- Title
- Electrochemical detection of human epidermal growth factor receptor 2 using an aptamer on cobalt phthalocyanines–Cerium oxide nanoparticle conjugate
- Creator
- Centane, Sixolile, Mgidlana, Sithi, Openda, Yolanda, Nyokong, Tebello
- Subject
- To be catalogued
- Date
- 2022
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/299835
- Identifier
- vital:57859
- Identifier
- xlink:href="https://doi.org/10.1016/j.bioelechem.2022.108146"
- Description
- The role of the biointerface design towards the development of an impedimetric biosensor for the electrochemical detection of human epidermal growth factor receptor 2 (HER2) is investigated. Two novel cobalt phthalocyanines: cobalt tetraphenyl acetic acid phthalocyanine and cobalt tetraphenyl propionic acid phthalocyanine are compared as signal amplifiers and immobilization platforms of the HB5 aptamer towards the electrochemical detection of HER2. In addition, the phthalocyanines are coupled with the metal based cerium oxide nanoparticles. The efficiency of each electrode modification step and the performance of the constructed aptasensors were assessed by impedance spectroscopy. The aptasensors showed very low limit of detection values (all less than 0.2 ng/mL) with high sensitivity and stability. Furthermore, the aptasensors showed very good performance even in human serum samples. Considering these results, the aptasensors demonstrate great potential for improved monitoring of human epidermal growth factor receptor 2 levels for the management of breast cancers.
- Format
- computer, online resource, application/pdf, 1 online resource (10 pages), pdf
- Publisher
- Elsevier
- Language
- English
- Relation
- Bioelectrochemistry, Centane, S., Mgidlana, S., Openda, Y. and Nyokong, T., 2022. Electrochemical detection of human epidermal growth factor receptor 2 using an aptamer on cobalt phthalocyanines–Cerium oxide nanoparticle conjugate. Bioelectrochemistry, 146, p.108146, Bioelectrochemistry volume 146 p. 108146 2022 1878-562X
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
- Rights
- Closed Access
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Collections
RU DST/NRF SARChI for Medicinal Chemistry and Nanotechnology
Nyokong, Tebello (Distinguished Professor)
RU Department of Chemistry
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Electrochemical detection of human epidermal growth factor receptor.pdf | 824 KB | Adobe Acrobat PDF | View Details Download |