Patriarchy and the participation of women in Zimbabwean national politics: a study of selected women Politicians in Matabeleland Region
- Authors: Manyevere, Sithabile
- Date: 2019
- Subjects: Women politicians Women -- Political activity -- Zimbabwe
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10353/17506 , vital:41082
- Description: The research sought to analyse how patriarchal perceptions have affected women in Zimbabwean national politics with specific focus on women politicians in Matabeleland region. The researcher observed that women politicians in this region seem to face multiple oppressions and yet seem to have been excluded in previous studies. The mixed method approach was adopted for the research. Questionnaires were used for the quantitative method, while key informant interviews and focus group discussions were utilised for the qualitative method. Findings from the survey revealed stereotypical perceptions such as that men are better leaders than women, women are not capable of holding decision making positions and the perception that politics is not safe for women. The findings from the key informants indicate that women politicians in Matabeleland face quite a number of challenges emanating from these patriarchal perceptions. The challenges include violence, humiliation and cultural stigmatization. Although women have attempted to resist patriarchy, it seems that the resistance has not been enough to eliminate the patriarchal mentality and the oppressions that accompany it. The research adopts a combination of feminist and intersectionality theory as a framework for analysis of the problem under investigation. The research potentially contributes to academic discourse by advancing literature on the multi-faceted aspects of patriarchy. The study recommends psychological and financial empowerment of women, electoral reforms and criminalization of offenders. The implementation of proper reforms and corrective measures envisage the long-awaited new dawn among women whom since time memorial, have been suppressed by deep-seated societal and patriarchal beliefs.
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- Date Issued: 2019
Evaluation of the medicinal potentials of Bulbine Abyssinica A. rich in the management of diabetes mellitus in the Eastern Cape, South Africa
- Authors: Kibiti, Cromwell Mwiti
- Date: 2016
- Subjects: Medicinal plants -- South Africa -- Eastern Cape Diabetes -- Alternative treatment -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10353/3077 , vital:28252
- Description: Diabetes mellitus is a chronic physiological carbohydrate metabolic disorder with significant impact on the economy, quality of life and life expectancy in South Africa. Herbal medicine has become the alternative therapy in the management of this disease. However, their safety and effectiveness have not been investigated. To address this, one of the plants used in Eastern Cape Province, South Africa, Bulbine abyssinica A. Rich (Asphodelaceae), was evaluated. Bulbine abyssinica is one of the species used in the management of diabetes mellitus. This plant was mentioned during an ethnobotanical survey conducted in Nkonkobe municipality of the Eastern Cape Province. Though a decoction prepared from the whole plant is used in the treatment of diabetes mellitus, the mechanism of action and its safety has not been elucidated. Thus, this research work was designed to contribute to the understanding of the possible mechanism of action of B. abyssinica as an antidiabetic medicinal plant and its toxic potentials to the users. The aqueous extract exhibited remarkable inhibitory activity onα-amylase (estimated inhibitory concentration (IC)50 value of 3.28 μg/ml), while the acetone extract exhibited weak inhibitory activity. The acetone extract exhibited notable α-glucosidase inhibitory activity (IC50 value of 4.27 μg/ml) while aqueous extract had significantly weak activity. The Lineweaver-Burk double reciprocal plots revealed that the aqueous extract exerts noncompetitive inhibition on the α-amylase activity while the acetone extract exerts a near competitive inhibitory pattern on the α-glucosidase activity. The extracts from the plant possessed high free radical scavenging activities, with acetone extract exhibiting the highest activities in all assay models used except with ferric reducing power and nitric oxide (NO) scavenging ability. The aqueous extract exhibited the highest ferric reducing power and nitric oxide radical mopping strength while the essential oil exhibited the highest scavenging activities with 1,1-diphenyl-2-picrylhydrazyl (DPPH) and relatively high ferric reducing power and nitric oxide scavenging ability. The acetone extract and the essential oil of this species exhibited higher albumin denaturation inhibition than the aqueous extract while the latter showed the greatest membrane lysis protection. The essential oil, acetone and aqueous extracts from this plant significantly inhibited the growth of Shigelle flexneri, Pseudomonas aeruginosa, Staphylococcus aureus and Enterococcus faecalis. Klebsiella pneumonia, Proteus vulgaris and Streptococcus pyogens growth were inhibited by acetone and aqueous extracts. The essential oil also showed inhibitory activity against Proteus vulgaris. However, the