010.488384
- Description: Torpor has been documented in a number of avian orders, but our understanding of the phylogenetic distribution of this phenomenon is far from complete, and several groups have yet to be investigated. We examined patterns of rest- and active-phase thermoregulation in Acacia Pied Barbets Lybius leucomelas and Crested Barbets Trachyphonus vaillantii held in outdoor aviaries, using surgically-implanted miniature data loggers to record body temperature (Tb). Both species exhibited large circadian rhythms of Tb, with maximum active-phase and minimum rest-phase Tb (ρTbmin) values of 42.3 ± 0.1 °C and 37.7 ± 0.6 °C, respectively, in Acacia Pied Barbets (n = 3) and 42.5 ± 0.4 °C and 37.0 ± 0.6 °C, respectively, in Crested Barbets (n = 5).
- Full Text:
Thinking about South African tabloid newspapers:
- Strelitz, Larry N, Steenveld, Lynette N
- Authors: Strelitz, Larry N , Steenveld, Lynette N
- Date: 2010
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/159825 , vital:40347 , DOI: 10.1080/02560054.2005.9653337
- Description: A popular view of tabloids is that they pander to the lowest common denominator of public taste, they simplify complex issues, and they generally fail to provide information that citizens need in order to make informed political judgments - the latter being the raison d’etre of serious newspapers. In summary, tabloids “lower the standards of public discourse” (Ornerbring and Jonson, 2004:283).
- Full Text:
- Authors: Strelitz, Larry N , Steenveld, Lynette N
- Date: 2010
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/159825 , vital:40347 , DOI: 10.1080/02560054.2005.9653337
- Description: A popular view of tabloids is that they pander to the lowest common denominator of public taste, they simplify complex issues, and they generally fail to provide information that citizens need in order to make informed political judgments - the latter being the raison d’etre of serious newspapers. In summary, tabloids “lower the standards of public discourse” (Ornerbring and Jonson, 2004:283).
- Full Text:
Third World Express: trains and “revolution” in Southern African poetry
- Authors: Wright, Laurence
- Date: 2010
- Language: English
- Type: text , article
- Identifier: vital:7066 , http://hdl.handle.net/10962/d1007453 , https://doi.org/10.4102/lit.v31i1.34
- Description: preprint , This article examines political dimensions of the train metaphor in selected southern African poems, some of them in English translation. Exploring work by Mongane Serote, B.W. Vilakazi, Demetrius Segooa, Phedi Tlhobolo, Thami Mseleku, Jeremy Cronin, Alan Lennox-Short, Anthony Farmer, Freedom T.V. Nyamubaya, Abduraghiem Johnstone and Mondli Gwala, the argument shows some of the ways in which the technological character of trains and railways is made to carry a message of political insurrection and revolution. The author shows that the political potential of the railway metaphor builds on the general response to railways evident in poems indebted to traditional African praise poetry. The piece also demonstrates that political contention within different strands of the southern African liberation movement could also find expression using the railway metaphor.
- Full Text:
- Authors: Wright, Laurence
- Date: 2010
- Language: English
- Type: text , article
- Identifier: vital:7066 , http://hdl.handle.net/10962/d1007453 , https://doi.org/10.4102/lit.v31i1.34
- Description: preprint , This article examines political dimensions of the train metaphor in selected southern African poems, some of them in English translation. Exploring work by Mongane Serote, B.W. Vilakazi, Demetrius Segooa, Phedi Tlhobolo, Thami Mseleku, Jeremy Cronin, Alan Lennox-Short, Anthony Farmer, Freedom T.V. Nyamubaya, Abduraghiem Johnstone and Mondli Gwala, the argument shows some of the ways in which the technological character of trains and railways is made to carry a message of political insurrection and revolution. The author shows that the political potential of the railway metaphor builds on the general response to railways evident in poems indebted to traditional African praise poetry. The piece also demonstrates that political contention within different strands of the southern African liberation movement could also find expression using the railway metaphor.
