Exploring the attitudes of selected community members on the interplay between incidences of poverty and the escalation of HIV/AIDS in Cofimvaba, Eastern Cape Province, South Africa
- Authors: Mrashula, Zodidi
- Date: 2017
- Subjects: AIDS (Disease) -- South Africa -- Eastern Cape , AIDS (Disease) -- Economic aspects , Poverty -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10353/7941 , vital:30987
- Description: Cofimvaba has had a noticeable increase of people who got infected with HIV/AIDS and is one of the poorest of the poor in the Eastern Cape. Hence, the researcher became interested to investigate the interplay between incidences of poverty and the prevalence of HIV/AIDS. The reasons for the continued increase of HIV infection in Cofimvaba were investigated. The study used a qualitative approach, was descriptive and explorative and specifically used a case study as a specific research design. The study investigated 32 participants, nine of whom were infected and diagnosed to be seropositive between the years 2012, and 2014; six community members; twelve from the volunteer care givers who were members from the support group. The study also investigated a number of key informants who included a traditional leader, a care giver, a nurse, a social worker and a community development practitioner. The study used a non-probability sampling methodology, but specifically purposive sampling technique. On data collection, the study triangulated both in-depth interviews and focus group discussions. The findings of the study revealed that people who are infected with HIV/AIDS are unemployed, illiterate and suffer from poverty. The study also found that poor people are more vulnerable to HIV/AIDS infections. The study findings were as follows: There is a lack knowledge about HIV/AIDS that leads to lack of prevention. It has been discovered that there is a high level of poverty and HIV/AIDS in Cofimvaba. High level of unemployment is a contributing factor of poverty and high level of HIV/AIDS in Cofimvaba. Level of unprotected sex as driver of HIV/AIDS has also been identified. There is an inextricable relationship poverty and prevalence of HIV/AIDS. Unreliability of the food parcel on people who are HIV positive leads to poverty. The study findings were also as: Caregivers breaching the ethos and principle of confidentiality leads to people not to to HIV/disclose their HIV/AIDS status. Migration driving vulnerability to HIV/AIDS. It has been insisted that transactional sex drives to HIV/AIDS. Low HIV/AIDS education makes people to be vulnerable to HIVAIDS., The fear of testing makes people unaware of their HIV/AIDS status. Also the excessive alcohol intake as a driver to HIV/AIDS vulnerability. It has also been noted that only women responded to the study and there was a high rate of death revealed on account of HIV/AIDS in Cofimvaba. The researcher has also made the following recommendations to the study: obligatory psychol-social support programs for PLWHA, extension and replication of community based organisation, collaboration between different stakeholders in the HIV/AIDS domain. Widen the horizon of training education and HIV/AIDS awareness campaigns and availability of counselling, job opportunity, social grants and food parcels.
- Full Text:
- Date Issued: 2017
- Authors: Mrashula, Zodidi
- Date: 2017
- Subjects: AIDS (Disease) -- South Africa -- Eastern Cape , AIDS (Disease) -- Economic aspects , Poverty -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10353/7941 , vital:30987
- Description: Cofimvaba has had a noticeable increase of people who got infected with HIV/AIDS and is one of the poorest of the poor in the Eastern Cape. Hence, the researcher became interested to investigate the interplay between incidences of poverty and the prevalence of HIV/AIDS. The reasons for the continued increase of HIV infection in Cofimvaba were investigated. The study used a qualitative approach, was descriptive and explorative and specifically used a case study as a specific research design. The study investigated 32 participants, nine of whom were infected and diagnosed to be seropositive between the years 2012, and 2014; six community members; twelve from the volunteer care givers who were members from the support group. The study also investigated a number of key informants who included a traditional leader, a care giver, a nurse, a social worker and a community development practitioner. The study used a non-probability sampling methodology, but specifically purposive sampling technique. On data collection, the study triangulated both in-depth interviews and focus group discussions. The findings of the study revealed that people who are infected with HIV/AIDS are unemployed, illiterate and suffer from poverty. The study also found that poor people are more vulnerable to HIV/AIDS infections. The study findings were as follows: There is a lack knowledge about HIV/AIDS that leads to lack of prevention. It has been discovered that there is a high level of poverty and HIV/AIDS in Cofimvaba. High level of unemployment is a contributing factor of poverty and high level of HIV/AIDS in Cofimvaba. Level of unprotected sex as driver of HIV/AIDS has also been identified. There is an inextricable relationship poverty and prevalence of HIV/AIDS. Unreliability of the food parcel on people who are HIV positive leads to poverty. The study findings were also as: Caregivers breaching the ethos and principle of confidentiality leads to people not to to HIV/disclose their HIV/AIDS status. Migration driving vulnerability to HIV/AIDS. It has been insisted that transactional sex drives to HIV/AIDS. Low HIV/AIDS education makes people to be vulnerable to HIVAIDS., The fear of testing makes people unaware of their HIV/AIDS status. Also the excessive alcohol intake as a driver to HIV/AIDS vulnerability. It has also been noted that only women responded to the study and there was a high rate of death revealed on account of HIV/AIDS in Cofimvaba. The researcher has also made the following recommendations to the study: obligatory psychol-social support programs for PLWHA, extension and replication of community based organisation, collaboration between different stakeholders in the HIV/AIDS domain. Widen the horizon of training education and HIV/AIDS awareness campaigns and availability of counselling, job opportunity, social grants and food parcels.
- Full Text:
- Date Issued: 2017
Spectroscopic and nonlinear optical characterisation of alpha substituted binuclear phthalocyanines
- Authors: Ngubeni, Grace Nomthandazo
- Date: 2017
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10962/5038 , vital:20757
- Full Text:
- Date Issued: 2017
- Authors: Ngubeni, Grace Nomthandazo
- Date: 2017
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10962/5038 , vital:20757
- Full Text:
- Date Issued: 2017
Synthesis and bioassay of rationally designed DXR inhibitors as potential antimalarial lead compounds
- Authors: Nokalipa, Iviwe Cwaita
- Date: 2017
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10962/4888 , vital:20740
- Description: Globally, the eradication of malaria has been challenging due to the problem of resistance that past and currently available drugs exhibit. This is exacerbated by the inherent need for anti-malarial drugs to be affordable to the poverty-stricken majority that is primarily affected by this burden. This research has focused on the development of potential inhibitors of 1-deoxy-D- xylulose-5 phosphate reductoisomerase (DXR), an essential enzyme in the mevalonate- independent pathway for the biosynthesis of isoprenoids in Plasmodium falciparum. DXR mediates the isomerisation and reduction of 1-deoxy-D-xylulose-5-phosphate into 2-C- methyl-D-erithrytol 4-phosphate. This enzyme has been determined to be a target for the development of novel antimalarial agents and extensive molecular modelling has been undertaken to develop inhibitors that fit into the DXR active site. The in silico docking data have been used to inform the design and synthesis of various N-benzyl-substituted phosphoramidate ligands that were determined to have potential as novel substrate mimics of fosmidomycin, a known DXR inhibitor. Synthesis of the N-benzyl-substituted phosphoramidate ligands involved a nine-step sequence commencing from diethyl phosphoramidate. In all, some 40 compounds have been prepared, some of them new, and were fully characterized using NMR. Attention has also been given to the mass spectrometric fragmentation patterns exhibited by selected intermediates. Four of the final products were evaluated for in vitro antimalarial activity using a PLDH assay and exhibited IC50 values < 100 µM.
- Full Text:
- Date Issued: 2017
- Authors: Nokalipa, Iviwe Cwaita
- Date: 2017
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10962/4888 , vital:20740
- Description: Globally, the eradication of malaria has been challenging due to the problem of resistance that past and currently available drugs exhibit. This is exacerbated by the inherent need for anti-malarial drugs to be affordable to the poverty-stricken majority that is primarily affected by this burden. This research has focused on the development of potential inhibitors of 1-deoxy-D- xylulose-5 phosphate reductoisomerase (DXR), an essential enzyme in the mevalonate- independent pathway for the biosynthesis of isoprenoids in Plasmodium falciparum. DXR mediates the isomerisation and reduction of 1-deoxy-D-xylulose-5-phosphate into 2-C- methyl-D-erithrytol 4-phosphate. This enzyme has been determined to be a target for the development of novel antimalarial agents and extensive molecular modelling has been undertaken to develop inhibitors that fit into the DXR active site. The in silico docking data have been used to inform the design and synthesis of various N-benzyl-substituted phosphoramidate ligands that were determined to have potential as novel substrate mimics of fosmidomycin, a known DXR inhibitor. Synthesis of the N-benzyl-substituted phosphoramidate ligands involved a nine-step sequence commencing from diethyl phosphoramidate. In all, some 40 compounds have been prepared, some of them new, and were fully characterized using NMR. Attention has also been given to the mass spectrometric fragmentation patterns exhibited by selected intermediates. Four of the final products were evaluated for in vitro antimalarial activity using a PLDH assay and exhibited IC50 values < 100 µM.
- Full Text:
- Date Issued: 2017
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