extracts were active against the growth of only three fungi species. The essential oil showed significant inhibitory activity against Trichophyton rubrum. The aqueous extract inhibited the growth of Microsporum gypseum while the acetone extract was active against Microsporum canis, and Microsporum gypseum. The carbohydrate, crude fibre, moisture, ash, crude protein and crude fat of approximately 74.8 percent, 8.9 percent, 8.8 percent, 8 percent, 7.7 percent and 0.6 percent, respectively, were detected in this plant. The species is characterized by moderate levels of oxalates, phytic acids, Vitamin A, Vitamin C and Vitamin E. Potassium and calcium were present in highest levels, while magnesium, iron, sodium, aluminium and phosphorus were moderately present. Manganese, zinc and copper where in low amounts. These vitamins and mineral elements were within their recommended daily allowance (RDA) in humans. The investigation also revealed appreciable amounts of total phenols, flavonoids, flavanols, proanthocyanidins and alkaloids in both acetone and aqueous extracts while saponins and tannins were in trace amounts. The essential oil was characterized by large quantities of terpenes (91.9 percent) and small fraction of esters (8.01 percent).
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- Date Issued: 2016
Diet of coastal filter feeders : impact of factors operating at different scales
- Authors: Puccinelli, Eleonora
- Date: 2015
- Subjects: Benthic animals -- Ecology -- South Africa , Benthic animals -- Nutrition
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:5929 , http://hdl.handle.net/10962/d1017807
- Description: Benthic filter feeders have a key functional role in the dynamics of coastal food web as an intermediate trophic level and bioengineers. A wide variety of factors, operating across multiple spatial scales (e.g. hydrographic regime, human activities), can affect the composition of the water column and thus the availability of food for benthic populations. Food availability in turn affects the growth, reproductive rates and survival of benthic organisms, and consequently, can influence the functioning of the entire ecosystem. This study aims to evaluate how various environmental factors may modify the diet of intertidal filter feeders living along the South African coast. Specifically, the effects of biogeography, upwelling, urbanization and freshwater input on the dietary regimes of five species of filter feeders (two mussel and three barnacle species) were investigated using fatty acid (FA) and stable isotope (SI) analyses.Strong interspecific differences were found among the five species considered. However, all species responded to factors operating at large (100s km) and meso (10s- 100s km) scales (i.e. biogeography and upwelling respectively). The barnacles exhibit habitat segregation and showed different FA and SI signatures from each other, while the two mussel species, an invasive and native species that co-occur in the same mussel beds, had partially overlapping diets. Differences in their diets were found only using FA analysis, while their SI signatures differed on only one occasion. This highlights the importance of using the appropriate tool, and ideally combined techniques, to investigate diets.FA and SI signatures of all species considered changed among the three biographical provinces (west, south and east coasts of South Africa) exhibiting similar patterns that reflect the two oceanographic regimes that characterize the coastline: the eutrophic Benguela Current on the west coast and the oligotrophic Agulhas Current on the other two coasts. Upwelling had a significant effect on FA and SI signatures, with stronger effects on the west coast than the south coast. The results indicate that benthic filter feeders at upwelling areas consumed a mix of coastal macroalgal detritus and phytoplankton, which was probably brought onshore during downwelling events. At smaller spatialscales and using repeated sampling, the influence of upwelling on the west coast was found to be pervasive, rather than discrete, so that it may be more appropriate to categorize upwelling by referring to upwelling centres and downstream areas. SI underlined a significant effect of urbanization on the diet of filter feeders with an enrichment in the δ¹⁵N being characteristic of anthropogenic effect. Although a large number of rivers characterize the South African coast, no distinct effect of freshwater input was found for either the SI or FA signatures of the filter feeders. This contrasts with earlier work on demersal species and suggests that freshwater input does not significantly affect food availability for intertidal filter feeders, and that other factors (e.g. hydrogeography) are more important in determining the diet of these populations. These results highlight that environmental and anthropogenic factors operating at different spatial and temporal scales have a profound effect on benthic ecosystems, and that they control the relationship between primary production and primary consumers in coastal areas. Above all, this work highlights the importance of understanding the spatial and temporal scales at which different factors affect feeding regimes, and their critical role in coastal food webs.
