How do urban dwellers identify with features within urban green spaces in the Eastern Cape?
- Authors: Manyani, Amanda
- Date: 2019
- Subjects: Land use, Urban -- South Africa , Greenbelts -- South Africa , City planning -- South Africa
- Language: English
- Type: text , Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10962/95596 , vital:31174
- Description: Public urban green spaces contain natural and artificial features which play crucial roles in supporting urban social-ecological systems, a fact now recognized globally. The various natural and artificial features contained in public urban green spaces are said to be key contributors to the quality of life and well-being of urban dwellers. Nevertheless, this has been largely ignored in urban design in South Africa, especially in the poorer township and Reconstruction Development Program (RDP) areas. At the individual household and community levels within the poorer communities, the provision of green spaces and trees, as well as recreation facilities, is well below world standards, and much less than what is available in the more affluent areas of South African towns. Additionally, most research on the links between nature and human well-being in urban contexts comes from developed world contexts which adopt a westernized view of the relationship. Yet, in many societies of the Global South, including South Africa, worldviews and experiences of nature in green spaces and use of other recreational features takes on different meanings to those of the Global North. To show these differences, a combination of methods was used in this study, different types of green spaces were assessed and evaluated by structured observations so as to record the features present within the spaces. A survey of 360 households was conducted by targeting green space users and households within 100 metres from a green space. Results indicated that, across all the green space types, formal green spaces had a low cover of shrubs, trees and herbs whilst having high lawn cover. Furthermore, vegetation had poor rating across all the green spaces since the vegetation was either overgrown herbs, dense thickets of shrubs and mostly alien trees that were either diseased or forked. Similar to the disparity in the composition and structure of vegetation within the green spaces, there was a wide variability in the composition of recreational features and amenities across the green spaces. The formal green spaces had the most amenities like play equipment, shelter and seating. Informal green spaces and commonages had little or no recreational features available. The attributes of these spaces therefore influenced the reasons for visiting as more than 90 % of the respondents simply used the spaces for transit. With regards to attitudes and preferences towards particular features, they were emerging sense of strong negative feelings towards natural features. Most respondents emphasized the need for green spaces that are well laid out with maintained lawns, recreational facilities and open vegetation. Thus, the current design and available features within the studied urban green spaces do not meet local needs and aspirations and thus do not contribute to better well-being and quality of life as much as they could. Specifically, the various health benefits linked with being in contact with nature in the public green spaces were not evident in this study. The South African specific context in green space use, perception and people’s preferences is thus crucial for urban planning and sustainability.
- Full Text:
- Authors: Manyani, Amanda
- Date: 2019
- Subjects: Land use, Urban -- South Africa , Greenbelts -- South Africa , City planning -- South Africa
- Language: English
- Type: text , Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10962/95596 , vital:31174
- Description: Public urban green spaces contain natural and artificial features which play crucial roles in supporting urban social-ecological systems, a fact now recognized globally. The various natural and artificial features contained in public urban green spaces are said to be key contributors to the quality of life and well-being of urban dwellers. Nevertheless, this has been largely ignored in urban design in South Africa, especially in the poorer township and Reconstruction Development Program (RDP) areas. At the individual household and community levels within the poorer communities, the provision of green spaces and trees, as well as recreation facilities, is well below world standards, and much less than what is available in the more affluent areas of South African towns. Additionally, most research on the links between nature and human well-being in urban contexts comes from developed world contexts which adopt a westernized view of the relationship. Yet, in many societies of the Global South, including South Africa, worldviews and experiences of nature in green spaces and use of other recreational features takes on different meanings to those of the Global North. To show these differences, a combination of methods was used in this study, different types of green spaces were assessed and evaluated by structured observations so as to record the features present within the spaces. A survey of 360 households was conducted by targeting green space users and households within 100 metres from a green space. Results indicated that, across all the green space types, formal green spaces had a low cover of shrubs, trees and herbs whilst having high lawn cover. Furthermore, vegetation had poor rating across all the green spaces since the vegetation was either overgrown herbs, dense thickets of shrubs and mostly alien trees that were either diseased or forked. Similar to the disparity in the composition and structure of vegetation within the green spaces, there was a wide variability in the composition of recreational features and amenities across the green spaces. The formal green spaces had the most amenities like play equipment, shelter and seating. Informal green spaces and commonages had little or no recreational features available. The attributes of these spaces therefore influenced the reasons for visiting as more than 90 % of the respondents simply used the spaces for transit. With regards to attitudes and preferences towards particular features, they were emerging sense of strong negative feelings towards natural features. Most respondents emphasized the need for green spaces that are well laid out with maintained lawns, recreational facilities and open vegetation. Thus, the current design and available features within the studied urban green spaces do not meet local needs and aspirations and thus do not contribute to better well-being and quality of life as much as they could. Specifically, the various health benefits linked with being in contact with nature in the public green spaces were not evident in this study. The South African specific context in green space use, perception and people’s preferences is thus crucial for urban planning and sustainability.
- Full Text:
How to engage with challenges facing Water and Sanitation Services (WSS) in small municipalities
- Clifford-Holmes, Jai K, Carnohan, Shane, Slinger, Jill W, Palmer, Carolyn G
- Authors: Clifford-Holmes, Jai K , Carnohan, Shane , Slinger, Jill W , Palmer, Carolyn G
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , report
- Identifier: http://hdl.handle.net/10962/437869 , vital:73418 , ISBN 978-1 4312-0988-0 , https://wrcwebsite.azurewebsites.net/wp-content/uploads/mdocs/SP 120-18 web.pdf
- Description: Smaller South African municipalities have many urgent calls on their resources AT THE SAME TIME. • The need to pay salaries is sometimes more important than other concerns. • It is not always clear how different problems affect each other. • It is difficult to decide what to do each day. • There are always urgent crises to attend to. • There are many meetings to attend. • Operational and political priorities can be different. Thinking of, and talking about your municipality as a SYSTEM will help you to ACT in ways that reduce the impact of these issues. This handbook relates specifically to water and sanitation issues.
- Full Text:
- Authors: Clifford-Holmes, Jai K , Carnohan, Shane , Slinger, Jill W , Palmer, Carolyn G
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , report
- Identifier: http://hdl.handle.net/10962/437869 , vital:73418 , ISBN 978-1 4312-0988-0 , https://wrcwebsite.azurewebsites.net/wp-content/uploads/mdocs/SP 120-18 web.pdf
- Description: Smaller South African municipalities have many urgent calls on their resources AT THE SAME TIME. • The need to pay salaries is sometimes more important than other concerns. • It is not always clear how different problems affect each other. • It is difficult to decide what to do each day. • There are always urgent crises to attend to. • There are many meetings to attend. • Operational and political priorities can be different. Thinking of, and talking about your municipality as a SYSTEM will help you to ACT in ways that reduce the impact of these issues. This handbook relates specifically to water and sanitation issues.
- Full Text:
How to engage with coal mines through Catchment Management Forums
- Munnik, Victor, Holleman, Helen, Wolff, Margaret G, Palmer, Carolyn G
- Authors: Munnik, Victor , Holleman, Helen , Wolff, Margaret G , Palmer, Carolyn G
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , report
- Identifier: http://hdl.handle.net/10962/437882 , vital:73419 , ISBN 978-1 4312-0990-3 , https://wrcwebsite.azurewebsites.net/wp-content/uploads/mdocs/SP 122-18 web.pdf
- Description: This book was written for the catchment management forum (CMF) in the Upper Komati Forum (UKF), and they share their experience in order to help other CMFs understand the damage coal mining does to our water resources. This booklet should be used with How to think and act in ways that make Adaptive IWRM practically possible and How to establish and run a Catchment Management Forum.
- Full Text:
- Authors: Munnik, Victor , Holleman, Helen , Wolff, Margaret G , Palmer, Carolyn G
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , report
- Identifier: http://hdl.handle.net/10962/437882 , vital:73419 , ISBN 978-1 4312-0990-3 , https://wrcwebsite.azurewebsites.net/wp-content/uploads/mdocs/SP 122-18 web.pdf
- Description: This book was written for the catchment management forum (CMF) in the Upper Komati Forum (UKF), and they share their experience in order to help other CMFs understand the damage coal mining does to our water resources. This booklet should be used with How to think and act in ways that make Adaptive IWRM practically possible and How to establish and run a Catchment Management Forum.
