Adreno-active substances and the pineal gland
- Authors: Midlane, Graham Wallace
- Date: 1979
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:3738 , http://hdl.handle.net/10962/d1001530
- Description: The pineal gland, a biochemically very active neuroendocrine transducer which is innervated by the sympathetic nervous system, was used in vivo to evaluate the effect of different þ-adrenoceptor agonists and antagonists on pineal enzyme levels. Hydroxyindole-O-methyltransferase (HIOMT), an enzyme with a circadian activity and unknown control was not significantly affected by these drugs. The activity of serotonin N-acetyltransferase, another pineal enzyme with a greater amplitude of circadian rhythmicity and which is under noradrenergic neural control, the degree of blockade depending on the selectivity and affinity of the agent used. An attempt was also made to alter the oestrous cycle of the rat by dosing with þ-active substances. Only propranolol had any effect on the oestrous cycle. It was not possible to establish an absolute link between the alteration in pineal enzyme activity and an influence on the oestrous cycle. It was concluded that the pineal enzyme studies are useful pharmacological means for evaluating þ-active substances
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- Authors: Midlane, Graham Wallace
- Date: 1979
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:3738 , http://hdl.handle.net/10962/d1001530
- Description: The pineal gland, a biochemically very active neuroendocrine transducer which is innervated by the sympathetic nervous system, was used in vivo to evaluate the effect of different þ-adrenoceptor agonists and antagonists on pineal enzyme levels. Hydroxyindole-O-methyltransferase (HIOMT), an enzyme with a circadian activity and unknown control was not significantly affected by these drugs. The activity of serotonin N-acetyltransferase, another pineal enzyme with a greater amplitude of circadian rhythmicity and which is under noradrenergic neural control, the degree of blockade depending on the selectivity and affinity of the agent used. An attempt was also made to alter the oestrous cycle of the rat by dosing with þ-active substances. Only propranolol had any effect on the oestrous cycle. It was not possible to establish an absolute link between the alteration in pineal enzyme activity and an influence on the oestrous cycle. It was concluded that the pineal enzyme studies are useful pharmacological means for evaluating þ-active substances
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The polysaccharides of Opuntia ficus-indica (L.) Mill. and Opuntia aurantiaca Lindl.
- Authors: McGarvie, Donald
- Date: 1977
- Subjects: Polysaccharides
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:4438 , http://hdl.handle.net/10962/d1007597
- Description: The partially acetylated acidic mucilage isolated from the cactus Opuntia ficus-indica consists of a highly branched molecule containing D-galactose, L-arabinose, D-xylose, D-galacturonic acid and L-rhamnose in the ratio 2.9:6.6:3.8:1.3 : 1.0. A partial hydrolysis study led to the isolation of fourteen oligosaccharides and a degraded polysaccharide. Periodate oxidation of the degraded polysaccharide and methylation analysis of the degraded and reduced degraded polysaccharides led to the proposal of a structure for the degraded polysaccharide consisting of a chain of alternating α-l,4-D-galactopyranosyluronic acid and β-1,2-Lrhamnopyranosyl units with branches consisting of short chains of β-1,6-D-galactopyranosyl units Iinked to C-3 of the rhamnose residues. An insight into the nature of the peripheral side-chains was obtained by methylation studies of the oligosaccharides and the native polysaccharide. The majority of the side-chains are terminated by D-xylopyranosyl and L-arabinofuranosyl units while there is a small proportion of D-galactopyranosyl end-groups. The remaining units of the peripheral chains consists of mainly 1,3- and 1,5-1 inked L-arabinofuranosyl units. The acidic polysaccharide isolated from the jointed cactus Opuntia aurantiaca contains D-galactose, L-arabinose, D-xylose, D-galacturonic acid and L-rhamnose in the ratio 5.9:5 .5:3.4: 1. 2:1.0 . A partial hydrolysis study revealed a similar series of galactose containing oligosaccharides as was identified from the mucilage of Opuntia ficus-indica. The degraded polysaccharide isolated from the partial hydrolysate was methylated and a possible structure proposed for the repeating unit. Methylation studies of the native polysaccharide indicated a polysaccharide with a more complex structure than that for the mucilage of Opuntia ficus-indica.