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- Date Issued: 2015
The perceived visual impacts and attitudes of the Grahamstown community towards the Waainek Wind-Farm
- Authors: Cruickshank, Kyle Mark
- Date: 2014
- Subjects: Renewable energy sources -- South Africa -- Grahamstown Wind power plants -- South Africa -- Grahamstown -- Public opinion Wind power plants -- Social aspects -- South Africa -- Grahamstown Wind power plants -- Environmental aspects -- South Africa -- Grahamstown Wind power plants -- Economic aspects -- South Africa Wind turbines -- South Africa
- Language: English
- Type: Thesis , Masters , MEcon
- Identifier: vital:1085 , http://hdl.handle.net/10962/d1011768
- Description: Renewable energy has become an important feature of most modern economies with clean and non-exhaustible sources of power being given a greater significance. Wind energy is one of the favoured renewable, as it is (2013) generally the cheapest and most mature technology available for commercial use. The South African government, as outlined by the Department of Energy's Integrated Resource Plan (IRP), aims to install 5 GW (Gigawatts) of wind energy by 2020. However, South Africa has had little experience in the wind energy industry which is limited to two projects, Klipheuwel (2002) and Darling (2008). Much effort has been dedicated to calculating balance sheet costs, which carries uncertainty due to the high reliance on country specific and site specific variables. An aspect which deserves more attention, and is often ignored, is the public‟s attitudes towards local wind farm developments, which have been known to "make or break" a project during the planning stages. Public backlashes have mostly been concerned with the visual "intrusiveness" of wind farms in the landscape. Detrimental effects on scenery, while seemingly innocuous, are acknowledged as being the single largest barrier to successful wind farm development. Individuals within an area become sentimentally attached to their surroundings, where significant rapid changes in the landscape are viewed as "damage". Economics recognises such declines in scenic resources as market failures, where an externalised cost is passed on to the public and is often not accounted for by private parties responsible for the liability. The primary objective therefore was to measure the magnitude of the visual impact, caused by the Waainek Wind Farm, on the Grahamstown community. Conventional NIMBY¹ (not in my back yard) reasoning, which seeks to explain local wind farm resistance, has attracted criticism with regard to its simplistic approach to wind farm problem identification. Contemporary arguments propose that NIMBY is a poor explanation for the trouble experienced on the local level because it groups problems into one all-encompassing term, leaving much of the discontent unexplained. Instead, the NIMBY explanation is really a broad set of unattended problems, largely resulting from the unsound practices present in the public participation process. Insufficient community involvement and disparities in the negotiation power structures have become the recent focus in wind farm literature. Essentially, these disparities force opposition groups to select factors which may seem more serious to developers, leading to ineffective remedial measures because the core underlying problems are not being remedied. Thus these considerations formed an additional area of investigation. No NIMBY effect was found for the Grahamstown community, as support for both the local and general level was roughly 80%. The public participation process on the other hand revealed that while many found the practices of the developer to be unfair, attitudes towards the wind farm were not adversely affected, especially for the lower income Grahamstown East areas. While the public participation process in this instance did not have any effect on people’s attitudes, careful inspection of the circumstances need to be given. Wind farms are new to South Africa, where the novelty and benefits are the focus of enthusiasm. Job opportunities as well as clean energy are positive drivers for attitudes; however given time, once the anticipation for wind farms dulls, real problems may