Compounds isolation and biological activities of Piptadeniastrum africanum (hook. f.) Brennan (Fabaceae) roots:
- Teinkela, Jean E M, Noundou, Xavier S, Mimba, Jeanne E Z, Meyer, Franck, Tabouguia, Octavie M, Nguedia, Jules C A, Hoppe, Heinrich C, Krause, Rui W M, Wintjens, René, Azebaze, Anatole G B
- Authors: Teinkela, Jean E M , Noundou, Xavier S , Mimba, Jeanne E Z , Meyer, Franck , Tabouguia, Octavie M , Nguedia, Jules C A , Hoppe, Heinrich C , Krause, Rui W M , Wintjens, René , Azebaze, Anatole G B
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/150084 , vital:38938 , https://doi.org/10.1016/j.jep.2020.112716
- Description: The dicotyledonous plant Piptadeniastrum africanum (hook.f.) Brennan (Fabaceae) is used in traditional medicine to treat various human complaints including bronchitis, coughing, urino-genital ailments, meningitis, abdominal pain, treatment of wounds, malaria and gastrointestinal ailments, and is used as a purgative and worm expeller. The present study describes the phytochemical investigation and the determination of the antimicrobial, antiplasmodial and antitrypanosomal activities of crude extract, fractions and compounds extracted from Piptadeniastrum africanum roots.
- Full Text:
- Date Issued: 2020
- Authors: Teinkela, Jean E M , Noundou, Xavier S , Mimba, Jeanne E Z , Meyer, Franck , Tabouguia, Octavie M , Nguedia, Jules C A , Hoppe, Heinrich C , Krause, Rui W M , Wintjens, René , Azebaze, Anatole G B
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/150084 , vital:38938 , https://doi.org/10.1016/j.jep.2020.112716
- Description: The dicotyledonous plant Piptadeniastrum africanum (hook.f.) Brennan (Fabaceae) is used in traditional medicine to treat various human complaints including bronchitis, coughing, urino-genital ailments, meningitis, abdominal pain, treatment of wounds, malaria and gastrointestinal ailments, and is used as a purgative and worm expeller. The present study describes the phytochemical investigation and the determination of the antimicrobial, antiplasmodial and antitrypanosomal activities of crude extract, fractions and compounds extracted from Piptadeniastrum africanum roots.
- Full Text:
- Date Issued: 2020
Synthesis and biological evaluation of bis-N2, N2′-(4-hydroxycoumarin-3-yl) ethylidene]-2, 3-dihydroxysuccinodihydrazides
- Manyeruke, Meloddy H, Tshiwawa, Thendamudzimu, Hoppe, Heinrich C, Isaacs, Michelle, Seldon, Ronnett, Warner, Digby F, Krause, Rui W M, Kaye, Perry T
- Authors: Manyeruke, Meloddy H , Tshiwawa, Thendamudzimu , Hoppe, Heinrich C , Isaacs, Michelle , Seldon, Ronnett , Warner, Digby F , Krause, Rui W M , Kaye, Perry T
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/193430 , vital:45331 , xlink:href="https://doi.org/10.1016/j.bmcl.2019.126911"
- Description: A series of N2,N2′-bis[4-hydroxycoumarin-3-yl)ethylidene]-2,3-dihydroxysuccino-hydrazides, containing 4-hydroxycoumarin, hydrazine and tartaric acid moieties, have been prepared and examined for possible biological activity. Several of these compounds exhibit promising HIV-1 integrase inhibition (IC50 = 3.5 μM), and anti-T. brucei (32% viability) and anti-mycobacterial (Visual MIC90 = 15.63 μM) activity.
- Full Text:
- Date Issued: 2020
- Authors: Manyeruke, Meloddy H , Tshiwawa, Thendamudzimu , Hoppe, Heinrich C , Isaacs, Michelle , Seldon, Ronnett , Warner, Digby F , Krause, Rui W M , Kaye, Perry T
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/193430 , vital:45331 , xlink:href="https://doi.org/10.1016/j.bmcl.2019.126911"
- Description: A series of N2,N2′-bis[4-hydroxycoumarin-3-yl)ethylidene]-2,3-dihydroxysuccino-hydrazides, containing 4-hydroxycoumarin, hydrazine and tartaric acid moieties, have been prepared and examined for possible biological activity. Several of these compounds exhibit promising HIV-1 integrase inhibition (IC50 = 3.5 μM), and anti-T. brucei (32% viability) and anti-mycobacterial (Visual MIC90 = 15.63 μM) activity.
- Full Text:
- Date Issued: 2020
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