- Title
- Physicochemical and photodynamic antimicrobial chemotherapy activity of morpholine-substituted phthalocyanines: Effect of point of substitution and central metal
- Creator
- Sindelo, Azole, Kobayashi, Nagao, Kimura, Mutsumi, Nyokong, Tebello
- Subject
- To be catalogued
- Date
- 2019
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/187438
- Identifier
- vital:44652
- Identifier
- xlink:href="https://doi.org/10.1016/j.jphotochem.2019.01.025"
- Description
- In this study, novel metal-free, zinc and indium 1(4),8(11),15(18),22(25)-tetramorpholine (1a, 2a, 3a respectively) and 2(3), 9(10), 16(17),23(24)-tetramorpholine (1b, 2b, 3b respectively) phthalocyanines were synthesized and complexes 2 and 3 were quaternized. The photophysical and photochemical properties were investigated in dimethylsulfoxide. The non-peripherally substituted phthalocyanines generated higher singlet oxygen than the peripherally substituted phthalocyanines. Photodynamic antimicrobial chemotherapy activities towards inactivation of Escherichia coli, Staphylococcus aureus and Candida albican were evaluated, where all the quaternized Pcs showed total elimination of the micro-organism with log reductions greater than 9. Though the neutral Pcs had log reductions less than 2, for C. albican the percentage reduction was 68.5% for 2b showing the antifungal properties of the morpholine group.
- Format
- computer, online resource, application/pdf, 1 online resource (10 pages), pdf
- Publisher
- Elsevier
- Language
- English
- Relation
- Journal of Photochemistry and Photobiology A: Chemistry, Sindelo, A., Kobayashi, N., Kimura, M. and Nyokong, T., 2019. Physicochemical and photodynamic antimicrobial chemotherapy activity of morpholine-substituted phthalocyanines: effect of point of substitution and central metal. Journal of Photochemistry and Photobiology A: Chemistry, 374, pp.58-67, Journal of Photochemistry and Photobiology A: Chemistry volume 374 p. 58 2019 1010-6030
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
- Rights
- Closed Access
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RU DST/NRF SARChI for Medicinal Chemistry and Nanotechnology
Nyokong, Tebello (Distinguished Professor)
RU Department of Chemistry
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details | SOURCE1 | Physicochemical and photodynamic antimicrobial chemotherapy activity of morpholine-substituted phthalocyanines.pdf | 693 KB | Adobe Acrobat PDF | View Details |