In vitro release of amoxycillin from lipophilic suppositories
- Webster, Jessica A, Dowse, Roslind, Walker, Roderick B
- Authors: Webster, Jessica A , Dowse, Roslind , Walker, Roderick B
- Date: 1998
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/184377 , vital:44213 , xlink:href="https://doi.org/10.3109/03639049809085636"
- Description: The in vitro release characteristics of amoxycillin from different lipophilic suppository bases were investigated using the USP rotating basket method. Suppositories containing 250 mg amoxycillin were prepared in theobroma oil and in the semisynthetic bases Witepsol W35, Suppocire A32, Novata BD, and Novata 299. Both freshly prepared and 1-month-old suppositories were tested. Analysis of amoxycillin was performed using a validated high-performance liquid chromatographic (HPLC) technique. Release profiles differed significantly between bases, with the greatest amount of amoxycillin being released from both newly made and 1-month-old Novata BD bases (87.57 ± 8.18 and 99.66 ± 6.63%, respectively), and the lowest amount released from the newly manufactured theobroma suppositories (8.82 ± 0.75%) and the 1-month-old Suppocire A32 suppositories (7.78 ± 0.27%).
- Full Text:
- Date Issued: 1998
- Authors: Webster, Jessica A , Dowse, Roslind , Walker, Roderick B
- Date: 1998
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/184377 , vital:44213 , xlink:href="https://doi.org/10.3109/03639049809085636"
- Description: The in vitro release characteristics of amoxycillin from different lipophilic suppository bases were investigated using the USP rotating basket method. Suppositories containing 250 mg amoxycillin were prepared in theobroma oil and in the semisynthetic bases Witepsol W35, Suppocire A32, Novata BD, and Novata 299. Both freshly prepared and 1-month-old suppositories were tested. Analysis of amoxycillin was performed using a validated high-performance liquid chromatographic (HPLC) technique. Release profiles differed significantly between bases, with the greatest amount of amoxycillin being released from both newly made and 1-month-old Novata BD bases (87.57 ± 8.18 and 99.66 ± 6.63%, respectively), and the lowest amount released from the newly manufactured theobroma suppositories (8.82 ± 0.75%) and the 1-month-old Suppocire A32 suppositories (7.78 ± 0.27%).
- Full Text:
- Date Issued: 1998
Pharmacokinetics of cyclizine following intravenous administration to human volunteers
- Kanfer, Isadore, Walker, Roderick B
- Authors: Kanfer, Isadore , Walker, Roderick B
- Date: 1996
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/184389 , vital:44214 , xlink:href="https://doi.org/10.1016/0928-0987(96)00177-7"
- Description: The pharmacokinetics of cyclizine, a piperazine derivative useful in the prevention and treatment of nausea and vomiting, was investigated in six healthy male volunteers following an intravenous bolus dose. The drug is extensively distributed with a mean volume of distribution of 16.50 ± 3.33 l/kg and a mean total clearance of 0.870 ± 0.105 l/h per kg. Urinary excretion data showed that less than one percent of the dose was excreted up to 36 h as unchanged drug in the urine. The extremely low mean renal clearance (0.005 ± 0.002 l/h per kg) for the parent drug comprised only a small proportion of total clearance indicating that urinary excretion of parent drug is not a major route of elimination for cyclizine. The drug appears to exhibit biexponential pharmacokinetics and has a terminal elimination half-life of approximately 13 h.
- Full Text:
- Date Issued: 1996
- Authors: Kanfer, Isadore , Walker, Roderick B
- Date: 1996
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/184389 , vital:44214 , xlink:href="https://doi.org/10.1016/0928-0987(96)00177-7"
- Description: The pharmacokinetics of cyclizine, a piperazine derivative useful in the prevention and treatment of nausea and vomiting, was investigated in six healthy male volunteers following an intravenous bolus dose. The drug is extensively distributed with a mean volume of distribution of 16.50 ± 3.33 l/kg and a mean total clearance of 0.870 ± 0.105 l/h per kg. Urinary excretion data showed that less than one percent of the dose was excreted up to 36 h as unchanged drug in the urine. The extremely low mean renal clearance (0.005 ± 0.002 l/h per kg) for the parent drug comprised only a small proportion of total clearance indicating that urinary excretion of parent drug is not a major route of elimination for cyclizine. The drug appears to exhibit biexponential pharmacokinetics and has a terminal elimination half-life of approximately 13 h.
- Full Text:
- Date Issued: 1996
Suppositories: An underutilized dosage form
- Webster, Jessica A, Dowse, Roslind, Walker, Roderick B
- Authors: Webster, Jessica A , Dowse, Roslind , Walker, Roderick B
- Date: 1996
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/184697 , vital:44264 , xlink:href="https://hdl.handle.net/10520/AJA16836707_911"
- Description: The rectal route is useful for the delivery of both local acting and systemic drugs. In certain cases suppositories are the best form of therapy, or else they are an effective alternative when oral therapy is not possible. However; doctors rarely prescribe them and patients are often reluctant to use them. Understanding how suppositories work, and their numerous uses, can overcome the aversion to this particular dosage form. Pharmacists are in an ideal position to educate doctors, other health care providers, and patients, on the benefits of using suppositories and their correct use, and to offer advice on any problems associated with their use.
- Full Text:
- Date Issued: 1996
- Authors: Webster, Jessica A , Dowse, Roslind , Walker, Roderick B
- Date: 1996
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/184697 , vital:44264 , xlink:href="https://hdl.handle.net/10520/AJA16836707_911"
- Description: The rectal route is useful for the delivery of both local acting and systemic drugs. In certain cases suppositories are the best form of therapy, or else they are an effective alternative when oral therapy is not possible. However; doctors rarely prescribe them and patients are often reluctant to use them. Understanding how suppositories work, and their numerous uses, can overcome the aversion to this particular dosage form. Pharmacists are in an ideal position to educate doctors, other health care providers, and patients, on the benefits of using suppositories and their correct use, and to offer advice on any problems associated with their use.
- Full Text:
- Date Issued: 1996