A data governance maturity evaluation model to enhance data management in Eastern Cape government departments
- Authors: Olaitan, Olutoyin
- Date: 2017
- Subjects: Electronic government information Data protection Public administration -- Data processing
- Language: English
- Type: Thesis , Doctoral , DPhil
- Identifier: http://hdl.handle.net/10353/7989 , vital:31448
- Description: The governance of data assets has become a topical issue in the public sector. Government departments are faced with increasingly complex data and information arising from multiple projects, different departments, divisions and several stakeholders seeking data for divergent end uses. However, an exploratory study of the literature regarding data governance in government departments of the Eastern Cape province of South Africa suggest that there are no clear data governance processes in place within the departments. The research question “How can a data governance maturity evaluation model enhance data governance processes in the Eastern Cape government departments” was derived as a result of a perceived need for government departments of the province to manage their critical data assets in a manner which promotes accurate, verifiable and relevant fiscal and strategic planning. Following the review of current literature in the data governance domain, a conceptual data governance evaluation maturity model was developed and produced. The conceptual model was influenced by the IBM data governance maturity model (2007) and it was aimed at addressing the gaps in the reference model to suit the context of the Eastern Cape government departments and the governance of their data assets. A qualitative phase of empirical data collection was conducted to test the components of the conceptual model. A quantitative instrument, derived from the findings of the qualitative study, as well as the components of the refined model was administered to 50 participants in the same departments where qualitative data was collected, with additional participants being drawn from three other departments. Pragmatism was the guiding philosophy for the research. The Contingency and Institutional theories form the theoretical grounding for the study. Design Science guidelines by Hevner et al (2004), Peffers et al’s (2008) Six Steps in Design Science and Drechsler & Hevner’s (2016) Fourth Cycle of Design Science were employed to construct, improve, validate and evaluate the final artefact. Findings confirmed the literature that data governance is lacking in government departments. It is asserted that the implementation of this model will improve the way data assets are recorded, used, archived and disposed in government departments of the Eastern Cape. The outcome of this research was the development and production of a data governance maturity evaluation model as well as a process document which gives a roadmap of how to move from one maturity level to another.
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- Date Issued: 2017
A political discourse analysis of social memory, collective identity and nation-building in the Sunday Mail and the Standard of Zimbabwe between 1999 and 2013
- Authors: Santos, Phillip
- Date: 2017
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/41753 , vital:25130
- Description: Although much effort has been expended on studying many sites of social memory, little attention has been directed at the media’s work of memory, especially in post-colonial Africa. The media’s work of memory is important because of its social standing as a communicative and cultural institution, and because social memory is imbricated in processes of both collective identity formation and nation-building which partly shape patterns of economic distribution, recognition, and representation in society. It is in this context that this study shows how Zimbabwe’s The Sunday Mail and The Standard newspapers used social memory to construct the country’s national identity between 1999 and 2013 in the context of a socio-economic and political crisis for the country’s poly-racial, and poly-ethno-linguistic communities. The study also explores how these newspapers worked as memory sites through their construction of Zimbabwe’s national identity during the period under study. It achieves these tasks by analysing how these newspapers reported on such issues as Zimbabwe’s colonial history, the country’s narrative of decolonisation, the Gukurahundi narrative, the land reform process, elections and independence celebrations. The study takes a critical realist approach to qualitative research, and uses Fairclough and Fairclough’s (2012) method of political discourse analysis as well as Aristotle’s approach to rhetoric for a close reading of the sampled newspaper articles. It is informed by Nancy Fraser’s Theory of Justice, Chantal Mouffe’s Model of Agonistic Pluralism, and Jurgen Habermas’s Discourse Ethics Theory. The study concludes that these two newspapers actively use social memory to construct versions of national identity for specific socio-political and economic ends. Editorials and opinions from The Sunday Mail, which construct Zimbabwean-ness in nativist terms represent the hegemonic appropriation of social memory to construct a sense of Zimbabwean nationhood. In contrast, The Standard uses social memory to construct Zimbabwean-ness in modernist terms with citizenship as the core organising principle of belonging. The political discourse analysis of The Sunday Mail’s and The Standard’s evocation of social memory shows that the two newspapers reflect the tension between indigenist and universalist imaginaries of belonging in Zimbabwe. But the newspapers’ construction of belonging in Zimbabwe is informed by justice claims as seen from each of their political standpoints. As such, their respective definitions of Zimbabweans’ justice claims in terms of their political standpoints, also propose how those justice claims should be addressed and who stands to benefit from them.
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- Date Issued: 2017
Development, manufacture and assessment of Clobetasol 17-propionate cream formulations
- Authors: Fauzee, Ayeshah Fateemah Beebee
- Date: 2011
- Subjects: Adrenocortical hormones , Adrenocortical hormones -- Physiological effect , Adrenocortical hormones -- Testing , Drugs -- Testing , Drugs -- Development , Dermatopharmacology
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:3856 , http://hdl.handle.net/10962/d1013324
- Description: Eczema or dermatitis is the most common dermatological condition accounting for one-third of all diagnoses in the total population surveyed in South Africa. The prevalence of seborrhoeic dermatitis, extreme photodermatitis and severe psoriasis has increased markedly over the last decade and this increase may be ascribed to the HIV epidemic, first diagnosed in South Africa in 1982. Potent innovator corticosteroids, such as clobetasol 17-propionate (CP) that are used to treat skin disorders, are expensive and there is therefore a need for the production of generic topical corticosteroid products. Formulation and manufacturing processes can be challenging aspects for formulation scientists to produce a robust product that will elicit an appropriate and desirable pharmacokinetic-pharmacodynamic profile. Laboratory scale CP creams were manufactured using different concentrations of Gelot® 64 and propylene glycol in order to establish a composition that would produce a formulation, with similar physical and chemical characteristics and in vitro release profile as an innovator product, Dermovate®. These formulations were assessed in terms of their viscosity, spreadability, pH, content uniformity and in vitro release characteristics using a Franz diffusion cell apparatus. A formulation containing 3% w/w Gelot® 64 and 46% v/v propylene glycol (CPLS-02) was found to exhibit similar viscosity and spreadability characteristics and released CP in a manner similar to Dermovate®. The mechanism of drug release was evaluated using mathematical models such as zero order, first order and Higuchi models. In addition, the in vitro release profiles were characterised by use of difference (f1) and similarity (f2 and Sd) factors. A scale-up formulation with the same % w/w composition as the laboratory scale was also investigated following manufacture using a Wintech® cream/ointment mixer. A Central Composite Design approach was used to investigate the effect of process variables on the performance of the scale-up cream formulations. The homogenisation speed, anchor speed, homogenisation time and cooling time were the process variables investigated. Thirty scale-up batches were manufactured and analysed in terms of their viscosity, spreadability, pH, % drug content and cumulative % drug released per unit area over 72 hours. Model fitting using Design-Expert® software was undertaken and revealed that a correlation between the process variables and the cream responses was most suitably described by quadratic polynomial relationships. The homogenisation speed had the most significant effect on the quality of the scale-up formulations, whereas the anchor speed had a secondary effect on the measured responses, for the formulations investigated. The qualitative interpretation and statistical analysis of the in vitro release data from the scale-up formulations using ANOVA and the f1, f2 and Sd factors revealed that one scale-up batch (CPSU-04), for which the process variables were a homogenisation speed of 1900 rpm, an anchor speed of 35 rpm, a homogenisation time of 100 minutes and a cooling time of 100 minutes, released CP at a similar rate and extent to Dermovate®. A diffusion-controlled mechanism appeared to be predominant in these formulations. A human skin blanching study, using both visual and chromameter assessments, was performed to establish whether batch CPSU-04 was bioequivalent to Dermovate®. The bioequivalence of the selected scale-up formulation to Dermovate® was confirmed, following the calculation of a 90% CI.
