- Title
- Synthesis of phthalocyanine conjugates with gold nanoparticles and liposomes for photodynamic therapy
- Creator
- Nombona, Nolwazi, Maduray, Kaminee, Antunes, Edith M, Karsten, Aletta, Nyokong, Tebello
- Subject
- To be catalogued
- Date
- 2012
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/245798
- Identifier
- vital:51406
- Identifier
- xlink:href="https://doi.org/10.1016/j.jphotobiol.2011.11.007"
- Description
- The efficiency of [2,9,17,23-tetrakis-(1,6-hexanedithiol)phthalocyaninato]zinc(II) as a photodynamic therapy (PDT) agent was investigated. This compound belongs to the second generation of photosensitizers currently tested for the cellular photo-damage of cancer cells. The production of reactive oxygen species (ROS) and phototoxicity of the photosensitizer were assessed. Healthy fibroblast cells and breast cancer (MCF-7) cells were treated with either free phthalocyanine or phthalocyanine bound to either gold nanoparticles or encapsulated in liposomes. Cell viability studies showed the optimum phototoxic effect on non-malignant cells to be 4.5 J cm−2. The PDT effect of the liposome bound phthalocyanine showed extensive damage of the breast cancer cells. Gold nanoparticles only showed a modest improvement in PDT activity.
- Format
- computer, online resource, application/pdf, 1 online resource (10 pages), pdf
- Publisher
- Elsevier
- Language
- English
- Relation
- Journal of Photochemistry and Photobiology B: Biology, Nombona, N., Maduray, K., Antunes, E., Karsten, A. and Nyokong, T., 2012. Synthesis of phthalocyanine conjugates with gold nanoparticles and liposomes for photodynamic therapy. Journal of Photochemistry and Photobiology B: Biology, 107, pp.35-44, Journal of Photochemistry and Photobiology B: Biology volume 107 p. 35 2015 1011-1344
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
- Rights
- Closed Access
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Antunes, Edith Martins (Dr)
RU DST/NRF SARChI for Medicinal Chemistry and Nanotechnology
Nyokong, Tebello (Distinguished Professor)
RU Department of Chemistry
SDG 03. Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
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| View Details | SOURCE1 | Synthesis of phthalocyanine conjugates with gold nanoparticles and liposomes.pdf | 690 KB | Adobe Acrobat PDF | View Details |