Synthesis, characterisation and evaluation of novel ferrocene-thiazole derivatives as antiplasmodial agents
- Authors: Hakizimana, Emmanuel Victor
- Date: 2017
- Subjects: Plasmodium , Malaria -- Chemotherapy , Plasmodium falciparum , Plasmodium -- Inhibitors , Drug resistance in microorganisms , Thiaszoles
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10962/5304 , vital:20807
- Description: Malaria is mosquito-transmitted disease which continues to pose threat to humanity, despite the efforts undertaken by the scientific community, government entities and international organizations. The major problem is that Plasmodium species have developed resistance against available drugs. In order to counter this problem, antimalarial drugs that are efficacious and with novel mode of action are of great necessity. Thiazole derivatives, in particular aminomethylthiazole analogues, have been shown to exhibit promising antimalarial activity against Plasmodium falciparum strains. Previous studies reported the hit compound MMV010539, which showed good antimalarial activity against both K1 (CQ and multidrug resistant strains) and NF54 (CQ sensitive strain). In this study, MMV010539 was deemed to be as an attractive compound to generate novel analogues by addition of ferrocenyl organometallic unit. The ferrocene based compounds have shown biological activity; and with ferroquine currently in clinical trials there has been increasing research into identifying new ferrocenyl-containing molecules as potential antimalarial agents. Herein, thiazole ferrocene based molecules 3.22a-e were synthesised in low to good yields. Their structural identities were confirmed using conventional spectroscopic techniques (¹H and ¹³C NMR, FT-IR spectroscopy and mass spectrometry). The cell cytotoxicity assay of all final compounds confirmed that all ferrocene-thiazole blends 3.22a-e were non-toxic against HeLa cell lines. However, the in vitro biological assay revealed that despite the absence of cell cytotoxicity these compounds poorly inhibited the growth of Plasmodium falciparum parasite. As the aim was to expand further the structure-activity relationship (SAR) of MMV010539, this study confirmed the previous findings that there is a limited structural modification that could be accommodated as indicated in Figure 3.3 (Panel C). Moreover, the combination of ferrocenyl moiety and various alkylamines resulted in compounds with poor antiplasmodial potency, further suggesting that the free amine (Panel A, Figure 3.3) is important for activity.
- Full Text:
- Authors: Hakizimana, Emmanuel Victor
- Date: 2017
- Subjects: Plasmodium , Malaria -- Chemotherapy , Plasmodium falciparum , Plasmodium -- Inhibitors , Drug resistance in microorganisms , Thiaszoles
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10962/5304 , vital:20807
- Description: Malaria is mosquito-transmitted disease which continues to pose threat to humanity, despite the efforts undertaken by the scientific community, government entities and international organizations. The major problem is that Plasmodium species have developed resistance against available drugs. In order to counter this problem, antimalarial drugs that are efficacious and with novel mode of action are of great necessity. Thiazole derivatives, in particular aminomethylthiazole analogues, have been shown to exhibit promising antimalarial activity against Plasmodium falciparum strains. Previous studies reported the hit compound MMV010539, which showed good antimalarial activity against both K1 (CQ and multidrug resistant strains) and NF54 (CQ sensitive strain). In this study, MMV010539 was deemed to be as an attractive compound to generate novel analogues by addition of ferrocenyl organometallic unit. The ferrocene based compounds have shown biological activity; and with ferroquine currently in clinical trials there has been increasing research into identifying new ferrocenyl-containing molecules as potential antimalarial agents. Herein, thiazole ferrocene based molecules 3.22a-e were synthesised in low to good yields. Their structural identities were confirmed using conventional spectroscopic techniques (¹H and ¹³C NMR, FT-IR spectroscopy and mass spectrometry). The cell cytotoxicity assay of all final compounds confirmed that all ferrocene-thiazole blends 3.22a-e were non-toxic against HeLa cell lines. However, the in vitro biological assay revealed that despite the absence of cell cytotoxicity these compounds poorly inhibited the growth of Plasmodium falciparum parasite. As the aim was to expand further the structure-activity relationship (SAR) of MMV010539, this study confirmed the previous findings that there is a limited structural modification that could be accommodated as indicated in Figure 3.3 (Panel C). Moreover, the combination of ferrocenyl moiety and various alkylamines resulted in compounds with poor antiplasmodial potency, further suggesting that the free amine (Panel A, Figure 3.3) is important for activity.
