- Title
- Melatonin protects against copper‐mediated free radical damage
- Creator
- Parmar, Paresh, Limson, Janice L, Nyokong, Tebello, Daya, Santy
- Subject
- To be catalogued
- Date
- 2002
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/289617
- Identifier
- vital:56654
- Identifier
- xlink:href=" https://doi.org/10.1034/j.1600-079X.2002.01859.x"
- Description
- Copper is an essential trace element which forms an integral component of many enzymes. While trace amounts of copper are needed to sustain life, excess copper is extremely toxic. Copper has been implicated in various neurodegenerative disorders, such as Wilson's and Alzheimer's diseases. Previous studies showed that melatonin, the principle secretory product of the pineal gland, binds Cupric chloride (Cu2+) and that this may have implications in copper-induced neurodegenerative diseases. In the present study, in vitro copper-mediated lipid peroxidation was induced. Melatonin (5 mM) protected against copper-mediated lipid peroxidation in liver homogenates. Electron micrographs of in vivo administered Cu2+ and melatonin show that melatonin affords some protection to rat hepatocytes in the presence of copper. Electrochemical studies performed show that melatonin, in addition to binding Cu2+, may provide protection against copper-mediated free radical damage by binding Cu1+. The findings of these studies provide further evidence for the neuroprotective role of melatonin.
- Format
- computer, online resource, application/pdf, 1 online resource (6 pages), pdf
- Publisher
- Wiley Library Online
- Language
- English
- Relation
- Journal of Pineal Research, Parmar, P., Limson, J., Nyokong, T. and Daya, S., 2002. Melatonin protects against copper‐mediated free radical damage. Journal of pineal research, 32(4), pp.237-242, Journal of Pineal Research volume 32 number 4 p. 237 2002 1600-079X
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Wiley Library Online Terms of Use Statement (https://onlinelibrary.wiley.com/terms-and-conditions)
- Rights
- Closed Access
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Collections
Daya, Santylal (Prof)
Limson, Janice (Prof)
Nyokong, Tebello (Distinguished Professor)
RU Department of Chemistry
RU Department of Pharmacy
SDG 09. Industry, Innovation and Infrastructure
SDG 03. Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Melatonin protects against copper‐mediated free radical damage - extra.pdf | 619 KB | Adobe Acrobat PDF | View Details Download |