- Full Text:
- Authors: McGarvie, Donald
- Date: 1977
- Subjects: Polysaccharides
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:4438 , http://hdl.handle.net/10962/d1007597
- Description: The partially acetylated acidic mucilage isolated from the cactus Opuntia ficus-indica consists of a highly branched molecule containing D-galactose, L-arabinose, D-xylose, D-galacturonic acid and L-rhamnose in the ratio 2.9:6.6:3.8:1.3 : 1.0. A partial hydrolysis study led to the isolation of fourteen oligosaccharides and a degraded polysaccharide. Periodate oxidation of the degraded polysaccharide and methylation analysis of the degraded and reduced degraded polysaccharides led to the proposal of a structure for the degraded polysaccharide consisting of a chain of alternating α-l,4-D-galactopyranosyluronic acid and β-1,2-Lrhamnopyranosyl units with branches consisting of short chains of β-1,6-D-galactopyranosyl units Iinked to C-3 of the rhamnose residues. An insight into the nature of the peripheral side-chains was obtained by methylation studies of the oligosaccharides and the native polysaccharide. The majority of the side-chains are terminated by D-xylopyranosyl and L-arabinofuranosyl units while there is a small proportion of D-galactopyranosyl end-groups. The remaining units of the peripheral chains consists of mainly 1,3- and 1,5-1 inked L-arabinofuranosyl units. The acidic polysaccharide isolated from the jointed cactus Opuntia aurantiaca contains D-galactose, L-arabinose, D-xylose, D-galacturonic acid and L-rhamnose in the ratio 5.9:5 .5:3.4: 1. 2:1.0 . A partial hydrolysis study revealed a similar series of galactose containing oligosaccharides as was identified from the mucilage of Opuntia ficus-indica. The degraded polysaccharide isolated from the partial hydrolysate was methylated and a possible structure proposed for the repeating unit. Methylation studies of the native polysaccharide indicated a polysaccharide with a more complex structure than that for the mucilage of Opuntia ficus-indica.
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The Hamilton-Jacobi theory in general relativity theory and certain Petrov type D metrics
- Authors: Matravers, David Richard
- Date: 1973
- Subjects: Hamilton-Jacobi equations , General relativity (Physics) , Generalized spaces
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:5422 , http://hdl.handle.net/10962/d1007551 , Hamilton-Jacobi equations , General relativity (Physics) , Generalized spaces
- Description: Introduction: The discovery of new solutions to Einstein's field equations has long been a problem in General Relativity. However due to new techniques of Newman and Penrose [1], Carter [2] and others there has been a considerable proliferation of new solutions in recent times. Consequently a new problem has arisen. How are we to interpret the new solutions physically? The tools available, despite a spate of papers in the past fifteen years, remain inadequate although often sophisticated. Any attempts at physical interpretations of metrics are beset with difficulties. There is always the possibility that two entirely different physical pictures will emerge. For example a direct approach would be to attempt an "infilling" of the metric, that is, an extension of the metric into the region occupied by the gravitating matter. However even for the Kerr [1] metric the infilling is by no means unique, in fact a most natural "infilling" turns out to be unphysical (Israel [1]). Yet few people would doubt the physical significance of the Kerr metric. Viewed in this light our attempt to discuss, among other things, the physical interpretation of type D metrics is slightly ambitious. However the problems with regard to this type of metric are not as formidable as for most of the other metrics, since we have been able to integrate the geodesic equations. Nevertheless it is still not possible to produce complete answers to all the questions posed. After a chapter on Mathematical preliminaries the study divides naturally into four sections. We start with an outline of the Hamilton-Jacobi theory of Rund [1] and then go on to show how this theory can be applied to the Carter [2] metrics. In the process we lay a foundation in the calculus of variations for Carter's work. This leads us to the construction of Killing tensors for all but one of the Kinnersley [1] type D vacuum metrics and the Cartei [2] metrics which are not necessarily vacuum metrics. The geodesic equations, for these metrics, are integrated using the Hamilton-Jacobi procedure. The remaining chapters are devoted to the Kinnersley [1] type D vacuum metrics. We omit his class I metrics since these are the Schwarzschild metrics, and have been studied in detail before. Chapter three is devoted to a general study of his class II a metric, a generalisation of the Kerr [1] and NUT (Newman, Tamburino and Unti [1]) metrics. We integrate the geodesic equations and discuss certain general properties: the question of geodesic completeness, the asymptotic properties, and the existence of Killing horizons. Chapter four is concerned with the interpretation of the new parameter 'l', that arises in the class II a and NUT metrics. This parameter was interpreted by Demianski and Newman [1] as a magnetic monopole of mass. Our work centers on the possibility of obtaining observable effects from the presence of 'l'. We have been able to show that its presence is observable, at least in principle, from a study of the motion of particles in the field. In the first place, if l is comparable to the mass of the gravitating system, a comparatively large perihelion shift is to be expected. The possibility of anomalous behaviour in the orbits of test particles, quite unlike anything that occurs in a Newtonian or Schwarzschild field, also arises. In the fifth chapter the Kinnersley class IV metrics are considered. These metrics, which in their simplest form have been known for some time, present serious problems and no interpretations have been suggested. Our discussion is essentially exploratory and the information that does emerge takes the form of suggestions rather than conclusions. Intrinsically the metrics give the impression that interesting results should be obtainable since they are asymptotically flat in certain directions. However the case that we have dealt with does not appear to represent a radiation metric.
