- Title
- No evidence for association between APOL1 kidney disease risk alleles and Human African Trypanosomiasis in two Ugandan populations:
- Creator
- Kimuda, Magambo P, Noyes, Harry, Mulindwa, Julius, Enyaru, John, Alibu, Vincent P, Sidibe, Issa, Mumba Ngoyi, Dieuodonne, Hertz-Fowler, Christiane, MacLeod, Annette, Tastan Bishop, Özlem, Matovu, Enock
- Date
- 2018
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/162924
- Identifier
- vital:40997
- Identifier
- https://doi.org/10.1371/journal.pntd.0006300
- Description
- Human African trypanosomiasis (HAT) manifests as an acute form caused by Trypanosoma brucei rhodesiense (Tbr) and a chronic form caused by Trypanosoma brucei gambiense (Tbg). Previous studies have suggested a host genetic role in infection outcomes, particularly for APOL1. We have undertaken candidate gene association studies (CGAS) in a Ugandan Tbr and a Tbg HAT endemic area, to determine whether polymorphisms in IL10, IL8, IL4, HLAG, TNFA, TNX4LB, IL6, IFNG, MIF, APOL1, HLAA, IL1B, IL4R, IL12B, IL12R, HP, HPR, and CFH have a role in HAT.
- Format
- 11 page, pdf
- Language
- English
- Relation
- PLoS neglected tropical diseases, Kimuda, M.P., Noyes, H., Mulindwa, J., Enyaru, J., Alibu, V.P., Sidibe, I., Mumba Ngoyi, D., Hertz-Fowler, C., MacLeod, A., Tastan Bishop, Ö. and Matovu, E., 2018. No evidence for association between APOL1 kidney disease risk alleles and Human African Trypanosomiasis in two Ugandan populations. PLoS neglected tropical diseases, 12(2), p.e0006300, PLoS neglected tropical diseases volume 12 number 2 1 10 February 2018 1935-2735
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the PLOS Terms of Use Statement ( https://www.plos.org/terms-of-use)
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Tastan Bishop, Ozlem (Prof)
RU Research Unit in Bioinformatics (RUBi)
RU Department of Biochemistry, Microbiology and Bioinformatics
SDG 03. Good Health and Well-Being
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