- Title
- pH-Dependent release of isoniazid from isonicotinic acid (4-hydroxy-benzylidene)-hydrazide loaded liposomes
- Creator
- Nkanga, Christian I, Tor-Anyiin, Terrumun A, Igoli, John O, Noundou, Xavier S, Krause, Rui W M
- Date
- 2018
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/126427
- Identifier
- vital:35884
- Identifier
- https://doi.org/10.9734/AJOCS/2017/37147
- Description
- Liposomes are considered as potential vehicles for the delivery of anti-tuberculosis drugs (ATBD) due to their rapid uptake by alveolar macrophages, where the mycobacterium often resides. This may provide macrophage-targeting effects that would be key to site specific ATBD delivery using pH-sensitive liposomes, considering the pH-gradient found in the phagocytotic pathway. In this study, isoniazid (INH) was conjugated to 4-hydroxy-benzaldehyde via a hydrazone bond to yield isonicotinic acid (4-hydroxy-benzylidene)-hydrazide (INH-HB). This conjugate was encapsulated in crude soybean lecithin liposomes using film hydration method. INH-HB loaded liposomes (IHL) were characterized by means of dynamic light scattering, transmission electron microscopy, differential scanning calorimetry and X-ray diffraction. The release of INH from IHL was evaluated in media of different pH using a dialysis method. The particle size, Zeta Potential and encapsulation efficiency of IHL were about 945 nm, −62 mV and 89% respectively. In media of pH 7.4, 6.4, 5.4 and 4.4; the IHL exhibited respectively 22, 69, 83 and 100% of release over 12 h. In addition to possible targeted delivery, this pH-dependent release behavior may be suitable for minimizing the loss of INH by leakage from liposomes. The characteristics of IHL are promising for potential site-specific delivery of ATBD.
- Format
- 5 pages, pdf
- Language
- English
- Relation
- Journal of Drug Delivery Science and Technology, Nkanga, C.I., Walker, R.B. and Krause, R.W., 2018. pH-Dependent release of isoniazid from isonicotinic acid (4-hydroxy-benzylidene)-hydrazide loaded liposomes. Journal of Drug Delivery Science and Technology, 45, pp.264-271., Journal of Drug Delivery Science and Technology number 3 number 4 1 5 2018 2456-7795
- Rights
- Journal of Drug Delivery Science and Technology
- Rights
- Use of this resource is governed by the terms and conditions of the Journal of Chemical Sciences Open Access Statement (http://www.sciencedomain.org/journal/55/about-journal)
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