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How general-purpose can a GPU be?

  • Authors: Machanick, Philip
  • Date: 2015
  • Language: English
  • Type: article , text
  • Identifier: http://hdl.handle.net/10962/61180 , vital:27988 , http://dx.doi.org/10.18489/sacj.v0i57.347
  • Description: The use of graphics processing units (GPUs) in general-purpose computation (GPGPU) is a growing field. GPU instruction sets, while implementing a graphics pipeline, draw from a range of single instruction multiple datastream (SIMD) architectures characteristic of the heyday of supercomputers. Yet only one of these SIMD instruction sets has been of application on a wide enough range of problems to survive the era when the full range of supercomputer design variants was being explored: vector instructions. Supercomputers covered a range of exotic designs such as hypercubes and the Connection Machine (Fox, 1989). The latter is likely the source of the snide comment by Cray: it had thousands of relatively low-speed CPUs (Tucker & Robertson, 1988). Since Cray won, why are we not basing our ideas on his designs (Cray Inc., 2004), rather than those of the losers? The Top 500 supercomputer list is dominated by general-purpose CPUs, and nothing like the Connection Machine that headed the list in 1993 still exists.
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How General-Purpose can a GPU be?

  • Authors: Machanick, Philip
  • Date: 2015
  • Subjects: To be catalogued
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/10962/439294 , vital:73563 , https://hdl.handle.net/10520/EJC181693
  • Description: The use of graphics processing units (GPUs) in general-purpose computation (GPGPU) is a growing field. GPU instruction sets, while implementing a graphics pipeline, draw from a range of single instruction multiple data stream (SIMD) architectures characteristic of the heyday of supercomputers. Yet only one of these SIMD instruction sets has been of application on a wide enough range of problems to survive the era when the full range of supercomputer design variants was being explored: vector instructions.
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Hsp70/Hsp90 organising protein (hop): beyond interactions with chaperones and prion proteins

  • Authors: Baindur-Hudson, Swati , Edkins, Adrienne L , Blatch, Gregory L
  • Date: 2015
  • Language: English
  • Type: text , book
  • Identifier: http://hdl.handle.net/10962/164852 , vital:41178 , ISBN 978-3-319-11730-0 , DOI: 10.1007/978-3-319-11731-7_3
  • Description: The Hsp70/Hsp90 organising protein (Hop), also known as stress-inducible protein 1 (STI1), has received considerable attention for diverse cellular functions in both healthy and diseased states. There is extensive evidence that intracellular Hop is a co-chaperone of the major chaperones Hsp70 and Hsp90, playing an important role in the productive folding of Hsp90 client proteins. Consequently, Hop is implicated in a number of key signalling pathways, including aberrant pathways leading to cancer. However, Hop is also secreted and it is now well established that Hop also serves as a receptor for the prion protein, PrPC.
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Human FN1 is regulated by the heat-shock response

  • Authors: Dhanani, Karim Colin Hassan
  • Date: 2015
  • Subjects: Uncatalogued
  • Language: English
  • Type: Master's theses , text
  • Identifier: http://hdl.handle.net/10962/193487 , vital:45336
  • Description: Heat shock protein 90 (Hsp90) and heat shock factors (HSFs) are known to be involved in the epigenetic regulation of several fundamental oncogenic genes. Fibronectin (FN) is an extracellular matrix (ECM) glycoprotein which plays key roles in cell adhesion and migration. Hsp90 binds directly to FN and Hsp90 inhibition has been shown to regulate FN protein levels and matrix formation. Where inhibition of Hsp90 with a C-terminal inhibitor (novobiocin) induced the loss of FN matrix, treatment with an N-terminal inhibitor (geldanamycin) increased FN matrix levels. GA treatment induced a strong dose and time dependent increase in FN1 promoter activity and increased total FN mRNA respectively. By contrast, NOV showed no increase in the promoter activity and no change in the expression of FN mRNA. As GA is known to induce the stress response, we investigated the relationship between the cell stress machinery and the transcriptional regulation of FN. Three putative heat shock elements (HSEs) were identified in the FN1 promoter. The loss of two of the three identified putative HSEs resulted in a loss in the basal transcriptional activity of the FN1 promoter in our reporter model. This was in addition to the loss of the induction of transcriptional activity with GA treatment observed with the full-length promoter. Binding of HSF1 to one of the putative HSEs, which was identified as potentially functional from the truncation analysis, was confirmed using ChIP. The occupancy of this HSE by HSF1 was shown to increase with GA treatment. These data support the hypothesis that FN1 is a functional HSF1 target gene. The 5' promoter regions of seven additional ECM protein encoding genes were analysed and mRNA levels were detected by quantitative RT-PCR upon treatment with GA. Collagen 4 _2 and laminin _3 mRNA were found to increase in the presence of GA, whereas collagen 4 _3 and osteopontin showed no change. Similarly to FN1, these data indicate that a subset of ECM genes may be under the regulation of the HSF1 mediated heat-shock response. This may have implications for our understanding of ECM dynamics in cancer, where the clinical application of Hsp90 inhibitors is intended. Additionally, our data provide a poten- tial underpinning for the role of the HSF1 mediated heat-shock response in several fibrotic and metabolic stress related pathologies. , Thesis (PhD) -- Faculty of Science, Biochemistry and Microbiology, 2015
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Human harvesting impacts on managed areas: ecological effects of socially-compatible shellfish reserves