- Full Text:
- Authors: Matravers, David Richard
- Date: 1973
- Subjects: Hamilton-Jacobi equations , General relativity (Physics) , Generalized spaces
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:5422 , http://hdl.handle.net/10962/d1007551 , Hamilton-Jacobi equations , General relativity (Physics) , Generalized spaces
- Description: Introduction: The discovery of new solutions to Einstein's field equations has long been a problem in General Relativity. However due to new techniques of Newman and Penrose [1], Carter [2] and others there has been a considerable proliferation of new solutions in recent times. Consequently a new problem has arisen. How are we to interpret the new solutions physically? The tools available, despite a spate of papers in the past fifteen years, remain inadequate although often sophisticated. Any attempts at physical interpretations of metrics are beset with difficulties. There is always the possibility that two entirely different physical pictures will emerge. For example a direct approach would be to attempt an "infilling" of the metric, that is, an extension of the metric into the region occupied by the gravitating matter. However even for the Kerr [1] metric the infilling is by no means unique, in fact a most natural "infilling" turns out to be unphysical (Israel [1]). Yet few people would doubt the physical significance of the Kerr metric. Viewed in this light our attempt to discuss, among other things, the physical interpretation of type D metrics is slightly ambitious. However the problems with regard to this type of metric are not as formidable as for most of the other metrics, since we have been able to integrate the geodesic equations. Nevertheless it is still not possible to produce complete answers to all the questions posed. After a chapter on Mathematical preliminaries the study divides naturally into four sections. We start with an outline of the Hamilton-Jacobi theory of Rund [1] and then go on to show how this theory can be applied to the Carter [2] metrics. In the process we lay a foundation in the calculus of variations for Carter's work. This leads us to the construction of Killing tensors for all but one of the Kinnersley [1] type D vacuum metrics and the Cartei [2] metrics which are not necessarily vacuum metrics. The geodesic equations, for these metrics, are integrated using the Hamilton-Jacobi procedure. The remaining chapters are devoted to the Kinnersley [1] type D vacuum metrics. We omit his class I metrics since these are the Schwarzschild metrics, and have been studied in detail before. Chapter three is devoted to a general study of his class II a metric, a generalisation of the Kerr [1] and NUT (Newman, Tamburino and Unti [1]) metrics. We integrate the geodesic equations and discuss certain general properties: the question of geodesic completeness, the asymptotic properties, and the existence of Killing horizons. Chapter four is concerned with the interpretation of the new parameter 'l', that arises in the class II a and NUT metrics. This parameter was interpreted by Demianski and Newman [1] as a magnetic monopole of mass. Our work centers on the possibility of obtaining observable effects from the presence of 'l'. We have been able to show that its presence is observable, at least in principle, from a study of the motion of particles in the field. In the first place, if l is comparable to the mass of the gravitating system, a comparatively large perihelion shift is to be expected. The possibility of anomalous behaviour in the orbits of test particles, quite unlike anything that occurs in a Newtonian or Schwarzschild field, also arises. In the fifth chapter the Kinnersley class IV metrics are considered. These metrics, which in their simplest form have been known for some time, present serious problems and no interpretations have been suggested. Our discussion is essentially exploratory and the information that does emerge takes the form of suggestions rather than conclusions. Intrinsically the metrics give the impression that interesting results should be obtainable since they are asymptotically flat in certain directions. However the case that we have dealt with does not appear to represent a radiation metric.
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The development of native policy in the Transkei and in Glen Gray between 1870 and 1900
- Authors: Griffiths, M S
- Date: 1939
- Subjects: Transkei (South Africa) -- History , Black people -- South Africa -- Legal status, Laws, etc. -- South Africa -- History
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:2607 , http://hdl.handle.net/10962/d1012098 , Transkei (South Africa) -- History , Black people -- South Africa -- Legal status, Laws, etc. -- South Africa -- History
- Description: The Transkeian Territories extend over a stretch of 17000 square miles between the north eastern border of the Cape Colony and the southern border of Natal. In 1870 this was an exclusively Native area ; inhabited by some half million natives tribally organised under independent chiefs and grouped into racial entities according to origln; customs, and language dialects.
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- Authors: Griffiths, M S
- Date: 1939
- Subjects: Transkei (South Africa) -- History , Black people -- South Africa -- Legal status, Laws, etc. -- South Africa -- History
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:2607 , http://hdl.handle.net/10962/d1012098 , Transkei (South Africa) -- History , Black people -- South Africa -- Legal status, Laws, etc. -- South Africa -- History
- Description: The Transkeian Territories extend over a stretch of 17000 square miles between the north eastern border of the Cape Colony and the southern border of Natal. In 1870 this was an exclusively Native area ; inhabited by some half million natives tribally organised under independent chiefs and grouped into racial entities according to origln; customs, and language dialects.
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