- Title
- Photodynamic therapy effect of zinc monoamino phthalocyanine–folic acid conjugate adsorbed on single walled carbon nanotubes on melanoma cells
- Creator
- Ogbodu, Racheal O, Ndhundhuma, Ivy, Karsten, Aletta, Nyokong, Tebello
- Type
- Article
- Identifier
- vital:7273
- Identifier
- http://hdl.handle.net/10962/d1020288
- Description
- This work reports on the photodynamic therapy effect of zinc monoamino phthalocyanine linked to folic acid represented as ZnMAPc-FA, which was further immobilized onto single walled carbon nanotube represented as ZnMAPc-FA-SWCNT on melanoma A375 cell line, the effect of SWCNT-FA (without ZnMAPc) was also examined. All the compounds were non-toxic to the melanoma A375 cell line in the absence of light. Upon irradiation of the melanoma A375 cell line with a 676 nm diode laser at a power density of 98 mW/cm2 at 5 J/cm2 about 60% and 63% cell death was observed in the presence of ZnMAPc-FA and ZnMAPc-FA-SWCNT respectively. SWCNT-FA had no significant photodynamic therapy or photothermal effect to the cell, only 23% of cell death was observed after irradiation.
- Description
- Original publication is available at http://dx.doi.org/10.1016/j.saa.2014.09.033
- Format
- 6 p, pdf
- Language
- English
- Relation
- Ogbodu, R. O., Ndhundhuma, I., Karsten, A. & Nyokong, T. 2015. Photodynamic therapy effect of zinc monoamino phthalocyanine–folic acid conjugate adsorbed on single walled carbon nanotubes on melanoma cells. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 137:1120–1125. Available: http://dx.doi.org/10.1016/j.saa.2014.09.033.
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Nyokong, Tebello (Distinguished Professor)