be revealed. Thus it is crucial to implement good practice procedures during the public participation process, especially when national adoption rates of wind energy are low. Early implementation of an effective public participation process system will ensure that when major problems do arise in future projects, experience and institutional processes would have had ample opportunity to evolve appropriately over a period of time. The double bounded Contingent Valuation Method was used to value the impact of the wind farm on the Waainek scenery through a hypothetical scenario based procedure which presented pictures of the landscape before and after the wind farm had been installed. Based on the perceived impact of the wind farm, respondents were asked their Willingness to Pay to relocate the development, based solely on visual impacts. Learning design Contingent Valuation (Bateman et al., 2008) is a novel technique employed to familiarize respondents with the hypothetical market institution as well as the scenic goods being valued. Average Willingness to Pay was found to be R67 per month, with a final total monthly negative visual impact of R104,000 to R121,000 per month for the entire Grahamstown community. Grahamstown Central (middle-high income) residents were more likely to pay than Grahamstown East (low-middle income) East residents because of socio-economic differences present in each area. A ranking exercise determined that while negative visual impacts are present, the overall benefits derived from the wind farm are potentially much higher. Additionally, positive scenic improvements were found, but were not measured due to time constraints, and would have worked to reduce the net visual impact of the Waainek Wind Farm. ¹Problem where individuals support the general concept of wind power, but when it comes to local implementation, opposition to the development arises within the same group.
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- Date Issued: 2014
Electrochemical studies of titanium, manganese and cobalt phthalocyanines
- Authors: Nombona, Nolwazi
- Date: 2009
- Subjects: Titanium , Manganese , Cobalt , Phthalocyanines , Electrochemistry , Electrodes , Self-assembly (Chemistry)
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4312 , http://hdl.handle.net/10962/d1004970 , Titanium , Manganese , Cobalt , Phthalocyanines , Electrochemistry , Electrodes , Self-assembly (Chemistry)
- Description: Syntheses, spectral, electrochemical and spectroelectrochemical studies of phenylthio and amino derivatised metallophthalocyanines complexes are reported. The complexes are immobilized onto a gold macro disk, gold ultramicroelectrode and gold coated fiber electrodes via self assembly with phenylthio MPc derivatives or onto a glassy carbon electrode via electropolymerisation with amino MPc derivatives. For the first time MPc SAMs were formed on gold coated fiber. The electrocatalytic behavior of the modified electrodes was studied for the detection of nitrite and L-cysteine, all modified electrodes showed improved electrocatalytic oxidation compared to the unmodified electrode. The MPc complexes catalyzed nitrite oxidation via a two-electron mechanism producing nitrate. Cobalt tetraaminophthalocyanine showed the best catalytic activity for nitrite oxidation in terms of overpotential lowering compared to other complexes and thus was used for nitrite detection in a food sample, the nitrite concentration was determined to be 59.13 ppm, well within the limit for cured meat products. Electrocatalytic oxidation of L-cysteine on SAM modified gold coated fiber was reported for the first time. The gold coated fiber and ultamicro cylinder electrode were less stable towards the electro-oxidation of cysteine compared to its oxidation on the gold disk. The gold disk electrode gave better catalytic performance in terms of stability and reduction of overpotential. The phenylthio cobalt phthalocyanine derivative gave the best catalytic activity for L-cysteine oxidation in terms of overpotential lowering compared to other phenylthio derivatized MPc complexes. The amount of L-cysteine in human urine was 2.4 mM, well within the urinary L-cysteine excretion range for a healthy human being.