- Full Text:
Synthesis, characterisation and evaluation of novel ferrocene-thiazole derivatives as antiplasmodial agents
- Authors: Hakizimana, Emmanuel Victor
- Date: 2017
- Subjects: Plasmodium , Malaria -- Chemotherapy , Plasmodium falciparum , Plasmodium -- Inhibitors , Drug resistance in microorganisms , Thiaszoles
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10962/96068 , vital:31232
- Description: Malaria is mosquito-transmitted disease which continues to pose threat to humanity, despite the efforts undertaken by the scientific community, government entities and international organizations. The major problem is that Plasmodium species have developed resistance against available drugs. In order to counter this problem, antimalarial drugs that are efficacious and with novel mode of action are of great necessity. Thiazole derivatives, in particular aminomethylthiazole analogues, have been shown to exhibit promising antimalarial activity against Plasmodium falciparum strains. Previous studies reported the hit compound MMV010539, which showed good antimalarial activity against both K1 (CQ and multidrug resistant strains) and NF54 (CQ sensitive strain). In this study, MMV010539 was deemed to be as an attractive compound to generate novel analogues by addition of ferrocenyl organometallic unit. The ferrocene based compounds have shown biological activity; and with ferroquine currently in clinical trials there has been increasing research into identifying new ferrocenyl-containing molecules as potential antimalarial agents. Herein, thiazole ferrocene based molecules 3.22a-e were synthesised in low to good yields. Their structural identities were confirmed using conventional spectroscopic techniques (¹H and ¹³C NMR, FT-IR spectroscopy and mass spectrometry). The cell cytotoxicity assay of all final compounds confirmed that all ferrocene-thiazole blends 3.22a-e were non-toxic against HeLa cell lines. However, the in vitro biological assay revealed that despite the absence of cell cytotoxicity these compounds poorly inhibited the growth of Plasmodium falciparum parasite. As the aim was to expand further the structure-activity relationship (SAR) of MMV010539, this study confirmed the previous findings that there is a limited structural modification that could be accommodated as indicated in Figure 3.3 (Panel C). Moreover, the combination of ferrocenyl moiety and various alkylamines resulted in compounds with poor antiplasmodial potency, further suggesting that the free amine (Panel A, Figure 3.3) is important for activity.
- Full Text:
- Authors: Hakizimana, Emmanuel Victor
- Date: 2017
- Subjects: Plasmodium , Malaria -- Chemotherapy , Plasmodium falciparum , Plasmodium -- Inhibitors , Drug resistance in microorganisms , Thiaszoles
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10962/96068 , vital:31232
- Description: Malaria is mosquito-transmitted disease which continues to pose threat to humanity, despite the efforts undertaken by the scientific community, government entities and international organizations. The major problem is that Plasmodium species have developed resistance against available drugs. In order to counter this problem, antimalarial drugs that are efficacious and with novel mode of action are of great necessity. Thiazole derivatives, in particular aminomethylthiazole analogues, have been shown to exhibit promising antimalarial activity against Plasmodium falciparum strains. Previous studies reported the hit compound MMV010539, which showed good antimalarial activity against both K1 (CQ and multidrug resistant strains) and NF54 (CQ sensitive strain). In this study, MMV010539 was deemed to be as an attractive compound to generate novel analogues by addition of ferrocenyl organometallic unit. The ferrocene based compounds have shown biological activity; and with ferroquine currently in clinical trials there has been increasing research into identifying new ferrocenyl-containing molecules as potential antimalarial agents. Herein, thiazole ferrocene based molecules 3.22a-e were synthesised in low to good yields. Their structural identities were confirmed using conventional spectroscopic techniques (¹H and ¹³C NMR, FT-IR spectroscopy and mass spectrometry). The cell cytotoxicity assay of all final compounds confirmed that all ferrocene-thiazole blends 3.22a-e were non-toxic against HeLa cell lines. However, the in vitro biological assay revealed that despite the absence of cell cytotoxicity these compounds poorly inhibited the growth of Plasmodium falciparum parasite. As the aim was to expand further the structure-activity relationship (SAR) of MMV010539, this study confirmed the previous findings that there is a limited structural modification that could be accommodated as indicated in Figure 3.3 (Panel C). Moreover, the combination of ferrocenyl moiety and various alkylamines resulted in compounds with poor antiplasmodial potency, further suggesting that the free amine (Panel A, Figure 3.3) is important for activity.
- Full Text:
Effects of the biocontrol agent, coelocephalapion camarae kissinger, galling on petiole tissues, plant growth and stored reserves in plant parts of two lantana camara L.(verbenaceae) varieties
- Authors: Kistensamy, Yoganambal
- Date: 2016
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10962/3126 , vital:20372
- Description: The agent evaluated in this study, Coelocephalapion camarae Kissinger (Brentidae), a petiole galling apionid, was released against Lantana camara L. (Verbenaceae) in South Africa and has the potential to significantly contribute to the control of this noxious weed. An important aspect of evaluating the effectiveness of a biocontrol agent; include the understanding of the mechanism in which the biocontrol agent causes damage to the plant and the plant’s response to this damage. Another aspect that was considered in evaluating the effects of the apionid was the varietal differences that exist within the weedy L. camara complex. Larval feeding of C. camarae damaged the tissue in the petioles causing gall formation and this was quantified on two common South African L. camara varieties (017 and 018). Up to 100% of the vascular tissue (xylem and phloem) of effected petioles was eaten by larvae, 25 days after ovipostion in both the L. camara varieties, effectively severing the vascular connection from the leaves. The effect of feeding and galling by different population densities of C. camarae, on biomass and total soluble sugar and starch concentrations of different plant parts was measured on these two varieties during autumn, and compared to a similar study, done during summer. Relatively low galling percentages were achieved in the experiments of this study. Plant growth was less affected by apionid feeding at similar galling levels, as higher galling densities in these trials were similar to those at low exposures in trials by Baars (2002). The dry weights of all individual and combined plant parts for lantana variety 017 was less for both adult density exposures after 70 days compared to the weights of its controls, although not statistically significant at P>0.05 The opposite effect, though barely noticeable was recorded for lantana variety 018; here, the dry weights of individual plant parts and as whole plants weighed more in the plants exposed to both densities of weevil feeding and galling after 70 days, compared to its controls. Coelocephalapion camarae herbivory may thus be more effective in inflicting damage on some L. camara varieties compared to others. The effects of late season carbohydrate storage revealed that, from early- to mid-autumn starch concentrations increased significantly in stems of both L. camara varieties and L. camara var. 018 had larger starch reserves for winter. In L. camara var. 018 stems, starch increased 52 times and concentrations doubled in stems of L. camara var 017. The increase in the sugar and decrease in starch concentrations in leaves of plants of both varieties exposed to apionids in this study was attributed to a possible reduction of available nitrogen and phosphorus, due to apionid feeding, whilst starch was reallocated within the plants to stems and roots. The increase in starch concentrations in stems of plants that were exposed to apionids may have been expected, as compensation for herbivory has been associated with, increases in photosynthetic rates and the mobilization of stored resources. Herbivory by the apionid early in the growing season may be easily compensated for by L. camara as there are nutrient flushes experienced by plants that allows the maximum uptake of nutrients facilitating recovery, whereas later in the season plants suffer lower nutrient availability and don’t recover so readily. Both early and late in the season the accumulated effects of C. camarae feeding over time will undoubtedly decrease fitness of most lantana varieties.