- Full Text:
Three's a crowd: the process of triadic translation in a South African psychiatric institution
- Authors: Slabbert, Meggan
- Date: 2010
- Subjects: Mental health services -- South Africa -- Eastern Cape , Psychiatric hospitals -- South Africa -- Eastern Cape , Translating and interpreting -- Psychological aspects , Translating and interpreting -- Social aspects , Content analysis (Communication) , South Africa -- Languages -- Translating and interpreting , Intercultural communication -- South Africa -- Eastern Cape , Culture conflict -- South Africa -- Eastern Cape , Communication and culture -- South Africa -- Eastern Cape , Physician and patient -- South Africa -- Eastern Cape , Communication in medicine -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Masters , MSocSc
- Identifier: vital:3056 , http://hdl.handle.net/10962/d1002565 , Mental health services -- South Africa -- Eastern Cape , Psychiatric hospitals -- South Africa -- Eastern Cape , Translating and interpreting -- Psychological aspects , Translating and interpreting -- Social aspects , Content analysis (Communication) , South Africa -- Languages -- Translating and interpreting , Intercultural communication -- South Africa -- Eastern Cape , Culture conflict -- South Africa -- Eastern Cape , Communication and culture -- South Africa -- Eastern Cape , Physician and patient -- South Africa -- Eastern Cape , Communication in medicine -- South Africa -- Eastern Cape
- Description: Mental health care in South Africa has long been governed by inequalities (Foster & Swartz, 1997). During apartheid, those who did not speak English and Afrikaans could not access mental health services in the same way as those who did (Foster & Swartz, 1997). One main reason for this is the majority of mental health practitioners could not, and were not required to speak languages other than English and Afrikaans (Swartz, 1991). The South African mental health literature suggests that language and communication must be prioritised if there is to be an improvement in mental health care services for those individuals who do not speak English and Afrikaans (Bantjes, 1999; Drennan & Swartz, 1999; Swartz & Drennan, 2000; Swartz & MacGregor, 2002). Drawing on Prasad's (2002) interpretation of Gadamer's critical hermeneutic theory and utilising thematic networks analysis (Attride-Stirling, 2001), this study investigated the process of translated clinical assessment interviews within a psychiatric hospital in the Eastern Cape Province within South Africa. Results of the study revealed that contextual factors, issues concerning linguistic and cultural heritage, clinicians' role expectations regarding translators' role performance, as well as relational dynamics regarding individual levels of control and influence within the translation triad, all impacted on the effectiveness of communication, translation and service provision. These fmdings are supported by literature on the theory and practice of translation that identifies these issues as prominent (Robinson, 2003). Specific recommendations regarding the formalisation of translation practices within the hospital setting, as well as the familiari~ation of clinical practitioners and psychiatric nurses with the intricacies of translation processes are offered.
- Full Text:
- Authors: Slabbert, Meggan
- Date: 2010
- Subjects: Mental health services -- South Africa -- Eastern Cape , Psychiatric hospitals -- South Africa -- Eastern Cape , Translating and interpreting -- Psychological aspects , Translating and interpreting -- Social aspects , Content analysis (Communication) , South Africa -- Languages -- Translating and interpreting , Intercultural communication -- South Africa -- Eastern Cape , Culture conflict -- South Africa -- Eastern Cape , Communication and culture -- South Africa -- Eastern Cape , Physician and patient -- South Africa -- Eastern Cape , Communication in medicine -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Masters , MSocSc
- Identifier: vital:3056 , http://hdl.handle.net/10962/d1002565 , Mental health services -- South Africa -- Eastern Cape , Psychiatric hospitals -- South Africa -- Eastern Cape , Translating and interpreting -- Psychological aspects , Translating and interpreting -- Social aspects , Content analysis (Communication) , South Africa -- Languages -- Translating and interpreting , Intercultural communication -- South Africa -- Eastern Cape , Culture conflict -- South Africa -- Eastern Cape , Communication and culture -- South Africa -- Eastern Cape , Physician and patient -- South Africa -- Eastern Cape , Communication in medicine -- South Africa -- Eastern Cape
- Description: Mental health care in South Africa has long been governed by inequalities (Foster & Swartz, 1997). During apartheid, those who did not speak English and Afrikaans could not access mental health services in the same way as those who did (Foster & Swartz, 1997). One main reason for this is the majority of mental health practitioners could not, and were not required to speak languages other than English and Afrikaans (Swartz, 1991). The South African mental health literature suggests that language and communication must be prioritised if there is to be an improvement in mental health care services for those individuals who do not speak English and Afrikaans (Bantjes, 1999; Drennan & Swartz, 1999; Swartz & Drennan, 2000; Swartz & MacGregor, 2002). Drawing on Prasad's (2002) interpretation of Gadamer's critical hermeneutic theory and utilising thematic networks analysis (Attride-Stirling, 2001), this study investigated the process of translated clinical assessment interviews within a psychiatric hospital in the Eastern Cape Province within South Africa. Results of the study revealed that contextual factors, issues concerning linguistic and cultural heritage, clinicians' role expectations regarding translators' role performance, as well as relational dynamics regarding individual levels of control and influence within the translation triad, all impacted on the effectiveness of communication, translation and service provision. These fmdings are supported by literature on the theory and practice of translation that identifies these issues as prominent (Robinson, 2003). Specific recommendations regarding the formalisation of translation practices within the hospital setting, as well as the familiari~ation of clinical practitioners and psychiatric nurses with the intricacies of translation processes are offered.
