- Title
- Transformations of manool. Tri-and tetracyclic norditerpenoids with in vitro activity against plasmodium falciparum
- Creator
- van Wyk, Albert W W, Lobb, Kevin A, Mino, Caira R, Hoppe, Heinrich C, Davies-Coleman, Michael T
- Subject
- To be catalogued
- Date
- 2007
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/450511
- Identifier
- vital:74956
- Identifier
- xlink:href="https://doi.org/10.1021/np0701071"
- Description
- The known 17-norisopimar-15-ene-8‚,13‚-diol (5) and five new semisynthetic norditerpenoids, ethyl 17-norabiet-13-(15)-E-en-8‚-ol-16-oate (6), ethyl 17-norabiet-13(15)-Z-en-8‚-ol-16-oate (7), 17-norpimaran-13R-ethoxy-8,16-olactone(8), 17-norisopimarane-8‚,15-diol (9), and 17-norarabiet-13(15)-ene-8‚,16-diol (10), were prepared from manool (11).Standard spectroscopic data including X-ray crystal analysis were used to determine the structures of5-10. All fivecompounds exhibited in Vitroantiplasmodial activity against the malarial parasitePlasmodium falciparumat varyingÌgmL-1concentrations.
- Format
- computer, online resource, application/pdf, 1 online resource (6 pages), pdf
- Publisher
- ACS Publications
- Language
- English
- Relation
- Journal of Natural Products, van Wyk, A.W., Lobb, K.A., Caira, M.R., Hoppe, H.C. and Davies-Coleman, M.T., 2007. Transformations of manool. Tri-and tetracyclic norditerpenoids with in vitro activity against plasmodium falciparum. Journal of natural products, 70(8), pp.1253-1258, Journal of Natural Products volume 70 number 8 p. 1253 2007 1520-6025
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the ACS Publications Terms of Use Statement (https://0-www.acs.org.wam.seals.ac.za/content/acs/en/terms.html)
- Rights
- Closed Access
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- Visitors: 110
- Downloads: 4
Collections
Davies-Coleman, Michael Trevor (Prof)
Lobb, Kevin Allan (Assoc Prof)
Hoppe, Heinrich C (Prof)
RU Department of Chemistry
SDG 03. Good Health and Well-Being
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