- Title
- ‘There is nothing to hold onto here’:
- Creator
- Shabangu, Samuel M, Babu, Balaji, Soy, Rodah C, Managa, Muthumuni, Sekhosana, Kutloano E, Nyokong, Tebello
- Date
- 2020
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/156410
- Identifier
- vital:39987
- Identifier
- DOI: 10.1080/00958972.2020.1739273
- Description
- Asymmetric mono-carboxy-porphyrins, (5-(4-carboxyphenyl)−10,15,20-tris(pentafluorophenyl)porphyrinato zinc(II) (1), 5-(4-carboxyphenyl)−10,15,20-triphenylporphyrinato zinc(II) (2) and 5-(4-carboxyphenyl)−10,15,20-tris(2-thienyl)porphyrinato zinc(II) (3), were linked to Ag nanoparticles (AgNPs) through amide bonds and self-assembly (the latter only for 3). The porphyrins and conjugates were used for photodynamic antimicrobial chemotherapy (PACT) against Staphylococcus aureus. PACT uses singlet oxygen for antimicrobial activity. Complex 3 and its conjugates had higher singlet oxygen quantum yields and higher log reduction when compared with the rest of the porphyrins and corresponding conjugates. These high log reductions for 3 and its conjugate were attributed to the presence of sulfur groups whereby there was more interaction with the bacterial membrane.
- Format
- 17 pages, pdf
- Language
- English
- Relation
- Journal of Coordination Chemistry, Shabangu, S.M., Babu, B., Soy, R.C., Managa, M., Sekhosana, K.E. and Nyokong, T., 2020. Photodynamic antimicrobial chemotherapy of asymmetric porphyrin-silver conjugates towards photoinactivation of Staphylococcus aureus. Journal of Coordination Chemistry, 73(4), pp.593-608., Journal of Coordination Chemistry volume 73 number 4 593 603 2020 1029-0389
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Taylor and Francis Online Terms and Conditions Statement (https://www.tandfonline.com/terms-and-conditions)
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RU DST/NRF SARChI for Medicinal Chemistry and Nanotechnology
Nyokong, Tebello (Distinguished Professor)
RU Department of Chemistry
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