In vitro permeation of progesterone from a gel through the shed skin of three different snake species
- Haigh, John M, Beyssac, E, Chanet, L, Aiache, J M
- Authors: Haigh, John M , Beyssac, E , Chanet, L , Aiache, J M
- Date: 1998
- Language: English
- Type: Article
- Identifier: vital:6366 , http://hdl.handle.net/10962/d1006066
- Description: The in vitro diffusion of progesterone from a gel formulation using the European Pharmacopoeia method for transdermal dosage forms is described. The membranes used were the dorsal and ventral portions of the shed skin of three different species of snake. Considerable differences are apparent between the dorsal and ventral sites and between the different species of snake. The dorsal area shows better permeability for progesterone and the permeability order for the different species is python>cobra>viper. These differences may be due to the thickness of the skin and the hinge:scale ratio. The results indicate that shed snake skin is not a model membrane for human skin.
- Full Text:
- Authors: Haigh, John M , Beyssac, E , Chanet, L , Aiache, J M
- Date: 1998
- Language: English
- Type: Article
- Identifier: vital:6366 , http://hdl.handle.net/10962/d1006066
- Description: The in vitro diffusion of progesterone from a gel formulation using the European Pharmacopoeia method for transdermal dosage forms is described. The membranes used were the dorsal and ventral portions of the shed skin of three different species of snake. Considerable differences are apparent between the dorsal and ventral sites and between the different species of snake. The dorsal area shows better permeability for progesterone and the permeability order for the different species is python>cobra>viper. These differences may be due to the thickness of the skin and the hinge:scale ratio. The results indicate that shed snake skin is not a model membrane for human skin.
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Bioavailability and activity of 0.1% amcinonide preparations: comparison with proprietary topical corticosteroid formulations of differing potencies
- Authors: Woodford, R , Haigh, John M
- Date: 1979
- Language: English
- Type: text , Article
- Identifier: vital:6447 , http://hdl.handle.net/10962/d1006634
- Description: The activity of a 0.1% amcinonide cream was compared with those of selected proprietary topical corticosteroid formulations of potencies differing according to the United Kingdom (U.K.) MIMS classification (very potent, potent and moderately potent) using a standard six hour vasoconstrictor assay with multiple reading times. Statistical analysis indicated that 0.1% amcinonide cream feU within the category of a very potent preparation. Three 0.1% amcinonide formulations (cream, combination cream and combination ointment, the last two containing anti-infective agents) were equipotent in the skin-blanching test.
- Full Text:
- Authors: Woodford, R , Haigh, John M
- Date: 1979
- Language: English
- Type: text , Article
- Identifier: vital:6447 , http://hdl.handle.net/10962/d1006634
- Description: The activity of a 0.1% amcinonide cream was compared with those of selected proprietary topical corticosteroid formulations of potencies differing according to the United Kingdom (U.K.) MIMS classification (very potent, potent and moderately potent) using a standard six hour vasoconstrictor assay with multiple reading times. Statistical analysis indicated that 0.1% amcinonide cream feU within the category of a very potent preparation. Three 0.1% amcinonide formulations (cream, combination cream and combination ointment, the last two containing anti-infective agents) were equipotent in the skin-blanching test.
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Complexes of mercury(II) and zinc(II) with primary aromatic amines
- Haigh, John M, Van Dam, M A, Thornton, D A
- Authors: Haigh, John M , Van Dam, M A , Thornton, D A
- Date: 1967
- Language: English
- Type: text , Article
- Identifier: vital:6370 , http://hdl.handle.net/10962/d1006072
- Description: A series of amine complexes has been prepared by reaction of zinc chloride and mercuric chloride with primary aromatic amines. A detailed assignment of the bands in the infra-red spectra of the complexes in the range 4000-625 cm [superscript]-1 is presented. The symmetric and asymmetric N-H stretching frequencies follow the relationship v(sym) = 345.5+ 0.876v(asym). The C-N stretching frequencies exhibit a linear relationship with the Hammett α-functions for the m- and p-substituted amines.
- Full Text:
- Authors: Haigh, John M , Van Dam, M A , Thornton, D A
- Date: 1967
- Language: English
- Type: text , Article
- Identifier: vital:6370 , http://hdl.handle.net/10962/d1006072
- Description: A series of amine complexes has been prepared by reaction of zinc chloride and mercuric chloride with primary aromatic amines. A detailed assignment of the bands in the infra-red spectra of the complexes in the range 4000-625 cm [superscript]-1 is presented. The symmetric and asymmetric N-H stretching frequencies follow the relationship v(sym) = 345.5+ 0.876v(asym). The C-N stretching frequencies exhibit a linear relationship with the Hammett α-functions for the m- and p-substituted amines.
- Full Text:
Infrared evidence for the transmission of electronic effects through a metal atom in a series of new cadmium complexes
- Haigh, John M, Van Dam, M A, Thornton, D A
- Authors: Haigh, John M , Van Dam, M A , Thornton, D A
- Date: 1967
- Language: English
- Type: text , Article
- Identifier: vital:6371 , http://hdl.handle.net/10962/d1006073
- Description: A series of novel cadmium complexes has been synthesized from the reaction of cadmium chloride, bromide and iodide with primary aromatic amines. The complexes are either mononuclear or polynuclear according to the nature of the halide and amine employed. A possible mechanism for their formation is proposed. The N - H stretching and bending frequencies are linearly related to the electronegativity of the co-ordinated halogen, indicating that the electron withdrawing capacity of the halogen is transmitted through the cadmium atom.
- Full Text:
- Authors: Haigh, John M , Van Dam, M A , Thornton, D A
- Date: 1967
- Language: English
- Type: text , Article
- Identifier: vital:6371 , http://hdl.handle.net/10962/d1006073
- Description: A series of novel cadmium complexes has been synthesized from the reaction of cadmium chloride, bromide and iodide with primary aromatic amines. The complexes are either mononuclear or polynuclear according to the nature of the halide and amine employed. A possible mechanism for their formation is proposed. The N - H stretching and bending frequencies are linearly related to the electronegativity of the co-ordinated halogen, indicating that the electron withdrawing capacity of the halogen is transmitted through the cadmium atom.
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