In vitro Anti-trypanosomal activities of indanone-based chalcones:
- Beteck, Richard M, Legoabe, Lesetje J, Isaacs, Michelle, Hoppe, Heinrich C
- Authors: Beteck, Richard M , Legoabe, Lesetje J , Isaacs, Michelle , Hoppe, Heinrich C
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/158280 , vital:40169 , https://doi.org/10.3354/meps12953
- Description: Human African trypanosomiasis is a neglected infectious disease that affects mostly people living in the rural areas of Africa. Current treatment options are limited to just four drugs that have been in use of four to nine decades. The life-threatening toxic side-effects associated with the use of these drugs are disconcerting. Poor efficacy, low oral bioavailability, and high cost are other shortcomings of current HAT treatments. Evaluating the potentials of known hits for other therapeutic areas may be a fast and convenient method to discover new hit compounds against alternative targets. A library of 34 known indanone based chalcones was screened against T.b. brucei and nine potent hits, having IC50 values between 0.5–8.9 µM, were found. The SAR studies of this series could provide useful information in guiding future exploration of this class of compounds in search of more potent, safe, and low cost anti-trypanosomal agents.
- Full Text:
- Date Issued: 2019
- Authors: Beteck, Richard M , Legoabe, Lesetje J , Isaacs, Michelle , Hoppe, Heinrich C
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/158280 , vital:40169 , https://doi.org/10.3354/meps12953
- Description: Human African trypanosomiasis is a neglected infectious disease that affects mostly people living in the rural areas of Africa. Current treatment options are limited to just four drugs that have been in use of four to nine decades. The life-threatening toxic side-effects associated with the use of these drugs are disconcerting. Poor efficacy, low oral bioavailability, and high cost are other shortcomings of current HAT treatments. Evaluating the potentials of known hits for other therapeutic areas may be a fast and convenient method to discover new hit compounds against alternative targets. A library of 34 known indanone based chalcones was screened against T.b. brucei and nine potent hits, having IC50 values between 0.5–8.9 µM, were found. The SAR studies of this series could provide useful information in guiding future exploration of this class of compounds in search of more potent, safe, and low cost anti-trypanosomal agents.
- Full Text:
- Date Issued: 2019
Should I stay or should I go?: Intra-population variability in movement behaviour of wide-ranging and resident coastal fishes
- Maggs, Jade Q, Cowley, Paul D, Porter, S N, Childs, Amber-Robyn
- Authors: Maggs, Jade Q , Cowley, Paul D , Porter, S N , Childs, Amber-Robyn
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/158290 , vital:40170 , https://doi.org/10.3354/meps12953
- Description: Life-cycle diversity is the existence of alternative strategies among coexisting individuals within the same population and is an important factor in the structuring and connectivity of fish stocks. Mark-recapture data, collected along the coastline of southern Africa from 1984-2015, were used to investigate the occurrence of different movement behaviours (resident vs. wide-ranging) in 5 fishery species with contrasting life histories. A total of 88245 individuals was tagged, with recapture rates ranging from 4-27% for the 5 species. Individuals were considered resident if recaptured within 0-5 km of the release site after 365 d at liberty or wide-ranging if recaptured more than 50 km from the release site within 365 d.
- Full Text:
- Date Issued: 2019
- Authors: Maggs, Jade Q , Cowley, Paul D , Porter, S N , Childs, Amber-Robyn
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/158290 , vital:40170 , https://doi.org/10.3354/meps12953
- Description: Life-cycle diversity is the existence of alternative strategies among coexisting individuals within the same population and is an important factor in the structuring and connectivity of fish stocks. Mark-recapture data, collected along the coastline of southern Africa from 1984-2015, were used to investigate the occurrence of different movement behaviours (resident vs. wide-ranging) in 5 fishery species with contrasting life histories. A total of 88245 individuals was tagged, with recapture rates ranging from 4-27% for the 5 species. Individuals were considered resident if recaptured within 0-5 km of the release site after 365 d at liberty or wide-ranging if recaptured more than 50 km from the release site within 365 d.
- Full Text:
- Date Issued: 2019
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