- Full Text:
How to manage water quantity and water quality together
- Retief, Hugo, Holleman, Helen, Palmer, Carolyn G
- Authors: Retief, Hugo , Holleman, Helen , Palmer, Carolyn G
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , report
- Identifier: http://hdl.handle.net/10962/437907 , vital:73421 , ISBN 978-1 4312-0987-3 , https://wrcwebsite.azurewebsites.net/wp-content/uploads/mdocs/SP%20119-18%20web.pdf
- Description: All over the world water resources are under pressure due to over-use and pollution, and finding ways to meet the need for water is becoming increasingly difficult. Nat-ural variation in rainfall also contributes to making planning and management of flow and water quality, and especially these together, complex and difficult. People have realised that it is important to consider many factors when managing water – they call this Integrated Water Resource Management (IWRM). Integrating many factors is in line with the ideas that all the “How to” handbooks are based on. Please do read the foundation handbook: “How to think and act in ways that make Adap-tive IWRM practically possible”. In this handbook we consider how to integrate flow and water quality. Although some writers think taking account of all the many fac-tors is too difficult, others – including the authors of this handbook – believe it is essential to try if we want to find the balance between use and protection. IWRM also recognises that it is vital to involve stakeholders in decision-making if protec-tion of our water resources is going to be successful.
- Full Text:
- Authors: Retief, Hugo , Holleman, Helen , Palmer, Carolyn G
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , report
- Identifier: http://hdl.handle.net/10962/437907 , vital:73421 , ISBN 978-1 4312-0987-3 , https://wrcwebsite.azurewebsites.net/wp-content/uploads/mdocs/SP%20119-18%20web.pdf
- Description: All over the world water resources are under pressure due to over-use and pollution, and finding ways to meet the need for water is becoming increasingly difficult. Nat-ural variation in rainfall also contributes to making planning and management of flow and water quality, and especially these together, complex and difficult. People have realised that it is important to consider many factors when managing water – they call this Integrated Water Resource Management (IWRM). Integrating many factors is in line with the ideas that all the “How to” handbooks are based on. Please do read the foundation handbook: “How to think and act in ways that make Adap-tive IWRM practically possible”. In this handbook we consider how to integrate flow and water quality. Although some writers think taking account of all the many fac-tors is too difficult, others – including the authors of this handbook – believe it is essential to try if we want to find the balance between use and protection. IWRM also recognises that it is vital to involve stakeholders in decision-making if protec-tion of our water resources is going to be successful.
- Full Text:
How to think and act in ways that make Adaptive IWRM practically possible
- Palmer, Carolyn G, Biggs, Harry, Rogers, Kevin H, du Toit, Derick, Pollard, Sharon
- Authors: Palmer, Carolyn G , Biggs, Harry , Rogers, Kevin H , du Toit, Derick , Pollard, Sharon
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , report
- Identifier: http://hdl.handle.net/10962/437937 , vital:73423 , ISBN 978-1 4312-0984-2 , https://wrcwebsite.azurewebsites.net/wp-content/uploads/mdocs/SP 116-18 web.pdf
- Description: “We cross the river by feeling the stones with our feet” (Chinese proverb). Most of the ideas in this handbook you already know from living your life. Here we put your everyday experience and knowledge into the language of managing water. In the last twenty years, there has been a lot of talk about new ways to make Integrated Water Resource Management or “IWRM” work, but not nearly as much useful knowledge about how to put those ideas into practice. We now know how to use a set of ideas and ways of understanding that help us to make IWRM really work prac-tically. We call this practical way of working: Adaptive IWRM. This is the first in a series of handbooks to come out of a WRC project Practising Adaptive IWRM (Inte-grated Water Resource Management (IWRM) in South Africa: towards practising a new paradigm* [TPNP]). The TPNP project researchers have had experience with many different situations in southern Africa, where people have grappled* with put-ting the ideas of complexity* and integration into practice.
- Full Text:
- Authors: Palmer, Carolyn G , Biggs, Harry , Rogers, Kevin H , du Toit, Derick , Pollard, Sharon
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , report
- Identifier: http://hdl.handle.net/10962/437937 , vital:73423 , ISBN 978-1 4312-0984-2 , https://wrcwebsite.azurewebsites.net/wp-content/uploads/mdocs/SP 116-18 web.pdf
- Description: “We cross the river by feeling the stones with our feet” (Chinese proverb). Most of the ideas in this handbook you already know from living your life. Here we put your everyday experience and knowledge into the language of managing water. In the last twenty years, there has been a lot of talk about new ways to make Integrated Water Resource Management or “IWRM” work, but not nearly as much useful knowledge about how to put those ideas into practice. We now know how to use a set of ideas and ways of understanding that help us to make IWRM really work prac-tically. We call this practical way of working: Adaptive IWRM. This is the first in a series of handbooks to come out of a WRC project Practising Adaptive IWRM (Inte-grated Water Resource Management (IWRM) in South Africa: towards practising a new paradigm* [TPNP]). The TPNP project researchers have had experience with many different situations in southern Africa, where people have grappled* with put-ting the ideas of complexity* and integration into practice.
- Full Text:
How to use Strategic Adaptive Management (SAM) and the Adaptive Planning Process (APP) to build a shared catchment future
- Palmer, Carolyn G, Rogers, Kevin H, Holleman, Helen, Wolff, Margaret G
- Authors: Palmer, Carolyn G , Rogers, Kevin H , Holleman, Helen , Wolff, Margaret G
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , report
- Identifier: http://hdl.handle.net/10962/437965 , vital:73425 , ISBN 978-1 4312-0991-0 , https://wrcwebsite.azurewebsites.net/wp-content/uploads/mdocs/SP 123-18 web.pdf
- Description: For members of Catchment Management Forums (CMFs) and Catchment Manage-ment Agencies (CMAs). CMFs are made up of people who represent all the stake-holders in a catchment. They are the people who know the catchment best, and therefore are in the best position to alert CMAs to local issues and to help develop the strategic plans for their local catchment. However, catchments are dynamic*, complex* systems that need a special planning approach – and that is what this handbook is about. If one part of a catchment is neglected and damaged, it affects the whole system and everyone living in it. We use and recommend a flexible, adap-tive approach in which everyone involved in the planning is both a teacher and a learner, and where everyone contributes their special wisdom to developing a sustainable plan for the catchment.
- Full Text:
- Authors: Palmer, Carolyn G , Rogers, Kevin H , Holleman, Helen , Wolff, Margaret G
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , report
- Identifier: http://hdl.handle.net/10962/437965 , vital:73425 , ISBN 978-1 4312-0991-0 , https://wrcwebsite.azurewebsites.net/wp-content/uploads/mdocs/SP 123-18 web.pdf
- Description: For members of Catchment Management Forums (CMFs) and Catchment Manage-ment Agencies (CMAs). CMFs are made up of people who represent all the stake-holders in a catchment. They are the people who know the catchment best, and therefore are in the best position to alert CMAs to local issues and to help develop the strategic plans for their local catchment. However, catchments are dynamic*, complex* systems that need a special planning approach – and that is what this handbook is about. If one part of a catchment is neglected and damaged, it affects the whole system and everyone living in it. We use and recommend a flexible, adap-tive approach in which everyone involved in the planning is both a teacher and a learner, and where everyone contributes their special wisdom to developing a sustainable plan for the catchment.
- Full Text:
Humor, innovation, and competition in Jamaican music:
- Authors: Stanley Niaah, Sonjah
- Date: 2019
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/146398 , vital:38522 , ISBN 9781351266628
- Description: Book abstract. An essential part of human expression, humor plays a role in all forms of art, and humorous and comedic aspects have always been part of popular music. For the first time, The Routledge Companion to Popular Music and Humor draws together scholarship exploring how the element of humor interacts with the artistic and social aspects of the musical experience. Discussing humor in popular music across eras from Tin Pan Alley to the present, and examining the role of humor in different musical genres, case studies of artists, and media forms, this volume is a groundbreaking collection that provides a go-to reference for scholars in music, popular culture, and media studies.
- Full Text:
- Authors: Stanley Niaah, Sonjah
- Date: 2019
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/146398 , vital:38522 , ISBN 9781351266628
- Description: Book abstract. An essential part of human expression, humor plays a role in all forms of art, and humorous and comedic aspects have always been part of popular music. For the first time, The Routledge Companion to Popular Music and Humor draws together scholarship exploring how the element of humor interacts with the artistic and social aspects of the musical experience. Discussing humor in popular music across eras from Tin Pan Alley to the present, and examining the role of humor in different musical genres, case studies of artists, and media forms, this volume is a groundbreaking collection that provides a go-to reference for scholars in music, popular culture, and media studies.
- Full Text:
I want them to be confident, to build an argument: an exploration of the structure of knowledge and knowers in Political Studies
- Hlatshwayo, Mlamuli Nkosingphile
- Authors: Hlatshwayo, Mlamuli Nkosingphile
- Date: 2019
- Subjects: Political science -- Study and teaching (Higher) -- South Africa , Education, Higher -- Curricula -- South Africa , Rhodes University. Department of Political Studies
- Language: English
- Type: text , Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/92392 , vital:30719
- Description: The 2015-2016 student movements in South African higher education sharply critique what was perceived to be the slow pace of institutional transformation and decolonisation in institutions of higher learning (see Badat, 2016; Heleta, 2016b; Mbembe, 2016). One of the academic fields that has come under scrutiny is Political Studies, which has been accused of being un-transformed, irrelevant and not reflecting local, indigenous scholarship in curricula or pedagogy (see for example Matthews, 2018; Mngomezulu & Hadebe, 2018; Tselapedi, 2016). Although this literature critiques neo-colonial predominance of western thought within the field, and the need to re-centre non-Western modes of being, thinking and intellectualising, I argue that this literature actually considers epistemologies without necessarily making a razor sharp critique at the underlying mechanisms and processes of Political Studies knowledge, and the extent to which it can be decolonised and transformed. It is on this gap that I make a contribution to the field.This study is positioned in the field of higher education decolonisation, with a specific focus on exploring knowledge and knower structures in Political Studies. I explore the various ways in which knowledge is valued and legitimated in the field of Political Studies by asking the “how” question – that is, how is knowledge legitimated in Political Studies? This includes a consideration of how the Postgraduate Diploma in International Studies (PDIS) programme, designed to promote and enable an “expert in African International Studies”, legitimates a certain kind of knower in the field. I employ Basil Bernstein’s pedagogic device as a theoretical foundation for exploring 1) what the field of Political Studies knowledge production looks like, 2) how knowledge is recontextualised from the field of production and into the PDIS curriculum, and 3), how that knowledge is legitimated and evaluated through the programnme’s assessment documents, and what they revel as valued and legitimate curriculum knowledge in the field. Karl Maton’s Legitimation Code theory (LCT), specifically Specialisation, is called upon to offer sharp analytical tools for investigating the underlying mechanisms and processes of the knower and knowledge structures that the programme legitimates. It particularly sheds some insight on the kinds of gazes that are valued in the field of Political Studies in general, and in the PDIS programme in particular. The case study for this research is Rhodes University, a historically white university which offered insight and contested history into the kinds of being, knowledges and knowers that were historically legitimated and valued in the institution, as well as the current institutional landscape, and challenges that the institution is grappling with. The data generation included the formally planned curriculum as contained in the programme’s curriculum documents. These included course outlines, seminar critiques, presentations, class participation; class discussions; essay questions and exams/exam portfolio. The data generation also included semi-structured interviews with the lecturers who were regarded as the “recontextualising agents”, who taught in the programme and who offered key insights on some of the curriculum choices regarding selection, pacing, sequencing and evaluation of the curriculum knowledge in the PDIS programme.This study revealed that that the PDIS programmes values and legitimates curriculum knowledge by ensuring that students have a critical understanding of African political economy, war and conflict on the African continent, as well as the challenges of peacekeeping and peace building in new and fragile African states. This was also seen in how the attributes and dispositions of knowers were also valued in how students needed to have social and cultural gazes in order to access the curriculum and to successfully participate as knowers in the field. This suggested that access to both curriculum knowledge and to being a valued knower in the field, could be said to be relatively open and unrestrictive. In this study, I first argue that looking critically at how Political Studies knowledge is recontextualised from the field of production and into the PDIS curriculum can be seen as a decolonising process as it enables us to see the underlying mechanisms and processes of how Political studies knowledge and knowers are valued and legitimated in the field. This offers us an insightful space to see to what extent the fields of production, recontextualisation, as well as reproduction of Political Studies in general, and the PDIS programme in particular, could be said to have a colonising gaze. It also offers insight on how we can go about exploring, transforming and decolonising Political Studies and the PDIS programme. Secondly, exploring the knowledge and knower structures of the PDIS programme can help curriculum designers, lecturers and students identify the knowledge and knower codes of the curriculum, and to critically reflect on their curriculum codes and how to enable epistemological access to students. Furthermore, this study can help lecturers and curriculum designers construct their curriculum in ways that are inclusive, open, and socially just, by being critically aware of the kind of knowledge that they choose to legitimate, and those they choose to disregard in their knowledge recontextualisation and its evaluation. , Unyaka wezi 2015-2016 wombhikisho wabafundi eningizimu afrika zemfundo ephakeme umcwaningi nokungabikhona kakhulu ukuthi kube kancane awuhambi zesikhungo kanye decolonisation ezikhungweni of higher learning (bheka badat, nowezi-2016; Heleta, 2016b; Mbembe, nowezi-2016). Enye yenkambu yezemfundo ephakeme ethe yaba ngaphansi kokuhlolisiswa kabanzi izifundo zezombusazwe, ebhekene nezingqinamba zokungashinsthi, ukungabi lusizo endaweni, ukungabi yisithombe somphakathi, nokukungangeneleli isifundo somdabu kwezemfundo noma i-pedagogy (bheka isibonelo Matthews, 2018; Mngomezulu & Hadebe, 2018; Tselapedi, nowezi-2016). Nakuba lo mbhalo ugxeka ineo-kholoni ikakhulukazi imicabango yasentshonalanga, nokudinga ukubuyekezwa indlela yokucabanga nobuhlakani okungasibo baseNtshonalanga. Ngiyaphikisana nokuthi lo mbhalo ubuyekeza i-epistomology ngempela ngaphandle kokucwaninga kabanzi ukusetsenziswa kobuhlakani nolwazi lwezemfundo yombusazwe, kanye nokwandisa izinguquko noshintsho. Ngizophonsa esivivaneni kulolu gebe olulapho. Lolu cwaningo lusesimeni sokwenza izinguquko kwinkundlazwelo yemfundo ephakeme, ikakhulu ukuhlola ulwazi kanye nezakhiwo ze-knower kwezemfundo yombusazwe. Ngibheka izindlela ezahlukene ngolwazi kanye nokuba semthethweni kwinkundlazwelo yezemfundo zombusazwe ngokubuza umbuzo “kanjani”-ngokuthi, ulwazi lubekwa kanjani ngokomthethwo wezemfundo yombusazwe? Lokhu kubandakanya inkokhelo yombuzo wokuthi kwenzakala kanjani ukuthi ipostgraduate Diploma in International Studies (pdis), yenzelwe ukukhuthaza kanye nokuba wumpetha kwi African International studies”, ukwenza semthethweni eminye yenkundlazwelo yama-knower. Ngisebenzisa ithiyori ya Basil Bernstein ukuhlola 1) Ibukeka kanjani inkundla yokuhkiqiza yezemfundo zezombusazwe, 2) ngolwazi lobuhlakani enkundleni lapho nasesikhathini uhlelo lwezemfundo PDIS yenza umkhiqizo kanye 3), futhi ukwazi ukuthi khona lusemthethweni uhlelo nokuhlola, nokuthi yini abayiveza ukuthi isemthethweni kwizifundo zolwazi. Ithiyori ka Karl matonâ legitimation code theory (lct), ikakhulu Specialisation, yiyona enganikeza kafuphi izinsiza zokuphenya indlela kanye nenqubo ye-knower kanye nolwazi lwesakhiwo esisemthethweni. Iveza kabanzi izindlela zokubheka ezisemqoka nezisematheni kwinkundla yezemfundo zombusazwe kanye nohlelo lwe PDIS ikakhulukazi Indawo lapho ngizoqhuba khona lolu cwaningo iNyuvesi yaseRhodes, ngokomlando iNyuvesi yabamhlophe enikezana ukuqonda nokuncintana komlando kokungena kwezinhlobo, ubuhlakani kanye nama-knower omlando osemthethweni kanye nokhethekile kulesi sikhungo, kanjalo ne-Landscape yesikhungo samanje, kanye nezinselelo lesi sikhungo sikahulumeni esibheke nazo. Idatha equkethwe ifaka izifundo ezihleliwe ngokomthetho njengokuba zitholakala ezifundweni ezihleliwe kumbhalo. Lokhu, kubandakanya isifundo esinye, amasemina abuyekeziwe, izethulo, nokubamba iqhaza ekilasini; izingxoxo zekilasi; imibuzo yendaba kanye nezivivinyo / nokuhlolwa kwezivivinyo. Idatha yesizukulwane iphinde ibandakanye izingxoxo ezihleliwe kanye nabafundisi abathathwa njengabantu abayizingcithabuchopho, abafundisiwe kulo mkhakha kanye naba neso ekukhethweni kwamanye amakharikhulamu abhekelele ukuhlunga, i-pacing, ukulandelela kanye nokuhlolwa kwekharikhulamu kulwazi lohlelo i-PDIS Lolu cwaningo ludalule ukuthi izinhlelo ze-PDIS zikubeka emqoka kanye nokubeka emthethweni ubuhlakani bekhurikhulamu ngokucophelela ukuthi abafundi bakuqonda ukubaluleka okulunzulu ngezomnotho wombusazwe wase Afrika, yimpi nokungqubuzana ezwenikazi lase-Afrika, ukugcina ukuthula kanye nezinkinga ekwakheni uxolo kanye nobuthakathaka / nophukayo kwezwekazi i-Afrika. Lokhu futhi kubonakele ngendlela yokubambisana kanye nokuziqhathulula kwama-knower aabalulekile ekufundiseni abafundi ngokudinga kokuba nezenhlalo kanye nesiko ukuze bakwazi ukuthola ikhurikhulamu kanye nokubamba iqhaza ngempumelelo njengama-knower kule nkundla. Lokhu kuchaze ukuthi ukufinyelela kuhlelo lokufunda kanye nokuba yilunga lama-knower, kungaba ukuba babonisane ngendlela evulelekile kanye nengenamkhawulo. Kulolu cwaningo, ngaqala ngabheka kabanzi ngokubalulekile ukuthi izifundo zezombusazwe ngolwazi lobuhlakani kwinkundlazwelo yokukhiqiza kanye nePDIS kungabonwa njengenguquko eyenza ukuba sikwazi ukubona ezinye izindlela zokusebenza kwezemfundo zombusazwe kanye nokubeka phambili ama-knower. Lokhu kusenza sibone ukubaluleka komkhiqizo wale nkundla, ukubuyekezwa kwezobuhlakani, kanye nomkhiqizo wezemfundo zombusazwe, kanye nohlelo lwe PDIS ikakhulukazi, kungathiwa ingaba nokubanjwa kokubheka. Iphinde isambulele kabanzi ukuthi singahlola, sense izinguquko kanye noshintsho kwezemfundo zombusazwe kanye nohlelo lwe PDIS. Okwesibili, ukuhlola ulwazi kanye nezakhiwo ze-knower ze-PDIS kungasiza abaklami bekhurikhulamu, abafundisi kanye nabafunsi ukukwazi ukuhlonza ulwazi nekhurikhulamu yekhodi ye-knower, kanye nokwazi ukubuyekeza kabanzi amakhodi ekhurikhulami yabo kanye nokwazi ukwenza i-epistemology ukuba abafundi bafinyelele kuyo. Ngaphezu kwalokhu, lolu cwaningo lungasiza abafundisi kanye nabaklamu bekhurikhulamu ukuba bakwazi ukwakha ikhurikhulamu yabo ngendlela ekhethekile, evulelekile, ngokwenhlalo nje, okubalulekile ukuthi uhlobo lophi lolwazi abakhetha lube semthethweni, kanye nalabo abakhetha ukungayilandeli inqubomgomo yolwazi kanye nokuhlola.