- Full Text:
Time course of performance changes and fatigue markers during training for the ironman triathlon
- Authors: Joiner, Alexander Jason
- Date: 2010
- Subjects: Ironman triathlons -- Training , Physical education and training -- Physiological aspects , Endurance sports -- Training , Sports -- Physiological aspects , Fatigue
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:5133 , http://hdl.handle.net/10962/d1005212 , Ironman triathlons -- Training , Physical education and training -- Physiological aspects , Endurance sports -- Training , Sports -- Physiological aspects , Fatigue
- Description:
Suboptimal preparation for the Ironman triathlon can have detrimental effects on mental and physical condition. The purpose of this longitudinal investigation was to examine the relationship between a number of performance changes and fatigue markers during training for an Ironman as well as immediately after the event, in an attempt to better understand the effects of ultraendurance training. Eighteen athletes training for the Ironman; South Africa, 2009 were recruited for the study. Over the 6 month data collection period body mass, training load (TRIMP and Session x RPE methods), physiological responses (waking heart rate, postural dizziness, sleep ratings), changes in psychological state (profile of mood states - POMS), reported immunological responses (symptoms of illness), biochemical changes (salivary cortisol and alpha amylase) and performance (8 km submaximal running time trial (TT) and race day performance) were measured. These responses were compared to a control sample (n=15). Results show a significant increase (p<0.05) in training load (3899.4 ± 2517.8) four weeks prior to the event. Fatigue scores significantly increased (p<0.05) concurrently with this significant increase (p<0.05) in training. TT performance did not significantly (p<0.05) alter during the time course of training. It was however strongly correlated to training load (R2=0.85) and modestly related to race performance (R2=0.65). The signs and symptoms of upper respiratory tract infections (URTI) were prevalent during the training period, decreasing during the taper and race period. Large standard deviations were found within the majority of the responses. During the final two weeks of preparation, tension scores were significantly increased (p<0.05) while training load significantly decreased (p<0.05) during the final week of preparation. Cortisol increased significantly (p<0.05) immediately post race (0.507±0.15
- Full Text:
- Authors: Joiner, Alexander Jason
- Date: 2010
- Subjects: Ironman triathlons -- Training , Physical education and training -- Physiological aspects , Endurance sports -- Training , Sports -- Physiological aspects , Fatigue
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:5133 , http://hdl.handle.net/10962/d1005212 , Ironman triathlons -- Training , Physical education and training -- Physiological aspects , Endurance sports -- Training , Sports -- Physiological aspects , Fatigue
- Description:
Suboptimal preparation for the Ironman triathlon can have detrimental effects on mental and physical condition. The purpose of this longitudinal investigation was to examine the relationship between a number of performance changes and fatigue markers during training for an Ironman as well as immediately after the event, in an attempt to better understand the effects of ultraendurance training. Eighteen athletes training for the Ironman; South Africa, 2009 were recruited for the study. Over the 6 month data collection period body mass, training load (TRIMP and Session x RPE methods), physiological responses (waking heart rate, postural dizziness, sleep ratings), changes in psychological state (profile of mood states - POMS), reported immunological responses (symptoms of illness), biochemical changes (salivary cortisol and alpha amylase) and performance (8 km submaximal running time trial (TT) and race day performance) were measured. These responses were compared to a control sample (n=15). Results show a significant increase (p<0.05) in training load (3899.4 ± 2517.8) four weeks prior to the event. Fatigue scores significantly increased (p<0.05) concurrently with this significant increase (p<0.05) in training. TT performance did not significantly (p<0.05) alter during the time course of training. It was however strongly correlated to training load (R2=0.85) and modestly related to race performance (R2=0.65). The signs and symptoms of upper respiratory tract infections (URTI) were prevalent during the training period, decreasing during the taper and race period. Large standard deviations were found within the majority of the responses. During the final two weeks of preparation, tension scores were significantly increased (p<0.05) while training load significantly decreased (p<0.05) during the final week of preparation. Cortisol increased significantly (p<0.05) immediately post race (0.507±0.15
- Full Text:
Timing of primary wing moult in sexually dimorphic passerines from the Western Cape, South Africa
- Bonnevie, Bo T, Oschadleus, Hans-Dieter
- Authors: Bonnevie, Bo T , Oschadleus, Hans-Dieter
- Date: 2010
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/448355 , vital:74724 , https://doi.org/10.2989/00306525.2010.455821
- Description: SAFRING ringing data was used to investigate the differences in the timing and duration of primary wing moult between males and females of sexually dimorphic passerines from the Western Cape, South Africa. In the sunbirds, weavers and canaries that were considered, the males generally started moult before the females, whereas this was not so for other species. In the species where males started moult before the females, the standard deviation of the start of moult was generally smaller in the males and the males generally took longer to moult. These differences in the patterns of moult are discussed in the context of differences in parental care between males and females of each species and within their taxonomic groups.
- Full Text:
- Authors: Bonnevie, Bo T , Oschadleus, Hans-Dieter
- Date: 2010
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/448355 , vital:74724 , https://doi.org/10.2989/00306525.2010.455821
- Description: SAFRING ringing data was used to investigate the differences in the timing and duration of primary wing moult between males and females of sexually dimorphic passerines from the Western Cape, South Africa. In the sunbirds, weavers and canaries that were considered, the males generally started moult before the females, whereas this was not so for other species. In the species where males started moult before the females, the standard deviation of the start of moult was generally smaller in the males and the males generally took longer to moult. These differences in the patterns of moult are discussed in the context of differences in parental care between males and females of each species and within their taxonomic groups.
- Full Text:
To be Xhosa or not to be Xhosa… that is the question:
- Authors: De Klerk, Vivian A
- Date: 2010
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/158096 , vital:40148 , https://doi.org/10.1080/01434630008666401
- Description: It has long been recognised that indigenous languages are endangered because of powerful social, political and economic pressures. In South Africa, the legacy of apartheid has left its indigenous languages particularly vulnerable, and since 1994 huge efforts have been made to reverse the situation. Despite the new language policy and accompanying legislation, it would seem that many Xhosa speakers themselves want English, and not Xhosa,for their children. This paper reports on a multi-faceted quantitative and qualitative survey in and around Grahamstown in the Eastern Cape Province, which focused on the steady trickle of speakers of Xhosa into English-medium schools in thearea, and examined the reasons underlying decisions to send Xhosa children to these schools and the subsequent linguistic and psycho-social effects of the move on the children.
- Full Text:
- Authors: De Klerk, Vivian A
- Date: 2010
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/158096 , vital:40148 , https://doi.org/10.1080/01434630008666401
- Description: It has long been recognised that indigenous languages are endangered because of powerful social, political and economic pressures. In South Africa, the legacy of apartheid has left its indigenous languages particularly vulnerable, and since 1994 huge efforts have been made to reverse the situation. Despite the new language policy and accompanying legislation, it would seem that many Xhosa speakers themselves want English, and not Xhosa,for their children. This paper reports on a multi-faceted quantitative and qualitative survey in and around Grahamstown in the Eastern Cape Province, which focused on the steady trickle of speakers of Xhosa into English-medium schools in thearea, and examined the reasons underlying decisions to send Xhosa children to these schools and the subsequent linguistic and psycho-social effects of the move on the children.
- Full Text:
Towards enhancing indigenous language acquisition skills through MMORPGs
- Kaschula, Russell H, Mostert, André M
- Authors: Kaschula, Russell H , Mostert, André M
- Date: 2010
- Subjects: Indigenous peoples -- Languages -- Study and teaching -- South Africa , Language and languags -- Computer-assisted instruction , Language and languags -- Study and teaching -- Technological innovation , Language acquisition , Computer games
- Language: English
- Type: article , text
- Identifier: http://hdl.handle.net/10962/59343 , vital:27559 , http://alternation.ukzn.ac.za/Files/docs/17.1/08 Kas FIN.pdf
- Description: The growing interest and access to massively multiplayer online role-playing games (MMORPG) has opened up significant new scope for educational methodologies, from standard language teaching options through to formalising the skills that a ‘player’ develops through their quests and other activities. This scope is extensive and has created numerous opportunities for innovation both within education and the world of work. This is evidenced by the increasing presence of educational establishments in the virtual world, with Second Life being the most popular for conventional educational purposes. In Second Life and many other realms participants are earning some income and in some cases enjoying a reasonable living from online activities, while developing their skills base. These MMORPGs may open opportunities for promoting language acquisition provided this is located within a suitably attractive realm; ‘players’ would then engage in activities that would contribute to their abilities to use the indigenous languages in everyday life. This article explores how such a system could be developed and the likely contribution it could make to promote a multilingual environment at school and post school levels. Further, it will identify the implications for the future of teaching and learning through the harnessing of MMORPGs.
- Full Text:
- Authors: Kaschula, Russell H , Mostert, André M
- Date: 2010
- Subjects: Indigenous peoples -- Languages -- Study and teaching -- South Africa , Language and languags -- Computer-assisted instruction , Language and languags -- Study and teaching -- Technological innovation , Language acquisition , Computer games
- Language: English
- Type: article , text
- Identifier: http://hdl.handle.net/10962/59343 , vital:27559 , http://alternation.ukzn.ac.za/Files/docs/17.1/08 Kas FIN.pdf
- Description: The growing interest and access to massively multiplayer online role-playing games (MMORPG) has opened up significant new scope for educational methodologies, from standard language teaching options through to formalising the skills that a ‘player’ develops through their quests and other activities. This scope is extensive and has created numerous opportunities for innovation both within education and the world of work. This is evidenced by the increasing presence of educational establishments in the virtual world, with Second Life being the most popular for conventional educational purposes. In Second Life and many other realms participants are earning some income and in some cases enjoying a reasonable living from online activities, while developing their skills base. These MMORPGs may open opportunities for promoting language acquisition provided this is located within a suitably attractive realm; ‘players’ would then engage in activities that would contribute to their abilities to use the indigenous languages in everyday life. This article explores how such a system could be developed and the likely contribution it could make to promote a multilingual environment at school and post school levels. Further, it will identify the implications for the future of teaching and learning through the harnessing of MMORPGs.
- Full Text:
Towards IPTV service discovery and selection in an IMS environment
- Tsietsi, Mosiuoa, Musvibe, Ray, Terzoli, Alfredo, Wells, George C
- Authors: Tsietsi, Mosiuoa , Musvibe, Ray , Terzoli, Alfredo , Wells, George C
- Date: 2010
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/430795 , vital:72716 , 10.1109/ICUMT.2010.5676637
- Description: The IP Multimedia Subsystem (IMS) is a telecommunication middleware architecture that behaves as a docking station for a wide range of mul-timedia services. Several so-called killer applications have been envi-sioned for this platform such as multimedia group communications and location based services (LBS), but one of the most common business cases for IMS remains IPTV (Internet Protocol TV). Several IMS stand-ards development bodies and non-IMS players have contributed knowledge to the topic of IPTV, and the mechanisms needed to support various IPTV services are well understood. In addition, there are exam-ples of researchers who have implemented IPTV services in their net-work testbeds. However, many of them do not make use of the full power of the specifications which describe the mechanisms of service discovery and service selection. These processes define support for customer device configuration, service personalisation and service se-lection in a multi-service provider ecosystem. This position paper pro-poses solutions to some of the open questions in this area and pro-vides an architecture for a testbed that properly supports service dis-covery and selection. An initial implementation addressing the topic of auto-configuration of IMS terminals for service discovery is also pre-sented.
