- Title
- Reaction of Perrhenate with Phthalocyanine Derivatives in the Presence of Reducing Agents and Rhenium Oxide Nanoparticles in Biomedical Applications
- Creator
- Ntsimango, Songeziwe, Gandidzanwa, Sendibitiyosi, Joseph, Sinelizwi V, Hosten, Eric C, Randall, Marvin, Edkins, Adrienne L, Khene, Samson M, Mashazi, Philani N, Nyokong, Tebello, Abrahams, Abubak’r, Tshentu, Zenixole R
- Subject
- To be catalogued
- Date
- 2022
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/300257
- Identifier
- vital:57910
- Identifier
- xlink:href="https://doi.org/10.1002/open.202200037"
- Description
- A novel alternative route to access rhenium(V)−phthalocyanine complexes through direct metalation of metal-free phthalocyanines (H2Pcs) with a rhenium(VII) salt in the presence of various two-electron reducing agents is presented. Direct ion metalation of tetraamino- or tetranitrophthalocyanine with perrhenate (ReO4−) in the presence of triphenylphosphine led to oxidative decomposition of the H2Pcs, giving their respective phthalonitriles. Conversely, treatment of H2Pcs with ReO4− employing sodium metabisulfite yielded the desired ReVO−Pc complex. Finally, reaction of H2Pcs with ReO4− and NaBH4 as reducing agent led to the formation of rhenium oxide (RexOy) nanoparticles (NPs). The NP synthesis was optimised, and the RexOy NPs were capped with folic acid (FA) conjugated with tetraaminophthalocyanine (TAPc) to enhance their cancer cell targeting ability. The cytotoxicity profile of the resultant RexOy−TAPc−FA NPs was assessed and found to be greater than 80 % viability in four cell lines, namely, MDA−MB-231, HCC7, HCC1806 and HEK293T. Non-cytotoxic concentrations were determined and employed in cancer cell localization studies. The particle size effect on localization of NPs was also investigated using confocal fluorescence and transmission electron microscopy. The smaller NPs (≈10 nm) were found to exhibit stronger fluorescence properties than the ≈50 nm NPs and exhibited better cell localization ability than the ≈50 nm NPs.
- Format
- computer, online resource, application/pdf, 1 online resource (13 pages), pdf
- Publisher
- Wiley Library Online
- Language
- English
- Relation
- ChemistryOpen, Ntsimango, S., Gandidzanwa, S., Joseph, S.V., Hosten, E.C., Randall, M., Edkins, A.L., Khene, S.M., Mashazi, P., Nyokong, T., Abrahams, A.R. and Tshentu, Z.R., 2022. Reaction of Perrhenate with Phthalocyanine Derivatives in the Presence of Reducing Agents and Rhenium Oxide Nanoparticles in Biomedical Applications. ChemistryOpen, 11(7), p.e202200037, ChemistryOpen volume 11 number 7 p.e. 202200037 2022 2191-1363
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Creative Commons CC BY 4.0 License (Attribution 4.0 International)https://creativecommons.org/licenses/by/4.0/
- Rights
- Open Access
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Collections
Tshentu, Zenixole Richman (Dr)
Khene, Samson Mielie (Assoc Prof)
Mashazi, Philani N (Associate Prof)
Edkins, Adrienne Lesley (Associate Prof)
RU DST/NRF SARChI for Medicinal Chemistry and Nanotechnology
Nyokong, Tebello (Distinguished Professor)
RU Department of Chemistry
SDG 03. Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details | SOURCE1 | Reaction of Perrhenate with Phthalocyanine Derivatives in the Presence of Reducing Agents.pdf | 9 MB | Adobe Acrobat PDF | View Details |