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- Date Issued: 2009
Liberalisation and regulation of trade in the Southern African Development Community (SADC) : a critical analysis of the SADC trade protocol's provisions and its implementation
- Authors: Dube, Memory
- Date: 2009
- Subjects: General Agreement on Tariffs and Trade (Organization) World Trade Organization Customs unions Foreign trade regulation Free trade -- Africa, Southern Southern African Development Community International trade
- Language: English
- Type: Thesis , Masters , LLM
- Identifier: vital:3716 , http://hdl.handle.net/10962/d1008204
- Description: The Southern African Development Community (SADC) declared a Free Trade Area on 17 August 2008. The Free Trade Area is the ultimate objective of the Trade Protocol on trade cooperation in SADC, signed in 1996. The Protocol is supported and complemented by the ambitious Regional Indicative Strategic Development Plan (RISDP). The idea behind the SADC Trade Protocol was to counter the developmental challenges facing SADC member states and to improve the productive and trade capacity of SADC countries. The implementation of the SADC Free Trade Area has been guided by the WTO/GATT regulatory framework on regional trade agreements, particularly GATT Article XXIV, the Understanding on the Interpretation of GATT Article XXIV, as well as the Decision on Differential and More Favourable Treatment, Reciprocity and Fuller Participation of Developing Countries (Enabling Clause). This research seeks to analyse the SADC Trade Protocol's provisions and the implementation of such provisions. To facilitate an understanding of factors that affect the implementation of the SADC Trade Protocol, SADC's institutional and operational framework is discussed from a legal-historical perspective. The provisions of the Trade Protocol are analysed for compliance with WTO/GA TT rules as well as for applicability within the SADC context. The provisions of the WTO/GA TT regulatory framework on regional trade agreements are also analysed with a view to determining whether they are applicable in developing country situations such as SADC. The Free Trade Area is seen as the first step towards regional economic integration in the region and is to be followed by a Customs Union, a Common Market and then eventually an Economic Community with its own central bank and regional currency. It is envisaged that the region will proceed through all these traditional theoretical phases of economic integration between 2008 and 2018. The implementation of the Trade Protocol has been beset with institutional, administrative and infrastructural challenges which pose obstacles to the attainment of the other stages of economic integration in the time frames prescribed in the RISDP. These challenges are assessed for impact on the regional economic integration of SADC by evaluating the progress towards implementing the Trade Protocol provisions and the implementation of measures taken towards the launch of the Free Trade Area. Emerging issues are also identified and analysed for their effect on the Free Trade Area and the general economic agenda of SADC. Of particular note is the Economic Partnership Agreements (EPAs) being negotiated with the European Union where SADC countries are negotiating in four different configurations. An analysis of this EPA situation reveals that it compounds a pre-existing problem: that of overlapping membership of regional trade agreements. Prior to the EPAs and the intensified drive towards the creation of the Customs Union, there was largely no need to rationalise the overlap in regional trade agreement memberships, but it is now a matter of urgency. The overlap in membership has complicated EPA negotiations and places serious doubts on the prospects of complete regional integration in SADC.This research concludes with observations on South Africa's complicated relationship with her SADC neighbours. South Africa's trade policies, as regards both the SADC region and the world, are discussed. Because of its political and economic dominance, South Africa's policies have a ripple effect on the rest of SADC; hence the need for South Africa to be vigilant in formulating and implementing its trade policies.
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- Date Issued: 2009
The feeding and spatial ecologies of the large carnivore guild on Kwandwe Private Game Reserve
- Authors: Bissett, Charlene
- Date: 2008
- Subjects: Wildlife conservation -- South Africa -- Eastern Cape Kwandwe Private Game Reserve Lion -- Behavior -- South Africa -- Eastern Cape Lion -- Nutrition -- South Africa -- Eastern Cape Cheetah -- Behavior -- South Africa -- Eastern Cape Cheetah -- Nutrition -- South Africa -- Eastern Cape African wild dog -- South Africa -- Eastern Cape Spatial behavior in animals Predation (Biology) Game reserves -- Management
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:5802 , http://hdl.handle.net/10962/d1006195
- Description: The reintroduction of lions, cheetahs and African wild dogs to Kwandwe Private Game Reserve in the Eastern Cape Province of South Africa created the opportunity to study the biology and behaviour of these large carnivores in an enclosed system. The research focused on space utilisation and feeding ecology of the predators, using standard observational methods. Changes in the structure of the carnivore guild, and changes in the prey base that occurred during the study were used as natural experiments to examine factors affecting space use and diet. In general, the diets of the predators were similar to previous studies and prey abundance was more important than prey species size in determining prey selection. Changes in the abundance of certain prey species was matched by a dietary switch in lions from kudu to warthog and an increase in the proportion of springbok kills by the cheetahs. There was no significant difference in the proportions of prey species detected by ad hoc or continuous observations. Core areas occupied by the predators were significantly smaller than home ranges except when females were denning. Home ranges overlapped both within and between species, but there was very little overlap of core areas. An increase in the number of lion prides in the area during the study resulted in an increase in overlap of home ranges of lions and cheetahs, but did not result in a change in home range size. Space use by female cheetahs with cubs increased as the cubs grew older. The use of thicket vegetation by cheetahs decreased with an increase in the number of lion prides. Minimum Daily Energy Expenditure, energy intake and net benefit were calculated for the predators using data from continuous observations. All predators exhibited a large net benefit and the net benefit for single female cheetahs was greater than for the members of the coalition. Net benefit for the alpha pair of African wild dogs was lower than that of the pack.