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- Date Issued: 2011
Studies in marine diterpene chemistry
- Authors: Van Wyk, Albert Wynand Wincke
- Date: 2008
- Subjects: Natural products Diterpenes Mollusks Marine metabolites Chemical oceanography
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:4354 , http://hdl.handle.net/10962/d1005019
- Description: This thesis comprises both a natural product investigation and a synthetic component. The natural product investigations are presented in Chapters Two and Three. In Chapter Two the isolation and spectroscopic identification of the new isocopalane diterpene 12S,13R,14Sisocopalan- 13-ol-12,14-diacetate (2.1) and two known 3-(14S)-isocopal-12-ene-15-oyl-1- acetyl-sn-glycerol (2.2) and 3-(14S)-isocopal-12-ene-15-oyl-2-acetyl-sn-glycerol (2.3) from a single, large, unidentified sub-Antarctic nudibranch, collected near Marion Island, approximately 2000 km south of Cape Town are described. Chapter Three discusses the isolation, spectroscopic structure elucidation and anti-oesophageal cancer activity (3.1-3.4 only) of two known labdane diterpenes 6β,7α-diacetoxylabda-8,13E-dien-15-ol (3.1) and 2α,6β,7α-triacetoxylabda-8,13E-dien-15-ol (3.2) and one new 6β,7α,15-triacetoxylabda 8,13E-diene (3.3), as well as new 3α,11-dihydroxy-9,11-seco-cholest-4,7-dien-6,9-dione (3.4) and cholest 7-en-3,5,7-triol (3.5) from the endemic pulmonate mollusc, Trimusculus costatus. The absolute configuration of 3.2, and hence 3.1 and 3.3 (from biogenetic arguments) was determined through X-ray diffraction of a single crystal of the camphanate ester of 3.2. The absolute configuration of the secondary hydroxyl at C-3 of 3.4 was established using the Modified Mosher’s method. The synthetic component of the thesis commences in Chapter Four with the semi-synthesis of labdane diterpene nitriles 9α-cyano-15,16-epoxy-7β-hydroxylabda-13(16),14-dien-6-one (4.1), 9α-cyano-15,16-epoxy-7-hydroxylabda-7,13(16),14-trien-6-one (4.2) and 9α-cyano-15,16- epoxy-6β,7β dihydroxylabda-13(16),14-diene (4.3) from the terrestrial labdane diterpene, hispanolone (4.4). This work is an extension of previous synthetic studies directed towards the synthesis of T. costatus metabolites. Diterpenes 4.1-4.3 exhibited in planta activity against the economically important crop pathogens, Magnaporthea grisea and Puccinia recondita. Chapter Five describes the successful semi-synthesis of two isomeric marine molluscan labdane diterpene aldehyde metabolites, labd-13E-ene-8β-ol-15-al (5.1) and labd-13Z-ene- 8β-ol-15-al (5.2) from the commercially available, terrestrial plant derived, labdane diterpene manool (5.3). Diterpenes 5.1 and 5.2, originally isolated from the Mediterranean nudibranch,Pleurobranchaea meckelii and selected diterpenes arising from this synthesis were evaluated for their activity against an oesophageal cancer cell line (WHCO1). Chapter Six further develops the research discussed in Chapter Five, where ethyl 17-norabiet-13(15)-E-en-8β-ol- 16-oate (5.49) and ethyl 17-norabiet-13(15)-Z-en-8β-ol-16-oate (5.50) were first semisynthesized serendipitously. Based on their structural relationship to naturally occurring tricyclic diterpenes with anti-plasmodial activity, tricyclic diterpenes, 17-norpimaran-13α- ethoxy-8,16-olactone (6.6), 17-norisopimar-15-ene-8β,13β-diol (6.7), 17-norisopimarane- 8β,16-diol (6.8) and 17-norabiet-13(15)-ene-8β,16-diol (6.9) were semi-synthesized from the terrestrial labdane diterpene, 5.3, and critically evaluated for their antimalarial potential from parasite inhibition and haemolytic studies.
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- Date Issued: 2008
The journal of the Reverend William Impey, 1838-1847 : a critical study of his work and theology
- Authors: Owen, David Rhys
- Date: 1993
- Subjects: Impey, William, 1818-1896 Methodist Church of Southern Africa -- Clergy -- Biography Methodist Church -- Missions Missionaries -- Biography
- Language: English
- Type: Thesis , Masters , MTh
- Identifier: vital:1243 , http://hdl.handle.net/10962/d1009691
- Description: William Impey (1818-1896) came to South Africa as a Wesleyan Methodist Missionary in 1839. He held various missionary and colonial appointments until 1860 when he succeeded William Shaw as Chairman of the Albany and Kaffraria District and General Superintendent of Wesleyan Methodist Missions in South-East Africa. Impey's major contribution was in the provision of education for the indigenous peoples of this region, especially as President of Healdtown (1868-1878). This institution eventually became one of the most highly thought of mission education academies in South Africa. To date little has been known of the life and work of William Impey despite his senior position in South African Wesleyan Methodism. J Whiteside's History of the Wesleyan Methodist Church of South Africa, the last comprehensive history of South African Methodism, published in 1906, only devotes a few lines to Impey. He does however make further reference to Impey's work in his section on education. The Methodist Archive at Manchester University, which contains the personal records of all 19th century Wesleyan Methodist ministers, also has very little information about Impey. The reason for this relative lack of information is that he resigned from the Wesleyan Methodist Church in 1878 on doctrinal grounds. Impey came under the influence of 19th century liberal theology and eventually drew the conclusion that he could no longer accept the doctrine of 'eternal punishment'. He believed that the only honest thing for him to do was to resign from the Wesleyan Methodist Church, which he believed required its ministers to adhere to this doctrine. He was accepted for ordination by the Anglican Church and served as a deacon in 1878 and then as a priest until his death in 1896. Impey's journal affords the reader an opportunity to have a glimpse into what life was like for a 19th century missionary living and working in South Africa. Perhaps its particular value lies in the many detailed entries Impey made about his personal spiritual experiences. The aim of this thesis is to place the life's work of William Impey in its historical and theological context in the belief that this will enable us better to understand the 19th century missionaries. It is hoped that this study will make a further contribution to our understanding of both 19th century missionaries and the times in which they lived and worked.