- Full Text:
- Authors: Tsietsi, Mosiuoa , Musvibe, Ray , Terzoli, Alfredo , Wells, George C
- Date: 2010
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/430795 , vital:72716 , 10.1109/ICUMT.2010.5676637
- Description: The IP Multimedia Subsystem (IMS) is a telecommunication middleware architecture that behaves as a docking station for a wide range of mul-timedia services. Several so-called killer applications have been envi-sioned for this platform such as multimedia group communications and location based services (LBS), but one of the most common business cases for IMS remains IPTV (Internet Protocol TV). Several IMS stand-ards development bodies and non-IMS players have contributed knowledge to the topic of IPTV, and the mechanisms needed to support various IPTV services are well understood. In addition, there are exam-ples of researchers who have implemented IPTV services in their net-work testbeds. However, many of them do not make use of the full power of the specifications which describe the mechanisms of service discovery and service selection. These processes define support for customer device configuration, service personalisation and service se-lection in a multi-service provider ecosystem. This position paper pro-poses solutions to some of the open questions in this area and pro-vides an architecture for a testbed that properly supports service dis-covery and selection. An initial implementation addressing the topic of auto-configuration of IMS terminals for service discovery is also pre-sented.
- Full Text:
Towards the synthesis of coumarin derivatives as potential dual-action HIV-1 protease and reverse transcriptase inhibitors
- Olomola, Temitope O, Klein, Rosalyn, Lobb, Kevin A, Sayed, Yasien, Kaye, Perry T
- Authors: Olomola, Temitope O , Klein, Rosalyn , Lobb, Kevin A , Sayed, Yasien , Kaye, Perry T
- Date: 2010
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/448963 , vital:74774 , xlink:href="https://doi.org/10.1016/j.tetlet.2010.09.121"
- Description: 3-(Chloromethyl)coumarins, obtained via acid-catalysed cyclisation of salicylaldehyde-derived Baylis– Hillman adducts, have been treated with propargylamine; reaction of the resulting 3-alkynylmethylcoumarins with azidothymidine (AZT) in the presence of a Cu(I) catalyst has afforded a series of cycloaddition products for evaluation, in their own right, as potential dual-action HIV-1 protease and non-nucleoside reverse transcriptase inhibitors, and as scaffolds for further structural elaboration.
- Full Text:
- Authors: Olomola, Temitope O , Klein, Rosalyn , Lobb, Kevin A , Sayed, Yasien , Kaye, Perry T
- Date: 2010
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/448963 , vital:74774 , xlink:href="https://doi.org/10.1016/j.tetlet.2010.09.121"
- Description: 3-(Chloromethyl)coumarins, obtained via acid-catalysed cyclisation of salicylaldehyde-derived Baylis– Hillman adducts, have been treated with propargylamine; reaction of the resulting 3-alkynylmethylcoumarins with azidothymidine (AZT) in the presence of a Cu(I) catalyst has afforded a series of cycloaddition products for evaluation, in their own right, as potential dual-action HIV-1 protease and non-nucleoside reverse transcriptase inhibitors, and as scaffolds for further structural elaboration.
- Full Text:
Trade union investment schemes: a blemish on the social movement unionism outlook of South African unions?
- Authors: Rubushe, Melikaya
- Date: 2010
- Subjects: Labor unions -- South Africa , Labor unions and communism , Cosatu , Economic development -- South Africa , National Union of Mineworkers (South Africa) , Labor unions -- Finance , Business enterprises, Black -- South Africa , Investments -- South Africa
- Language: English
- Type: Thesis , Masters , MSocSc
- Identifier: vital:3331 , http://hdl.handle.net/10962/d1003119 , Labor unions -- South Africa , Labor unions and communism , Cosatu , Economic development -- South Africa , National Union of Mineworkers (South Africa) , Labor unions -- Finance , Business enterprises, Black -- South Africa , Investments -- South Africa
- Description: South African trade unions affiliated to Congress of South African Trade Unions (COSATU) have taken advantage of the arrival of democracy and newly found opportunities available through Black Economic Empowerment to venture into the world of business by setting up their own investment companies. The declared desire behind these ventures was to break the stranglehold of white capital on the economy and to extend participation in the economic activities of the country to previously disadvantaged communities. Using the National Union of Mineworkers and the Mineworkers’ Investment Company as case studies, this dissertation seeks to determine whether unions affiliated to the Congress of South African Trade Unions (COSATU) are advancing the struggle for socialism through their investment schemes. Secondly, the dissertation determines whether, in the activities of the schemes, internal democracy is preserved and strengthened. The theoretical framework of this dissertation emerges from arguments advanced by Lenin and Gramsci on the limitations of trade unions in terms of their role in the struggle against capitalism. In addition, the argument draws on the assertions by Michels regarding the proneness of trade union leadership to adopt oligarchic tendencies in their approach to leadership. Of interest is how, according to Gramsci, trade unions are prone to accepting concessions from the capitalist system that renders them ameliorative rather than transformative. Drawing from Michels’ ‘iron law of oligarchy’, the thesis examines whether there is space for ordinary members of the unions to express views on the working of the union investment companies. By looking at the extent to which the investment initiatives of the companies mirror the preferences of the ordinary members of the unions, one can determine the level of disjuncture between the two. The study relies on data collected through interviews and documentary material. Interviews provide first-hand knowledge of how respondents experience the impact of the investment schemes. This provides a balanced analysis given that documents reflect policy stances whereas interviews provide data on whether these have the stated impact. What the study shows is a clear absence of space for ordinary members to directly influence the workings of union investment companies. It is also established that, in their current form, the schemes operate more as a perpetuation of the capitalist logic than offering an alternative system.