- Full Text:
- Authors: Kistensamy, Yoganambal
- Date: 2016
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10962/3126 , vital:20372
- Description: The agent evaluated in this study, Coelocephalapion camarae Kissinger (Brentidae), a petiole galling apionid, was released against Lantana camara L. (Verbenaceae) in South Africa and has the potential to significantly contribute to the control of this noxious weed. An important aspect of evaluating the effectiveness of a biocontrol agent; include the understanding of the mechanism in which the biocontrol agent causes damage to the plant and the plant’s response to this damage. Another aspect that was considered in evaluating the effects of the apionid was the varietal differences that exist within the weedy L. camara complex. Larval feeding of C. camarae damaged the tissue in the petioles causing gall formation and this was quantified on two common South African L. camara varieties (017 and 018). Up to 100% of the vascular tissue (xylem and phloem) of effected petioles was eaten by larvae, 25 days after ovipostion in both the L. camara varieties, effectively severing the vascular connection from the leaves. The effect of feeding and galling by different population densities of C. camarae, on biomass and total soluble sugar and starch concentrations of different plant parts was measured on these two varieties during autumn, and compared to a similar study, done during summer. Relatively low galling percentages were achieved in the experiments of this study. Plant growth was less affected by apionid feeding at similar galling levels, as higher galling densities in these trials were similar to those at low exposures in trials by Baars (2002). The dry weights of all individual and combined plant parts for lantana variety 017 was less for both adult density exposures after 70 days compared to the weights of its controls, although not statistically significant at P>0.05 The opposite effect, though barely noticeable was recorded for lantana variety 018; here, the dry weights of individual plant parts and as whole plants weighed more in the plants exposed to both densities of weevil feeding and galling after 70 days, compared to its controls. Coelocephalapion camarae herbivory may thus be more effective in inflicting damage on some L. camara varieties compared to others. The effects of late season carbohydrate storage revealed that, from early- to mid-autumn starch concentrations increased significantly in stems of both L. camara varieties and L. camara var. 018 had larger starch reserves for winter. In L. camara var. 018 stems, starch increased 52 times and concentrations doubled in stems of L. camara var 017. The increase in the sugar and decrease in starch concentrations in leaves of plants of both varieties exposed to apionids in this study was attributed to a possible reduction of available nitrogen and phosphorus, due to apionid feeding, whilst starch was reallocated within the plants to stems and roots. The increase in starch concentrations in stems of plants that were exposed to apionids may have been expected, as compensation for herbivory has been associated with, increases in photosynthetic rates and the mobilization of stored resources. Herbivory by the apionid early in the growing season may be easily compensated for by L. camara as there are nutrient flushes experienced by plants that allows the maximum uptake of nutrients facilitating recovery, whereas later in the season plants suffer lower nutrient availability and don’t recover so readily. Both early and late in the season the accumulated effects of C. camarae feeding over time will undoubtedly decrease fitness of most lantana varieties.
- Full Text:
Hungry on arrival
- Authors: Mofokeng, Kabelo
- Date: 2016
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:6020 , http://hdl.handle.net/10962/d1021244
- Description: My collection embraces different kinds of poetry, I also write my own journey through my home in Pimville Soweto, the urban sounds and multilingual speech patterns as I move through it. Other poems draw on the Sesotho culture and tradition which still runs strongly in my family, and here I integrate the different kinds of sounds and associations of Sesotho and English in the same poem. I am inspired by the works and lives of artists and poets such as, Mafika Gwala, Jackson Hlungwani, and Herbie Tsoaeli amongst others. Other poems emerging are dense and self-reflective manifesting a transitional period whereby the poet experiments with form and style in the manner of Arthur Nortje and Angifi Dladla.
- Full Text:
- Authors: Mofokeng, Kabelo
- Date: 2016
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:6020 , http://hdl.handle.net/10962/d1021244
- Description: My collection embraces different kinds of poetry, I also write my own journey through my home in Pimville Soweto, the urban sounds and multilingual speech patterns as I move through it. Other poems draw on the Sesotho culture and tradition which still runs strongly in my family, and here I integrate the different kinds of sounds and associations of Sesotho and English in the same poem. I am inspired by the works and lives of artists and poets such as, Mafika Gwala, Jackson Hlungwani, and Herbie Tsoaeli amongst others. Other poems emerging are dense and self-reflective manifesting a transitional period whereby the poet experiments with form and style in the manner of Arthur Nortje and Angifi Dladla.
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Notebook of unremembered poems
- Authors: McKeown, Jean Wallace
- Date: 2016
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:6013 , http://hdl.handle.net/10962/d1021233
- Description: My poems contain narrative elements and explore themes of identity, motherhood, sexuality, and fear of relinquishing control. Sharon Olds, in her book Stag’s Leap, sums up my intention: “and I saw again how blessed my life has been, / first, to have been able to love, / then, to have the parting now behind me.” My collection chronicles a path towards acceptance of self from childhood onwards, and, more than that, a pleasure and pride in self, and I have tried to find the forms which will reflect this path in the reader’s own experience. Most of the poems are written in a conversational voice and a free-form style which gives me creative licence to explore transition and transformation.
- Full Text:
- Authors: McKeown, Jean Wallace
- Date: 2016
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:6013 , http://hdl.handle.net/10962/d1021233
- Description: My poems contain narrative elements and explore themes of identity, motherhood, sexuality, and fear of relinquishing control. Sharon Olds, in her book Stag’s Leap, sums up my intention: “and I saw again how blessed my life has been, / first, to have been able to love, / then, to have the parting now behind me.” My collection chronicles a path towards acceptance of self from childhood onwards, and, more than that, a pleasure and pride in self, and I have tried to find the forms which will reflect this path in the reader’s own experience. Most of the poems are written in a conversational voice and a free-form style which gives me creative licence to explore transition and transformation.
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Dominant and non-dominant group's perceptions of the government-led economic transformation process in South Africa: report
- Authors: Dlamini, Thobile G. K
- Date: 2009
- Subjects: Group identity -- South Africa Post-apartheid era -- South Africa South Africa -- Ethnic relations Social change -- South Africa South Africa -- Social conditions -- 1994- South Africa -- Economic conditions -- 1991-
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:2963 , http://hdl.handle.net/10962/d1002472
- Description: The enormous social, economic, and political government-led societal transformation South Africans have experienced over the past 15 years have brought about numerous societal and identity changes. The aim of the present study was to explore how dominant (White participants) and non-dominant (Black participants) groups experiencing the government-led societal transformation process deal with perceptions of intergroup differences based on Social Identity Theory (Tajfel & Turner, 1979, 1986) and related field research. Social Identity Theory predicts that in the presence of intergroup differences group members irrespective of their status position will apply identity management strategies to either improve or maintain their status position. The relationships between perceptions of intergroup relations and identity management strategies as proposed by Social Identity Theory were tested studying 170 second year Rhodes University psychology students. Sixty participants indicated themselves as Black South Africans (representing non-dominant group) and 110 participants identified themselves as White South Africans (dominant group). The results revealed that dominant and non-dominant groups differ systematically regarding the functional interaction between beliefs about the intergroup situation and identity management strategies. The results of the study indicate too, that ingroup identification differentiates between individual and collective strategies irrespective of the group’s status position.
- Full Text:
- Authors: Dlamini, Thobile G. K
- Date: 2009
- Subjects: Group identity -- South Africa Post-apartheid era -- South Africa South Africa -- Ethnic relations Social change -- South Africa South Africa -- Social conditions -- 1994- South Africa -- Economic conditions -- 1991-
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:2963 , http://hdl.handle.net/10962/d1002472
- Description: The enormous social, economic, and political government-led societal transformation South Africans have experienced over the past 15 years have brought about numerous societal and identity changes. The aim of the present study was to explore how dominant (White participants) and non-dominant (Black participants) groups experiencing the government-led societal transformation process deal with perceptions of intergroup differences based on Social Identity Theory (Tajfel & Turner, 1979, 1986) and related field research. Social Identity Theory predicts that in the presence of intergroup differences group members irrespective of their status position will apply identity management strategies to either improve or maintain their status position. The relationships between perceptions of intergroup relations and identity management strategies as proposed by Social Identity Theory were tested studying 170 second year Rhodes University psychology students. Sixty participants indicated themselves as Black South Africans (representing non-dominant group) and 110 participants identified themselves as White South Africans (dominant group). The results revealed that dominant and non-dominant groups differ systematically regarding the functional interaction between beliefs about the intergroup situation and identity management strategies. The results of the study indicate too, that ingroup identification differentiates between individual and collective strategies irrespective of the group’s status position.