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- Date Issued: 2008
A study of the teaching of reading in Grade 1 in the Caprivi region, Namibia
- Authors: Nzwala, Kenneth
- Date: 2007
- Subjects: Reading (Primary) -- Namibia Teachers -- Attitudes -- Namibia Teaching -- Namibia
- Language: English
- Type: Thesis , Masters , MEd
- Identifier: vital:1785 , http://hdl.handle.net/10962/d1003670
- Description: This study was conducted in order to understand how Grade 1 teachers teach reading in mother tongue with a focus, firstly, on teacher beliefs and how such beliefs influence teachers’ practice, and secondly, on the methods they use to teach reading. The study was carried out in the Caprivi Region of Namibia. It took the form of an interpretive case study. Three schools were selected for study: one urban, one peri-urban and one rural. The purpose of this sampling was to consider the influence of context on teachers’ practice. The data was gathered by using semi-structured interviews with open ended questions, as well as lesson observations and stimulated recall with the individual teachers after every lesson. This was important in order to have clarity on areas that were not clear during lesson presentations. The key findings are that the teachers I studied taught reading without using books, and there was an absence of shared reading with the learners. Other key findings are: teachers had great love for stories; they had a problem of language, and had no proper understanding of the concept ‘literacy’.
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- Date Issued: 2007
The transition from Oshikwanyama to English as a medium of instruction: a case study of a rural Namibian school
- Authors: Shilongo, Teressia N
- Date: 2007
- Subjects: Education -- Namibia Kuanyama language -- Study and teaching -- Namibia English language -- Study and teaching -- Namibia Language and education -- Namibia Rural schools -- Namibia
- Language: English
- Type: Thesis , Masters , MEd
- Identifier: vital:1805 , http://hdl.handle.net/10962/d1003690
- Description: The study investigates how rural Grade 4 teachers and learners experience the transition from Oshikwanyama to English as a medium of instruction. The study was conducted at a rural school in Oshana region in northern Namibia. The research site and participants were purposefully selected. Grade 4 teachers and learners were interviewed and observed. Relevant documents were also analyzed. The purpose was to understand participants’ experiences, perceptions and practices in relation to their experience of the transition to English medium instruction. The study revealed out that both Grade 4 teachers and learners are struggling to teach and learn through the medium of English. This was borne out by participants’ responses, classroom practices and document analysis, especially learners’ oral presentation and written work. The conclusion is drawn that limitations in English proficiency overshadow the good intentions of the curriculum. This was evident in the fact that Grade 4 learners at a selected school found it difficult to cope with the demands of the curriculum. In addition, most of the learners have poor literacy skills even in their mother tongue, Oshikwanyama. In the linguistic sense, proficiency in the first language can pave the way for second language to flourish. If the reverse is the case then the learner might find it difficult to acquire linguistic skills in the second language. The study concludes that for the sake of effective learning, an intervention on professional development needs to be in place. This might help rural lower primary teachers to upgrade their existing skills particularly in terms of the English language proficiency as well as how to prepare learners for the transition to English.
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- Date Issued: 2007
Patient education : the effect on patient behaviour
- Authors: Shiri, Clarris
- Date: 2006
- Subjects: Patient education -- South Africa -- Eastern Cape Patient compliance -- South Africa -- Eastern Cape Hypertension -- Treatment -- South Africa Health care services -- South Africa Community health services -- South Africa
- Language: English
- Type: Thesis , Masters , MPharm
- Identifier: vital:3790 , http://hdl.handle.net/10962/d1003268
- Description: Evidence suggests that the prevalence of certain non-communicable diseases, such as hypertension, is increasing rapidly, and that patients with these diseases are making significant demands on the health services of the nations in sub-Saharan Africa. However, these countries also face other health-related challenges such as communicable diseases and underdevelopmentrelated diseases. Developing countries like South Africa have limited resources, in terms of man power and financial capital, to address the challenges that they are facing. Non-communicable diseases cannot be ignored and since health care providers cannot meet the challenges, it is worthwhile to empower patients to be involved in the management of their conditions. Patient education is a tool that can be used to enable patients to manage their chronic conditions and thereby reduce the morbidity and mortality rates of these conditions. The aim of this study was to investigate the effect of a patient education intervention on participants’ levels of knowledge about hypertension and its therapy, beliefs about medicines and adherence to anti-hypertensive therapy. The intervention consisted of talks and discussions with all the participants as one group and as individuals. There was also written information given to the participants. Their levels of knowledge about hypertension and its therapy were measured using one-on-one interviews and self-administered questionnaires. Beliefs about medicines were measured using the Beliefs about Medicines Questionnaire (BMQ) whilst adherence levels were measured using pill counts, elf-reports and prescription refill records. The participants’ blood pressure readings and body mass indices were also recorded throughout the study. The parameters before and after the educational intervention were compared using statistical analyses. The participants’ levels of knowledge about hypertension and its therapy significantly increased whilst their beliefs about medicines were positively modified after the educational intervention. There were also increases, though not statistically significant, in the participants’ levels of adherence to anti-hypertensive therapy. Unexpectedly, the blood pressure readings and body mass indices increased significantly. The participants gave positive feedback regarding the educational intervention and indicated a desire for similar programmes to be run continuously. They also suggested that such programmes be implemented for other common chronic conditions such as asthma and diabetes. This study proved that patient education programmes can be implemented to modify patients’ levels of knowledge about their conditions and the therapy, beliefs about medicines and adherence to therapy. However, such programmes need to be conducted over a long period of time since changes involving behaviour take a long time.
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- Date Issued: 2006
A comparative study of egg development in two species of Siphonariid limpets with contrasting developmental modes
- Authors: Pal, Purba
- Date: 2004
- Subjects: Siphonariidae -- Eggs Siphonariidae -- Spawning Limpets
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:5826 , http://hdl.handle.net/10962/d1007663
- Description: The family Siphonariidae is considered primitive amongst the basommatophorans although the ancestry and evolutionary relationships of these marine pulmonates are far from settled. This thesis investigates and compares different aspects of egg development and the female reproductive system in two sympatric species of Siphonaria with different developmental mode (S. capensis, a planktonic developer and S. serrata, a direct developer). The study on the seasonality of gametogenesis and spawning shows that they are both spring/summer spawners with continuous sperm production. The egg production is highest in spring and summer with a brief interruption in winter months. The gametogenic cycle when examinated, reveals that both species are simultaneous hermaphrodites once sexually mature. Amongst various factors that are investigated, density of animals has a positive effect on the number of spawn only during peak spawning. Larger individuals of S. capensis and S. serrata contains more mature oocytes in the gonad indicating that the shell length and fecundity of these two limpets are positively correlated. By contrast, parasitism by trematodes has a drastic effect on the reproductive output of these limpets leaving them completely castrated. Egg development in S. capensis and S. serrata shows that both produce yolk auto synthetically (with the help of organelles like RER, Golgi bodies) but S. serrata also incorporates some high molecular weight precursors via endocytotis. The structure as well as the biochemical composition of the egg ribbons is also different between these two species with higher carbohydrate and protein content of collar shaped spawn of S. serrata. S. capensis produces egg ribbons of less fibrous nature containing thinner egg capsules compared to the direct developer. A comparison of both the glandular complex and spermatheca between these two limpets shows no inter specific difference in the structure although the glandular complex of the siphonariids shows fine structural and histochemical similarities with the albumen gland and membrane gland of the opisthobranchs. The structure of the spermatheca suggests that in both species the organ most possibly receives sperm (for degradation only?) and may transport them via the spermathecal duct (for fertilization?). Finally, it is suggested that S. capensis and S. serrata exhibit primitive features (e.g., an autosynthetic mode of vitellogenesis in S. capensis and a single glandular complex composed of an albumen and a mucous gland) compared to other basommatophorans, which should be considered in future phylogenetic investigations.
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- Date Issued: 2004
Biologically active natural products from South African marine invertebrates
- Authors: Hooper, Gregory John
- Date: 1997
- Subjects: Natural products -- South Africa Marine metabolites -- South Africa Marine invertebrates -- South Africa
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:3761 , http://hdl.handle.net/10962/d1003239
- Description: This thesis describes the chemical and biological investigation of the extracts of six different marine invertebrate organisms collected along the South African coastline. The work on these extracts has resulted in the isolation and structural elucidation of twenty-one previously undescribed secondary metabolites; The history of marine natural product chemistry in South Africa has not previously been reviewed and so a comprehensive review covering the literature from the 1940's up until the end of 1995 is presented here. The marine ascidian Pseudodistoma species collected in the Tsitsikamma Marine Reserve was shown to contain four new unsaturated amino alcohols [47], [48], [49] and [50] which were isolated as their acetyl derivatives. These compounds exhibited strong antimicrobial activity. Four new pyrroloiminoquinone alkaloids, the tsitsikammamines A [90] to D [93],were isolated from a new genus of Latrunculid sponge collected in the Tsitsikamma Marine Reserve. These highly pigmented compounds also possessed strong antimicrobial activity. An investigation of two phenotypic colour variants of the soft coral Capnella thyrsoidea resulted in the isolation of the known steroid 5α-pregna-1, 20-dien-3-one [97] and an additional six new metabolites, 16β-hydroxy-5α-pregna-1 ,20-dien-3-one 16-acetate [98], 3α,16β-dihydroxy-5α-pregna-1, 20-diene 3,16-diacetate [99] and four xenicane diterpenes, the tsitsixenicins A [100] to D [103]. This is the first reported isolation of xenicane diterpenes from the soft coral family Nephtheiidae. Tsitsixenicin A and B showed good anti-inflammatory activity by inhibiting superoxide production in both rabbit and human cell neutrophils. A further four new metabolites were isolated from two soft corals which could only be identified to the genus level and were designated Alcyonium species A and species B. Alcyonium species A was collected in the Tsitsikamma Marine Reserve and yielded two new polyhydroxysterols, cholest-5-ene-3β, 7β, 19-triol 19-acetate [121] and cholest-5,24-diene-3β, 7β, 19-triol 19-acetate [122]. The soft coral Alcyonium species B was collected off Aliwal Shoal and was found to contain two known xenicane diterpenes, 9-deacetoxy-14, 15-deepoxyxeniculin [110] and zahavin A [16], and two new xenicane diterpenes, 7 -epoxyzahavin A [123] and xeniolide C [124]. Compounds [110], [16] and [123] exhibited strong anti-inflammatory activity and compounds [110] and [16] showed good antithrombotic activity. The endemic soft coral A/cyanium fauri collected at Riet Point near Port Alfred yielded the new sesquiterpene hydroquinone rietone [141] in high yierd, fogether with the minor compounds 8'-acetoxyrietone [142] and 8'-desoxyrietone [143]. Rietone exhibited moderate activity in the NCl's in-vitro anti-HIV bioassays.
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- Date Issued: 1997