- Full Text:
- Authors: Rubushe, Melikaya
- Date: 2010
- Subjects: Labor unions -- South Africa , Labor unions and communism , Cosatu , Economic development -- South Africa , National Union of Mineworkers (South Africa) , Labor unions -- Finance , Business enterprises, Black -- South Africa , Investments -- South Africa
- Language: English
- Type: Thesis , Masters , MSocSc
- Identifier: vital:3331 , http://hdl.handle.net/10962/d1003119 , Labor unions -- South Africa , Labor unions and communism , Cosatu , Economic development -- South Africa , National Union of Mineworkers (South Africa) , Labor unions -- Finance , Business enterprises, Black -- South Africa , Investments -- South Africa
- Description: South African trade unions affiliated to Congress of South African Trade Unions (COSATU) have taken advantage of the arrival of democracy and newly found opportunities available through Black Economic Empowerment to venture into the world of business by setting up their own investment companies. The declared desire behind these ventures was to break the stranglehold of white capital on the economy and to extend participation in the economic activities of the country to previously disadvantaged communities. Using the National Union of Mineworkers and the Mineworkers’ Investment Company as case studies, this dissertation seeks to determine whether unions affiliated to the Congress of South African Trade Unions (COSATU) are advancing the struggle for socialism through their investment schemes. Secondly, the dissertation determines whether, in the activities of the schemes, internal democracy is preserved and strengthened. The theoretical framework of this dissertation emerges from arguments advanced by Lenin and Gramsci on the limitations of trade unions in terms of their role in the struggle against capitalism. In addition, the argument draws on the assertions by Michels regarding the proneness of trade union leadership to adopt oligarchic tendencies in their approach to leadership. Of interest is how, according to Gramsci, trade unions are prone to accepting concessions from the capitalist system that renders them ameliorative rather than transformative. Drawing from Michels’ ‘iron law of oligarchy’, the thesis examines whether there is space for ordinary members of the unions to express views on the working of the union investment companies. By looking at the extent to which the investment initiatives of the companies mirror the preferences of the ordinary members of the unions, one can determine the level of disjuncture between the two. The study relies on data collected through interviews and documentary material. Interviews provide first-hand knowledge of how respondents experience the impact of the investment schemes. This provides a balanced analysis given that documents reflect policy stances whereas interviews provide data on whether these have the stated impact. What the study shows is a clear absence of space for ordinary members to directly influence the workings of union investment companies. It is also established that, in their current form, the schemes operate more as a perpetuation of the capitalist logic than offering an alternative system.
- Full Text:
Transcending objectifications and dualisms: farm workers and civil society in contemporary Zimbabwe
- Sadomba, Zvakanyorwa W, Helliker, Kirk D
- Authors: Sadomba, Zvakanyorwa W , Helliker, Kirk D
- Date: 2010
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/71242 , vital:29822 , https://doi.org/10.1177/0021909609357417
- Description: In the academic literature, civil society is often conceptualized in terms of objectifications and subject—object dichotomies. This is the case with regard to both social movements and non-governmental organizations. This article seeks to transcend such argumentation by providing ‘thick descriptions’ of the agency of farm workers and civil society in the context of land reform in contemporary Zimbabwe. We examine a land-based social movement (and the role of farm workers within it) and the involvement of a particular non-governmental organization in farm worker livelihoods. On this basis, we offer a re-formulation of civil society as a social field marked by ambivalences and tensions.
- Full Text: false
- Authors: Sadomba, Zvakanyorwa W , Helliker, Kirk D
- Date: 2010
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/71242 , vital:29822 , https://doi.org/10.1177/0021909609357417
- Description: In the academic literature, civil society is often conceptualized in terms of objectifications and subject—object dichotomies. This is the case with regard to both social movements and non-governmental organizations. This article seeks to transcend such argumentation by providing ‘thick descriptions’ of the agency of farm workers and civil society in the context of land reform in contemporary Zimbabwe. We examine a land-based social movement (and the role of farm workers within it) and the involvement of a particular non-governmental organization in farm worker livelihoods. On this basis, we offer a re-formulation of civil society as a social field marked by ambivalences and tensions.
- Full Text: false
Transformativity: recognising melancholic power, and renegotiating vulnerability
- Authors: Knowles, Corinne Ruth
- Date: 2010
- Subjects: Transformational leadership -- South Africa Educational change -- South Africa Universities and colleges -- South Africa Sex discrimination in higher education -- South Africa
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:2789 , http://hdl.handle.net/10962/d1002999
- Description: South African universities are embedded in an unequal society. Transformation strategies and interventions in the sector attempt to address this, but arguably, the policies and practices which aim to bring about transformation are merely platforms for potential change and do not guarantee the achievement of their aspirations. This study engages with the notion of transformation in one university, looking at how an organisation for women has contributed to transformation in individuals and in the institution. It explores the idea that vulnerability is the starting point of transformation, and must be recognized and incorporated into how an organisation, institution or individual regards vulnerable groups, in order to build a more equitable society. The reframing of vulnerability is a process of acknowledging the way power works, and arguably, power’s melancholic nature and expression in society and in universities has particular challenges with regard to how vulnerable groups experience their vulnerability. If the framing of an individual as vulnerable does not also provide that individual with the conditions that shelter the vulnerability they experience, leading to a renegotiation of whom they can become, their “vulnerable” status is entrenched. The study explores ways in which an organisation for women uses its legitimized platform for renegotiating subjectivities, norms and performances, and the potential this has for transformativity.
- Full Text:
- Authors: Knowles, Corinne Ruth
- Date: 2010
- Subjects: Transformational leadership -- South Africa Educational change -- South Africa Universities and colleges -- South Africa Sex discrimination in higher education -- South Africa
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:2789 , http://hdl.handle.net/10962/d1002999
- Description: South African universities are embedded in an unequal society. Transformation strategies and interventions in the sector attempt to address this, but arguably, the policies and practices which aim to bring about transformation are merely platforms for potential change and do not guarantee the achievement of their aspirations. This study engages with the notion of transformation in one university, looking at how an organisation for women has contributed to transformation in individuals and in the institution. It explores the idea that vulnerability is the starting point of transformation, and must be recognized and incorporated into how an organisation, institution or individual regards vulnerable groups, in order to build a more equitable society. The reframing of vulnerability is a process of acknowledging the way power works, and arguably, power’s melancholic nature and expression in society and in universities has particular challenges with regard to how vulnerable groups experience their vulnerability. If the framing of an individual as vulnerable does not also provide that individual with the conditions that shelter the vulnerability they experience, leading to a renegotiation of whom they can become, their “vulnerable” status is entrenched. The study explores ways in which an organisation for women uses its legitimized platform for renegotiating subjectivities, norms and performances, and the potential this has for transformativity.
- Full Text:
Trophic ecology of grey-headed albatrosses from Marion Island, Southern Ocean: insights from stomach contents and diet tracers
- Richoux, Nicole B, Jaquemet, Se´bastien, Bonnevie, Bo T, Cherel, Yves, McQuaid, Christopher D
- Authors: Richoux, Nicole B , Jaquemet, Se´bastien , Bonnevie, Bo T , Cherel, Yves , McQuaid, Christopher D
- Date: 2010
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/458019 , vital:75710 , xlink:href="https://doi.org/10.1007/s00227-010-1448-y"
- Description: During chick-rearing, albatrosses can alternate between long foraging trips that provide the main source of food for the adults and short foraging trips that they use to feed their young. This flexibility in foraging behaviour can lead to differences in diet composition between adults and chicks and implies that they may be vulnerable in different ways to food shortages. The trophic ecology of the Grey-headed albatross Thalassarche chrysostoma was investigated at the sub-Antarctic Prince Edward Islands during the chick-rearing period in April 2006 using a combination of approaches. Diets of adults and chicks were assessed using stable isotope ratios and fatty acid (FA) profiles of blood and/or stomach oils, in addition to stomach contents analysis. Fish from the family Macrouridae and cephalopods (particularly the onychoteuthid Kondakovia longimana) were the primary prey, whereas crustaceans (krill Euphausia superba) represented a smaller proportion of the stomach contents. Stomach oil FA profiles contained more monounsaturated FA than the profiles of plasma, which were richer in saturated FA and arachidonic acid (20:4n-6). There was also a distinct separation of adults from chicks, with higher levels of monounsaturates in chick plasma, and higher saturated FA levels (particularly 16:0) in the adult plasma. Stable carbon isotope ratios of whole blood were similar in adults and chicks, whereas stable nitrogen isotope ratios showed significant enrichment by >1‰ in chicks. The combined FA, stable isotopes and stomach contents analyses suggest clear differences in diet quality between adults and chicks, with chicks feeding at a higher trophic position through feeding more on highly nutritious fish and adults keeping much of the less nutritious zooplankton for themselves.
- Full Text:
- Authors: Richoux, Nicole B , Jaquemet, Se´bastien , Bonnevie, Bo T , Cherel, Yves , McQuaid, Christopher D
- Date: 2010
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/458019 , vital:75710 , xlink:href="https://doi.org/10.1007/s00227-010-1448-y"
- Description: During chick-rearing, albatrosses can alternate between long foraging trips that provide the main source of food for the adults and short foraging trips that they use to feed their young. This flexibility in foraging behaviour can lead to differences in diet composition between adults and chicks and implies that they may be vulnerable in different ways to food shortages. The trophic ecology of the Grey-headed albatross Thalassarche chrysostoma was investigated at the sub-Antarctic Prince Edward Islands during the chick-rearing period in April 2006 using a combination of approaches. Diets of adults and chicks were assessed using stable isotope ratios and fatty acid (FA) profiles of blood and/or stomach oils, in addition to stomach contents analysis. Fish from the family Macrouridae and cephalopods (particularly the onychoteuthid Kondakovia longimana) were the primary prey, whereas crustaceans (krill Euphausia superba) represented a smaller proportion of the stomach contents. Stomach oil FA profiles contained more monounsaturated FA than the profiles of plasma, which were richer in saturated FA and arachidonic acid (20:4n-6). There was also a distinct separation of adults from chicks, with higher levels of monounsaturates in chick plasma, and higher saturated FA levels (particularly 16:0) in the adult plasma. Stable carbon isotope ratios of whole blood were similar in adults and chicks, whereas stable nitrogen isotope ratios showed significant enrichment by >1‰ in chicks. The combined FA, stable isotopes and stomach contents analyses suggest clear differences in diet quality between adults and chicks, with chicks feeding at a higher trophic position through feeding more on highly nutritious fish and adults keeping much of the less nutritious zooplankton for themselves.