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- Authors: Hlatshwayo, Mlamuli Nkosingphile
- Date: 2019
- Subjects: Political science -- Study and teaching (Higher) -- South Africa , Education, Higher -- Curricula -- South Africa , Rhodes University. Department of Political Studies
- Language: English
- Type: text , Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/92392 , vital:30719
- Description: The 2015-2016 student movements in South African higher education sharply critique what was perceived to be the slow pace of institutional transformation and decolonisation in institutions of higher learning (see Badat, 2016; Heleta, 2016b; Mbembe, 2016). One of the academic fields that has come under scrutiny is Political Studies, which has been accused of being un-transformed, irrelevant and not reflecting local, indigenous scholarship in curricula or pedagogy (see for example Matthews, 2018; Mngomezulu & Hadebe, 2018; Tselapedi, 2016). Although this literature critiques neo-colonial predominance of western thought within the field, and the need to re-centre non-Western modes of being, thinking and intellectualising, I argue that this literature actually considers epistemologies without necessarily making a razor sharp critique at the underlying mechanisms and processes of Political Studies knowledge, and the extent to which it can be decolonised and transformed. It is on this gap that I make a contribution to the field.This study is positioned in the field of higher education decolonisation, with a specific focus on exploring knowledge and knower structures in Political Studies. I explore the various ways in which knowledge is valued and legitimated in the field of Political Studies by asking the “how” question – that is, how is knowledge legitimated in Political Studies? This includes a consideration of how the Postgraduate Diploma in International Studies (PDIS) programme, designed to promote and enable an “expert in African International Studies”, legitimates a certain kind of knower in the field. I employ Basil Bernstein’s pedagogic device as a theoretical foundation for exploring 1) what the field of Political Studies knowledge production looks like, 2) how knowledge is recontextualised from the field of production and into the PDIS curriculum, and 3), how that knowledge is legitimated and evaluated through the programnme’s assessment documents, and what they revel as valued and legitimate curriculum knowledge in the field. Karl Maton’s Legitimation Code theory (LCT), specifically Specialisation, is called upon to offer sharp analytical tools for investigating the underlying mechanisms and processes of the knower and knowledge structures that the programme legitimates. It particularly sheds some insight on the kinds of gazes that are valued in the field of Political Studies in general, and in the PDIS programme in particular. The case study for this research is Rhodes University, a historically white university which offered insight and contested history into the kinds of being, knowledges and knowers that were historically legitimated and valued in the institution, as well as the current institutional landscape, and challenges that the institution is grappling with. The data generation included the formally planned curriculum as contained in the programme’s curriculum documents. These included course outlines, seminar critiques, presentations, class participation; class discussions; essay questions and exams/exam portfolio. The data generation also included semi-structured interviews with the lecturers who were regarded as the “recontextualising agents”, who taught in the programme and who offered key insights on some of the curriculum choices regarding selection, pacing, sequencing and evaluation of the curriculum knowledge in the PDIS programme.This study revealed that that the PDIS programmes values and legitimates curriculum knowledge by ensuring that students have a critical understanding of African political economy, war and conflict on the African continent, as well as the challenges of peacekeeping and peace building in new and fragile African states. This was also seen in how the attributes and dispositions of knowers were also valued in how students needed to have social and cultural gazes in order to access the curriculum and to successfully participate as knowers in the field. This suggested that access to both curriculum knowledge and to being a valued knower in the field, could be said to be relatively open and unrestrictive. In this study, I first argue that looking critically at how Political Studies knowledge is recontextualised from the field of production and into the PDIS curriculum can be seen as a decolonising process as it enables us to see the underlying mechanisms and processes of how Political studies knowledge and knowers are valued and legitimated in the field. This offers us an insightful space to see to what extent the fields of production, recontextualisation, as well as reproduction of Political Studies in general, and the PDIS programme in particular, could be said to have a colonising gaze. It also offers insight on how we can go about exploring, transforming and decolonising Political Studies and the PDIS programme. Secondly, exploring the knowledge and knower structures of the PDIS programme can help curriculum designers, lecturers and students identify the knowledge and knower codes of the curriculum, and to critically reflect on their curriculum codes and how to enable epistemological access to students. Furthermore, this study can help lecturers and curriculum designers construct their curriculum in ways that are inclusive, open, and socially just, by being critically aware of the kind of knowledge that they choose to legitimate, and those they choose to disregard in their knowledge recontextualisation and its evaluation. , Unyaka wezi 2015-2016 wombhikisho wabafundi eningizimu afrika zemfundo ephakeme umcwaningi nokungabikhona kakhulu ukuthi kube kancane awuhambi zesikhungo kanye decolonisation ezikhungweni of higher learning (bheka badat, nowezi-2016; Heleta, 2016b; Mbembe, nowezi-2016). Enye yenkambu yezemfundo ephakeme ethe yaba ngaphansi kokuhlolisiswa kabanzi izifundo zezombusazwe, ebhekene nezingqinamba zokungashinsthi, ukungabi lusizo endaweni, ukungabi yisithombe somphakathi, nokukungangeneleli isifundo somdabu kwezemfundo noma i-pedagogy (bheka isibonelo Matthews, 2018; Mngomezulu & Hadebe, 2018; Tselapedi, nowezi-2016). Nakuba lo mbhalo ugxeka ineo-kholoni ikakhulukazi imicabango yasentshonalanga, nokudinga ukubuyekezwa indlela yokucabanga nobuhlakani okungasibo baseNtshonalanga. Ngiyaphikisana nokuthi lo mbhalo ubuyekeza i-epistomology ngempela ngaphandle kokucwaninga kabanzi ukusetsenziswa kobuhlakani nolwazi lwezemfundo yombusazwe, kanye nokwandisa izinguquko noshintsho. Ngizophonsa esivivaneni kulolu gebe olulapho. Lolu cwaningo lusesimeni sokwenza izinguquko kwinkundlazwelo yemfundo ephakeme, ikakhulu ukuhlola ulwazi kanye nezakhiwo ze-knower kwezemfundo yombusazwe. Ngibheka izindlela ezahlukene ngolwazi kanye nokuba semthethweni kwinkundlazwelo yezemfundo zombusazwe ngokubuza umbuzo “kanjani”-ngokuthi, ulwazi lubekwa kanjani ngokomthethwo wezemfundo yombusazwe? Lokhu kubandakanya inkokhelo yombuzo wokuthi kwenzakala kanjani ukuthi ipostgraduate Diploma in International Studies (pdis), yenzelwe ukukhuthaza kanye nokuba wumpetha kwi African International studies”, ukwenza semthethweni eminye yenkundlazwelo yama-knower. Ngisebenzisa ithiyori ya Basil Bernstein ukuhlola 1) Ibukeka kanjani inkundla yokuhkiqiza yezemfundo zezombusazwe, 2) ngolwazi lobuhlakani enkundleni lapho nasesikhathini uhlelo lwezemfundo PDIS yenza umkhiqizo kanye 3), futhi ukwazi ukuthi khona lusemthethweni uhlelo nokuhlola, nokuthi yini abayiveza ukuthi isemthethweni kwizifundo zolwazi. Ithiyori ka Karl matonâ legitimation code theory (lct), ikakhulu Specialisation, yiyona enganikeza kafuphi izinsiza zokuphenya indlela kanye nenqubo ye-knower kanye nolwazi lwesakhiwo esisemthethweni. Iveza kabanzi izindlela zokubheka ezisemqoka nezisematheni kwinkundla yezemfundo zombusazwe kanye nohlelo lwe PDIS ikakhulukazi Indawo lapho ngizoqhuba khona lolu cwaningo iNyuvesi yaseRhodes, ngokomlando iNyuvesi yabamhlophe enikezana ukuqonda nokuncintana komlando kokungena kwezinhlobo, ubuhlakani kanye nama-knower omlando osemthethweni kanye nokhethekile kulesi sikhungo, kanjalo ne-Landscape yesikhungo samanje, kanye nezinselelo lesi sikhungo sikahulumeni esibheke nazo. Idatha equkethwe ifaka izifundo ezihleliwe ngokomthetho njengokuba zitholakala ezifundweni ezihleliwe kumbhalo. Lokhu, kubandakanya isifundo esinye, amasemina abuyekeziwe, izethulo, nokubamba iqhaza ekilasini; izingxoxo zekilasi; imibuzo yendaba kanye nezivivinyo / nokuhlolwa kwezivivinyo. Idatha yesizukulwane iphinde ibandakanye izingxoxo ezihleliwe kanye nabafundisi abathathwa njengabantu abayizingcithabuchopho, abafundisiwe kulo mkhakha kanye naba neso ekukhethweni kwamanye amakharikhulamu abhekelele ukuhlunga, i-pacing, ukulandelela kanye nokuhlolwa kwekharikhulamu kulwazi lohlelo i-PDIS Lolu cwaningo ludalule ukuthi izinhlelo ze-PDIS zikubeka emqoka kanye nokubeka emthethweni ubuhlakani bekhurikhulamu ngokucophelela ukuthi abafundi bakuqonda ukubaluleka okulunzulu ngezomnotho wombusazwe wase Afrika, yimpi nokungqubuzana ezwenikazi lase-Afrika, ukugcina ukuthula kanye nezinkinga ekwakheni uxolo kanye nobuthakathaka / nophukayo kwezwekazi i-Afrika. Lokhu futhi kubonakele ngendlela yokubambisana kanye nokuziqhathulula kwama-knower aabalulekile ekufundiseni abafundi ngokudinga kokuba nezenhlalo kanye nesiko ukuze bakwazi ukuthola ikhurikhulamu kanye nokubamba iqhaza ngempumelelo njengama-knower kule nkundla. Lokhu kuchaze ukuthi ukufinyelela kuhlelo lokufunda kanye nokuba yilunga lama-knower, kungaba ukuba babonisane ngendlela evulelekile kanye nengenamkhawulo. Kulolu cwaningo, ngaqala ngabheka kabanzi ngokubalulekile ukuthi izifundo zezombusazwe ngolwazi lobuhlakani kwinkundlazwelo yokukhiqiza kanye nePDIS kungabonwa njengenguquko eyenza ukuba sikwazi ukubona ezinye izindlela zokusebenza kwezemfundo zombusazwe kanye nokubeka phambili ama-knower. Lokhu kusenza sibone ukubaluleka komkhiqizo wale nkundla, ukubuyekezwa kwezobuhlakani, kanye nomkhiqizo wezemfundo zombusazwe, kanye nohlelo lwe PDIS ikakhulukazi, kungathiwa ingaba nokubanjwa kokubheka. Iphinde isambulele kabanzi ukuthi singahlola, sense izinguquko kanye noshintsho kwezemfundo zombusazwe kanye nohlelo lwe PDIS. Okwesibili, ukuhlola ulwazi kanye nezakhiwo ze-knower ze-PDIS kungasiza abaklami bekhurikhulamu, abafundisi kanye nabafunsi ukukwazi ukuhlonza ulwazi nekhurikhulamu yekhodi ye-knower, kanye nokwazi ukubuyekeza kabanzi amakhodi ekhurikhulami yabo kanye nokwazi ukwenza i-epistemology ukuba abafundi bafinyelele kuyo. Ngaphezu kwalokhu, lolu cwaningo lungasiza abafundisi kanye nabaklamu bekhurikhulamu ukuba bakwazi ukwakha ikhurikhulamu yabo ngendlela ekhethekile, evulelekile, ngokwenhlalo nje, okubalulekile ukuthi uhlobo lophi lolwazi abakhetha lube semthethweni, kanye nalabo abakhetha ukungayilandeli inqubomgomo yolwazi kanye nokuhlola.
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Identification and evaluation of bioactive natural products as potential inhibitors of human microtubule affinity-regulating kinase 4 (MARK4)
- Mohammad, Taj, Khan, Faez I, Lobb, Kevin A, Islam, Asimul, Ahmad, Faizan, Hassan, M Imtaiyaz
- Authors: Mohammad, Taj , Khan, Faez I , Lobb, Kevin A , Islam, Asimul , Ahmad, Faizan , Hassan, M Imtaiyaz
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/447159 , vital:74588 , xlink:href="https://doi.org/10.1080/07391102.2018.1468282"
- Description: Microtubule affinity-regulating kinase 4 (MARK4) has recently been identified as a potential drug target for several complex diseases including cancer, diabetes and neurodegenerative disorders. Inhibition of MARK4 activity is an appealing therapeutic option to treat such diseases. Here, we have performed structure-based virtual high-throughput screening of 100,000 naturally occurring compounds from ZINC database against MARK4 to find its potential inhibitors. The resulted hits were selected, based on the binding affinities, docking scores and selectivity. Further, binding energy calculation, Lipinski filtration and ADMET prediction were carried out to find safe and better hits against MARK4. Best 10 compounds bearing high specificity and binding efficiency were selected, and their binding pattern to MARK4 was analyzed in detail. Finally, 100 ns molecular dynamics simulation was performed to evaluate; the dynamics stability of MARK4-compound complex. In conclusion, these selected natural compounds from ZINC database might be potential leads against MARK4, and can further be exploited in drug design and development for associated diseases.
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- Authors: Mohammad, Taj , Khan, Faez I , Lobb, Kevin A , Islam, Asimul , Ahmad, Faizan , Hassan, M Imtaiyaz
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/447159 , vital:74588 , xlink:href="https://doi.org/10.1080/07391102.2018.1468282"
- Description: Microtubule affinity-regulating kinase 4 (MARK4) has recently been identified as a potential drug target for several complex diseases including cancer, diabetes and neurodegenerative disorders. Inhibition of MARK4 activity is an appealing therapeutic option to treat such diseases. Here, we have performed structure-based virtual high-throughput screening of 100,000 naturally occurring compounds from ZINC database against MARK4 to find its potential inhibitors. The resulted hits were selected, based on the binding affinities, docking scores and selectivity. Further, binding energy calculation, Lipinski filtration and ADMET prediction were carried out to find safe and better hits against MARK4. Best 10 compounds bearing high specificity and binding efficiency were selected, and their binding pattern to MARK4 was analyzed in detail. Finally, 100 ns molecular dynamics simulation was performed to evaluate; the dynamics stability of MARK4-compound complex. In conclusion, these selected natural compounds from ZINC database might be potential leads against MARK4, and can further be exploited in drug design and development for associated diseases.
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Identification of Novel Potential Inhibitors of Pteridine Reductase 1 in Trypanosoma brucei via Computational Structure-Based Approaches and in Vitro Inhibition Assays
- Kimuda, Magambo Phillip, Laming, Dustin, Hoppe, Heinrich C, Tastan Bishop, Özlem
- Authors: Kimuda, Magambo Phillip , Laming, Dustin , Hoppe, Heinrich C , Tastan Bishop, Özlem
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/124675 , vital:35647 , https://doi:10.3390/molecules24010142
- Description: Pteridine reductase 1 (PTR1) is a trypanosomatid multifunctional enzyme that provides a mechanism for escape of dihydrofolate reductase (DHFR) inhibition. This is because PTR1 can reduce pterins and folates. Trypanosomes require folates and pterins for survival and are unable to synthesize them de novo. Currently there are no anti-folate based Human African Trypanosomiasis (HAT) chemotherapeutics in use. Thus, successful dual inhibition of Trypanosoma brucei dihydrofolate reductase (TbDHFR) and Trypanosoma brucei pteridine reductase 1 (TbPTR1) has implications in the exploitation of anti-folates. We carried out molecular docking of a ligand library of 5742 compounds against TbPTR1 and identified 18 compounds showing promising binding modes. The protein-ligand complexes were subjected to molecular dynamics to characterize their molecular interactions and energetics, followed by in vitro testing. In this study, we identified five compounds which showed low micromolar Trypanosome growth inhibition in in vitro experiments that might be acting by inhibition of TbPTR1. Compounds RUBi004, RUBi007, RUBi014, and RUBi018 displayed moderate to strong antagonism (mutual reduction in potency) when used in combination with the known TbDHFR inhibitor, WR99210. This gave an indication that the compounds might inhibit both TbPTR1 and TbDHFR. RUBi016 showed an additive effect in the isobologram assay. Overall, our results provide a basis for scaffold optimization for further studies in the development of HAT anti-folates.
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- Authors: Kimuda, Magambo Phillip , Laming, Dustin , Hoppe, Heinrich C , Tastan Bishop, Özlem
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/124675 , vital:35647 , https://doi:10.3390/molecules24010142
- Description: Pteridine reductase 1 (PTR1) is a trypanosomatid multifunctional enzyme that provides a mechanism for escape of dihydrofolate reductase (DHFR) inhibition. This is because PTR1 can reduce pterins and folates. Trypanosomes require folates and pterins for survival and are unable to synthesize them de novo. Currently there are no anti-folate based Human African Trypanosomiasis (HAT) chemotherapeutics in use. Thus, successful dual inhibition of Trypanosoma brucei dihydrofolate reductase (TbDHFR) and Trypanosoma brucei pteridine reductase 1 (TbPTR1) has implications in the exploitation of anti-folates. We carried out molecular docking of a ligand library of 5742 compounds against TbPTR1 and identified 18 compounds showing promising binding modes. The protein-ligand complexes were subjected to molecular dynamics to characterize their molecular interactions and energetics, followed by in vitro testing. In this study, we identified five compounds which showed low micromolar Trypanosome growth inhibition in in vitro experiments that might be acting by inhibition of TbPTR1. Compounds RUBi004, RUBi007, RUBi014, and RUBi018 displayed moderate to strong antagonism (mutual reduction in potency) when used in combination with the known TbDHFR inhibitor, WR99210. This gave an indication that the compounds might inhibit both TbPTR1 and TbDHFR. RUBi016 showed an additive effect in the isobologram assay. Overall, our results provide a basis for scaffold optimization for further studies in the development of HAT anti-folates.
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Identification of possible natural compounds as potential inhibitors against Plasmodium M1 alanyl aminopeptidase
- Soliman, Omar Samir Abdel Ghaffar
- Authors: Soliman, Omar Samir Abdel Ghaffar
- Date: 2019
- Subjects: Plasmodium , Malaria -- Chemotherapy , Plasmodium -- Inhibitors , Drug resistance in microorganisms , Aminopeptidases
- Language: English
- Type: text , Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10962/72284 , vital:30026
- Description: Malaria is a major tropical health problem with a 29% mortality rate among people of all ages; it also affects 35% of the children. Despite the decrease in mortality rate in recent years, malaria still results in around 2000 deaths per day. Malaria is caused by Plasmodium parasites and is transmitted to humans via the bites from infected female Anopheles mosquitoes during blood meals. There are five different Plasmodium species that can cause human malaria, which include Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, Plasmodium ovale and Plasmodium knowlesi. Among these five species, the most pathogenic ones are Plasmodium falciparum and Plasmodium vivax. Malaria is usually hard to diagnose because the symptoms are not exclusive to malaria and very similar to flu, e.g., fever, muscle pain, and chills, which lead to the misdiagnosis of malaria cases. Malaria is lethal if not treated because it can cause severe complications in the respiratory tract, liver, metabolic acidosis, and hypoglycemia. The malaria parasite life cycle includes two types of hosts, i.e., a human host and female Anopheles mosquito host. Malaria continuously develops resistance to the available drugs, which is one of the major challenges in disease control. This situation confirms the need to develop new drugs that target virulence factors of malaria. The malarial parasite has three main life cycle stages, which include the host liver stage, host blood stage and vector stage. In the blood stage, parasites degrade hemoglobin to amino acids, which is important as these parasites cannot produce their own amino acids. Different proteases are involved in this hemoglobin degradation process. M1 alanyl aminopeptidase is one of these proteases involved at the end of hemoglobin degradation. This study focused on M1 alanyl aminopeptidase as a potential drug target. M1 alanyl aminopeptidase consists of four domains: N-terminal domain, catalytic domain, middle domain and C-terminal domain. The catalytic domain remains conserved among different Plasmodium species. Inhibition of this enzyme might prevent Plasmodium growth as it can’t produce its own amino acids. In this study, sequence analysis was carried out in both human and Plasmodium M1 alanyl aminopeptidase to identify conserved and divergent regions between them. 3D protein models of the M1 alanyl aminopeptidase from Plasmodium species were built and validated. Then the generated models were used for virtual screening against 623 compounds retrieved from the South African Natural Compounds Database (SANCDB, https://sancdb.rubi.ru.ac.za/). Virtual screening was done using blind and targeted docking methods. Docking was used to identify compounds with selective high binding affinity to the active site of the parasite protein. In this study, one SANCDB compound was selected for each protein: SANC00531 was selected against P. falciparum M1 alanyl aminopeptidase, SANC00469 against P. knowlesi, SANC00660 against P. vivax, SANC00144 against P. ovale and SANC00109 against P. malariae. It was found that Plamsodium M1 alanyl aminopeptidase can be used as a potential drug target as it showed selective binding against different inhibitor compounds. This result will be investigated in future work though molecular dynamic analysis to investigate the stability of protein-ligand complexes.
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- Authors: Soliman, Omar Samir Abdel Ghaffar
- Date: 2019
- Subjects: Plasmodium , Malaria -- Chemotherapy , Plasmodium -- Inhibitors , Drug resistance in microorganisms , Aminopeptidases
- Language: English
- Type: text , Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10962/72284 , vital:30026
- Description: Malaria is a major tropical health problem with a 29% mortality rate among people of all ages; it also affects 35% of the children. Despite the decrease in mortality rate in recent years, malaria still results in around 2000 deaths per day. Malaria is caused by Plasmodium parasites and is transmitted to humans via the bites from infected female Anopheles mosquitoes during blood meals. There are five different Plasmodium species that can cause human malaria, which include Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, Plasmodium ovale and Plasmodium knowlesi. Among these five species, the most pathogenic ones are Plasmodium falciparum and Plasmodium vivax. Malaria is usually hard to diagnose because the symptoms are not exclusive to malaria and very similar to flu, e.g., fever, muscle pain, and chills, which lead to the misdiagnosis of malaria cases. Malaria is lethal if not treated because it can cause severe complications in the respiratory tract, liver, metabolic acidosis, and hypoglycemia. The malaria parasite life cycle includes two types of hosts, i.e., a human host and female Anopheles mosquito host. Malaria continuously develops resistance to the available drugs, which is one of the major challenges in disease control. This situation confirms the need to develop new drugs that target virulence factors of malaria. The malarial parasite has three main life cycle stages, which include the host liver stage, host blood stage and vector stage. In the blood stage, parasites degrade hemoglobin to amino acids, which is important as these parasites cannot produce their own amino acids. Different proteases are involved in this hemoglobin degradation process. M1 alanyl aminopeptidase is one of these proteases involved at the end of hemoglobin degradation. This study focused on M1 alanyl aminopeptidase as a potential drug target. M1 alanyl aminopeptidase consists of four domains: N-terminal domain, catalytic domain, middle domain and C-terminal domain. The catalytic domain remains conserved among different Plasmodium species. Inhibition of this enzyme might prevent Plasmodium growth as it can’t produce its own amino acids. In this study, sequence analysis was carried out in both human and Plasmodium M1 alanyl aminopeptidase to identify conserved and divergent regions between them. 3D protein models of the M1 alanyl aminopeptidase from Plasmodium species were built and validated. Then the generated models were used for virtual screening against 623 compounds retrieved from the South African Natural Compounds Database (SANCDB, https://sancdb.rubi.ru.ac.za/). Virtual screening was done using blind and targeted docking methods. Docking was used to identify compounds with selective high binding affinity to the active site of the parasite protein. In this study, one SANCDB compound was selected for each protein: SANC00531 was selected against P. falciparum M1 alanyl aminopeptidase, SANC00469 against P. knowlesi, SANC00660 against P. vivax, SANC00144 against P. ovale and SANC00109 against P. malariae. It was found that Plamsodium M1 alanyl aminopeptidase can be used as a potential drug target as it showed selective binding against different inhibitor compounds. This result will be investigated in future work though molecular dynamic analysis to investigate the stability of protein-ligand complexes.
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If you strike a woman: an analysis of how women are represented in political cartoons of South Africa’s Women’s Day, 2009-2017
- Authors: Levin, Bianca
- Date: 2019
- Subjects: Caricatures and cartoons -- South Africa , Women in mass media -- South Africa , Political cartoons -- South Africa
- Language: English
- Type: text , Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10962/92661 , vital:30731
- Description: On 7 August 2017, two days prior to South Africa’s National Women’s Day, video footage of a representative of the State, Mduduzi Manana, beating up a woman went viral. This marred the Women’s Day celebrations of that year, as it became clear to the public that the he was not going to be punished. As important political commentators, cartoonists used Manana’s actions as an opportunity to depict the violence women face, even in a month dedicated to women. In these cartoons, Manana became the face of a patriarchal system, one which has deeply affected the quality of life for women who, to date, cannot claim their Constitutional rights. This thesis is interested in the mini-narratives of such cartoons, ones which offer a view on the status of South African women. Through this qualitative study, a textual analysis in the spirit of Critical Discourse Analysis of seven selected cartoons leads to a discussion of what their representations of women means for gender justice. What this research shows is that the representations that cartoons offer of the position of women in South Africa are complex. These cartoons articulate that South Africa has a long way to go to reach equality and gender justice. In order for gender justice to be realised, the representation of women needs to evolve into one which recognises women’s plight but does not relegate them to the state of victimhood.
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- Authors: Levin, Bianca
- Date: 2019
- Subjects: Caricatures and cartoons -- South Africa , Women in mass media -- South Africa , Political cartoons -- South Africa
- Language: English
- Type: text , Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10962/92661 , vital:30731
- Description: On 7 August 2017, two days prior to South Africa’s National Women’s Day, video footage of a representative of the State, Mduduzi Manana, beating up a woman went viral. This marred the Women’s Day celebrations of that year, as it became clear to the public that the he was not going to be punished. As important political commentators, cartoonists used Manana’s actions as an opportunity to depict the violence women face, even in a month dedicated to women. In these cartoons, Manana became the face of a patriarchal system, one which has deeply affected the quality of life for women who, to date, cannot claim their Constitutional rights. This thesis is interested in the mini-narratives of such cartoons, ones which offer a view on the status of South African women. Through this qualitative study, a textual analysis in the spirit of Critical Discourse Analysis of seven selected cartoons leads to a discussion of what their representations of women means for gender justice. What this research shows is that the representations that cartoons offer of the position of women in South Africa are complex. These cartoons articulate that South Africa has a long way to go to reach equality and gender justice. In order for gender justice to be realised, the representation of women needs to evolve into one which recognises women’s plight but does not relegate them to the state of victimhood.
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Impacts of gum-resin harvest and Lantana camara invasion on the population structure and dynamics of Boswellia serrata in the Western Ghats, India
- Soumya, Kori V, Shackleton, Charlie M, Setty, Siddappa R
- Authors: Soumya, Kori V , Shackleton, Charlie M , Setty, Siddappa R
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/177549 , vital:42832 , https://doi.org/10.1016/j.foreco.2019.117618
- Description: Assessing the effects of harvesting on the population dynamics of important non-timber forest products (NTFPs) species is important for informing species conservation options, guiding sustainable harvesting practices and offtake and supporting local livelihoods. However, harvesting is rarely the only pressure on NTFP populations, and it is vital that the effects of interactive pressures be considered. This applies to Boswellia serrata, an NTFP tree species which is widely harvested for gum-resin used in religious practices. However, in many settings populations are in decline, presumably due to heavy harvesting, but other factors may play a role, such as altered fire regimes and invasive species. Here we report on the effects of harvesting and invasion by Lantana camara on B. serrata populations in three protected areas in the Western Ghats biodiversity hotspot in southern India. We considered tree and juvenile density, size class distribution, and growth, mortality, and recruitment rates in harvested and unharvested populations over two years.
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- Authors: Soumya, Kori V , Shackleton, Charlie M , Setty, Siddappa R
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/177549 , vital:42832 , https://doi.org/10.1016/j.foreco.2019.117618
- Description: Assessing the effects of harvesting on the population dynamics of important non-timber forest products (NTFPs) species is important for informing species conservation options, guiding sustainable harvesting practices and offtake and supporting local livelihoods. However, harvesting is rarely the only pressure on NTFP populations, and it is vital that the effects of interactive pressures be considered. This applies to Boswellia serrata, an NTFP tree species which is widely harvested for gum-resin used in religious practices. However, in many settings populations are in decline, presumably due to heavy harvesting, but other factors may play a role, such as altered fire regimes and invasive species. Here we report on the effects of harvesting and invasion by Lantana camara on B. serrata populations in three protected areas in the Western Ghats biodiversity hotspot in southern India. We considered tree and juvenile density, size class distribution, and growth, mortality, and recruitment rates in harvested and unharvested populations over two years.
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Implications of the US–China Tit-for-Tat tariff escalation: A literature review of standard trade theory and empirical evidence on economic consequences and effects on both countries
- Authors: Mutambara, Tsitsi E
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/478272 , vital:78170 , 10.18639/MERJ.2019.952971
- Description: This study reviewed standard international trade theories as they pertain to the impact of trade restrictions. Current empirical studies were reviewed to see whether evidence supports trade theory predictions. Conventional price impacts in standard models of international trade show that trade restrictions are detrimental for trade for both countries involved, and the empirical evidence from current studies confirmed this. The current tit-for-tat tariff escalation between China and the United States has led to, among other things, increased domestic prices to both American consumers and producers; lower export prices to some of the Chinese exporters and American firms based in China; reduced import and export trade between the two countries that would lead to costly adjustments in supply chains; loss in net welfare and employment; and loss in competitive advantage to firms in both countries that produce for export. Therefore, efforts should be made to de-escalate these trade tensions.
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- Authors: Mutambara, Tsitsi E
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/478272 , vital:78170 , 10.18639/MERJ.2019.952971
- Description: This study reviewed standard international trade theories as they pertain to the impact of trade restrictions. Current empirical studies were reviewed to see whether evidence supports trade theory predictions. Conventional price impacts in standard models of international trade show that trade restrictions are detrimental for trade for both countries involved, and the empirical evidence from current studies confirmed this. The current tit-for-tat tariff escalation between China and the United States has led to, among other things, increased domestic prices to both American consumers and producers; lower export prices to some of the Chinese exporters and American firms based in China; reduced import and export trade between the two countries that would lead to costly adjustments in supply chains; loss in net welfare and employment; and loss in competitive advantage to firms in both countries that produce for export. Therefore, efforts should be made to de-escalate these trade tensions.
- Full Text:
Implications of the US–China Tit-for-Tat tariff escalation: A literature review of standard trade theory and empirical evidence on economic consequences and effects on both countries
- Authors: Mutambara, Tsitsi E
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/473156 , vital:77611 , DOI : 10.18639/MERJ.2019.952971
- Description: This study reviewed standard international trade theories as they pertain to the impact of trade restrictions. Current empirical studies were reviewed to see whether evidence supports trade theory predictions. Conventional price impacts in standard models of international trade show that trade restrictions are detrimental for trade for both countries involved, and the empirical evidence from current studies confirmed this. The current tit-for-tat tariff escalation between China and the United States has led to, among other things, increased domestic prices to both American consumers and producers; lower export prices to some of the Chinese exporters and American firms based in China; reduced import and export trade between the two countries that would lead to costly adjustments in supply chains; loss in net welfare and employment; and loss in competitive advantage to firms in both countries that produce for export. Therefore, efforts should be made to de-escalate these trade tensions.
- Full Text:
- Authors: Mutambara, Tsitsi E
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/473156 , vital:77611 , DOI : 10.18639/MERJ.2019.952971
- Description: This study reviewed standard international trade theories as they pertain to the impact of trade restrictions. Current empirical studies were reviewed to see whether evidence supports trade theory predictions. Conventional price impacts in standard models of international trade show that trade restrictions are detrimental for trade for both countries involved, and the empirical evidence from current studies confirmed this. The current tit-for-tat tariff escalation between China and the United States has led to, among other things, increased domestic prices to both American consumers and producers; lower export prices to some of the Chinese exporters and American firms based in China; reduced import and export trade between the two countries that would lead to costly adjustments in supply chains; loss in net welfare and employment; and loss in competitive advantage to firms in both countries that produce for export. Therefore, efforts should be made to de-escalate these trade tensions.
