An investigation of chlorbutol in ophthalmic and parenteral solutions

Title: An investigation of chlorbutol in ophthalmic and parenteral solutions
Creator: Summers, Robert Stanley
Subject: Parenteral solutions
Subject: Solutions (Pharmacy)
Subject: Ocular pharmacology
Date: 1967
Type: Thesis
Type: Masters
Type: MSc
Identifier: vital:3842
Identifier: http://hdl.handle.net/10962/d1007694
Identifier: Parenteral solutions
Identifier: Solutions (Pharmacy)
Identifier: Ocular pharmacology
Description: From Introduction Chlorbutol , which is tri-chlor-tertiary-butanol, was first prepared by Willgerodt in 1886 (1). The reaction he used for its preparation is still used today, though slightly modified (2)(3)(4), and is suggested by its original name "acetone-chloroform". The substance was prepared by adding solid potassium hydroxide to a cold mixture of acetone and chloroform (5 ). Chlorbutol is a derivative of the trichlorinated derivative of methane, and its formation may best be described by the use of structural formulae.
Format: 167 p., pdf
Publisher: Rhodes University, Faculty of Pharmacy, Pharmacy
Language: English
Rights: Summers, Robert Stanley

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