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- Date Issued: 1993
An examination of the achievement of the Jesuit Order in South Africa, 1879-1934
- Authors: Ryan, Judy Anne
- Date: 1990
- Subjects: Jesuits -- South Africa -- History Jesuits -- South Africa -- History
- Language: English
- Type: text , Thesis , Masters , MA
- Identifier: vital:2522 , http://hdl.handle.net/10962/d1001851
- Description: The Society of Jesus, founded in 1540 by St Ignatius of Loyola, dispatched the first group of five priests and three brothers to the Cape in 1875. Their destination was St Aidan's College (1875-1973) in Grahamstown which they would staff. Two of the priests went to Graaff-Reinet where the Society established a mission house and noviciate (1875-1889). On 1 July 1878 the Zambesi Mission was founded with Henry Depelchin as its appointed leader. The Mission was placed under the direct control of the Jesuit General. St Aidan's became the headquarters of the Zambesi Mission and it was hoped that trainees for the Mission would emerge from the College. The first group of missionaries bound for the Zambesi regions left Grahamstown in 1879. Negotiations followed with the Ndebele chiefdom in Bulawayo and stations were established at Tati, Empandeni and Pandamatenga. Unsuccessful probes into Barotseland and Gazaland followed and a decade later the mission to Zambesia was abandoned and the Jesuits returned to the south where there had been further expansion of the Order's activities. Dunbrody (1882-1934), situated on the Sundays River, had been set up as a base for the Zambesi Mission, as an educational centre for Blacks and as a farm. Keilands (1886-1908) was an attempt to establish a missionary base for the extension of activities into the Transkei. Vleischfontein (1884-1894) in the Western Transvaal, was developed as a staging post between Zambesia and the Cape. In 1924 the Order attempted to develop parish work in Claremont, but initially nowhere else. By 1890 the Jesuits were ready to return to Matabeleland and in the post colonial years a string of stations were founded. Partly to conserve its manpower for the Zambesi enterprise and for financial and economic reasons, Graaff-Reinet was abandoned in 1889, followed by Vleischfontein, Keilands, the parish at Claremont, and Dunbrody. By 1934, the terminal point of the thesis, the only Jesuit presence in South Africa was at St Aidan's which was saved from closure by Papal intervention.
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- Date Issued: 1990
Liverpool of the Cape: Port Elizabeth harbour development 1820-70
- Authors: Inggs, Eric Jonathan
- Date: 1987
- Subjects: Harbors -- South Africa -- Port Elizabeth , Exports -- South Africa -- Port Elizabeth , Imports -- South Africa -- East London , Eastern Cape (South Africa) -- History , Port Elizabeth (South Africa) -- History
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:1038 , http://hdl.handle.net/10962/d1004646 , Harbors -- South Africa -- Port Elizabeth , Exports -- South Africa -- Port Elizabeth , Imports -- South Africa -- East London , Eastern Cape (South Africa) -- History , Port Elizabeth (South Africa) -- History
- Description: From the abstract: Fairy tales aside this study is an analysis of Port Elizabeth harbour development during its first half century from 1820-70. Despite the fact that Port Elizabeth quickly came to dominate Cape trade very little was actually done to improve its port facilities. Superficially the impression one gains from the available material is that everything was done by government not to develop a harbour at Algoa Bay. But the real question is: was harbour development really necessary at Port Elizabeth during the period under consideration? The answer must be no. The lack of facilities certainly did not hinder the massive expansion of wool exports that took place before 1870.
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- Date Issued: 1987
Extinction as consummation: an exposition of Virginia Woolf's mataphysic of visionary relation
- Authors: Ryan, Rory
- Date: 1979
- Subjects: Woolf, Virginia, 1882-1941 , Virginia Woolf
- Language: English
- Type: text , Thesis , Masters , MA
- Identifier: vital:2171 , http://hdl.handle.net/10962/d1001822
- Description: What follows is an attempt to circumscribe Virginia Woolf's ideas on life and death, the relation between self and all that which is not self, and the nature of reality, in short, Woolf's vision. I hope that whatever unity and structure may exist in the vision will not be overlooked, and moreover, I intend to avoid imposing a unity where none exists, whether the absence of unity is intentional or accidental
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- Date Issued: 1979