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Improved palmprint segmentation for robust identification and verification
- Brown, Dane L, Bradshaw, Karen L
- Authors: Brown, Dane L , Bradshaw, Karen L
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/460576 , vital:75966 , xlink:href="https://doi.org/10.1109/SITIS.2019.00013"
- Description: This paper introduces an improved approach to palmprint segmentation. The approach enables both contact and contactless palmprints to be segmented regardless of constraining finger positions or whether fingers are even depicted within the image. It is compared with related systems, as well as more comprehensive identification tests, that show consistent results across other datasets. Experiments include contact and contactless palmprint images. The proposed system achieves highly accurate classification results, and highlights the importance of effective image segmentation. The proposed system is practical as it is effective with small or large amounts of training data.
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- Authors: Brown, Dane L , Bradshaw, Karen L
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/460576 , vital:75966 , xlink:href="https://doi.org/10.1109/SITIS.2019.00013"
- Description: This paper introduces an improved approach to palmprint segmentation. The approach enables both contact and contactless palmprints to be segmented regardless of constraining finger positions or whether fingers are even depicted within the image. It is compared with related systems, as well as more comprehensive identification tests, that show consistent results across other datasets. Experiments include contact and contactless palmprint images. The proposed system achieves highly accurate classification results, and highlights the importance of effective image segmentation. The proposed system is practical as it is effective with small or large amounts of training data.
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In conversation with South African artist Viwe Madinda: after her performance “Kwathi Kaloku Ngatsomi” during the National Arts Festival
- Authors: Muvhuti, Barnabas
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/146948 , vital:38579 , https://africanah.org/viwe-madinda/
- Description: Focusing on Viwe Madinda’s Kwathi Kaloku Ngatsomi, a live art performance staged under the Arts Lounge Program, during South Africa’s 2019 National Arts Festival in Makhanda, this conversation dwells on the significance of the performance. It explores the key symbolic gestures the artist and her mother employed to convey the underlying message. In the aftermath of the performance, Barnabas Ticha Muvhuti sat down with Viwe Madinda to discuss and unpack some of the key moments in the work. What follows is an edited transcript of the conversation which took place at the Arts Lounge at the Arts of Africa and Global Souths Research Program at Rhodes University.
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- Authors: Muvhuti, Barnabas
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/146948 , vital:38579 , https://africanah.org/viwe-madinda/
- Description: Focusing on Viwe Madinda’s Kwathi Kaloku Ngatsomi, a live art performance staged under the Arts Lounge Program, during South Africa’s 2019 National Arts Festival in Makhanda, this conversation dwells on the significance of the performance. It explores the key symbolic gestures the artist and her mother employed to convey the underlying message. In the aftermath of the performance, Barnabas Ticha Muvhuti sat down with Viwe Madinda to discuss and unpack some of the key moments in the work. What follows is an edited transcript of the conversation which took place at the Arts Lounge at the Arts of Africa and Global Souths Research Program at Rhodes University.
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In conversation with Zimbabwean artist Kresiah Mukwazhi:
- Authors: Muvhuti, Barnabas
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/146959 , vital:38580 , https://africanah.org/in-conversation-with-kresiah-mukwazhi/
- Description: Kresiah Mukwazhi is a Harare-based multidisciplinary artist who is a Fellow of the “Arts of Africa and Global Souths” Residencies for Artists and Writers (RAW) programme in the Fine Art Department at Rhodes University in Makhanda, South Africa. During the 2019 National Arts Festival, she performed Summoned from Luzari as part of the Arts Lounge festival programme. Her two-months residency resulted in the Although I am Young, I am the Mother of this House open studio session in which the audience was invited to engage with the artist and the ideas she has been, is and will be working on. The persona Hes Keresiya, which came to life on that day, is one of the ideas. In this conversation, Barnabas Ticha Muvhuti asks Mukwazhi about her work during the residency and her artistic practice in general.
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- Authors: Muvhuti, Barnabas
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/146959 , vital:38580 , https://africanah.org/in-conversation-with-kresiah-mukwazhi/
- Description: Kresiah Mukwazhi is a Harare-based multidisciplinary artist who is a Fellow of the “Arts of Africa and Global Souths” Residencies for Artists and Writers (RAW) programme in the Fine Art Department at Rhodes University in Makhanda, South Africa. During the 2019 National Arts Festival, she performed Summoned from Luzari as part of the Arts Lounge festival programme. Her two-months residency resulted in the Although I am Young, I am the Mother of this House open studio session in which the audience was invited to engage with the artist and the ideas she has been, is and will be working on. The persona Hes Keresiya, which came to life on that day, is one of the ideas. In this conversation, Barnabas Ticha Muvhuti asks Mukwazhi about her work during the residency and her artistic practice in general.
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In Parenthesis:
- Authors: de Jager, Maureen
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/147880 , vital:38681 , DOI: 10.1080/02560046.2019.1684966
- Description: IN PARENTHESIS is a practice-based essay which takes shape, parasitically, amidst the “found text” of an existing book, British author Thomas Pakenham's The Boer War (1979, Johannesburg: Jonathan Ball). The “author-reader” interjects into the found text of this authoritative history book, inserting her words amongst those of Pakenham's. What becomes apparent, however, is that the text into which she interjects is not The Boer War verbatim, but a dramatically abridged version. The book's primary content has been edited out. What remains is The Boer War whittled down to a litany of Pakenham's parentheses (the history book distilled into an essence of the seemingly non-essential). Into this stream of bracketed matter, the author-reader writes, ruminating on the parenthesis as ethos (as prison and portal, barricade and breach, enclave and embrace). In turn, her ruminations invite reflection on the conundrum of writing history, of writing this history (and, indeed, of writing per se).
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- Authors: de Jager, Maureen
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/147880 , vital:38681 , DOI: 10.1080/02560046.2019.1684966
- Description: IN PARENTHESIS is a practice-based essay which takes shape, parasitically, amidst the “found text” of an existing book, British author Thomas Pakenham's The Boer War (1979, Johannesburg: Jonathan Ball). The “author-reader” interjects into the found text of this authoritative history book, inserting her words amongst those of Pakenham's. What becomes apparent, however, is that the text into which she interjects is not The Boer War verbatim, but a dramatically abridged version. The book's primary content has been edited out. What remains is The Boer War whittled down to a litany of Pakenham's parentheses (the history book distilled into an essence of the seemingly non-essential). Into this stream of bracketed matter, the author-reader writes, ruminating on the parenthesis as ethos (as prison and portal, barricade and breach, enclave and embrace). In turn, her ruminations invite reflection on the conundrum of writing history, of writing this history (and, indeed, of writing per se).
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In Search of the “Goodlife": Border Crossing and Agency in Luis Alberto Urrea's Into the Beautiful North and Graciela Limón's The River Flows North
- Authors: Naidu, Samantha
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/158046 , vital:40142 , https://doi.org/10.1080/18125441.2019.16474490
- Description: This article explores representations of complex diasporic subjectivities that resist, or attempt to resist, obsolete nationalist notions of citizenship and identity by crossing the US– Mexico border (and, in so doing, crossing other intangible borders) in search of a better life. Two examples of border literature, Luis Alberto Urrea's Into the Beautiful North (2009) and Graciela Limón's The River Flows North (2009), have been selected for analysis. These texts, in describing various diaspora spaces—to enlist Avtar Brah's term (Cartographies of Diaspora. London: Routledge, 1996)—also examine how those who do not migrate are affected by migration. In Writing the Goodlife: Mexican American Literature and the Environment (Tucson: University of Arizona Press, 2016), Priscilla Solis Ybarra reveals how the past century and a half's Mexican-American literature contains valuable new approaches to creating and sustaining new forms of transnational relations between humans, and ecologically sound relationships between humans and nature.
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- Authors: Naidu, Samantha
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/158046 , vital:40142 , https://doi.org/10.1080/18125441.2019.16474490
- Description: This article explores representations of complex diasporic subjectivities that resist, or attempt to resist, obsolete nationalist notions of citizenship and identity by crossing the US– Mexico border (and, in so doing, crossing other intangible borders) in search of a better life. Two examples of border literature, Luis Alberto Urrea's Into the Beautiful North (2009) and Graciela Limón's The River Flows North (2009), have been selected for analysis. These texts, in describing various diaspora spaces—to enlist Avtar Brah's term (Cartographies of Diaspora. London: Routledge, 1996)—also examine how those who do not migrate are affected by migration. In Writing the Goodlife: Mexican American Literature and the Environment (Tucson: University of Arizona Press, 2016), Priscilla Solis Ybarra reveals how the past century and a half's Mexican-American literature contains valuable new approaches to creating and sustaining new forms of transnational relations between humans, and ecologically sound relationships between humans and nature.
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