A Feasibility Study on the Efficacy of Functional Near-Infrared Spectrometry (fNIRS) to Measure Prefrontal Activation in Paediatric HIV
- Zondo, Sizwe, Ferreira-Correia, Aline, Cockcroft, Kate
- Authors: Zondo, Sizwe , Ferreira-Correia, Aline , Cockcroft, Kate
- Date: 2024
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/450556 , vital:74960 , xlink:href="https://www.hindawi.com/journals/js/2024/4970794/"
- Description: Human immunodeficiency virus (HIV) infection is associated with disturbed neurotransmission and aberrant cortical networks. Although advances in the imaging of brain microarchitecture following neuroHIV has added to our knowledge of structural and functional changes associated with HIV, no data exists on paediatric HIV using optical neuroimaging techniques. This study investigated the feasibility of optical neuroimaging in paediatric HIV using functional near-infrared spectrometry (fNIRS). We measured prefrontal brain activation while participants executed a sustained attention task. We specifically tested whether patients living with HIV and study controls could perform the study protocol and whether we could measure the typical fNIRS haemodynamic response associated with neuronal activity. Eighteen participants (10 HIV participants, mean age: 13.9, SD = 1.66 years; 8 controls, mean age: 14.8, SD = 1.28 years), matched for sex, grade, and socio-economic status, were included in the study. All participants completed the Stroop colour word test (SCWT). Oxygenated haemoglobin concentration and the deoxygenated haemoglobin signal were recorded from the dorsolateral prefrontal cortex and the frontopolar area (FA) using fNIRS. The control group performed significantly better in terms of reaction time on the congruent and incongruent condition (congruent: t (16) = −3.36, : incongruent: ). A pooled group analysis of the sample indicated significant activation in the DLPF and FA to the congruent condition of the SCWT (). Although cortical activation was noted in the DLPF and the FA in each of the groups when analysed independently, this neural activation did not reach statistical significance. The results show promise that fNIRS techniques are feasible for assessing prefrontal cortical activity in paediatric HIV. Future studies should seek to reduce the signal-to-noise ratio and consider inter-individual variability when measuring prefrontal activation in paediatric samples.
- Full Text:
- Date Issued: 2024
- Authors: Zondo, Sizwe , Ferreira-Correia, Aline , Cockcroft, Kate
- Date: 2024
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/450556 , vital:74960 , xlink:href="https://www.hindawi.com/journals/js/2024/4970794/"
- Description: Human immunodeficiency virus (HIV) infection is associated with disturbed neurotransmission and aberrant cortical networks. Although advances in the imaging of brain microarchitecture following neuroHIV has added to our knowledge of structural and functional changes associated with HIV, no data exists on paediatric HIV using optical neuroimaging techniques. This study investigated the feasibility of optical neuroimaging in paediatric HIV using functional near-infrared spectrometry (fNIRS). We measured prefrontal brain activation while participants executed a sustained attention task. We specifically tested whether patients living with HIV and study controls could perform the study protocol and whether we could measure the typical fNIRS haemodynamic response associated with neuronal activity. Eighteen participants (10 HIV participants, mean age: 13.9, SD = 1.66 years; 8 controls, mean age: 14.8, SD = 1.28 years), matched for sex, grade, and socio-economic status, were included in the study. All participants completed the Stroop colour word test (SCWT). Oxygenated haemoglobin concentration and the deoxygenated haemoglobin signal were recorded from the dorsolateral prefrontal cortex and the frontopolar area (FA) using fNIRS. The control group performed significantly better in terms of reaction time on the congruent and incongruent condition (congruent: t (16) = −3.36, : incongruent: ). A pooled group analysis of the sample indicated significant activation in the DLPF and FA to the congruent condition of the SCWT (). Although cortical activation was noted in the DLPF and the FA in each of the groups when analysed independently, this neural activation did not reach statistical significance. The results show promise that fNIRS techniques are feasible for assessing prefrontal cortical activity in paediatric HIV. Future studies should seek to reduce the signal-to-noise ratio and consider inter-individual variability when measuring prefrontal activation in paediatric samples.
- Full Text:
- Date Issued: 2024
The perspectives of some amaXhosa healthcare workers regarding mental distress: an interpretive phenomenological analysis
- Authors: Ngqamfana, Siphosethu
- Date: 2023-10-13
- Subjects: Mental distress , Xhosa (African people) Social life and customs , Stigma (Social psychology) , Health professional , Eurocentrism , Afrocentrism , Sociocultural perspective
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/425031 , vital:72203
- Description: Mental distress is a universal phenomenon experienced by many individuals despite age, race, gender, occupation, or socio-cultural context and is slowly becoming a major contributor to the burden of disease in South Africa. However, mental distress fails to take precedence in SA because of inherent intricacies in understandings about it, as a result of ways of being conceptualised and interpreted differently across cultures. This research study explored amaXhosa healthcare workers’ understandings, knowledge, practices, and attitudes regarding mental distress amongst some amaXhosa people. The study aimed to investigate what mental distress means for some people who belong to the amaXhosa ethnic group, to uncover how they conceptualise mental distress, seek help or what behaviours prevent help-seeking. It aimed to highlight any prevalent attitudes of stigma and discrimination, to build insight into overlooked aspects in psychotherapy practice especially when dealing with non-western populations. The study utilised interpretative phenomenological analysis (IPA) as its analytical lens; to explore and to enter as far as possible into the worlds of participants to generate rich data and in-depth analysis. Four participants were recruited through both purposive and snowball sampling and data were gathered using individual semi-structured interviews. From the data collected, the findings illustrate a limited understanding of mental distress amongst some amaXhosa people due to lack of education and awareness on the subject, leading to the apparent silence in discussing such matters and inadvertently predisposing it to being viewed as taboo. The predominant themes as evidenced by the data were the use of language that sensationalises mental distress; misinformation; Afrocentric beliefs that rationalise mental distress; alienation and segregation of those affected; and the primary healthcare system as a source of reinforcing prevalent stigma and discrimination. The findings show a link between constructs around mental distress and the prevalent socioiii cultural environment, denoting that some perspectives can be linked to observations or modelling in childhood, from people in the respective communities in which people live. , Thesis (MA) -- Faculty of Humanities, Psychology, 2023
- Full Text:
- Date Issued: 2023-10-13
- Authors: Ngqamfana, Siphosethu
- Date: 2023-10-13
- Subjects: Mental distress , Xhosa (African people) Social life and customs , Stigma (Social psychology) , Health professional , Eurocentrism , Afrocentrism , Sociocultural perspective
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/425031 , vital:72203
- Description: Mental distress is a universal phenomenon experienced by many individuals despite age, race, gender, occupation, or socio-cultural context and is slowly becoming a major contributor to the burden of disease in South Africa. However, mental distress fails to take precedence in SA because of inherent intricacies in understandings about it, as a result of ways of being conceptualised and interpreted differently across cultures. This research study explored amaXhosa healthcare workers’ understandings, knowledge, practices, and attitudes regarding mental distress amongst some amaXhosa people. The study aimed to investigate what mental distress means for some people who belong to the amaXhosa ethnic group, to uncover how they conceptualise mental distress, seek help or what behaviours prevent help-seeking. It aimed to highlight any prevalent attitudes of stigma and discrimination, to build insight into overlooked aspects in psychotherapy practice especially when dealing with non-western populations. The study utilised interpretative phenomenological analysis (IPA) as its analytical lens; to explore and to enter as far as possible into the worlds of participants to generate rich data and in-depth analysis. Four participants were recruited through both purposive and snowball sampling and data were gathered using individual semi-structured interviews. From the data collected, the findings illustrate a limited understanding of mental distress amongst some amaXhosa people due to lack of education and awareness on the subject, leading to the apparent silence in discussing such matters and inadvertently predisposing it to being viewed as taboo. The predominant themes as evidenced by the data were the use of language that sensationalises mental distress; misinformation; Afrocentric beliefs that rationalise mental distress; alienation and segregation of those affected; and the primary healthcare system as a source of reinforcing prevalent stigma and discrimination. The findings show a link between constructs around mental distress and the prevalent socioiii cultural environment, denoting that some perspectives can be linked to observations or modelling in childhood, from people in the respective communities in which people live. , Thesis (MA) -- Faculty of Humanities, Psychology, 2023
- Full Text:
- Date Issued: 2023-10-13
The prevalence of alcohol use disorders among university students in developing countries: a systematic review and meta-analysis
- Authors: Ndlovu, Philani
- Date: 2023-10-13
- Subjects: College students Alcohol use Developing countries , Prevalence , College students Conduct of life , College students Attitudes , Alcohol Physiological effect
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/425019 , vital:72202
- Description: High alcohol misuse is associated with many challenges, including (a) unsafe sex, problems with the criminal justice system, absenteeism, academic failure, death, injury, and alcohol related harm, both in the developing and developed world. Despite the above, no meta-analysis had been conducted in the literature to comprehensively study the prevalence of Alcohol Use Disorders (AUDs) amongst university students in the developing world. This study reviewed literature related to AUDs among university students in developing countries. It described the concept of AUD and the harmful effects of excessive alcohol use, including biological, cognitive, psycho-social, and economic impacts on the individual and the family. , Thesis (MA) -- Faculty of Humanities, Psychology, 2023
- Full Text:
- Date Issued: 2023-10-13
- Authors: Ndlovu, Philani
- Date: 2023-10-13
- Subjects: College students Alcohol use Developing countries , Prevalence , College students Conduct of life , College students Attitudes , Alcohol Physiological effect
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/425019 , vital:72202
- Description: High alcohol misuse is associated with many challenges, including (a) unsafe sex, problems with the criminal justice system, absenteeism, academic failure, death, injury, and alcohol related harm, both in the developing and developed world. Despite the above, no meta-analysis had been conducted in the literature to comprehensively study the prevalence of Alcohol Use Disorders (AUDs) amongst university students in the developing world. This study reviewed literature related to AUDs among university students in developing countries. It described the concept of AUD and the harmful effects of excessive alcohol use, including biological, cognitive, psycho-social, and economic impacts on the individual and the family. , Thesis (MA) -- Faculty of Humanities, Psychology, 2023
- Full Text:
- Date Issued: 2023-10-13
Salt in my footsteps
- Authors: Radebe, Mxolisi Vusumuzi
- Date: 2021-04
- Subjects: Creative writing (Higher education) -- South Africa , South African poetry (English) -- 21st century , South African fiction (English) -- 21st century
- Language: English
- Type: thesis , text , Masters , MA
- Identifier: http://hdl.handle.net/10962/178201 , vital:42920
- Description: My thesis is a collection of poems which focus on human experiences related to my background. I grew up in a countryside village, freely experiencing nature in unrestricted walks to the rivers and mountains; communal living instilled in me the humanitarian values which I uphold to the present. I use short and long lyrical prose poems to bring life and humanise the untold or unexpressed stories of my community. My use of simple everyday language and clear, concrete but surprising images that resonate with deeper meanings and emotions is influenced by Seitlhamo Motsapi’s poems, especially his collection of poems titled earthstepper/the ocean is very shallow and Mxolisi Nyezwa’s poetry book, Song Trials. Spanish poems in English translations by the 20th century Spanish poets: Blas de Otero, Juan Roman Jimenez and Federico Garcia Lorca, published in the book titled Roots and Wings have had a huge impact on my construction of images. I also draw from the free-form and narrative prose poetry experiments of poets: Mangaliso Buzani, vangile gantsho and Ivy Alvarez. , Thesis (MA) -- Faculty of Humanities, School of Languages and Literatures, 2021
- Full Text:
- Date Issued: 2021-04
- Authors: Radebe, Mxolisi Vusumuzi
- Date: 2021-04
- Subjects: Creative writing (Higher education) -- South Africa , South African poetry (English) -- 21st century , South African fiction (English) -- 21st century
- Language: English
- Type: thesis , text , Masters , MA
- Identifier: http://hdl.handle.net/10962/178201 , vital:42920
- Description: My thesis is a collection of poems which focus on human experiences related to my background. I grew up in a countryside village, freely experiencing nature in unrestricted walks to the rivers and mountains; communal living instilled in me the humanitarian values which I uphold to the present. I use short and long lyrical prose poems to bring life and humanise the untold or unexpressed stories of my community. My use of simple everyday language and clear, concrete but surprising images that resonate with deeper meanings and emotions is influenced by Seitlhamo Motsapi’s poems, especially his collection of poems titled earthstepper/the ocean is very shallow and Mxolisi Nyezwa’s poetry book, Song Trials. Spanish poems in English translations by the 20th century Spanish poets: Blas de Otero, Juan Roman Jimenez and Federico Garcia Lorca, published in the book titled Roots and Wings have had a huge impact on my construction of images. I also draw from the free-form and narrative prose poetry experiments of poets: Mangaliso Buzani, vangile gantsho and Ivy Alvarez. , Thesis (MA) -- Faculty of Humanities, School of Languages and Literatures, 2021
- Full Text:
- Date Issued: 2021-04
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