In vitro-in vivo evaluation of a sustained release phenylpropanolamine oral dosage form
- Dowse, Roslind, Haigh, John M, Kanfer, Isadore
- Authors: Dowse, Roslind , Haigh, John M , Kanfer, Isadore
- Date: 1982
- Language: English
- Type: Article
- Identifier: vital:6360 , http://hdl.handle.net/10962/d1006052
- Description: There is increasing interest in measuring pharmacokinetic parameters of phenylpropanolamine (PPA), a sympathomimetic amine used in over-the-counter nasal decongestants and anorectic formulations. A high pressure liquid chromatographic (HPLC) procedure was developed to enable direct ultraviolet detection of PPA, after extraction from serum and urine, without prior derivatization of the drug. This method was used to assay samples obtained from a bioavailability study of BUBtained-releasePPA tablets. The mean serum and urine profiles obtained are presented. The sustained-release tablets were subjected to dissolution testing utilizing the United States Pharmacopoeia (USP XIX) rotating basket method. An internal standard was incorporated into the dissolution fluid to enable direct analysis of the samples by HPLC. A comparison of three different dissolution fluid regimens was carried out to determine if release of the drug was affected by the change in pH of the medium and to select the most convenient method for the final dissolution studies. Some preliminary observations relating to correlations between rate of drug release from the sustained-release dosage form and percent drug absorbed are presented.
- Full Text:
- Date Issued: 1982
- Authors: Dowse, Roslind , Haigh, John M , Kanfer, Isadore
- Date: 1982
- Language: English
- Type: Article
- Identifier: vital:6360 , http://hdl.handle.net/10962/d1006052
- Description: There is increasing interest in measuring pharmacokinetic parameters of phenylpropanolamine (PPA), a sympathomimetic amine used in over-the-counter nasal decongestants and anorectic formulations. A high pressure liquid chromatographic (HPLC) procedure was developed to enable direct ultraviolet detection of PPA, after extraction from serum and urine, without prior derivatization of the drug. This method was used to assay samples obtained from a bioavailability study of BUBtained-releasePPA tablets. The mean serum and urine profiles obtained are presented. The sustained-release tablets were subjected to dissolution testing utilizing the United States Pharmacopoeia (USP XIX) rotating basket method. An internal standard was incorporated into the dissolution fluid to enable direct analysis of the samples by HPLC. A comparison of three different dissolution fluid regimens was carried out to determine if release of the drug was affected by the change in pH of the medium and to select the most convenient method for the final dissolution studies. Some preliminary observations relating to correlations between rate of drug release from the sustained-release dosage form and percent drug absorbed are presented.
- Full Text:
- Date Issued: 1982
"Ian Scott Henderson: a tribute"
- Authors: Henderson, Derek Scott
- Date: 1981-11-12
- Language: English
- Type: Text
- Identifier: vital:7441 , http://hdl.handle.net/10962/d1018318
- Full Text:
- Date Issued: 1981-11-12
- Authors: Henderson, Derek Scott
- Date: 1981-11-12
- Language: English
- Type: Text
- Identifier: vital:7441 , http://hdl.handle.net/10962/d1018318
- Full Text:
- Date Issued: 1981-11-12
Message from the Vice-Chancellor for 1981 intervarsity
- Authors: Henderson, Derek Scott
- Date: 1981-08-06
- Language: English
- Type: Text
- Identifier: vital:7437 , http://hdl.handle.net/10962/d1018314
- Full Text:
- Date Issued: 1981-08-06
- Authors: Henderson, Derek Scott
- Date: 1981-08-06
- Language: English
- Type: Text
- Identifier: vital:7437 , http://hdl.handle.net/10962/d1018314
- Full Text:
- Date Issued: 1981-08-06
2009 L'Oreal-UNESCO Award for Women in Science: Africa-Arab State
- Language: English
- Type: Article
- Identifier: vital:7190 , http://hdl.handle.net/10962/d1006354
- Description: Old Rhodians in the news
- Full Text:
- Language: English
- Type: Article
- Identifier: vital:7190 , http://hdl.handle.net/10962/d1006354
- Description: Old Rhodians in the news
- Full Text:
A blow on the beach
- Authors: Naidoo, G.R
- Language: English
- Type: Article
- Identifier: vital:13616 , http://hdl.handle.net/10962/d1012486
- Description: Photocopied article from the magazine Drum about the farewell South African tour of Chris McGregor's Blue Notes. On the first page, there is a portrait of each member of the band and as well as a portrait of the magazine reporter. A picture covering the second page and starting on the first one shows the Blue Notes playing on a beach's sand in Durban (from left to right: Dudu Pukwana holding his alto saxophone, Mongezi Feza playing trumpet, Chris McGregor playing piano, Johnny Dyani is standing right behind him playing Double Bass and Louis Moholo playing drums on the right side of the picture). A picture of Chris McGregor playing piano is also on the third page of this article.
- Full Text:
- Authors: Naidoo, G.R
- Language: English
- Type: Article
- Identifier: vital:13616 , http://hdl.handle.net/10962/d1012486
- Description: Photocopied article from the magazine Drum about the farewell South African tour of Chris McGregor's Blue Notes. On the first page, there is a portrait of each member of the band and as well as a portrait of the magazine reporter. A picture covering the second page and starting on the first one shows the Blue Notes playing on a beach's sand in Durban (from left to right: Dudu Pukwana holding his alto saxophone, Mongezi Feza playing trumpet, Chris McGregor playing piano, Johnny Dyani is standing right behind him playing Double Bass and Louis Moholo playing drums on the right side of the picture). A picture of Chris McGregor playing piano is also on the third page of this article.
- Full Text:
Address to new students 1979
- Authors: Henderson, Derek Scott
- Language: English
- Type: Text
- Identifier: vital:7379 , http://hdl.handle.net/10962/d1017268
- Full Text:
- Authors: Henderson, Derek Scott
- Language: English
- Type: Text
- Identifier: vital:7379 , http://hdl.handle.net/10962/d1017268
- Full Text:
Camden Jazz week
- Unknown
- Authors: Unknown
- Subjects: McGregor, Chris--1936-1990 , Brotherhood of Breath (Musical group) , Shepp, Archie , Ibrahim, Abdullah , Moholo, Louis T.--1940-
- Language: English
- Type: Article
- Identifier: vital:13762 , http://hdl.handle.net/10962/d1012778
- Description: Original program for the "Camden Jazz week" festival in London, England.
- Full Text:
- Authors: Unknown
- Subjects: McGregor, Chris--1936-1990 , Brotherhood of Breath (Musical group) , Shepp, Archie , Ibrahim, Abdullah , Moholo, Louis T.--1940-
- Language: English
- Type: Article
- Identifier: vital:13762 , http://hdl.handle.net/10962/d1012778
- Description: Original program for the "Camden Jazz week" festival in London, England.
- Full Text:
Chris McGregor and the Blue Notes to play in the Durban City Hall before going overseas
- Unknown
- Authors: Unknown
- Subjects: McGregor, Chris--1936-1990 , Blue Notes (Musical group : South Africa) , Dyani, Johnny Mbizo , Jazz Musicians , Jazz
- Language: English
- Type: Article
- Identifier: vital:13690 , http://hdl.handle.net/10962/d1012698
- Description: Photocopied article from the newspaper The Daily News about Chris McGregor's Blue Notes. The band is going overseas to take part of the Antibes' Jazz Festival. There is a picture of Johnny Dyani playing Double Bass and Chris McGregor playing piano with this article.
- Full Text:
- Authors: Unknown
- Subjects: McGregor, Chris--1936-1990 , Blue Notes (Musical group : South Africa) , Dyani, Johnny Mbizo , Jazz Musicians , Jazz
- Language: English
- Type: Article
- Identifier: vital:13690 , http://hdl.handle.net/10962/d1012698
- Description: Photocopied article from the newspaper The Daily News about Chris McGregor's Blue Notes. The band is going overseas to take part of the Antibes' Jazz Festival. There is a picture of Johnny Dyani playing Double Bass and Chris McGregor playing piano with this article.
- Full Text:
Coca Cola Jazz Festival 1963
- Unknown
- Authors: Unknown
- Subjects: McGregor, Chris--1936-1990 , Blue Notes (Musical group : South Africa) , Jazz
- Language: English
- Type: Text
- Identifier: vital:13768 , http://hdl.handle.net/10962/d1012785
- Description: Original program for the "Coca Cola Jazz Festival 1963" in Cape Town, South Africa.
- Full Text:
- Authors: Unknown
- Subjects: McGregor, Chris--1936-1990 , Blue Notes (Musical group : South Africa) , Jazz
- Language: English
- Type: Text
- Identifier: vital:13768 , http://hdl.handle.net/10962/d1012785
- Description: Original program for the "Coca Cola Jazz Festival 1963" in Cape Town, South Africa.
- Full Text:
Eulogy for Rolf Braae
- Authors: Henderson, Derek Scott
- Subjects: Braae, Rolf -- 1979-
- Language: English
- Type: Text
- Identifier: vital:7392 , http://hdl.handle.net/10962/d1017281
- Full Text:
- Authors: Henderson, Derek Scott
- Subjects: Braae, Rolf -- 1979-
- Language: English
- Type: Text
- Identifier: vital:7392 , http://hdl.handle.net/10962/d1017281
- Full Text:
Indestructible Beats
- Unknown
- Authors: Unknown
- Subjects: McGregor, Chris--1936-1990 , Jazz , Indestructible Beats (Musical group)
- Language: English
- Type: Text
- Identifier: vital:13773 , http://hdl.handle.net/10962/d1012800
- Description: Photocopied poster of the Trio Indestructible Beats. "Resistance Music and Culture has been crucial in keeping alive the spirit of the South African people and has brought new audiences to understand the reality of Apartheid".
- Full Text:
- Authors: Unknown
- Subjects: McGregor, Chris--1936-1990 , Jazz , Indestructible Beats (Musical group)
- Language: English
- Type: Text
- Identifier: vital:13773 , http://hdl.handle.net/10962/d1012800
- Description: Photocopied poster of the Trio Indestructible Beats. "Resistance Music and Culture has been crucial in keeping alive the spirit of the South African people and has brought new audiences to understand the reality of Apartheid".
- Full Text:
International Jazz Festival
- Unknown
- Authors: Unknown
- Subjects: McGregor, Chris--1936-1990 , Moholo, Louis T.--1940- , Pukwana, Dudu , Dyani, Johnny Mbizo , Ibrahim, Abdullah
- Language: German
- Type: Text
- Identifier: vital:13775 , http://hdl.handle.net/10962/d1012802
- Description: Original program for the International Jazz Festival of Zürich, Switzerland.
- Full Text:
- Authors: Unknown
- Subjects: McGregor, Chris--1936-1990 , Moholo, Louis T.--1940- , Pukwana, Dudu , Dyani, Johnny Mbizo , Ibrahim, Abdullah
- Language: German
- Type: Text
- Identifier: vital:13775 , http://hdl.handle.net/10962/d1012802
- Description: Original program for the International Jazz Festival of Zürich, Switzerland.
- Full Text:
Jazzpressions
- Unknown
- Authors: Unknown
- Subjects: McGregor, Chris--1936-1990 , Jazzpressions , Jazz
- Language: French
- Type: Text
- Identifier: vital:13781 , http://hdl.handle.net/10962/d1012808
- Description: Original poster for the Jazzpressions festival in Strasbourg, France.
- Full Text:
- Authors: Unknown
- Subjects: McGregor, Chris--1936-1990 , Jazzpressions , Jazz
- Language: French
- Type: Text
- Identifier: vital:13781 , http://hdl.handle.net/10962/d1012808
- Description: Original poster for the Jazzpressions festival in Strasbourg, France.
- Full Text:
Program - Le Monde de la Musique
- Unknown
- Authors: Unknown
- Subjects: McGregor, Chris--1936-1990 , Brotherhood of Breath (Musical group) , Shepp, Archie , Collins, Albert
- Language: French
- Type: Text
- Identifier: vital:13787 , http://hdl.handle.net/10962/d1012820
- Description: Original program from the French magazine "Le Monde de la Musique".
- Full Text:
- Authors: Unknown
- Subjects: McGregor, Chris--1936-1990 , Brotherhood of Breath (Musical group) , Shepp, Archie , Collins, Albert
- Language: French
- Type: Text
- Identifier: vital:13787 , http://hdl.handle.net/10962/d1012820
- Description: Original program from the French magazine "Le Monde de la Musique".
- Full Text:
Sponono and African Jazz
- Authors: Walker, Oliver
- Language: English
- Type: Article
- Identifier: vital:13668 , http://hdl.handle.net/10962/d1012580
- Description: Photocopied article from the newspaper The Star about a concert by Chris McGregor's Blue Note jazz band and hymnal choruses from Sponono, organized by Union Artists. 25 men and women shared folk musics and jazz on stage in the University Hall.
- Full Text:
- Authors: Walker, Oliver
- Language: English
- Type: Article
- Identifier: vital:13668 , http://hdl.handle.net/10962/d1012580
- Description: Photocopied article from the newspaper The Star about a concert by Chris McGregor's Blue Note jazz band and hymnal choruses from Sponono, organized by Union Artists. 25 men and women shared folk musics and jazz on stage in the University Hall.
- Full Text: