- Title
- Biological activities of plant extracts from Ficus elastica and Selaginella vogelli: an antimalarial, antitrypanosomal and cytotoxity evaluation
- Creator
- Meyer, Franck, Isaacs, Michelle, Noundou, Xavier S, Krause, Rui W M, Teinkela, J E M, Hoppe, Heinrich C, Mpondo, Albert E M, Azebaze, Anatole G B, Nguemfo, Edwige L, Wintjens, Rene
- Date
- 2018
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/126142
- Identifier
- vital:35853
- Identifier
- https://doi.org/10.1016/j.sjbs.2017.07.002
- Description
- The cytotoxic, antiplasmodial, and antitrypanosomal activities of two medicinal plants traditionally used in Cameroon were evaluated. Wood of Ficus elastica Roxb. ex Hornem. aerial roots (Moraceae) and Selaginella vogelii Spring (Selaginellaceae) leaves were collected from two different sites in Cameroon. In vitro cell-growth inhibition activities were assessed on methanol extract of plant materials against Plasmodium falciparum strain 3D7 and Trypanosoma brucei brucei, as well as against HeLa human cervical carcinoma cells. Criteria for activity were an IC50 value 10 μg/mL. The extract of S. vogelii did not significantly reduce the viability of P. falciparum at a concentration of 25 μg/mL but dramatically affected the trypanosome growth with an IC50 of 2.4 μg/mL. In contrast, at the same concentration, the extract of F. elastica exhibited plasmodiacidal activity (IC50 value of 9.5 μg/mL) and trypanocidal (IC50 value of 0.9 μg/mL) activity. Both extracts presented low cytotoxic effects on HeLa cancer cell line. These results indicate that the selected medicinal plants could be further investigated for identifying compounds that may be responsible for the observed activities and that may represent new leads in parasitical drug discovery.
- Format
- 6 pages, pdf
- Language
- English
- Relation
- Saudi journal of biological sciences, Teinkela, J.M., Noundou, X.S., Fannang, S., Meyer, F., Vardamides, J.C., Mpondo, E.M., Krause, R.W.M., Azebaze, A.G.B. and Nguedia, J.C.A., 2017. In vitro antimicrobial activity of the methanol extract and compounds from the wood of Ficus elastica Roxb. ex Hornem. aerial roots. South African journal of botany, 111, pp.302-306., Saudi journal of biological sciences number 25 number 1 117 122 2018 2213-7106
- Rights
- Saudi Journal of Biological Sciences
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
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Krause, Rui Werner Maçedo (Prof)
Hoppe, Heinrich C (Prof)
Isaacs, Michelle (Mrs)
RU Department of Chemistry
RU Department of Biochemistry, Microbiology and Bioinformatics
SDG 03. Good Health and Well-Being
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