- Title
- In vitro-in vivo evaluation of a sustained release phenylpropanolamine oral dosage form
- Creator
- Dowse, Roslind, Haigh, John M, Kanfer, Isadore
- Date
- 1982
- Type
- Article
- Identifier
- vital:6360
- Identifier
- http://hdl.handle.net/10962/d1006052
- Description
- There is increasing interest in measuring pharmacokinetic parameters of phenylpropanolamine (PPA), a sympathomimetic amine used in over-the-counter nasal decongestants and anorectic formulations. A high pressure liquid chromatographic (HPLC) procedure was developed to enable direct ultraviolet detection of PPA, after extraction from serum and urine, without prior derivatization of the drug. This method was used to assay samples obtained from a bioavailability study of BUBtained-releasePPA tablets. The mean serum and urine profiles obtained are presented. The sustained-release tablets were subjected to dissolution testing utilizing the United States Pharmacopoeia (USP XIX) rotating basket method. An internal standard was incorporated into the dissolution fluid to enable direct analysis of the samples by HPLC. A comparison of three different dissolution fluid regimens was carried out to determine if release of the drug was affected by the change in pH of the medium and to select the most convenient method for the final dissolution studies. Some preliminary observations relating to correlations between rate of drug release from the sustained-release dosage form and percent drug absorbed are presented.
- Format
- 3 p.
- Language
- English
- Relation
- Dowse, R. and Haigh, J.M. and Kanfer, I. (1982) In vitro-in vivo evaluation of a sustained release phenylpropanolamine oral dosage form. South African Pharmaceutical Journal, 49 . pp. 485-487.
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Collections
Kanfer, Isadore (Prof)
Haigh, John M (Prof)
Dowse, Ros (Emeritus Assoc Prof)
RU Department of Pharmacy
SDG 03. Good Health and Well-Being
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