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"Ufunda de ufe" : the story of a village psychologist in a rural, South African school setting
- Authors: Theunissen, Maureen Ezelle
- Date: 2002
- Subjects: Participant observation , Rural children -- Education -- South Africa , Life skills -- Study and teaching -- South Africa
- Language: English
- Type: Thesis , Masters , MSocSc
- Identifier: vital:689 , http://hdl.handle.net/10962/d1004538 , Participant observation , Rural children -- Education -- South Africa , Life skills -- Study and teaching -- South Africa
- Description: In 2001, participatory research, incorporating various participatory rural appraisal techniques, was conducted in five, rural, primary schools in the Eastern Cape, South Africa. The participatory research was aimed at identifying and addressing schools' needs in terms of lifeskills education in a changing South Africa and educational environment. This whole process has been written up as a case study and further analysed in an attempt to describe the emerging role of the psychologist, working in participation with educators, in this kind of setting. Going beyond description, the researcher reflects upon the function and nature of the role of the psychologist within the developmental participatory process. In doing so, the article addresses the need for participatory research results to be further analysed in generating theory, particularly within Psychology. The article highlights some of the strengths of qualitative research, and the primacy of the personal in that endeavour.
- Full Text:
- Authors: Theunissen, Maureen Ezelle
- Date: 2002
- Subjects: Participant observation , Rural children -- Education -- South Africa , Life skills -- Study and teaching -- South Africa
- Language: English
- Type: Thesis , Masters , MSocSc
- Identifier: vital:689 , http://hdl.handle.net/10962/d1004538 , Participant observation , Rural children -- Education -- South Africa , Life skills -- Study and teaching -- South Africa
- Description: In 2001, participatory research, incorporating various participatory rural appraisal techniques, was conducted in five, rural, primary schools in the Eastern Cape, South Africa. The participatory research was aimed at identifying and addressing schools' needs in terms of lifeskills education in a changing South Africa and educational environment. This whole process has been written up as a case study and further analysed in an attempt to describe the emerging role of the psychologist, working in participation with educators, in this kind of setting. Going beyond description, the researcher reflects upon the function and nature of the role of the psychologist within the developmental participatory process. In doing so, the article addresses the need for participatory research results to be further analysed in generating theory, particularly within Psychology. The article highlights some of the strengths of qualitative research, and the primacy of the personal in that endeavour.
- Full Text:
An investigation into the significance of celebration in Black preaching
- Authors: Moeketsi, Isaac Tseko
- Date: 1994
- Subjects: Preaching -- Africa , Public worship , Christianity -- Africa , African Independent Church , Independent churches -- Africa
- Language: English
- Type: Thesis , Masters , MTh
- Identifier: vital:1298 , http://hdl.handle.net/10962/d1015662
- Description: The Christian faith in God is undergirded by the good news of God's intervention in human life. This intervention of God is good news because the sin of humankind has resulted in alienation with God as well as rendering humankind incapable of restoring fellowship with God. This good news of God's intervention in human affairs through the act of His son Jesus Christ is the centre of Christian kerygma. One outstanding feature of this proclamation is celebration. Salvation offered and given to ailing humankind is cause for celebration for God has paved the way for reconciliation. In Black preaching this note of celebration is remarkably achieved in the extravagant use of figures of speech and imagery drawn from traditional African religiosity, for the African human life in whatever state and condition is cause for celebration. The African responds to life at all levels of encounter with celebration. In sorrow and joy, in sad moments and moments of delight, in want and in plenty, the voice of the African will always rise up in spontaneous acts of celebration. In normal human conversation the use of the African idiom and allegory drawn from their cultural worldview creates unique style. In the use of these the African past is expressly drawn into the present to emphasize the belief in life as a gift from God, a gift to be acknowledged and celebrated. Therefore living through all sorts and conditions of life sharpens the deep feeling and expression of this celebration. The song, praise and dance for the African therefore flows from this spiritual engagement with God in life. The biblical message and the daily experience of life is for the African preacher a stage from which the human drama with God is understood. The nature of God is seen in relation to God's encounter with sinful humankind. God's mercy and grace inspires humans to live their life in confident trust in God. The vicissitudes of life for the African have no dampening effect for life rather they sharpen the awareness of God's surpassing mercy and sustaining steadfastness upon his creatures. Thus in similar vein with the African moroki, the Black preacher calls and inspires his/her audience to celebrate, to engage with life in perfect African celebration.
