- Title
- Synthesis and trypanocidal activity of substituted 2, 4-diarylquinoline derivatives
- Creator
- Oluwafemi, Kola A, Phunguphungu, Siyolise, Gqunu, Sinalo, Isaacs, Michelle, Hoppe, Heinrich C, Klein, Rosalyn, Kaye, Perry T
- Subject
- To be catalogued
- Date
- 2021
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/477683
- Identifier
- vital:78111
- Identifier
- xlink:href="https://doi.org/10.24820/ark.5550190.p011.499"
- Description
- A small library of nine, novel 2, 4-diarylquinoline derivatives has been prepared in high yield via convenient one-or two-step routes from a series of substituted 2-aminobenzophenones. None of the products exhibited toxicity at 20 μM against human cervix adenocarcinoma (HeLa) cells, while many of them exhibited encouraging trypanocidal activity against T. brucei brucei (a parasite responsible for African cattle trypanosomiasis)-some with IC50 values in the range 2.8–6.2 μM.
- Format
- computer, online resource, application/pdf, 1 online resource (9 pages), pdf
- Publisher
- ARKIVOC
- Language
- English
- Relation
- ARKIVOC, Oluwafemia, K.A., Phunguphungua, S., Gqunua, S., Isaacs, M., Hoppeb, H.C., Klein, R. and Kayea, P.T., 2021. Synthesis and trypanocidal activity of substituted 2, 4-diarylquinoline derivatives. ARKIVOC, 8, pp.277-285, ARKIVOC volume 8 p. 277 2021 1551-7012
- Rights
- Publisher
- Rights
- This paper is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
- Rights
- Open Access
- Hits: 16
- Visitors: 19
- Downloads: 4
Collections
Klein, Rosalyn (Assoc Prof)
Isaacs, Michelle (Mrs)
RU Centre for Chemico- and Biomedicinal Research (CCBR)
Hoppe, Heinrich C (Prof)
Kaye, Perry T (Distinguished Fellow Emeritus Professor)
RU Department of Chemistry
SDG 03. Good Health and Well-Being
RU Department of Biochemistry, Microbiology and Bioinformatics
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Synthesis and trypanocidal activity of substituted 2,4-diarylquinoline derivatives.pdf | 1 MB | Adobe Acrobat PDF | View Details Download |