  • Authors: Aswani, Shankar , Flores, Carola F , Broitman, Bernardo R
  • Date: 2015
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/10962/124664 , vital:35644 , https://doi.10.1007/s11160-014-9376-4
  • Description: We examined how human harvesting impacts on managed areas affect the abundance and size distribution of the edible mangrove shellfish Anadara granosa and Polymesoda spp. in the Roviana Lagoon, Solomon Islands. We tested two hypotheses: (1) in areas permanently and temporally closed to human exploitation, abundance and size distribution of these shellfish species is significantly greater than in sites open to exploitation and (2) moderate human disturbance of shell beds, particularly of Polymesoda spp., increases their abundance. Firstly, we studied perceptions of environmental states and processes coupled to foraging and management interventions to assess sociocultural influences on harvesting practices and ascertain the types of management regime that people would consider in a context where poaching and interloping are common practices. Secondly, we compared shellfish abundance and shell size from areas that were permanently protected, temporally reserved for communal harvest, and permanently open for exploitation. Thirdly, drawing from women’s local knowledge, we measured the abundance of Polymesoda spp. in relation to mud compactness in quadrats across the three management regimes. Results showed that both species were significantly more abundant in permanent and temporally closed sites than in open sites. In the mud compactness study, however, while shell abundance was greater in moderately compacted quadrats, there was no statistical relationship between mud compactness and shell abundance within or across the three management regimes. Results suggest that even under the strong impacts of poaching, temporally closed areas have more clams than open areas and are as effective as areas that are permanently closed nominally. The results also suggest that human harvesting regimes can influence the effectiveness of local management decisions and thus are important when designing community-based conservation programs in the Solomon Islands and other Pacific Islands.
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Human myiasis in rural South Africa is under-reported

  • Authors: Kuria, Simon K , Villet, Martin H , Kingu, H J C , Dhaffala, Adupa
  • Date: 2015
  • Subjects: To be catalogued
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/10962/442425 , vital:73983 , https://www.ajol.info/index.php/samj/article/view/114028
  • Description: Background. Myiasis is the infestation of live tissue of humans and other vertebrates by larvae of flies. Worldwide, myiasis of humans is seldom reported, although the trend is gradually changing in some countries. Reports of human myiasis in Africa are few. Several cases of myiasis were recently seen at the Mthatha Hospital Complex, Mthatha, Eastern Cape Province, South Africa (SA).
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Human, vector and parasite Hsp90 proteins: a comparative bioinformatics analysis

  • Authors: Faya, Ngonidzashe , Penkler, David L , Tastan Bishop, Özlem
  • Date: 2015
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/10962/148038 , vital:38704 , DOI: 10.1016/j.fob.2015.11.003
  • Description: The treatment of protozoan parasitic diseases is challenging, and thus identification and analysis of new drug targets is important. Parasites survive within host organisms, and some need intermediate hosts to complete their life cycle. Changing host environment puts stress on parasites, and often adaptation is accompanied by the expression of large amounts of heat shock proteins (Hsps). Among Hsps, Hsp90 proteins play an important role in stress environments. Yet, there has been little computational research on Hsp90 proteins to analyze them comparatively as potential parasitic drug targets. Here, an attempt was made to gain detailed insights into the differences between host, vector and parasitic Hsp90 proteins by large-scale bioinformatics analysis.
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Identification of novel SNPSTRs by 454 sequencing in Nguni and Sotho-Tswana populations

  • Authors: Laurence, Jo-Anne Elizabeth
  • Date: 2015
  • Language: English
  • Type: text , Thesis , Masters , MSc
  • Identifier: http://hdl.handle.net/10962/55885 , vital:26752
  • Description: DNA profiling is currently performed by analysis of the electropherogram that results following the amplification of a panel of Short Tandem Repeat (STR) loci. A need has arisen, however, for the development of a typing method that generates results which are compatible and comparable with existing databases, but that have a higher discrimination power by supplying sequence data as well as repeat-number data. Recent studies that explore these alternative typing methodologies have revealed the existence of a number of STR variants. There is, however, little information about the exact nature and prevalence of these sub-alleles. There have also been limited population studies of the genetic profiles of sub-Saharan African populations, despite the fact that evidence suggests that there is greater genetic structure and genetic diversity in these populations. In this study, a processing protocol for the generation of 454 sequencing-ready amplicons of vWA, D2S441, D3S1358, D13S317, D21S11 and D7S820 loci was developed. This protocol was applied to buccal swabs collected from 144 individuals of the Nguni and Sotho-Tswana population groups. A total of 145 485 reads were obtained from the sequencing of these amplicons, of which 97 400 and 48 085 reads were obtained for the Nguni and Sotho-Tswana populations respectively. The proportional representation for each locus ranged from 8-20%, and the allele calls and observed frequencies of these alleles suggested a high degree of relatedness between population groups. The sequencing results, furthermore, enabled the identification of a number of previously undescribed STR variants and SNPSTRs; with allele 13´ for D13S317 representing a SNP that may be predictive of Nguni-ancestry. The results also demonstrated the usefulness of next generation sequencing for increasing the number of discernible alleles for STR profiling.
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If I Stay Right Here

  • Authors: Ngamlana, Chwayita
  • Date: 2015
  • Subjects: Uncatalogued
  • Language: English
  • Type: Master's theses , text
  • Identifier: http://hdl.handle.net/10962/193498 , vital:45337
  • Description: My novella concerns the dynamics of a relationship between two girls. It shows the heterosexual‐like nature of the relationship rather than dwelling on the pressures on lesbians from society as a whole. At its core is the raw emotion and passion of the relationship, which is at the same time toxic, destructive and volatile because of their class differences and other insecurities. The work is influenced by the grit, openness, and innovation of several contemporary writers. , Thesis (MA) -- Faculty of Humanities, Institute for the Study of English in Africa, 2015
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IFLA WLIC 2015 Volunteers/Delegates feedback session 8 September 2015, Rhodes University Library

  • Date: 2015
  • Language: English
  • Type: Text
  • Identifier: vital:7958 , http://hdl.handle.net/10962/d1019838
  • Description: IFLA WLIC 2015 feedback session by Rhodes University Library Staff who attended the Congress as Volunteers and Delegates, Grahamstown, 8 September 2015.
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Immersive audio content creation using mobile devices and ethernet avb

  • Authors: Rouget, Antoine , Foss, Richard
  • Date: 2015
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/10962/426786 , vital:72391 , https://www.aes.org/e-lib/browse.cfm?elib=18009
  • Description: The goal of immersive sound systems is to localize multiple sound sources such that listeners are enveloped in sound. This paper describes an immersive sound system that allows for the creation of immersive sound content and real time control over sound source localization. It is a client/server system where the client is a mobile device. The server receives localization control messages from the client and uses an Ethernet AVB network to distribute appropriate mix levels to speakers with in-built signal processing.
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Impact of marine inundation after a period of drought on the lakeshore vegetation of Lake St Lucia, South Africa: resilience of estuarine vegetation

  • Authors: Sieben, E J J , Ellery, William F N , Dullo, B W , Grootjans, A P
  • Date: 2015
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/10962/144443 , vital:38346 , DOI: 10.2989/16085914.2015.1032208
  • Description: The shore of Lake St Lucia in the vicinity of Catalina Bay, in the southern part of the lake, receives freshwater input as surface and groundwater seepage from the adjacent elevated coastal plain. Vegetation, water quality and landform were recorded on the lakeshore and on the dry lakebed near one of these seepage zones. This was done along a gradient perpendicular to the lakeshore and along the lakeshore away from the fluvial source of freshwater input. A number of plant communities were found along a gradient of water salinity from the shoreline (fresh water) towards the centre of the lake, and also away from the fluvial input of water (increasingly saline). Species richness decreased with increasing salinity. The first study was conducted in 2006 after a prolonged drought associated with low lake levels and closure of the mouth, and repeated again in 2010 three years after breaching of the estuarine mouth by a tropical cyclone at sea, which caused inundation of the partly dry lakebed with sea water. The vegetation of the lakeshore after these major disturbances was remarkably similar in the two time periods, suggesting rapid recovery near freshwater seepage zones, following an influx of sea water.
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Impact of poaching on the marketability of safari lodges in the Eastern Cape

  • Authors: Loader, Rory James
  • Date: 2015
  • Subjects: Safari lodges -- South Africa -- Eastern Cape -- Marketing , Poaching -- South Africa -- Eastern Cape , Ecotourism -- South Africa -- Eastern Cape , Wildlife crimes -- South Africa -- Eastern Cape
  • Language: English
  • Type: Thesis , Masters , MBA
  • Identifier: vital:845 , http://hdl.handle.net/10962/d1016405
  • Description: This research is presented in three sections. Section 1 presents the research report in an academic paper format. Section 2 provides a comprehensive literature review and Section 3 describes the research methodology and methods employed during the research. The tourism industry is the fastest growing sector within the South African Economy, with over 2.6 million foreign tourists visiting South Africa each year. Wildlife, landscapes and scenery are cited as the primary attractions for visiting the country, with over 45 percent of tourists visiting at least one wildlife or nature reserve during their stay in South Africa (Kerley et al., 2011:2). Sixty percent of those tourists travelled for leisure purposes, with 643,883 of the tourists utilising safari lodge accommodation during their visit (Ruggles-Brise, 2013). The Eastern Cape achieved 3.1 percent; of those tourist arrivals, with a bed-night contribution of 734,339, compared to the 16.8 percent (1.9million) and 10.5 percent (1.07million) for Mpumalanga and Limpopo provinces respectively (Ruggles-Brise, 2013). The Eastern Cape lodges represent less than half the bed-nights achieved by Mpumalanga and Limpopo lodges. Due to the number of possible bed-nights available to lodges in the Eastern Cape, it is increasingly important for individual lodges to provide a unique experience, in order to be competitive in attracting guests (Saayman, 2013:81). This was used form part of the foundation to this research in determining the marketability of three lodges in the Eastern Cape, which was derived from the attractiveness of the lodges, determined by guests visiting the lodges. This research follows on from four previous surveys commissioned by INDALO, the Eastern Cape Private Nature Reserve Association in 2004 Sims-Castley et al. 2004), 2006 (Langholz et al., 2006), 2008 (Snowball et al., 2008) and 2011 (Kerley et al., 2011). Part of the research was to identify the main attractions of the reserves. These previous surveys provided a foundation for this research to follow on investigating guest motivations for visiting the three sample lodges and to determine visitor perception of poaching and whether it would impact their motivations for visiting the reserve. In order to address the goals of the research qualitative data was gathered during survey interviews conducted at the three sampled reserves. Seventy five (75) guests were interviewed, equally over the three reserves. Quantitative data was also gathered during the interview surveys, utilising Likert scale questions, prompting guests to choose their top attractions, from which basic descriptive statistics were used to analyse the data being able to determine possible trends amongst respondents and lodges. Results verified guest motivations from the previous surveys, confirming that game viewing, especially the “Big 5” remained the most important attraction for visitors to the reserves while the availability of natural scenery and landscape, high end accommodation and service, the proximity to the garden route and being located in a malaria free area were also see as attractive attributes of the lodges as per the previous surveys. Where the gap in the research was indicated based on guests perception of poaching and whether it would impact their motivations for visit these lodges, impacting that lodges marketability (attractiveness). Results indicated that if they were unable to view the iconic ‘Big Five’ at the reserve due to the extent of poaching. Respondents indicated that the impact would likely and very likely impact their decision to choose the reserves over another reserve that could. Indicating the potential impact that poaching would have on lodges if they were to lose their iconic species which would spell the loss in attractiveness and therefore marketability.
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Impact of the global financial crisis on economic growth: implications for South Africa and other developing economies

  • Authors: Savy, Neil Edward
  • Date: 2015
  • Subjects: Global Financial Crisis, 2008-2009 , Gross domestic product -- Developing countries , Gross domestic product -- South Africa , Economic forecasting -- South Africa , Economic forecasting -- Developing countries , Economic development -- South Africa , Economic development -- Developing countries
  • Language: English
  • Type: Thesis , Masters , MCom
  • Identifier: vital:1117 , http://hdl.handle.net/10962/d1017542
  • Description: This paper examines the impact of the recent global financial crisis on economic growth in developing economies and South Africa in particular. It explores whether the events experienced by developing countries conform to what would be anticipated from economic theory. This is done by firstly comparing country growth forecasts for 2012 captured in 2008 at the beginning of the crisis to actual 2012 GDP growth data. Secondly, panel data analysis is used to investigate three important transmission channels, namely those of Trade, Capital Flows and Exchange Rates for 25 developing economies. The results suggest that economic forecasters in 2008 on average overestimated GDP growth for 2012 by -21.6 percent (excluding Venezuela). The only important transmission channel identified using Trend analysis to explain this negative impact on growth was capital flows. However when using Panel regression analysis all three channels were found to explain the economic impact of the crisis on GDP growth for developing countries, conforming to economic theory. It was discovered that, contrary to what was initially expected, portfolio inflows actually increased for most developing countries during the crisis. This possibly can be explained by the impact of quantitative easing in the USA. South Africa was found to have been negatively impacted by the global financial crisis, but to a lesser extent when compared to most other developing countries. The findings are important for global investors looking for new investment opportunities. The extent to which individual economies are “decoupled” from developed economies’ performance provides possible opportunities for diversifying risk through a geographic spread of investor portfolios.
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Implementation of multilingualism in South African higher education : exploring the use of isiXhosa in teaching and learning at Rhodes University

  • Authors: Gambushe, Wanga
  • Date: 2015
  • Subjects: Language and education -- South Africa , Multilingual education -- South Africa , Native language and education -- South Africa , Education, Higher -- South Africa , Language policy -- South Africa , Cytology -- Study and teaching (Higher) -- South Africa , Xhosa (African people) -- Education (Higher)
  • Language: English
  • Type: Thesis , Masters , MA
  • Identifier: vital:3649 , http://hdl.handle.net/10962/d1017890
  • Description: This study explores the implementation of multilingualism at Rhodes University (RU), by examining the teaching and learning practices of lecturers, demonstrators and students within the Cell Biology module, offered by the Biological Sciences and Botany departments at RU. This examination is in line with RU’s Language Policy (2005/2014), which recognises multilingualism and the development of isiXhosa as an academic/scientific language. The study and the choice for the location of the study within RU was motivated by what seemed to be a pattern of under achievement of LOTE speaking students studying Cell Biology. This pattern necessitated a further inquiry into the language aspect of the teaching and learning of Cell Biology. The goals of this research were to investigate spaces where LOTE students use their home languages and the motivations behind their usage of those languages. Due to the varying proficiencies of LOTE students in their mother tongue, this study sought to investigate the language capabilities of LOTE students in their home languages. The perceptions of the main role players in the Cell Biology module were sought, in order to get an idea of what students, lecturers and demonstrators thought about multilingualism in teaching and learning practices in the Cell Biology module. This study has discovered that there is a disparity in achievement between LOTE and English speaking students, with English students outperforming LOTE students consistently in the period investigated. On the language capabilities of LOTE students in their mother tongue, it was discovered that they have enough linguistic capital for a mother tongue intervention to succeed. There were mixed views about the use of LOTE in HE, but students were mostly in favour of the use of LOTE. A number of recommendations are made as to how multilingualism can be implemented in Cell Biology. In this study I argue that there is a need to use the mother tongue of LOTE students in order to support learning, the mother tongue intervention is supported by scholars such as Paxton (2007, 2009; Madiba 2011, 2012, 2014). The use of the mother tongue to support learning should be a short-term measure while the process of the development of African languages is underway, because languages develop as they are used, and form follows function (Madiba 2008). Ultimately, African languages should be developed and use as academic languages in HE not only in order to fulfil the legislative imperatives such as the Constitution and the Language Policy Higher Education but also to increase access and success among LOTE students.
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Implementing uncertainty analysis in water resources assessment and planning

  • Authors: Hughes, Denis A , Mohobane, T , Mallory, S
  • Date: 2015
  • Subjects: To be catalogued
  • Language: English
  • Type: text , report
  • Identifier: http://hdl.handle.net/10962/438281 , vital:73448 , ISBN 978-1-4312-0629-2 , https://wrcwebsite.azurewebsites.net/wp-content/uploads/mdocs/2056-1-14.pdf
  • Description: The main objective of the project was to contribute to the incorporation of uncer-tainty assessments in practical water resource decision-making in South Africa. There are three main components to this objective. The first is the quantification of realistic levels of uncertainty that are as low as possible given the available infor-mation (reducing uncertainty). The second is the availability of tools to implement uncertainty analysis across the broad spectrum of data analysis and modelling plat-forms that form part of practical water resources assessment (including hydrologi-cal and water resources yield models). The third relates to the issue of using uncer-tain information in the process of making decisions about the design, development or operation of water resources systems. The latter includes social, political and economic uncertainties as well as the hydrological uncertainties that are directly addressed in this report. None of these are independent and all are associated with the fundamental issue that all of the role players should understand the key con-cepts of uncertainty and that virtually all of the information we use to make deci-sions is uncertain. One of the major challenges in this project as well as the previous WRC-supported project on uncertainty methods, was the lack of understanding of some of the key issues, or a lack of appreciation of the importance of uncertainty in all water resources decision-making.
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Improved triplet state parameters for indium octacarboxy phthalocyanines when conjugated to quantum dots and magnetite nanoparticles

  • Authors: Tshangana, Charmaine , Nyokong, Tebello
  • Date: 2015
  • Subjects: To be catalogued
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/10962/189337 , vital:44838 , xlink:href="https://doi.org/10.1016/j.molstruc.2015.02.040"
  • Description: Fe3O4 magnetic nanoparticles (MNPs) and glutathione (GSH) capped CdSe@ZnS quantum dots (QDs) were separately coordinated to indium octacarboxy phthalocyanine (InPc(COOH)8) to form ClInPc(COOH)8–MNPs and ClInPc(COOH)8–GSH–CdSe@ZnS, respectively. The photophysical parameters (triplet state and fluorescence quantum yields and lifetimes) were determined for the conjugates. The triplet quantum yields increased from ΦT = 0.49 for InPc(COOH)8 alone to ΦT = 0.61 and 0.56 for InPc(COOH)8 in the conjugates: ClInPc(COOH)8–MNPs and ClInPc(COOH)8–GSH–CdSe@ZnS, respectively. The lifetimes also became longer for the conjugates compared to Pc alone.
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In a town called Harmony

  • Authors: Tsibolane, Pitso
  • Date: 2015
  • Subjects: South African fiction (English) -- 21st century , Creative writing (Higher education) , South African fiction (English) -- Study and teaching (Higher)
  • Language: English
  • Type: Thesis , Masters , MA
  • Identifier: vital:5995 , http://hdl.handle.net/10962/d1017779
  • Description: A novella of crime and suspense set in the townships surrounding the mining town of Welkom Two friends, both ex-miners, start a welding business only to see it fail because of interference by corrupt officials To make ends meet, they are drawn into the world of illegal gold-mining, working with criminals who employ ‘zama-zamas’: desperate foreign nationals who are prepared to live and work in the abandoned mine tunnels underground The friends make money, but the dark practices of illegal mining put a strain on their relationship, their values, and their family ties.
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In search of the comprador: self-exoticisation in selected texts from the South Asian and Middle Eastern diasporas