- Full Text:
- Authors: Moeketsi, Isaac Tseko
- Date: 1994
- Subjects: Preaching -- Africa , Public worship , Christianity -- Africa , African Independent Church , Independent churches -- Africa
- Language: English
- Type: Thesis , Masters , MTh
- Identifier: vital:1298 , http://hdl.handle.net/10962/d1015662
- Description: The Christian faith in God is undergirded by the good news of God's intervention in human life. This intervention of God is good news because the sin of humankind has resulted in alienation with God as well as rendering humankind incapable of restoring fellowship with God. This good news of God's intervention in human affairs through the act of His son Jesus Christ is the centre of Christian kerygma. One outstanding feature of this proclamation is celebration. Salvation offered and given to ailing humankind is cause for celebration for God has paved the way for reconciliation. In Black preaching this note of celebration is remarkably achieved in the extravagant use of figures of speech and imagery drawn from traditional African religiosity, for the African human life in whatever state and condition is cause for celebration. The African responds to life at all levels of encounter with celebration. In sorrow and joy, in sad moments and moments of delight, in want and in plenty, the voice of the African will always rise up in spontaneous acts of celebration. In normal human conversation the use of the African idiom and allegory drawn from their cultural worldview creates unique style. In the use of these the African past is expressly drawn into the present to emphasize the belief in life as a gift from God, a gift to be acknowledged and celebrated. Therefore living through all sorts and conditions of life sharpens the deep feeling and expression of this celebration. The song, praise and dance for the African therefore flows from this spiritual engagement with God in life. The biblical message and the daily experience of life is for the African preacher a stage from which the human drama with God is understood. The nature of God is seen in relation to God's encounter with sinful humankind. God's mercy and grace inspires humans to live their life in confident trust in God. The vicissitudes of life for the African have no dampening effect for life rather they sharpen the awareness of God's surpassing mercy and sustaining steadfastness upon his creatures. Thus in similar vein with the African moroki, the Black preacher calls and inspires his/her audience to celebrate, to engage with life in perfect African celebration.
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Art and authority : aspects of Russian art since 1917
- Authors: Thompson, Rowan Douglas
- Date: 1991
- Subjects: Authority in art Art, Russian Art, Russian -- 20th century
- Language: English
- Type: Thesis , Masters , MFA
- Identifier: vital:2450 , http://hdl.handle.net/10962/d1007298
- Description: From Introduction: The Artist was denied any role in Plato's Republic because of his ability to impair reason by imitating reality through his works. Aristotle, however, welcomed the artist because of his ability to express ideas about society through artistic form. Ernst Fischer agrees with the latter view, "Art enables man to comprehend reality, and not only helps him to bear it but increases his determination to make it more human and more worthy of mankind. Art is itself a social reality, society needs the artist ... and it has a right to demand of him that he should be conscious of his social function" (Fischer: 1963:46). Fischer adds to Aristotle's view by stating that society has a right to demand a social function from the artist. This issue has been the subject of controversial debate throughout the history of art. In a society based on class, the classes try to recruit art to serve their particular purposes. Art is seen by some as a powerful weapon - a means by which people can be swayed towards certain ideals. At the time of the Counter Reformation Italian artists were given strict instructions by the Jesuits on how to persuade and educate the people with their paintings. Napoleon urged his men of letters, painters and architects to refer to the classical ideals of ancient Greece and Rome to shape the emergent French Republic. The French philosopher, Dennis Diderot, stressed the futility of art unless it expressed great prinCiples or lessons for the spectator. Ideals of justice, courage and patriotism were embodied in the Neo-Classical movement. The didactic paintings of Jacques Louis David portray the above ideals. History records several attempts by those in power to coerce artists into conforming to their idea of society, indicating that authoritative manipulation of the arts is not purely a twentieth century phenomenon. This thesis intends to examine aspects of Russian art since 1917. Because Soviet art was dominated by policies which enabled authorities to determine its content, its history raises ideological issues which are relevant to the study of art. The theories of Suprematism, Constructivism and Socialist Realism will be discussed and conclusions will be drawn as to whether these theories succeeded as art movements which were ostensibly designed for the improvement of mankind. Present attitudes toward the visual arts in Russia will also be examined. However, in order to examine the above it is necessary to place the development of art into historical perspective.
- Full Text:
- Authors: Thompson, Rowan Douglas
- Date: 1991
- Subjects: Authority in art Art, Russian Art, Russian -- 20th century
- Language: English
- Type: Thesis , Masters , MFA
- Identifier: vital:2450 , http://hdl.handle.net/10962/d1007298
- Description: From Introduction: The Artist was denied any role in Plato's Republic because of his ability to impair reason by imitating reality through his works. Aristotle, however, welcomed the artist because of his ability to express ideas about society through artistic form. Ernst Fischer agrees with the latter view, "Art enables man to comprehend reality, and not only helps him to bear it but increases his determination to make it more human and more worthy of mankind. Art is itself a social reality, society needs the artist ... and it has a right to demand of him that he should be conscious of his social function" (Fischer: 1963:46). Fischer adds to Aristotle's view by stating that society has a right to demand a social function from the artist. This issue has been the subject of controversial debate throughout the history of art. In a society based on class, the classes try to recruit art to serve their particular purposes. Art is seen by some as a powerful weapon - a means by which people can be swayed towards certain ideals. At the time of the Counter Reformation Italian artists were given strict instructions by the Jesuits on how to persuade and educate the people with their paintings. Napoleon urged his men of letters, painters and architects to refer to the classical ideals of ancient Greece and Rome to shape the emergent French Republic. The French philosopher, Dennis Diderot, stressed the futility of art unless it expressed great prinCiples or lessons for the spectator. Ideals of justice, courage and patriotism were embodied in the Neo-Classical movement. The didactic paintings of Jacques Louis David portray the above ideals. History records several attempts by those in power to coerce artists into conforming to their idea of society, indicating that authoritative manipulation of the arts is not purely a twentieth century phenomenon. This thesis intends to examine aspects of Russian art since 1917. Because Soviet art was dominated by policies which enabled authorities to determine its content, its history raises ideological issues which are relevant to the study of art. The theories of Suprematism, Constructivism and Socialist Realism will be discussed and conclusions will be drawn as to whether these theories succeeded as art movements which were ostensibly designed for the improvement of mankind. Present attitudes toward the visual arts in Russia will also be examined. However, in order to examine the above it is necessary to place the development of art into historical perspective.
- Full Text:
The visionary artist
- Authors: Lambert, Moira
- Date: 1980
- Subjects: Blake, William, 1757-1827 Blake, William, 1757-1827 -- Symbolism
- Language: English
- Type: Thesis , Masters , MFA
- Identifier: vital:2441 , http://hdl.handle.net/10962/d1006113
- Description: Reading and personal experiences have often drawn my attention to the exceptionally high incidence of despair, "nervous disorder", alcoholism, nihilism and even suicide, among modern artists. I would like in this work to look at the visionary, Blake, against the problem of 'breaking the sound-barrier' and against the background of disastrous attempts at this by modern artists.
- Full Text:
- Authors: Lambert, Moira
- Date: 1980
- Subjects: Blake, William, 1757-1827 Blake, William, 1757-1827 -- Symbolism
- Language: English
- Type: Thesis , Masters , MFA
- Identifier: vital:2441 , http://hdl.handle.net/10962/d1006113
- Description: Reading and personal experiences have often drawn my attention to the exceptionally high incidence of despair, "nervous disorder", alcoholism, nihilism and even suicide, among modern artists. I would like in this work to look at the visionary, Blake, against the problem of 'breaking the sound-barrier' and against the background of disastrous attempts at this by modern artists.
- Full Text:
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