- Title
- Structure-based analysis of single nucleotide variants in the renin-angiotensinogen complex:
- Creator
- Brown, David K, Sheik Amamuddy, Olivier, Tastan Bishop, Özlem
- Date
- 2017
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/147994
- Identifier
- vital:38700
- Identifier
- https://doi.org/10.1016/j.gheart.2017.01.006
- Description
- The renin-angiotensin system (RAS) plays an important role in regulating blood pressure and controlling sodium levels in the blood. Hyperactivity of this system has been linked to numerous conditions including hypertension, kidney disease, and congestive heart failure. Three classes of drugs have been developed to inhibit RAS. In this study, we provide a structure-based analysis of the effect of single nucleotide variants (SNVs) on the interaction between renin and angiotensinogen with the aim of revealing important residues and potentially damaging variants for further inhibitor design purposes.
- Format
- 12 pages, pdf
- Language
- English
- Relation
- Global heart, Brown, D.K., Amamuddy, O.S. and Bishop, Ö.T., 2017. Structure-based analysis of single nucleotide variants in the renin-angiotensinogen complex. Global heart, 12(2), pp.121-132., Global heart volume 12 number 2 121 132 June 2017 2211-8179
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and conditions statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
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Sheik Amamuddy, Olivier (Dr)
RU Research Unit in Bioinformatics (RUBi)
Tastan Bishop, Ozlem (Prof)
RU Department of Biochemistry, Microbiology and Bioinformatics
SDG 03. Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details | SOURCE1 | Structure-based analysis of single nucleotide variants in the renin-angiotensinogen complex.pdf | 647 KB | Adobe Acrobat PDF | View Details |