  • Authors: Shabangu, Mohammad
  • Date: 2015
  • Subjects: Rushdie, Salman. Midnight's children -- Criticism and interpretation , Kureishi, Hanif. Buddha of suburbia -- Criticism and interpretation , Hosseini, Khaled. Kite runner -- Criticism and interpretation , Hosseini, Khaled. Thousand splendid suns -- Criticism and interpretation , Compradors , Exoticism in literature , Literature and transnationalism -- Middle East , Literature and transnationalism -- South Asia , Middle Eastern literature (English) -- History and criticism , South Asian literature (English) -- History and criticism
  • Language: English
  • Type: Thesis , Masters , MSocSc
  • Identifier: vital:2328 , http://hdl.handle.net/10962/d1017770
  • Description: This thesis is concerned with transnational literature and writers of the Middle Eastern and South Asian diasporas. It argues that the diasporic position of the authors enables their roles as comprador subjects. The thesis maintains that the figure of the comprador is always acted upon by its ontological predisposition, so that diasporic positionality often involves a single subject which straddles and speaks from two or more different subject positions. Comprador authors can be said to be co-opted by Western metropolitan publishing companies who stand to benefit by marketing the apparent marginality of the homelands about which these authors write. The thesis therefore proceeds from the notion that such a diasporic position is the paradoxical condition of the transnational subject or writer. I submit that there is, to some degree, a questionable element in the common political and cultural suggestions that emerge upon closer evaluation of diasporic literature. Indeed, a charge of complicity has been levelled against authors who write, apparently, to service two distinct entities – the wish to speak on behalf of a minority collective, as well as the imperial ‘centre’ which is the intended interlocutor of the comprador author. However, it is this difference, the implied otherness or marginality of the outsider within, which I argue is sometimes used by diasporic writers as a way of articulating with ‘authenticity’ the cultures and politics of their erstwhile localities. This thesis is concerned, therefore, with the representation of ‘the East’ in four novels by diasporic, specifically comprador writers, namely Salman Rushdie’s Midnight’s Children, Hanif Kureishi’s The Buddha of Suburbia, and Khaled Hosseini’s The Kite Runner and A Thousand Splendid Suns. I suggest that the ‘third-world’ and transnational literature can also be a selling point for the transnational subject, whose representations may at times pander to preconceived ideas about ‘the Orient’ and its people. As an illustration of this double-bind, I offer a close reading of all the novels to suggest that on the one hand, the comprador author writes within the paradigm of the ‘writing back’ movement, as a counter-discourse to the Orientalist representations of the homeland. However, the corollary is that such an attempt to ‘write back’, in a sense, re-inscribes the very discourse it wishes to subvert, especially because the literature is aimed at a ‘Western’ audience. Moreover, the template of the comprador could be used to explain how a transnational post-9/11 text from an Afghan-American, for instance, may be put to the service of the imperial machine, and read, therefore, as a supporting document to the U.S. policy on Afghanistan.
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In silico analysis of human Hsp90 for the identification of novel anti-cancer drug target sites and natural compound inhibitors

  • Authors: Penkler, David Lawrence
  • Date: 2015
  • Subjects: Heat shock proteins , Cancer -- Treatment , Molecular chaperones , Homeostasis , Carcinogenesis , Chemotherapy , Ligand binding (Biochemistry) , Protein-protein interactions
  • Language: English
  • Type: Thesis , Masters , MSc
  • Identifier: vital:4162 , http://hdl.handle.net/10962/d1018938
  • Description: The 90-KDa heat shock protein (Hsp90) is part of the molecular chaperone family, and as such it is involved in the regulation of protein homeostasis within cells. Specifically, Hsp90 aids in the folding of nascent proteins and re-folding of denatured proteins. It also plays an important role in the prevention of protein aggregation. Hsp90’s functionality is attributed to its several staged, multi-conformational ATPase cycle, in which associated client proteins are bound and released. Hsp90 is known to be associated with a wide array of client proteins, some of which are thought to be involved in multiple oncogenic processes. Indeed Hsp90 is known to be directly involved in perpetuating the stability and function of multiple mutated, chimeric and over-expressed signalling proteins that are known to promote the growth and survival of cancer cells. Hsp90 inhibitors are thus thought to be promising therapeutic agents for cancer treatment. A lack of a 3D structure of human Hsp90 however has restricted Hsp90 inhibitor development in large to in vivo investigations. This study, aims to investigate and calculate hypothetical homology models of the full human Hsp90 protein, and to probe these structural models for novel drug target sites using several in silico techniques. A multi-template homology modelling methodology was developed and in conjunction with protein-protein docking techniques, two functionally important human Hsp90 structural models were calculated; the nucleotide free “v-like” open and nucleotide bound closed conformations. Based on the conservation of ligand binding, virtual screening experiments conducted on both models using 316 natural compounds indigenous to South Africa, revealed three novel putative target sites. Two binding pockets in close association with important Hsp90-Hop interaction residues and a single binding pocket on the dimerization interface in the C-terminal domain. Targeted molecular docking experiments at these sites revealed two compounds (721395-11-5 and 264624-39-7) as putative inhibitors, both showing strong binding affinities for at least one of the three investigated target sites. Furthermore both compounds were found to only violate one Lipinski’s rules, suggesting their potential as candidates for further drug development. The combined work described here provides a putative platform for the development of next generation inhibitors of human Hsp90.
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