- Title
- The photodynamic antimicrobial chemotherapy of Stapphylococcus aureus using an asymmetrical zinc phthalocyanine conjugated to silver and iron oxide based nanoparticles
- Creator
- Mapukata, Sivuyisiwe, Nwahara, Nnamdi, Nyokong, Tebello
- Subject
- To be catalogued
- Date
- 2020
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/186078
- Identifier
- vital:44461
- Identifier
- xlink:href="https://doi.org/10.1016/j.jphotochem.2020.112813"
- Description
- The synthesis and characterisation of asymmetrical zinc(II) 2(3)-mono-isophthalic acid-9(10),16(17),23 (24)-tri (tert-butylphenoxy) phthalocyanine (complex 4) are reported. The phthalocyanine is conjugated to cysteamine capped silver nanoparticles (Cys-Ag NPs), amine functionalised iron oxide magnetic nanoparticles (NH2-Fe3O4 NPs) and a core-shell composite of the two (Cys-Fe3O4@Ag) via amide bonds. The photo-physico-chemical properties of complex 4 and its respective nanoconjugates (4-Ag, 4-Fe3O4 NPs and 4-Fe3O4@Ag NPs) are also reported. The nanoconjugates showed improved triplet and singlet oxygen quantum yields compared to complex 4. The antibacterial activity of complex 4 and its nanoconjugates were also evaluated on S. aureus wherein their activity was found to be mainly visible light driven with the best catalyst being 4-Fe3O4@Ag. The work therefore demonstrates the feasibility of phthalocyanine-nanoparticle based compounds as potential agents in real life antibacterial treatment
- Format
- computer, online resource, application/pdf, 1 online resource (15 pages), pdf
- Publisher
- Elsevier
- Language
- English
- Relation
- Journal of Photochemistry and Photobiology A: Chemistry, Mapukata, S., Nwahara, N. and Nyokong, T., 2020. The photodynamic antimicrobial chemotherapy of Stapphylococcus aureus using an asymmetrical zinc phthalocyanine conjugated to silver and iron oxide based nanoparticles. Journal of Photochemistry and Photobiology A: Chemistry, 402, p.112813, Journal of Photochemistry and Photobiology A: Chemistry volume 402 p. 112813 2020 1010-6030
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
- Rights
- Closed Access
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RU DST/NRF SARChI for Medicinal Chemistry and Nanotechnology
Nyokong, Tebello (Distinguished Professor)
RU Department of Chemistry
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details | SOURCE1 | The photodynamic antimicrobial chemotherapy of Stapphylococcus aureus.pdf | 854 KB | Adobe Acrobat PDF | View Details |