- Full Text:
Tuning the physico-electrochemical properties of novel cobalt (II) octa [(3, 5-biscarboxylate)-phenoxy] phthalocyanine complex using phenylamine-functionalised SWCNTs
- Agboola, Bolade O, Ozoemena, Kenneth I, Nyokong, Tebello, Fukuda, Takamitsu, Kobayashi, Nagao
- Authors: Agboola, Bolade O , Ozoemena, Kenneth I , Nyokong, Tebello , Fukuda, Takamitsu , Kobayashi, Nagao
- Date: 2010
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/261692 , vital:53435 , xlink:href="https://doi.org/10.1016/j.carbon.2009.10.023"
- Description: The integration of phenylamine-functionalised SWCNTs (SWCNT-phenylamine) with a novel cobalt (II) octa[(3,5-biscarboxylate)-phenoxy] phthalocyanine (CoOBPPc) complex has been described. The physical and electrochemical properties of the CoOBPPc-SWCNT-phenylamine hybrid were evaluated using spectroscopy (IR and UV–vis), field emission scanning electron microscopy and electrochemistry (cyclic voltammetry and electrochemical impedance spectroscopy). Integration of SWCNT-phenylamine resulted in the physical transformation of the CoOBCPPc from the usually bluish colour of cobalt phthalocyanine complexes to a beautiful bright green colour. In addition, the heterogeneous electron transfer kinetics and electrocatalytic properties of the CoOBCPPc were greatly enhanced following the attachment of the SWCNT-phenylamine. The potential electrocatalytic application of the hybrid was tested using β-nicotinamide adenine dinucleotide (NADH) as a model biological analyte. Interestingly, the onset oxidation potential of this analyte was significantly reduced (300 mV) by this hybrid compared to the bare electrode.
- Full Text:
- Authors: Agboola, Bolade O , Ozoemena, Kenneth I , Nyokong, Tebello , Fukuda, Takamitsu , Kobayashi, Nagao
- Date: 2010
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/261692 , vital:53435 , xlink:href="https://doi.org/10.1016/j.carbon.2009.10.023"
- Description: The integration of phenylamine-functionalised SWCNTs (SWCNT-phenylamine) with a novel cobalt (II) octa[(3,5-biscarboxylate)-phenoxy] phthalocyanine (CoOBPPc) complex has been described. The physical and electrochemical properties of the CoOBPPc-SWCNT-phenylamine hybrid were evaluated using spectroscopy (IR and UV–vis), field emission scanning electron microscopy and electrochemistry (cyclic voltammetry and electrochemical impedance spectroscopy). Integration of SWCNT-phenylamine resulted in the physical transformation of the CoOBCPPc from the usually bluish colour of cobalt phthalocyanine complexes to a beautiful bright green colour. In addition, the heterogeneous electron transfer kinetics and electrocatalytic properties of the CoOBCPPc were greatly enhanced following the attachment of the SWCNT-phenylamine. The potential electrocatalytic application of the hybrid was tested using β-nicotinamide adenine dinucleotide (NADH) as a model biological analyte. Interestingly, the onset oxidation potential of this analyte was significantly reduced (300 mV) by this hybrid compared to the bare electrode.
- Full Text:
Two new species of Prosopistomatidae (Ephemeroptera) from South Africa and Swaziland
- Authors: Barber-James, Helen M
- Date: 2010
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/452385 , vital:75124 , https://hdl.handle.net/10520/EJC32841
- Description: Three species of Prosopistoma Latreille, 1833 are currently described from Africa. The immature nymph of Prosopistoma deguernei Vayssière, 1893 was described from Senegal, and the nymph and winged stages of Prosopistoma africanum Gillies, 1954 are known from Tanzania. The southern African species Prosopistoma crassi Gillies, 1954, initially described as a nymph from KwaZulu-Natal, South Africa, has subsequently been collected in a number of South African rivers. Two further species from South Africa are described here, the nymph of Prosopistoma amanzamnyama sp. n., and the nymph and female subimago of Prosopistoma mccaffertyi sp. n.
- Full Text:
- Authors: Barber-James, Helen M
- Date: 2010
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/452385 , vital:75124 , https://hdl.handle.net/10520/EJC32841
- Description: Three species of Prosopistoma Latreille, 1833 are currently described from Africa. The immature nymph of Prosopistoma deguernei Vayssière, 1893 was described from Senegal, and the nymph and winged stages of Prosopistoma africanum Gillies, 1954 are known from Tanzania. The southern African species Prosopistoma crassi Gillies, 1954, initially described as a nymph from KwaZulu-Natal, South Africa, has subsequently been collected in a number of South African rivers. Two further species from South Africa are described here, the nymph of Prosopistoma amanzamnyama sp. n., and the nymph and female subimago of Prosopistoma mccaffertyi sp. n.
- Full Text: