A new indole alkaloid and other constituents from Monodora minor and Uvaria tanzaniae: their antitrypanosomal and antiplasmodial evaluation
- Christopher, Robert, Mgani, Quintino A, Nyandoro, Stephen S, Rousseau, Amanda L, Isaacs, Michelle, Hoppe, Heinrich C
- Authors: Christopher, Robert , Mgani, Quintino A , Nyandoro, Stephen S , Rousseau, Amanda L , Isaacs, Michelle , Hoppe, Heinrich C
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/429347 , vital:72603 , xlink:href="https://doi.org/10.1080/14786419.2019.1710705"
- Description: Phytochemical investigation of the methanolic extract of Monodora minor Engl. and Diels (Annonaceae) stem bark yielded a new indole (E)-4-(1H-indol-5-yl)-but-3-en-2-one (1), a known indole 5-formyl-1H-indole (2) and an ubiquitous steroid sitosterol (3). The investigations of the methanolic extract of Uvaria tanzaniae Verdc. (Annonaceae) root bark yielded two previously reported C-benzylated dihydrochalcones namely uvaretin (4) and diuvaretin (5). Structures of the isolated compounds were elucidated based on NMR spectroscopy and high resolution electron ionization mass spectrometry (HR-EI-MS) data. All compounds were tested against Trypanosoma brucei brucei and Plasmodium falciparum. At a single concentration (20 μM) in the antitrypanosomal and antiplasmodial assays, compound 4 exhibited remarkable activities against T. brucei brucei and P. falciparum with percentage inhibition of 97.3% and 83.0% respectively, whereas compounds 1, 2, 3 and 5 were inactive. In a dose response antiplasmodial assay compound 4 exhibited moderate activity against P. falciparum with an IC50 value of 7.20 μM.
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- Authors: Christopher, Robert , Mgani, Quintino A , Nyandoro, Stephen S , Rousseau, Amanda L , Isaacs, Michelle , Hoppe, Heinrich C
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/429347 , vital:72603 , xlink:href="https://doi.org/10.1080/14786419.2019.1710705"
- Description: Phytochemical investigation of the methanolic extract of Monodora minor Engl. and Diels (Annonaceae) stem bark yielded a new indole (E)-4-(1H-indol-5-yl)-but-3-en-2-one (1), a known indole 5-formyl-1H-indole (2) and an ubiquitous steroid sitosterol (3). The investigations of the methanolic extract of Uvaria tanzaniae Verdc. (Annonaceae) root bark yielded two previously reported C-benzylated dihydrochalcones namely uvaretin (4) and diuvaretin (5). Structures of the isolated compounds were elucidated based on NMR spectroscopy and high resolution electron ionization mass spectrometry (HR-EI-MS) data. All compounds were tested against Trypanosoma brucei brucei and Plasmodium falciparum. At a single concentration (20 μM) in the antitrypanosomal and antiplasmodial assays, compound 4 exhibited remarkable activities against T. brucei brucei and P. falciparum with percentage inhibition of 97.3% and 83.0% respectively, whereas compounds 1, 2, 3 and 5 were inactive. In a dose response antiplasmodial assay compound 4 exhibited moderate activity against P. falciparum with an IC50 value of 7.20 μM.
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A novel dimeric exoglucanase (GH5_38)
- Mafa, Mpho S, Dirr, Heinrich W, Malgas, Samkelo, Krause, Rui W M, Pletschke, Brett I
- Authors: Mafa, Mpho S , Dirr, Heinrich W , Malgas, Samkelo , Krause, Rui W M , Pletschke, Brett I
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/193976 , vital:45412 , xlink:href="https://doi.org/10.3390/molecules25030746"
- Description: An exoglucanase (Exg-D) from the glycoside hydrolase family 5 subfamily 38 (GH5_38) was heterologously expressed and structurally and biochemically characterised at a molecular level for its application in alkyl glycoside synthesis. The purified Exg-D existed in both dimeric and monomeric forms in solution, which showed highest activity on mixed-linked β-glucan (88.0 and 86.7 U/mg protein, respectively) and lichenin (24.5 and 23.7 U/mg protein, respectively). They displayed a broad optimum pH range from 5.5 to 7 and a temperature optimum from 40 to 60 °C. Kinetic studies demonstrated that Exg-D had a higher affinity towards β-glucan, with a Km of 7.9 mg/mL and a kcat of 117.2 s−1, compared to lichenin which had a Km of 21.5 mg/mL and a kcat of 70.0 s−1. The circular dichroism profile of Exg-D showed that its secondary structure consisted of 11% α-helices, 36% β-strands and 53% coils. Exg-D performed transglycosylation using p-nitrophenyl cellobioside as a glycosyl donor and several primary alcohols as acceptors to produce methyl-, ethyl- and propyl-cellobiosides. These products were identified and quantified via thin-layer chromatography (TLC) and liquid chromatography–mass spectrometry (LC-MS). We concluded that Exg-D is a novel and promising oligomeric glycoside hydrolase for the one-step synthesis of alkyl glycosides with more than one monosaccharide unit.
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- Authors: Mafa, Mpho S , Dirr, Heinrich W , Malgas, Samkelo , Krause, Rui W M , Pletschke, Brett I
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/193976 , vital:45412 , xlink:href="https://doi.org/10.3390/molecules25030746"
- Description: An exoglucanase (Exg-D) from the glycoside hydrolase family 5 subfamily 38 (GH5_38) was heterologously expressed and structurally and biochemically characterised at a molecular level for its application in alkyl glycoside synthesis. The purified Exg-D existed in both dimeric and monomeric forms in solution, which showed highest activity on mixed-linked β-glucan (88.0 and 86.7 U/mg protein, respectively) and lichenin (24.5 and 23.7 U/mg protein, respectively). They displayed a broad optimum pH range from 5.5 to 7 and a temperature optimum from 40 to 60 °C. Kinetic studies demonstrated that Exg-D had a higher affinity towards β-glucan, with a Km of 7.9 mg/mL and a kcat of 117.2 s−1, compared to lichenin which had a Km of 21.5 mg/mL and a kcat of 70.0 s−1. The circular dichroism profile of Exg-D showed that its secondary structure consisted of 11% α-helices, 36% β-strands and 53% coils. Exg-D performed transglycosylation using p-nitrophenyl cellobioside as a glycosyl donor and several primary alcohols as acceptors to produce methyl-, ethyl- and propyl-cellobiosides. These products were identified and quantified via thin-layer chromatography (TLC) and liquid chromatography–mass spectrometry (LC-MS). We concluded that Exg-D is a novel and promising oligomeric glycoside hydrolase for the one-step synthesis of alkyl glycosides with more than one monosaccharide unit.
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A novel gold (I)-mediated intramolecular transamidation of benzoyl thiourea derivatives to form benzamides via dethiocyanation
- Odame, Felix, Woodcock, Guillaume, Hosten, Eric C, Lobb, Kevin A, Tshentu, Zenixole R
- Authors: Odame, Felix , Woodcock, Guillaume , Hosten, Eric C , Lobb, Kevin A , Tshentu, Zenixole R
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/446988 , vital:74575 , xlink:href="https://doi.org/10.1016/j.jorganchem.2020.121359"
- Description: A novel gold(I)-mediated intramolecular transamidation of thiourea derivatives to yield benzamides via dethiocyanation have been achieved by the reaction of 3-(1,3-benzothiazol-2-yl)-1-(benzoyl)thiourea derivatives in the presence of gold(I) precursors. The compounds have been characterized using IR, NMR, GC-MS and microanalysis. The single crystal XRD of 3-(1,3-benzothiazol-2-yl)-1-(3-bromobenzoyl)thiourea (5), 3-(1,3-benzothiazol-2-yl)-1-(3-methoxybenzoyl)thiourea (6), N-(benzothiazol-2-yl)benzamide (10), N-(benzothiazol-2-yl)-3-chlorobenzamide (11), N-(benzothiazol-2-yl)-4-nitrobenzamide (12), N-(benzothiazol-2-yl)-3-bromobenzamide (14) have been discussed. The novel transformation is thought to proceed by a gold(I)-mediated intramolecular transamidation reaction which releases thiocyanate to yield the benzamide. Density functional theory calculations have been used to support the proposed mechanism for this transformation.
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- Authors: Odame, Felix , Woodcock, Guillaume , Hosten, Eric C , Lobb, Kevin A , Tshentu, Zenixole R
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/446988 , vital:74575 , xlink:href="https://doi.org/10.1016/j.jorganchem.2020.121359"
- Description: A novel gold(I)-mediated intramolecular transamidation of thiourea derivatives to yield benzamides via dethiocyanation have been achieved by the reaction of 3-(1,3-benzothiazol-2-yl)-1-(benzoyl)thiourea derivatives in the presence of gold(I) precursors. The compounds have been characterized using IR, NMR, GC-MS and microanalysis. The single crystal XRD of 3-(1,3-benzothiazol-2-yl)-1-(3-bromobenzoyl)thiourea (5), 3-(1,3-benzothiazol-2-yl)-1-(3-methoxybenzoyl)thiourea (6), N-(benzothiazol-2-yl)benzamide (10), N-(benzothiazol-2-yl)-3-chlorobenzamide (11), N-(benzothiazol-2-yl)-4-nitrobenzamide (12), N-(benzothiazol-2-yl)-3-bromobenzamide (14) have been discussed. The novel transformation is thought to proceed by a gold(I)-mediated intramolecular transamidation reaction which releases thiocyanate to yield the benzamide. Density functional theory calculations have been used to support the proposed mechanism for this transformation.
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A novel, improved throughput bioassay for determining the delative speed of antimalarial drug action using fluorescent vitality probes
- Authors: Laming, Dustin
- Date: 2020
- Subjects: Plasmodium falciparum , Malaria -- Treatment -- Africa , Antimalarials , Malaria vaccine
- Language: English
- Type: text , Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/139902 , vital:37810
- Description: Malaria is one of the most prevalent diseases in Africa and Plasmodium falciparum is widely accepted as the most virulent of the malaria parasite species, with a fatality rate of 15 – 20 % of reported cases of infection. While various treatments have been accepted into early stage clinical trials, there has been little progress towards a proven vaccine. Pending a long-term solution, endemic countries rely heavily on the development of innovative drugs that are not only efficacious but are also quick acting. Traditional methods of evaluating antimalarial killing speeds via morphological assessments are inherently flawed by tedious, subjective interpretations of the heterogenous parasite morphology encountered in routine parasite culture conditions. This has led to the introduction of alternative assay formats to determine how rapidly compounds act on parasites in vitro: a parasite reduction ratio (PRR) assay that measures the recovery of parasite cultures from drug exposure; determining the shift in IC50 values of compounds when dose-response assays are carried out for different time periods; a bioluminescence relative rate of kill (BRRoK) assay that compares the extent to which compounds reduce firefly luciferase activity in transgenic parasites. Recent whole cell in vitro screening efforts have resulted in the generation of chemically diverse compound libraries such as the Medicines for Malaria Venture’s Pathogen Box, which houses 125 novel compounds with in vitro antiplasmodial activity. Assessing the relative killing speeds of these compounds would aid prioritizing fast-acting compounds that can be exploited as starting points for further development. This study aimed to develop a bioassay using the calcein-acetoxymethyl and propidium iodide fluorescent vitality probes, which would allow the relative speed of drug action on Plasmodium falciparum malaria parasites to be assessed and ranked in relation to each other using a quantitative, improved throughput approach. Initially applied to human (HeLa) cells, the assay was used to compare the relative speeds of action of 3 potential anti-cancer compounds by fluorescence microscopy. Subsequently adapted to P. falciparum, the assay was able to rank the relative speeds of action of standard antimalarials by fluorescence microscopy and two flow cytometry formats. Application of a multiwell flow cytometer increased throughput and enabled the assessment of experimental compounds, which included a set of artemisinin analogs and 125 antimalarial compounds in the MMV Pathogen Box. The latter culminated in the identification of five rapidly parasiticidal compounds in relation to the other compounds in the library, which may act as benchmark references for future studies and form the basis of the next generation of fast acting antimalarials that could be used to combat modern, resistant malaria.
- Full Text:
- Authors: Laming, Dustin
- Date: 2020
- Subjects: Plasmodium falciparum , Malaria -- Treatment -- Africa , Antimalarials , Malaria vaccine
- Language: English
- Type: text , Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/139902 , vital:37810
- Description: Malaria is one of the most prevalent diseases in Africa and Plasmodium falciparum is widely accepted as the most virulent of the malaria parasite species, with a fatality rate of 15 – 20 % of reported cases of infection. While various treatments have been accepted into early stage clinical trials, there has been little progress towards a proven vaccine. Pending a long-term solution, endemic countries rely heavily on the development of innovative drugs that are not only efficacious but are also quick acting. Traditional methods of evaluating antimalarial killing speeds via morphological assessments are inherently flawed by tedious, subjective interpretations of the heterogenous parasite morphology encountered in routine parasite culture conditions. This has led to the introduction of alternative assay formats to determine how rapidly compounds act on parasites in vitro: a parasite reduction ratio (PRR) assay that measures the recovery of parasite cultures from drug exposure; determining the shift in IC50 values of compounds when dose-response assays are carried out for different time periods; a bioluminescence relative rate of kill (BRRoK) assay that compares the extent to which compounds reduce firefly luciferase activity in transgenic parasites. Recent whole cell in vitro screening efforts have resulted in the generation of chemically diverse compound libraries such as the Medicines for Malaria Venture’s Pathogen Box, which houses 125 novel compounds with in vitro antiplasmodial activity. Assessing the relative killing speeds of these compounds would aid prioritizing fast-acting compounds that can be exploited as starting points for further development. This study aimed to develop a bioassay using the calcein-acetoxymethyl and propidium iodide fluorescent vitality probes, which would allow the relative speed of drug action on Plasmodium falciparum malaria parasites to be assessed and ranked in relation to each other using a quantitative, improved throughput approach. Initially applied to human (HeLa) cells, the assay was used to compare the relative speeds of action of 3 potential anti-cancer compounds by fluorescence microscopy. Subsequently adapted to P. falciparum, the assay was able to rank the relative speeds of action of standard antimalarials by fluorescence microscopy and two flow cytometry formats. Application of a multiwell flow cytometer increased throughput and enabled the assessment of experimental compounds, which included a set of artemisinin analogs and 125 antimalarial compounds in the MMV Pathogen Box. The latter culminated in the identification of five rapidly parasiticidal compounds in relation to the other compounds in the library, which may act as benchmark references for future studies and form the basis of the next generation of fast acting antimalarials that could be used to combat modern, resistant malaria.
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A personality-based surveillance model for Facebook apps
- Authors: Van der Schyff, Karl Izak
- Date: 2020
- Subjects: Facebook (Electronic resource) , Electronic surveillance -- Psychological aspects , Online social networks -- Psychological aspects , Social media -- Psychological aspects , Personality
- Language: English
- Type: text , Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/145534 , vital:38447
- Description: The surveillance of data through the use of Facebook Apps is an ongoing and persistent problem that impacts millions of users. Nonetheless, limited research has been conducted investigating to what extent a Facebook user’s personality influences their awareness of such surveillance practices. Thus, to understand this situation better, the current study inductively developed four propositions from secondary data sources as part of a detailed content analysis. Spanning three search and analysis phases the content analysis led to the development of the research model. Guided by the propositions and research questions, a questionnaire was developed based on the relevant constructs prescribed by the Theory of Planned Behaviour. This questionnaire was used, and a total of 651 responses were collected from Facebook users over the age of 18 years old and residing in the United States of America. Primary data took place at both a univariate and multivariate level with a specific focus on the development of a structural model. Interpretation of the structural model revealed that out of all the Big Five personality traits, Conscientiousness exhibited the strongest relationship with information security awareness followed by Openness to Experience and Neuroticism, respectively. The results further indicated that the model constructs based on attitude, social norms and awareness significantly influenced the intended use of Facebook Apps. The study also contributes by indicating which personality traits are most vulnerable to Facebook App surveillance. For example, it was found that individuals high in Conscientiousness are the least vulnerable with individuals high in Extraversion being the most vulnerable. Since the results indicate that not all the personality traits are significantly related to the model constructs, additional factors may contribute to App surveillance in this context. Concerning this, factors such as user apathy, information privacy, privacy concerns, control and Facebook dependency are discussed as a means to argue why this might be the case.
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- Authors: Van der Schyff, Karl Izak
- Date: 2020
- Subjects: Facebook (Electronic resource) , Electronic surveillance -- Psychological aspects , Online social networks -- Psychological aspects , Social media -- Psychological aspects , Personality
- Language: English
- Type: text , Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/145534 , vital:38447
- Description: The surveillance of data through the use of Facebook Apps is an ongoing and persistent problem that impacts millions of users. Nonetheless, limited research has been conducted investigating to what extent a Facebook user’s personality influences their awareness of such surveillance practices. Thus, to understand this situation better, the current study inductively developed four propositions from secondary data sources as part of a detailed content analysis. Spanning three search and analysis phases the content analysis led to the development of the research model. Guided by the propositions and research questions, a questionnaire was developed based on the relevant constructs prescribed by the Theory of Planned Behaviour. This questionnaire was used, and a total of 651 responses were collected from Facebook users over the age of 18 years old and residing in the United States of America. Primary data took place at both a univariate and multivariate level with a specific focus on the development of a structural model. Interpretation of the structural model revealed that out of all the Big Five personality traits, Conscientiousness exhibited the strongest relationship with information security awareness followed by Openness to Experience and Neuroticism, respectively. The results further indicated that the model constructs based on attitude, social norms and awareness significantly influenced the intended use of Facebook Apps. The study also contributes by indicating which personality traits are most vulnerable to Facebook App surveillance. For example, it was found that individuals high in Conscientiousness are the least vulnerable with individuals high in Extraversion being the most vulnerable. Since the results indicate that not all the personality traits are significantly related to the model constructs, additional factors may contribute to App surveillance in this context. Concerning this, factors such as user apathy, information privacy, privacy concerns, control and Facebook dependency are discussed as a means to argue why this might be the case.
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A q-metholological approach to audience reception of public awareness messages on sexual violence
- Authors: Bennie, Rachel
- Date: 2020
- Subjects: Psychology -- Research -- Methodology , Psychology -- Research , Communication in social action -- South Africa , Psychology -- Research -- South Africa , Women -- Violence against -- South Africa , Women -- Violence against -- South Africa -- Prevention
- Language: English
- Type: text , Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10962/140805 , vital:37920
- Description: Public awareness poster campaigns are an often-used method for raising awareness about, and engaging audiences on the topic of rape and other forms of sexual violence (Potter, 2012). However, poster campaigns, as social artefacts, operate in a public arena in which numerous discourses about a phenomenon are produced, reproduced and interact with each other, with sometimes unintended/unanticipated discursive consequences (Böhmke, Bennie, Minnie, Moore, Pilusa & Pollock, 2015). How messages aimed at raising awareness of sexual violence are framed has the potential to reproduce dominant social narratives and gendered subject positions in ways that reinforce notions of men as active sexual agents and potential perpetrators, and women as sexually passive and potential victims (Gavey, 2005). Other approaches, such as bystander intervention, seek to move away from a focus on victims and perpetrators to emphasise the role that community members can play in risk detection, safety promotion and the prevention of sexual violence (McMahon & Banyard, 2012). Since a range of possible messages about sexual violence can be communicated through poster campaigns, it is important to critically examine the content and orientation of campaign material. This study focused on intended audience views regarding messages about sexual violence contained in anti-sexual violence poster materials. The purpose was to collaborate with a selected audience to better understand which messages are effective and which strategies of communication are perceived to be less so. Through the use of Q-methodology, volunteer participants were invited to express their opinions in relation to messages about sexual violence from a range of posters from several international campaigns. The analysis focused on uncovering the discursive subject positions that participants’ express in their attitudinal responses to the poster messages, providing not only a description of these positions, but also illustrating the level of resonance that the poster messages may find with intended audiences. The aim of the study is to potentially inform the development of more focused campaign material, tailored to the specific context from which participants were drawn. Analysis shows clear patterns of audience resistance towards stereotypical representations of sexual violence and messages that are geared towards the simple prohibition of behaviours. The findings highlight the need for the development of alternative strategies of engagement that focus on specific engagement with understandings of sexual violence in the context of intimate and/or acquaintance relationships and which are aimed at inviting audiences to take up a position in relation to sexual violence phenomena that troubles the reproduction of received notions of gendered subjectivities and (hetero) sexuality
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- Authors: Bennie, Rachel
- Date: 2020
- Subjects: Psychology -- Research -- Methodology , Psychology -- Research , Communication in social action -- South Africa , Psychology -- Research -- South Africa , Women -- Violence against -- South Africa , Women -- Violence against -- South Africa -- Prevention
- Language: English
- Type: text , Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10962/140805 , vital:37920
- Description: Public awareness poster campaigns are an often-used method for raising awareness about, and engaging audiences on the topic of rape and other forms of sexual violence (Potter, 2012). However, poster campaigns, as social artefacts, operate in a public arena in which numerous discourses about a phenomenon are produced, reproduced and interact with each other, with sometimes unintended/unanticipated discursive consequences (Böhmke, Bennie, Minnie, Moore, Pilusa & Pollock, 2015). How messages aimed at raising awareness of sexual violence are framed has the potential to reproduce dominant social narratives and gendered subject positions in ways that reinforce notions of men as active sexual agents and potential perpetrators, and women as sexually passive and potential victims (Gavey, 2005). Other approaches, such as bystander intervention, seek to move away from a focus on victims and perpetrators to emphasise the role that community members can play in risk detection, safety promotion and the prevention of sexual violence (McMahon & Banyard, 2012). Since a range of possible messages about sexual violence can be communicated through poster campaigns, it is important to critically examine the content and orientation of campaign material. This study focused on intended audience views regarding messages about sexual violence contained in anti-sexual violence poster materials. The purpose was to collaborate with a selected audience to better understand which messages are effective and which strategies of communication are perceived to be less so. Through the use of Q-methodology, volunteer participants were invited to express their opinions in relation to messages about sexual violence from a range of posters from several international campaigns. The analysis focused on uncovering the discursive subject positions that participants’ express in their attitudinal responses to the poster messages, providing not only a description of these positions, but also illustrating the level of resonance that the poster messages may find with intended audiences. The aim of the study is to potentially inform the development of more focused campaign material, tailored to the specific context from which participants were drawn. Analysis shows clear patterns of audience resistance towards stereotypical representations of sexual violence and messages that are geared towards the simple prohibition of behaviours. The findings highlight the need for the development of alternative strategies of engagement that focus on specific engagement with understandings of sexual violence in the context of intimate and/or acquaintance relationships and which are aimed at inviting audiences to take up a position in relation to sexual violence phenomena that troubles the reproduction of received notions of gendered subjectivities and (hetero) sexuality
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A reappraisal of the origin of the Hotazel Fe-Mn Formation in an evolving early Earth system through the application of mineral-specific geochemistry, speciation techniques and stable isotope systematics
- Authors: Mhlanga, Xolane Reginald
- Date: 2020
- Subjects: Manganese ores -- South Africa -- Hotazel , Manganese ores -- Geology , Iron ores -- South Africa -- Hotazel , Iron ores -- Geology , Geochemistry -- South Africa -- Hotazel , Isotope geology -- South Africa -- Hotazel , Geology, Stratigraphic -- Archaean , Geology, Stratigraphic -- Proterozoic , Transvaal Supergroup (South Africa) , Great Oxidation Event
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/146123 , vital:38497
- Description: Marine chemical sediments such as Banded Iron Formations deposited during the Archean-Palaeoproterozoic are studied extensively because they represent a period in the development of the Earth’s early history where the atmospheric O₂ content was below the present levels (PAL) of 21%. Prior to the Great Oxidation Event (GOE) at ca. 2.4 Ga, highly ferruginous and anoxic marine environments were dominated by extensive BIF deposition such as that of the Griqualand West Basin of the Transvaal Supergroup in South Africa. This basin is also thought to record the transition into the first rise of atmospheric O₂ in our planet, from the Koegas Subgroup to the Hotazel Formation dated at ca. 2.43 Ga (Gumsley et al., 2017). Two drill cores from the north eastern part of the Kalahari Manganese Field characterized by a well-preserved and complete intersection of the cyclic Mn-Fe Hotazel Formation were studied at a high resolution (sampled at approximately one-meter interval). Such high-resolution approach is being employed for the first time in this project, capturing in detail the three manganese rich layers intercalated with BIF and the transitions between these lithofacies. The micro-banded BIF is made up of three major phases, namely Fe-Ca-Mg carbonates (ankerite, siderite and calcite), magnetite, and silicates (chert and minor Fe-silicates); laminated transitional lutite consist of mainly hematite, chert and Mn-carbonates, whereas the manganese ore layers are made up of mostly calcic carbonates (Mn-calcite and Ca-kutnahorite) in the form of laminations and ovoids, while Mn-silicates include dominant braunite and lesser friedelite. All three lithofacies are very fine grained (sub-mm scale) and so petrographic and mineralogical observations were obtained mostly through scanning electron microscope analysis for detailed textural relationships with focus on the carbonate fraction. Bulk geochemical studies of the entire stratigraphy of the Hotazel Formation have previously provided great insights into the cyclic nature of the deposit but have not adequately considered the potential of the carbonate fraction of the rocks as a valuable proxy for understanding the chemistry of the primary depositional environment and insights into the redox processes that were at play. This is because these carbonates have always been attributed to diagenetic processes below the sediment-water interface such as microbially-mediated dissimilatory iron/manganese reduction (DIR/DMR) where the precursor/primary Fe-Mn oxyhydroxides have been reduced to result in the minerals observed today. The carbonate fraction of the BIF is made up of ankerite and siderite which co-exist in a chert matrix as anhedral to subhedral grains with no apparent replacement textures. This suggests co-precipitation of the two species which is at apparent odds with classic diagenetic models. Similarly, Mn-carbonates in the hematite lutite and manganese ore (Mn-calcite, kutnahorite, and minor rhodocrosite) co-exist in laminae and ovoids with no textures observed that would suggest an obvious sequential mode of formation during diagenesis. In this light, a carbonate-specific geochemical analysis based on the sequential Fe extraction technique of Poulton and Canfield (2005) was employed to decipher further the cyclic nature of the Hotazel Formation and its primary versus diagenetic controls. Results from the carbonate fraction analysis of the three lithofacies show a clear fractionation of iron and manganese during primary – rather than diagenetic - carbonate precipitation, suggesting a decoupling between DIR and DMR which is ultimately interpreted to have taken place in the water column. Bulk-rock concentration results for minor and trace elements such as Zr, Ti, Sc and Al have been used for the determination of either siliciclastic or volcanic detrital inputs as they are generally immobile in most natural aqueous solutions. These elements are in very low concentrations in all three lithofacies suggesting that the depositional environment had vanishingly small contributions from terrigenous or volcanic detritus. In terms of redox-sensitive transition metals, only Mo and Co appear to show an affinity for high Mn facies in the Hotazel sequence. Cobalt in particular attains a very low abundance in the Hotazel BIF layers at an average of ~ 4 ppm. This is similar to average pre-GOE BIF in South Africa and worldwide. Maxima in Co abundance are associated with transitional hematite lutite and Mn ore layers, but maxima over 100ppm are seen in within the hematite lutite and not within the Mn ore proper where maxima in Mn are recorded. This suggests a clear and direct association with the hematite fraction in the rocks, which is modally much higher in the lutites but drops substantially in the Mn layers themselves. The similarities of bulk-rock BIF and modern-day seawater REE patterns has been used as a key argument for primary controls in REE behaviour and minimal diagenetic modification. Likewise, the three lithofacies of the Hotazel Formation analysed in this study all share similar characteristics with a clear seawater signal through gentle positive slopes in the normalised abundance of LREE versus HREE. Negative Ce anomalies prevail in the entire sample set analysed, which has been interpreted before as a proxy for oxic seawater conditions. However, positive Ce anomalies that are traditionally linked to scavenging and deposition of primary tetravalent Mn oxyhydroxides (e.g., as observed in modern day ferromanganese nodules) are completely absent from the current dataset. The lack of a positive Ce anomaly in the manganese ore and peak Co association with ferric oxides and not with peak Mn, suggests that primary deposition must have occurred within an environment that was not fully oxidizing with respect to manganese. The use of stable isotopes (i.e., C and Fe) was employed to gain insights into redox processes, whether these are thought to have happened below the sediment-water interface or in contemporaneous seawater. At a small scale, all lithofacies of the Hotazel Formation record bulk-rock δ¹³C values that are low and essentially invariant about the average value of -9.5 per mil. This is independent of sharp variations in overall modal mineralogy, relative carbonate abundance and carbonate chemistry, which is clearly difficult to reconcile with in-situ diagenetic processes that predict highly variable δ¹³C signals in response to complex combinations of precursor sediment mineralogy, pore-fluid chemistry, organic carbon supply and open vs closed system diagenesis. At a stratigraphic scale, the carbonate δ¹³C (-5 to -13‰) variations between the different lithologies could instead represent temporal changes in water-column chemistry against well-developed physico-chemical gradients, depth of deposition and biological processes. The low iron isotope values recorded in the hematite lutite and manganese ore samples can be attributed to fractionation effects of initial oxidation of ferrous iron to form Fe-oxyhydroxides in the shallow parts of the basin, from an already isotopically highly depleted aqueous Fe-pool as proposed previously. The slightly higher but still negative bulk-rock δ⁵⁶Fe values of the host BIF can be attributed to water-column Fe isotopic effects at deeper levels between primary Fe oxyhydroxides and an isotopically heavier Fe(II) pool, which was subsequently preserved during diagenetic recrystallization. All above findings were combined into a conceptual model of deposition for the three different lithologies of the Hotazel Formation. The model predicts that free molecular oxygen must have been present within the shallow oceanic environment and implicates both Mn and Fe as active redox “players” compared to classic models that apply to the origin of worldwide BIF prior to the GOE. The deposition of the Hotazel strata is interpreted to have occurred through the following three stages: (1) BIF deposition occurred in a relatively deep oceanic environment above the Ongeluk lavas during marine transgression, where a redoxcline and seawater stratification separated hydrothermally sourced iron and manganese, in response to an active Mn-shuttle mechanism linked to Mn redox cycling. Abundant ferrous iron must have been oxidized by available oxygen but also by oxidised Mn species (MnOOH) and possibly even some soluble Mn(III) complexes. Through this process, Mn(III) was being effectively reduced back into solution along with cobalt(III), as Mn(II) and Co(II) respectively, thus creating maxima in their concentrations. A drawdown of Fe(OH)₃ particles was therefore the only net precipitation mechanism at this stage. Carbonate species of Fe and the abundant magnetite would possibly have formed by reaction between the ferric hydroxides and the deeper Fe(II) pool, while organic matter would also have reacted in the water-column via DIR, accounting for the low δ¹³C signature of Fe carbonate minerals. (2) Hematite lutite formation would have occurred at a relatively shallower environment during marine regression. At this stage, reductive cycling of Fe was minimal in the absence of a deeper Fe(II) reservoir reacting with the ferric primary precipitates. Therefore, DIR progressively gave way to manganese reduction and organic carbon oxidation (DMR), which reduced MnOOH to form Mn(II)-rich carbonates in the form of kutnahorite and Mn-calcite. Co-bearing Fe(OH)₃ would have precipitated and was ultimately preserved as Co-bearing hematite during diagenesis. (3) Deposition of manganese-rich sediment occurred at even shallower oceanic depths (maximum regression) where aerobic organic carbon oxidation replaced DMR, resulting in Ca-rich carbonates such as Mn-bearing calcite and Ca-kutnahorite, yet with a low carbon isotope signature recording aerobic conditions of organic carbon cycling. Mn(III) reduction at this stage was curtailed, leading to massive precipitation of MnOOH which was diagenetically transformed into braunite and friedelite. Simultaneous precipitation of Co-bearing Fe(OH)₃ would have continued but at much more subdued rates. Repeated transgressive-regressive cycles resulted in the cyclic BIF-hematite lutite- manganese ore nature of the Hotazel Formation in an oxidized oceanic environment at the onset of the Great Oxidation Event, which was nonetheless never oxic enough to drive Mn(II) oxidation fully to its tetravalent state. The mineralogy and species-specific geochemistry of the Hotazel strata, and more specifically the carbonate fraction thereof, appear to faithfully capture the chemistry of the primary depositional environment in a progressively evolving Earth System. This project opens the door for more studies focusing on better constraining primary versus diagenetic depositional 2020 Hotazel Fe and Mn deposition mechanisms of iron and manganese during the period leading up to the GOE, and possibly re-defining the significance of Fe and Mn as invaluable redox proxies in a rapidly changing planet.
- Full Text:
- Authors: Mhlanga, Xolane Reginald
- Date: 2020
- Subjects: Manganese ores -- South Africa -- Hotazel , Manganese ores -- Geology , Iron ores -- South Africa -- Hotazel , Iron ores -- Geology , Geochemistry -- South Africa -- Hotazel , Isotope geology -- South Africa -- Hotazel , Geology, Stratigraphic -- Archaean , Geology, Stratigraphic -- Proterozoic , Transvaal Supergroup (South Africa) , Great Oxidation Event
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/146123 , vital:38497
- Description: Marine chemical sediments such as Banded Iron Formations deposited during the Archean-Palaeoproterozoic are studied extensively because they represent a period in the development of the Earth’s early history where the atmospheric O₂ content was below the present levels (PAL) of 21%. Prior to the Great Oxidation Event (GOE) at ca. 2.4 Ga, highly ferruginous and anoxic marine environments were dominated by extensive BIF deposition such as that of the Griqualand West Basin of the Transvaal Supergroup in South Africa. This basin is also thought to record the transition into the first rise of atmospheric O₂ in our planet, from the Koegas Subgroup to the Hotazel Formation dated at ca. 2.43 Ga (Gumsley et al., 2017). Two drill cores from the north eastern part of the Kalahari Manganese Field characterized by a well-preserved and complete intersection of the cyclic Mn-Fe Hotazel Formation were studied at a high resolution (sampled at approximately one-meter interval). Such high-resolution approach is being employed for the first time in this project, capturing in detail the three manganese rich layers intercalated with BIF and the transitions between these lithofacies. The micro-banded BIF is made up of three major phases, namely Fe-Ca-Mg carbonates (ankerite, siderite and calcite), magnetite, and silicates (chert and minor Fe-silicates); laminated transitional lutite consist of mainly hematite, chert and Mn-carbonates, whereas the manganese ore layers are made up of mostly calcic carbonates (Mn-calcite and Ca-kutnahorite) in the form of laminations and ovoids, while Mn-silicates include dominant braunite and lesser friedelite. All three lithofacies are very fine grained (sub-mm scale) and so petrographic and mineralogical observations were obtained mostly through scanning electron microscope analysis for detailed textural relationships with focus on the carbonate fraction. Bulk geochemical studies of the entire stratigraphy of the Hotazel Formation have previously provided great insights into the cyclic nature of the deposit but have not adequately considered the potential of the carbonate fraction of the rocks as a valuable proxy for understanding the chemistry of the primary depositional environment and insights into the redox processes that were at play. This is because these carbonates have always been attributed to diagenetic processes below the sediment-water interface such as microbially-mediated dissimilatory iron/manganese reduction (DIR/DMR) where the precursor/primary Fe-Mn oxyhydroxides have been reduced to result in the minerals observed today. The carbonate fraction of the BIF is made up of ankerite and siderite which co-exist in a chert matrix as anhedral to subhedral grains with no apparent replacement textures. This suggests co-precipitation of the two species which is at apparent odds with classic diagenetic models. Similarly, Mn-carbonates in the hematite lutite and manganese ore (Mn-calcite, kutnahorite, and minor rhodocrosite) co-exist in laminae and ovoids with no textures observed that would suggest an obvious sequential mode of formation during diagenesis. In this light, a carbonate-specific geochemical analysis based on the sequential Fe extraction technique of Poulton and Canfield (2005) was employed to decipher further the cyclic nature of the Hotazel Formation and its primary versus diagenetic controls. Results from the carbonate fraction analysis of the three lithofacies show a clear fractionation of iron and manganese during primary – rather than diagenetic - carbonate precipitation, suggesting a decoupling between DIR and DMR which is ultimately interpreted to have taken place in the water column. Bulk-rock concentration results for minor and trace elements such as Zr, Ti, Sc and Al have been used for the determination of either siliciclastic or volcanic detrital inputs as they are generally immobile in most natural aqueous solutions. These elements are in very low concentrations in all three lithofacies suggesting that the depositional environment had vanishingly small contributions from terrigenous or volcanic detritus. In terms of redox-sensitive transition metals, only Mo and Co appear to show an affinity for high Mn facies in the Hotazel sequence. Cobalt in particular attains a very low abundance in the Hotazel BIF layers at an average of ~ 4 ppm. This is similar to average pre-GOE BIF in South Africa and worldwide. Maxima in Co abundance are associated with transitional hematite lutite and Mn ore layers, but maxima over 100ppm are seen in within the hematite lutite and not within the Mn ore proper where maxima in Mn are recorded. This suggests a clear and direct association with the hematite fraction in the rocks, which is modally much higher in the lutites but drops substantially in the Mn layers themselves. The similarities of bulk-rock BIF and modern-day seawater REE patterns has been used as a key argument for primary controls in REE behaviour and minimal diagenetic modification. Likewise, the three lithofacies of the Hotazel Formation analysed in this study all share similar characteristics with a clear seawater signal through gentle positive slopes in the normalised abundance of LREE versus HREE. Negative Ce anomalies prevail in the entire sample set analysed, which has been interpreted before as a proxy for oxic seawater conditions. However, positive Ce anomalies that are traditionally linked to scavenging and deposition of primary tetravalent Mn oxyhydroxides (e.g., as observed in modern day ferromanganese nodules) are completely absent from the current dataset. The lack of a positive Ce anomaly in the manganese ore and peak Co association with ferric oxides and not with peak Mn, suggests that primary deposition must have occurred within an environment that was not fully oxidizing with respect to manganese. The use of stable isotopes (i.e., C and Fe) was employed to gain insights into redox processes, whether these are thought to have happened below the sediment-water interface or in contemporaneous seawater. At a small scale, all lithofacies of the Hotazel Formation record bulk-rock δ¹³C values that are low and essentially invariant about the average value of -9.5 per mil. This is independent of sharp variations in overall modal mineralogy, relative carbonate abundance and carbonate chemistry, which is clearly difficult to reconcile with in-situ diagenetic processes that predict highly variable δ¹³C signals in response to complex combinations of precursor sediment mineralogy, pore-fluid chemistry, organic carbon supply and open vs closed system diagenesis. At a stratigraphic scale, the carbonate δ¹³C (-5 to -13‰) variations between the different lithologies could instead represent temporal changes in water-column chemistry against well-developed physico-chemical gradients, depth of deposition and biological processes. The low iron isotope values recorded in the hematite lutite and manganese ore samples can be attributed to fractionation effects of initial oxidation of ferrous iron to form Fe-oxyhydroxides in the shallow parts of the basin, from an already isotopically highly depleted aqueous Fe-pool as proposed previously. The slightly higher but still negative bulk-rock δ⁵⁶Fe values of the host BIF can be attributed to water-column Fe isotopic effects at deeper levels between primary Fe oxyhydroxides and an isotopically heavier Fe(II) pool, which was subsequently preserved during diagenetic recrystallization. All above findings were combined into a conceptual model of deposition for the three different lithologies of the Hotazel Formation. The model predicts that free molecular oxygen must have been present within the shallow oceanic environment and implicates both Mn and Fe as active redox “players” compared to classic models that apply to the origin of worldwide BIF prior to the GOE. The deposition of the Hotazel strata is interpreted to have occurred through the following three stages: (1) BIF deposition occurred in a relatively deep oceanic environment above the Ongeluk lavas during marine transgression, where a redoxcline and seawater stratification separated hydrothermally sourced iron and manganese, in response to an active Mn-shuttle mechanism linked to Mn redox cycling. Abundant ferrous iron must have been oxidized by available oxygen but also by oxidised Mn species (MnOOH) and possibly even some soluble Mn(III) complexes. Through this process, Mn(III) was being effectively reduced back into solution along with cobalt(III), as Mn(II) and Co(II) respectively, thus creating maxima in their concentrations. A drawdown of Fe(OH)₃ particles was therefore the only net precipitation mechanism at this stage. Carbonate species of Fe and the abundant magnetite would possibly have formed by reaction between the ferric hydroxides and the deeper Fe(II) pool, while organic matter would also have reacted in the water-column via DIR, accounting for the low δ¹³C signature of Fe carbonate minerals. (2) Hematite lutite formation would have occurred at a relatively shallower environment during marine regression. At this stage, reductive cycling of Fe was minimal in the absence of a deeper Fe(II) reservoir reacting with the ferric primary precipitates. Therefore, DIR progressively gave way to manganese reduction and organic carbon oxidation (DMR), which reduced MnOOH to form Mn(II)-rich carbonates in the form of kutnahorite and Mn-calcite. Co-bearing Fe(OH)₃ would have precipitated and was ultimately preserved as Co-bearing hematite during diagenesis. (3) Deposition of manganese-rich sediment occurred at even shallower oceanic depths (maximum regression) where aerobic organic carbon oxidation replaced DMR, resulting in Ca-rich carbonates such as Mn-bearing calcite and Ca-kutnahorite, yet with a low carbon isotope signature recording aerobic conditions of organic carbon cycling. Mn(III) reduction at this stage was curtailed, leading to massive precipitation of MnOOH which was diagenetically transformed into braunite and friedelite. Simultaneous precipitation of Co-bearing Fe(OH)₃ would have continued but at much more subdued rates. Repeated transgressive-regressive cycles resulted in the cyclic BIF-hematite lutite- manganese ore nature of the Hotazel Formation in an oxidized oceanic environment at the onset of the Great Oxidation Event, which was nonetheless never oxic enough to drive Mn(II) oxidation fully to its tetravalent state. The mineralogy and species-specific geochemistry of the Hotazel strata, and more specifically the carbonate fraction thereof, appear to faithfully capture the chemistry of the primary depositional environment in a progressively evolving Earth System. This project opens the door for more studies focusing on better constraining primary versus diagenetic depositional 2020 Hotazel Fe and Mn deposition mechanisms of iron and manganese during the period leading up to the GOE, and possibly re-defining the significance of Fe and Mn as invaluable redox proxies in a rapidly changing planet.
- Full Text:
A reconceptualisation of music performance anxiety
- Authors: Van Schoor, Nina
- Date: 2020
- Subjects: Performance anxiety , Music -- Performance -- Psychological aspects , Anxiety
- Language: English
- Type: text , Thesis , Masters , MMus
- Identifier: http://hdl.handle.net/10962/167631 , vital:41498
- Description: Music Performance Anxiety (MPA) refers to the potentially debilitating anxiety experienced before and/or during the public performance of music, despite adequate preparation. MPA is generally treated by means of drug therapy, cognitive behavioural therapy, psychoanalysis or various relaxation techniques. This research aims to present a different approach to dealing with MPA, based on a reconceptualisation of the concept. As a result, it attempts to unpack all three concepts inherent in the term from both a psychological and philosophical viewpoint. The study used autoethnography as a methodology, as I wished to explore my own lived experience of MPA and anxiety in general, in conjunction with that of my two participants, two other student Western Art music performers, and how our methods for confronting MPA within the performance context itself suggests a more complex understanding of performance and MPA than is reflected in the current literature. Thus the data was collected from two first-person interviews as well as a self-reflective written account. The results of the analysis were that existential anxiety is potentially a contributing factor to MPA, and that performance itself can potentially provide the very means for overcoming not only MPA, but all forms of anxiety, due to the cathartic quality of music as well as performance, especially when the liminal or interstructural, nature of performing and its ritualistic function is explored. This exploration reveals the world and self-disclosing nature of agency and Play, or the potential within experiences to resolve conflicts and reveal otherness. This requires a degree of existential courage, or an affirmative response to the unknown, which is more relational than the definition suggests. In conclusion, this study reconceptualises MPA as a potentially potent existential experience, and that the anxiety in response to it is considered as a reaction to the catharsis inherent in being an agent, rather than merely as an obstacle to be controlled.
- Full Text:
- Authors: Van Schoor, Nina
- Date: 2020
- Subjects: Performance anxiety , Music -- Performance -- Psychological aspects , Anxiety
- Language: English
- Type: text , Thesis , Masters , MMus
- Identifier: http://hdl.handle.net/10962/167631 , vital:41498
- Description: Music Performance Anxiety (MPA) refers to the potentially debilitating anxiety experienced before and/or during the public performance of music, despite adequate preparation. MPA is generally treated by means of drug therapy, cognitive behavioural therapy, psychoanalysis or various relaxation techniques. This research aims to present a different approach to dealing with MPA, based on a reconceptualisation of the concept. As a result, it attempts to unpack all three concepts inherent in the term from both a psychological and philosophical viewpoint. The study used autoethnography as a methodology, as I wished to explore my own lived experience of MPA and anxiety in general, in conjunction with that of my two participants, two other student Western Art music performers, and how our methods for confronting MPA within the performance context itself suggests a more complex understanding of performance and MPA than is reflected in the current literature. Thus the data was collected from two first-person interviews as well as a self-reflective written account. The results of the analysis were that existential anxiety is potentially a contributing factor to MPA, and that performance itself can potentially provide the very means for overcoming not only MPA, but all forms of anxiety, due to the cathartic quality of music as well as performance, especially when the liminal or interstructural, nature of performing and its ritualistic function is explored. This exploration reveals the world and self-disclosing nature of agency and Play, or the potential within experiences to resolve conflicts and reveal otherness. This requires a degree of existential courage, or an affirmative response to the unknown, which is more relational than the definition suggests. In conclusion, this study reconceptualises MPA as a potentially potent existential experience, and that the anxiety in response to it is considered as a reaction to the catharsis inherent in being an agent, rather than merely as an obstacle to be controlled.
- Full Text:
A relational approach to landscape stewardship: Towards a new perspective for multi-actor collaboration
- Cockburn, Jessica J, Rosenberg, Eureta, Copteros, Athina, Cornelius, Susanna F, Libala, Notiswa, Metcalfe, Liz, van der Waal, Benjamin
- Authors: Cockburn, Jessica J , Rosenberg, Eureta , Copteros, Athina , Cornelius, Susanna F , Libala, Notiswa , Metcalfe, Liz , van der Waal, Benjamin
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/370098 , vital:66297 , xlink:href="https://doi.org/10.3390/land9070224"
- Description: Landscape stewardship is increasingly understood within the framing of complex social-ecological systems. To consider the implications of this, we focus on one of the key characteristics of complex social-ecological systems: they are relationally constituted, meaning that system characteristics emerge out of dynamic relations between system components. We focus on multi-actor collaboration as a key form of relationality in landscapes, seeking a more textured understanding of the social relations between landscape actors. We draw on a set of ‘gardening tools’ to analyse the boundary-crossing work of multi-actor collaboration. These tools comprise three key concepts: relational expertise, common knowledge, and relational agency. We apply the tools to two cases of landscape stewardship in South Africa: the Langkloof Region and the Tsitsa River catchment. These landscapes are characterised by economically, socio-culturally, and politically diverse groups of actors. Our analysis reveals that history and context strongly influence relational processes, that boundary-crossing work is indeed difficult, and that doing boundary-crossing work in smaller pockets within a landscape is helpful. The tools also helped to identify three key social-relational practices which lend a new perspective on boundary-crossing work: 1. belonging while differing, 2. growing together by interacting regularly and building common knowledge, and 3. learning and adapting together with humility and empathy.
- Full Text:
- Authors: Cockburn, Jessica J , Rosenberg, Eureta , Copteros, Athina , Cornelius, Susanna F , Libala, Notiswa , Metcalfe, Liz , van der Waal, Benjamin
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/370098 , vital:66297 , xlink:href="https://doi.org/10.3390/land9070224"
- Description: Landscape stewardship is increasingly understood within the framing of complex social-ecological systems. To consider the implications of this, we focus on one of the key characteristics of complex social-ecological systems: they are relationally constituted, meaning that system characteristics emerge out of dynamic relations between system components. We focus on multi-actor collaboration as a key form of relationality in landscapes, seeking a more textured understanding of the social relations between landscape actors. We draw on a set of ‘gardening tools’ to analyse the boundary-crossing work of multi-actor collaboration. These tools comprise three key concepts: relational expertise, common knowledge, and relational agency. We apply the tools to two cases of landscape stewardship in South Africa: the Langkloof Region and the Tsitsa River catchment. These landscapes are characterised by economically, socio-culturally, and politically diverse groups of actors. Our analysis reveals that history and context strongly influence relational processes, that boundary-crossing work is indeed difficult, and that doing boundary-crossing work in smaller pockets within a landscape is helpful. The tools also helped to identify three key social-relational practices which lend a new perspective on boundary-crossing work: 1. belonging while differing, 2. growing together by interacting regularly and building common knowledge, and 3. learning and adapting together with humility and empathy.
- Full Text:
A search for enhanced photodynamic activity against Staphylococcus aureus planktonic cells and biofilms: the evaluation of phthalocyanine–detonation nanodiamond–Ag nanoconjugates
- Openda, Yolande Ikala, Matshitse, Refilwe, Nyokong, Tebello
- Authors: Openda, Yolande Ikala , Matshitse, Refilwe , Nyokong, Tebello
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/163825 , vital:41073 , DOI: 10.1039/D0PP00075B
- Description: The present work reports on the synthesis and characterization of novel zinc (2) and indium (3) 2-amino-4-bromophenoxy substituted phthalocyanines (Pcs) along with the self-assembled nanoconjugates formed via π–π stacking interaction onto detonation nanodiamonds (DNDs) to form 2@DNDs and 3@DNDs. 2@DNDs and 3@DNDs were covalently linked to chitosan–silver mediated nanoparticles (CSAg) to form 2@DNDs-CSAg and 3@DNDs-CSAg nanoconjugates. High singlet oxygen quantum yields in DMSO of 0.69 and 0.72 for Pcs alone and 0.90 and 0.92 for 2@DNDs-CSAg and 3@DNDs-CSAg, respectively, were obtained.
- Full Text:
- Authors: Openda, Yolande Ikala , Matshitse, Refilwe , Nyokong, Tebello
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/163825 , vital:41073 , DOI: 10.1039/D0PP00075B
- Description: The present work reports on the synthesis and characterization of novel zinc (2) and indium (3) 2-amino-4-bromophenoxy substituted phthalocyanines (Pcs) along with the self-assembled nanoconjugates formed via π–π stacking interaction onto detonation nanodiamonds (DNDs) to form 2@DNDs and 3@DNDs. 2@DNDs and 3@DNDs were covalently linked to chitosan–silver mediated nanoparticles (CSAg) to form 2@DNDs-CSAg and 3@DNDs-CSAg nanoconjugates. High singlet oxygen quantum yields in DMSO of 0.69 and 0.72 for Pcs alone and 0.90 and 0.92 for 2@DNDs-CSAg and 3@DNDs-CSAg, respectively, were obtained.
- Full Text:
A skin that took them through
- Authors: Kgame, Mbali
- Date: 2020
- Subjects: South African fiction (English) -- 21st century , African fiction (English) -- History and criticism , Short stories, South African (English) -- 21st century , Diaries -- Authorship
- Language: English
- Type: text , Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10962/147638 , vital:38656
- Description: This project comprises of interlinked fictional short stories capturing experiences of the “invisibilised’’ young people- the street kids, drug addicts, cashiers, childminders, the sick, first graduates etc. These stories are a way to interrogate the fallacy of a “free and fair” South Africa by noting events taking place within homes, communities and countrywide. Told in a playful, innocent, curious, childlike voice and reasoning, my work draws inspiration from Werewere Likings ‘The Amputated Memory,’ for its ability to narrate the current without divorcing the past. I draw inspiration from Liking’s way of writing family connectivity and employing an emerging voice of the narrator starting from being a child scribbling to later becoming an elder. Nana Kwame Adjei-Brenyah’s ‘Black Friday’ for scanning into young black people’s experiences in a society where their bodies move as misfits. My work also draws from Lesley Nneka Arimah’s ‘What It Means When a Man Falls from the Sky’ for the interlinked stories. Lastly the stories in this project take from Sindiwe Magona’s Mother to Mother for humanising bodies that have been reduced to frames.
- Full Text:
- Authors: Kgame, Mbali
- Date: 2020
- Subjects: South African fiction (English) -- 21st century , African fiction (English) -- History and criticism , Short stories, South African (English) -- 21st century , Diaries -- Authorship
- Language: English
- Type: text , Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10962/147638 , vital:38656
- Description: This project comprises of interlinked fictional short stories capturing experiences of the “invisibilised’’ young people- the street kids, drug addicts, cashiers, childminders, the sick, first graduates etc. These stories are a way to interrogate the fallacy of a “free and fair” South Africa by noting events taking place within homes, communities and countrywide. Told in a playful, innocent, curious, childlike voice and reasoning, my work draws inspiration from Werewere Likings ‘The Amputated Memory,’ for its ability to narrate the current without divorcing the past. I draw inspiration from Liking’s way of writing family connectivity and employing an emerging voice of the narrator starting from being a child scribbling to later becoming an elder. Nana Kwame Adjei-Brenyah’s ‘Black Friday’ for scanning into young black people’s experiences in a society where their bodies move as misfits. My work also draws from Lesley Nneka Arimah’s ‘What It Means When a Man Falls from the Sky’ for the interlinked stories. Lastly the stories in this project take from Sindiwe Magona’s Mother to Mother for humanising bodies that have been reduced to frames.
- Full Text:
A snapshot of early childhood care and education in South Africa: institutional offerings, challenges and recommendations
- Authors: Harrison, Giulietta D
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/160312 , vital:40433 , https://doi.org/10.4102/sajce.v10i1.797
- Description: This article draws from a research report on the Project for Inclusive Early Childhood Care and Education (PIECCE), which surveyed attitudes, training strategies, materials and entrance requirements across most relevant higher education institutions (HEIs), non-governmental organisations (NGOs) and technical and vocational education and training colleges (TVETs). The aim of this study was to identify what institutions were offering in terms of training teachers in the birth-to-four age group, to identify the challenges and provide recommendations based on the findings.
- Full Text:
- Authors: Harrison, Giulietta D
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/160312 , vital:40433 , https://doi.org/10.4102/sajce.v10i1.797
- Description: This article draws from a research report on the Project for Inclusive Early Childhood Care and Education (PIECCE), which surveyed attitudes, training strategies, materials and entrance requirements across most relevant higher education institutions (HEIs), non-governmental organisations (NGOs) and technical and vocational education and training colleges (TVETs). The aim of this study was to identify what institutions were offering in terms of training teachers in the birth-to-four age group, to identify the challenges and provide recommendations based on the findings.
- Full Text:
A social-ecological investigation into urban domestic gardens and avifauna in medium-sized towns of the Eastern Cape, South Africa
- Authors: Tricam, Shayla
- Date: 2020
- Subjects: Urban ecology (Biology) -- South Africa , Biotic communites -- South Africa , Gardens -- South Africa -- Managemenet , Birds – Ecology – South Africa , Gardening to attract birds -- South Africa
- Language: English
- Type: text , Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10962/145314 , vital:38427
- Description: Urban domestic gardens are an often overlooked component of urban green infrastructure, despite their potential to contribute to the preservation of urban biodiversity. As opposed to public greenspaces, private gardens are individually owned and managed, thus act as social-ecological systems, where the cumulative actions of urban residents can scale up to influence ecological patterns and processes on a larger scale. The diversity of fauna and flora within urban gardens provide a range of ecosystem goods and services, as well as less tangible benefits in the form of recreation, education and culture. However, little is known about the contribution of urban domestic gardens to urban biodiversity and its potential conservation value in South Africa. This study investigated urban domestic gardens along a socio-economic gradient in two medium-sized towns, Grahamstown and Port Alfred in the Eastern Cape, South Africa. This study found distinct differences among urban resident garden management practices as well as the avifauna which were seen within the gardens across the socio-economic gradient. The Garden Management Intensity index was higher within affluent households compared to other socio-economic levels, with subsequent management scores not differing statistically along the gradient. While there was variation within garden management practices, as well as the number of residents who participated in supplementary bird feeding, little variation was seen in the activities which were enjoyed by the residents, indicating numerous benefits the garden environment provides for all urban residents. The bird community composition along the socio-economic gradient displayed patterns directly reflecting the “luxury effect”, where households with a higher socio-economic status had harbour gardens with greater levels of biodiversity. This study showed that affluent gardens displayed far greater diversity, richness and abundance of urban birds. Multivariate analyses confirmed the patterns by highlighting a distinct bird community in the affluent zone, compared to other two socio-economic zones, which housed a second bird community. Furthermore, the main driver of the bird community composition was dominated by vegetation complexity, most notably tree cover within the gardens. Therefore, this study highlighted that patterns of ecological inequality are highly evident in medium-sized towns in South Africa, where older, affluent suburbs households display greater diversity and abundance of birdlife, compared to subsequent socio-economic zones within the study. Prioritisation with regards to the benefits a garden environment brings to urban residents in terms of a connection to nature, access to urban greenery, and relationship to urban wildlife is vital and should be promoted and planned for across all socio-economic zones.
- Full Text:
- Authors: Tricam, Shayla
- Date: 2020
- Subjects: Urban ecology (Biology) -- South Africa , Biotic communites -- South Africa , Gardens -- South Africa -- Managemenet , Birds – Ecology – South Africa , Gardening to attract birds -- South Africa
- Language: English
- Type: text , Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10962/145314 , vital:38427
- Description: Urban domestic gardens are an often overlooked component of urban green infrastructure, despite their potential to contribute to the preservation of urban biodiversity. As opposed to public greenspaces, private gardens are individually owned and managed, thus act as social-ecological systems, where the cumulative actions of urban residents can scale up to influence ecological patterns and processes on a larger scale. The diversity of fauna and flora within urban gardens provide a range of ecosystem goods and services, as well as less tangible benefits in the form of recreation, education and culture. However, little is known about the contribution of urban domestic gardens to urban biodiversity and its potential conservation value in South Africa. This study investigated urban domestic gardens along a socio-economic gradient in two medium-sized towns, Grahamstown and Port Alfred in the Eastern Cape, South Africa. This study found distinct differences among urban resident garden management practices as well as the avifauna which were seen within the gardens across the socio-economic gradient. The Garden Management Intensity index was higher within affluent households compared to other socio-economic levels, with subsequent management scores not differing statistically along the gradient. While there was variation within garden management practices, as well as the number of residents who participated in supplementary bird feeding, little variation was seen in the activities which were enjoyed by the residents, indicating numerous benefits the garden environment provides for all urban residents. The bird community composition along the socio-economic gradient displayed patterns directly reflecting the “luxury effect”, where households with a higher socio-economic status had harbour gardens with greater levels of biodiversity. This study showed that affluent gardens displayed far greater diversity, richness and abundance of urban birds. Multivariate analyses confirmed the patterns by highlighting a distinct bird community in the affluent zone, compared to other two socio-economic zones, which housed a second bird community. Furthermore, the main driver of the bird community composition was dominated by vegetation complexity, most notably tree cover within the gardens. Therefore, this study highlighted that patterns of ecological inequality are highly evident in medium-sized towns in South Africa, where older, affluent suburbs households display greater diversity and abundance of birdlife, compared to subsequent socio-economic zones within the study. Prioritisation with regards to the benefits a garden environment brings to urban residents in terms of a connection to nature, access to urban greenery, and relationship to urban wildlife is vital and should be promoted and planned for across all socio-economic zones.
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A socio-political analysis of the adoption of certain AmaXhosa surnames
- Authors: Johnson, Stembele
- Date: 2020
- Subjects: Names, Personal -- Xhosa , Names, Personal -- Xhosa -- Political aspects , Names, Personal -- Xhosa -- Sociological aspects , Xhosa (African people) -- Social life and customs , Onomastics -- South Africa
- Language: English
- Type: text , Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10962/164298 , vital:41107
- Description: It is always assumed when you have a white surname that you have a white lineage or your forefathers were white, and that was always my struggle in school to explain the meaning of my surname and where it came from. Not only European surnames used by amaXhosa are difficult to explain but also many isiXhosa surnames are very hard to break down and explain. This is because many word from th e isiXhosa language, that are used in surnames are no longer used and if one does not know the history of certain names then it would be difficult to know the meaning of a surname or misinterpret its meaning to the modern words of isiXhosa that we know. S urnames are not of African origin, they came from the West, but because of colonialism surnames were enforced on African people. Most of the surnames they used, are said to be names of their forefathers (ancestors), and there is a small amount or none that links to femininity in these surnames. Surnames are part of naming and naming is part of onomastics. Naming is a very important tool used among various African cultures to convey certain messages, either to an individual, family members or a community. On omastics is multidisciplinary in nature. It can be approached from different perspectives. These include linguistic, historical, sociological, philosophical, economical and other perspectives. This research looks at the depth of certain amaXhosa surnames and even their links to other names like, nicknames and clan names etc.
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- Authors: Johnson, Stembele
- Date: 2020
- Subjects: Names, Personal -- Xhosa , Names, Personal -- Xhosa -- Political aspects , Names, Personal -- Xhosa -- Sociological aspects , Xhosa (African people) -- Social life and customs , Onomastics -- South Africa
- Language: English
- Type: text , Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10962/164298 , vital:41107
- Description: It is always assumed when you have a white surname that you have a white lineage or your forefathers were white, and that was always my struggle in school to explain the meaning of my surname and where it came from. Not only European surnames used by amaXhosa are difficult to explain but also many isiXhosa surnames are very hard to break down and explain. This is because many word from th e isiXhosa language, that are used in surnames are no longer used and if one does not know the history of certain names then it would be difficult to know the meaning of a surname or misinterpret its meaning to the modern words of isiXhosa that we know. S urnames are not of African origin, they came from the West, but because of colonialism surnames were enforced on African people. Most of the surnames they used, are said to be names of their forefathers (ancestors), and there is a small amount or none that links to femininity in these surnames. Surnames are part of naming and naming is part of onomastics. Naming is a very important tool used among various African cultures to convey certain messages, either to an individual, family members or a community. On omastics is multidisciplinary in nature. It can be approached from different perspectives. These include linguistic, historical, sociological, philosophical, economical and other perspectives. This research looks at the depth of certain amaXhosa surnames and even their links to other names like, nicknames and clan names etc.
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A sociological analysis of the involvement of men in campaigns against sexual violence towards women at Rhodes University: the aftermath of the #RUReference protest
- Authors: Roboji, Philasande Milisa
- Date: 2020
- Subjects: #RUReferenceList , Rhodes University -- Students -- Attitudes , Rape in universities and colleges -- South Africa , Social movements -- South Africa -- Makhanda , Women college students -- Violence against -- South Africa , Male college students -- South Africa -- Attitudes
- Language: English
- Type: text , Thesis , Masters , MSocSci
- Identifier: http://hdl.handle.net/10962/148059 , vital:38706
- Description: Gender-based violence more especially sexual violence towards women is one of the biggest social issus affecting South Africa including higher institutions of learning, universities in this context. In recent years, we have seen students in universities protesting sexual violence demanding universities to improve their ways of dealing with this violence. The motivation behind this thesis is the notion that sexual violence is a women’s issue and how most men in our communities and universities do not involve themselves in campaigns that are designed to end sexual violence towards women. There is an assumption that women should be the ones fighting against sexual violence because it affects them when in fact sexual violence affects everyone and more importantly, is mostly perpetuated by men. Therefore, the main purpose of this thesis was to sociologically analyze the involvement of men in campaigns against sexual violence towards women and the aftermath of the #RUReferenceList protest that took place at Rhodes University in 2016. This protest started immediately after a list of students who were said to be alleged sexual perpetrators was published online. Attached to this primary objective, the sub-goals that informed the entire study were to investigate how the involvement of men in the #RUReferenceList protest has contributed to challenging rape culture at Rhodes University. Also, to investigate if there are any ongoing campaigns and/or projects that includes men and that are still addressing the issue of sexual violence towards women. There is however, a dearth of research on the involvement of men in campaigns against sexual violence in South Africa. Therefore, it was difficult finding existing literature that touches on the involvement of men in campaigns against sexual violence towards women particularly in the context of universities. This thesis was conducted within the premises of Rhodes University through a qualitative research approach in a form of in-depth interviews. Five participants were selected through purposive sampling which included the Chair of the Gender Action Forum, one former student representative council member, a sub-warden from a male residence and two students. The findings of this research are not the full representation of the entire university but opinions and perspective of the participants that were interviewed. Their opinions and perspectives have a potential of contributing to the factors and reasons as to why majority of men have not engaged themselves in issues of gender-based violence or involved themselves in campaigns against sexual violence towards women.
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- Authors: Roboji, Philasande Milisa
- Date: 2020
- Subjects: #RUReferenceList , Rhodes University -- Students -- Attitudes , Rape in universities and colleges -- South Africa , Social movements -- South Africa -- Makhanda , Women college students -- Violence against -- South Africa , Male college students -- South Africa -- Attitudes
- Language: English
- Type: text , Thesis , Masters , MSocSci
- Identifier: http://hdl.handle.net/10962/148059 , vital:38706
- Description: Gender-based violence more especially sexual violence towards women is one of the biggest social issus affecting South Africa including higher institutions of learning, universities in this context. In recent years, we have seen students in universities protesting sexual violence demanding universities to improve their ways of dealing with this violence. The motivation behind this thesis is the notion that sexual violence is a women’s issue and how most men in our communities and universities do not involve themselves in campaigns that are designed to end sexual violence towards women. There is an assumption that women should be the ones fighting against sexual violence because it affects them when in fact sexual violence affects everyone and more importantly, is mostly perpetuated by men. Therefore, the main purpose of this thesis was to sociologically analyze the involvement of men in campaigns against sexual violence towards women and the aftermath of the #RUReferenceList protest that took place at Rhodes University in 2016. This protest started immediately after a list of students who were said to be alleged sexual perpetrators was published online. Attached to this primary objective, the sub-goals that informed the entire study were to investigate how the involvement of men in the #RUReferenceList protest has contributed to challenging rape culture at Rhodes University. Also, to investigate if there are any ongoing campaigns and/or projects that includes men and that are still addressing the issue of sexual violence towards women. There is however, a dearth of research on the involvement of men in campaigns against sexual violence in South Africa. Therefore, it was difficult finding existing literature that touches on the involvement of men in campaigns against sexual violence towards women particularly in the context of universities. This thesis was conducted within the premises of Rhodes University through a qualitative research approach in a form of in-depth interviews. Five participants were selected through purposive sampling which included the Chair of the Gender Action Forum, one former student representative council member, a sub-warden from a male residence and two students. The findings of this research are not the full representation of the entire university but opinions and perspective of the participants that were interviewed. Their opinions and perspectives have a potential of contributing to the factors and reasons as to why majority of men have not engaged themselves in issues of gender-based violence or involved themselves in campaigns against sexual violence towards women.
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A sociological analysis of the sex education of young adult white womxn and their understandings and practices of ‘Safe Sex’
- Authors: Guerra, Cassandra Gadelha
- Date: 2020
- Subjects: Sex instruction , Sex instruction for girls , Women, White -- Psychology , Women, White -- Sexual behavior
- Language: English
- Type: text , Thesis , Masters , MSocSci
- Identifier: http://hdl.handle.net/10962/147267 , vital:38610
- Description: This research sets out to examine the experiences and perspectives of young adult white womxn regarding their respective sex education. This is in terms of how sex education may shape and influence sexual practices. The relevance of exploring the sex education of this group is to gain an understanding of how constructions of sex education may facilitate the negotiation of sexual practices, particularly as these practices relate to the negotiation of ‘safe sex’. This involves an exploration of definitions of ‘safe sex’ as well as an examination of the various sources of sex education. This research argues that sex education has been socially constructed within a ‘heterosexual matrix’ where both gender identities and sexuality are constructed in heterosexual terms in accordance with compulsory heterosexuality. Furthermore, that sex education as well as understandings and practices of ‘safe sex’ intersect with other social categories such as race, gender and sexuality. Much of the sex-related research conducted in South Africa focuses on people of colour, as a result very little is known about the sexual behaviours and practices of the white demographic. This research accounts for the absence of analysis of sexual practices and behaviour among white people by examining the sex education and sexual practices of young adult white womxn between the ages of 19 and 24. The research observed key sources of sex education which included parents, schools, religious institutions and the internet. Findings indicate that the sex education of participants reflected ideals of heteronormativity and misogyny which were found to directly influence their understandings and practices of both sex and ‘safe sex’. Furthermore, that the sex education participants received has ultimately failed to promote ‘safe’ sexual practices.
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- Authors: Guerra, Cassandra Gadelha
- Date: 2020
- Subjects: Sex instruction , Sex instruction for girls , Women, White -- Psychology , Women, White -- Sexual behavior
- Language: English
- Type: text , Thesis , Masters , MSocSci
- Identifier: http://hdl.handle.net/10962/147267 , vital:38610
- Description: This research sets out to examine the experiences and perspectives of young adult white womxn regarding their respective sex education. This is in terms of how sex education may shape and influence sexual practices. The relevance of exploring the sex education of this group is to gain an understanding of how constructions of sex education may facilitate the negotiation of sexual practices, particularly as these practices relate to the negotiation of ‘safe sex’. This involves an exploration of definitions of ‘safe sex’ as well as an examination of the various sources of sex education. This research argues that sex education has been socially constructed within a ‘heterosexual matrix’ where both gender identities and sexuality are constructed in heterosexual terms in accordance with compulsory heterosexuality. Furthermore, that sex education as well as understandings and practices of ‘safe sex’ intersect with other social categories such as race, gender and sexuality. Much of the sex-related research conducted in South Africa focuses on people of colour, as a result very little is known about the sexual behaviours and practices of the white demographic. This research accounts for the absence of analysis of sexual practices and behaviour among white people by examining the sex education and sexual practices of young adult white womxn between the ages of 19 and 24. The research observed key sources of sex education which included parents, schools, religious institutions and the internet. Findings indicate that the sex education of participants reflected ideals of heteronormativity and misogyny which were found to directly influence their understandings and practices of both sex and ‘safe sex’. Furthermore, that the sex education participants received has ultimately failed to promote ‘safe’ sexual practices.
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A sociological understanding of contemporary child marriage in Mabvuku, Harare, Zimbabwe
- Authors: Madzivire, Shamso Christine
- Date: 2020
- Subjects: Child marriage -- Zimbabwe -- Mabvuku , Child marriage -- Zimbabwe -- Case studies , Shona (African people) -- Social life and customs , Marriage customs and rites -- Zimbabwe , Shona (African people) -- Marriage customs and rites , Marriage -- Zimbabwe
- Language: English
- Type: text , Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/142566 , vital:38091
- Description: Child marriage is a phenomenon that has been increasingly recognised as a global problem since the late nineteenth century. Since then, scholars across many disciplines along with various agencies such as government bodies and non-governmental organisations have tirelessly engaged in research exploring the causes and consequences of this practice and in developing prevention and mitigation strategies. These research efforts have been concentrated in some parts of the world and not others, with the findings in many cases being generalised problematically across different geographical areas. This thesis stands as a response to the dearth of academic research on child marriage in present-day Zimbabwe and simultaneously highlights the significance of studying the specificities of child marriage under particular historical and spatial conditions. The main objective of this thesis is to explore and understand child marriage as a part of modernday marriage practices in Zimbabwe, through a case study of child marriage in Mabvuku in Harare. In addressing this objective, it is hoped that new ways of thinking around this phenomenon will become evident. In addressing this main objective, the thesis considers the experiences of child brides, the drivers and consequences of child and post-child marriage experiences. It does this seeking to understand child marriage with reference to the types of marital unions which exist amongst Shona people in pre-colonial times and in post-colonial Zimbabwe. The thesis adopts a qualitative research methodology which involved in-depth semistructured interviews with 25 women in Mabvuku who were married before the age of 18, along with focus group discussions with community workers and interviews with pertinent government and non-government representatives. Due to certain challenges with current theorising about child marriage, there is an attempt to build theory by drawing upon in particular the Zimbabwean notion and practice of hunhu. A key conclusion is that child marriage in present-day Zimbabwe is in part a result of family transitions which arose during the time of colonialism and continue to this day.
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- Authors: Madzivire, Shamso Christine
- Date: 2020
- Subjects: Child marriage -- Zimbabwe -- Mabvuku , Child marriage -- Zimbabwe -- Case studies , Shona (African people) -- Social life and customs , Marriage customs and rites -- Zimbabwe , Shona (African people) -- Marriage customs and rites , Marriage -- Zimbabwe
- Language: English
- Type: text , Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/142566 , vital:38091
- Description: Child marriage is a phenomenon that has been increasingly recognised as a global problem since the late nineteenth century. Since then, scholars across many disciplines along with various agencies such as government bodies and non-governmental organisations have tirelessly engaged in research exploring the causes and consequences of this practice and in developing prevention and mitigation strategies. These research efforts have been concentrated in some parts of the world and not others, with the findings in many cases being generalised problematically across different geographical areas. This thesis stands as a response to the dearth of academic research on child marriage in present-day Zimbabwe and simultaneously highlights the significance of studying the specificities of child marriage under particular historical and spatial conditions. The main objective of this thesis is to explore and understand child marriage as a part of modernday marriage practices in Zimbabwe, through a case study of child marriage in Mabvuku in Harare. In addressing this objective, it is hoped that new ways of thinking around this phenomenon will become evident. In addressing this main objective, the thesis considers the experiences of child brides, the drivers and consequences of child and post-child marriage experiences. It does this seeking to understand child marriage with reference to the types of marital unions which exist amongst Shona people in pre-colonial times and in post-colonial Zimbabwe. The thesis adopts a qualitative research methodology which involved in-depth semistructured interviews with 25 women in Mabvuku who were married before the age of 18, along with focus group discussions with community workers and interviews with pertinent government and non-government representatives. Due to certain challenges with current theorising about child marriage, there is an attempt to build theory by drawing upon in particular the Zimbabwean notion and practice of hunhu. A key conclusion is that child marriage in present-day Zimbabwe is in part a result of family transitions which arose during the time of colonialism and continue to this day.
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A STAT3 of addiction: adipose tissue, adipocytokine signalling and STAT3 as mediators of metabolic remodelling in the tumour microenvironment
- Kadye, Rose, Stoffels, Mihlali, Fanucci, Sidne, Mbanxa, Siso, Prinsloo, Earl
- Authors: Kadye, Rose , Stoffels, Mihlali , Fanucci, Sidne , Mbanxa, Siso , Prinsloo, Earl
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/149395 , vital:38846 , https://doi.org/10.3390/cells9041043
- Description: Metabolic remodelling of the tumour microenvironment is a major mechanism by which cancer cells survive and resist treatment. The pro-oncogenic inflammatory cascade released by adipose tissue promotes oncogenic transformation, proliferation, angiogenesis, metastasis and evasion of apoptosis. STAT3 has emerged as an important mediator of metabolic remodelling. As a downstream effector of adipocytokines and cytokines, its canonical and non-canonical activities affect mitochondrial functioning and cancer metabolism. In this review, we examine the central role played by the crosstalk between the transcriptional and mitochondrial roles of STAT3 to promote survival and further oncogenesis within the tumour microenvironment with a particular focus on adipose-breast cancer interactions.
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- Authors: Kadye, Rose , Stoffels, Mihlali , Fanucci, Sidne , Mbanxa, Siso , Prinsloo, Earl
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/149395 , vital:38846 , https://doi.org/10.3390/cells9041043
- Description: Metabolic remodelling of the tumour microenvironment is a major mechanism by which cancer cells survive and resist treatment. The pro-oncogenic inflammatory cascade released by adipose tissue promotes oncogenic transformation, proliferation, angiogenesis, metastasis and evasion of apoptosis. STAT3 has emerged as an important mediator of metabolic remodelling. As a downstream effector of adipocytokines and cytokines, its canonical and non-canonical activities affect mitochondrial functioning and cancer metabolism. In this review, we examine the central role played by the crosstalk between the transcriptional and mitochondrial roles of STAT3 to promote survival and further oncogenesis within the tumour microenvironment with a particular focus on adipose-breast cancer interactions.
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A structural modeling notation for the typed functional paradigm
- Authors: Motara, Yusuf, M
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/428948 , vital:72548 , https://doi.org/10.1145/3341105.3373863
- Description: Although typed functional programming is becoming increasingly important for practical software development, it remains inaccessible from a modeling perspective. This paper develops and theoretically justifies an initial best-practices notation for the typed functional paradigm. A small case study explores how the same scenario is modeled differently in the object-oriented and typed functional paradigms, and it is argued that the notation developed is a necessary step on the path to a more comprehensive notation for modeling within the paradigm.
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- Authors: Motara, Yusuf, M
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/428948 , vital:72548 , https://doi.org/10.1145/3341105.3373863
- Description: Although typed functional programming is becoming increasingly important for practical software development, it remains inaccessible from a modeling perspective. This paper develops and theoretically justifies an initial best-practices notation for the typed functional paradigm. A small case study explores how the same scenario is modeled differently in the object-oriented and typed functional paradigms, and it is argued that the notation developed is a necessary step on the path to a more comprehensive notation for modeling within the paradigm.
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A study of why some physic concepts in the South African Physical Science curriculum are poorly understood in order to develop a targeted action-research intervention for Newton’s second law
- Authors: Cobbing, Kathleen Margaret
- Date: 2020
- Subjects: Physics -- Study and teaching (Secondary) -- South Africa , Physics -- Examinations, questions, etc. -- South Africa , Motion -- Study and teaching (Secondary) -- South Africa
- Language: English
- Type: text , Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10962/146903 , vital:38575
- Description: Globally, many students show a poor understanding of concepts in high school physics and lack the necessary problem-solving skills that the course demands. The application of Newton’s second law was found to be particularly problematic through document analysis of South African examination feedback reports, as well as from an analysis of the physics examinations at a pair of well-resourced South African independent schools that follow the Independent Examination Board curriculum. Through an action-research approach, a resource for use by students was designed and modified to improve students’ understanding of this concept, while modelling problemsolving methods. The resource consisted of brief revision notes, worked examples and scaffolded exercises. The design of the resource was influenced by the theory of cognitive apprenticeship, cognitive load theory and conceptual change theory. One of the aims of the resource was to encourage students to translate between the different representations of a problem situation: symbolic, abstract, model and concrete. The impact of this resource was evaluated at a pair of schools using a mixed methods approach. This incorporated pre- and post-tests for a quantitative assessment, qualitative student evaluations and the analysis of examination scripts. There was an improvement from pre- to post-test for all four iterations of the intervention and these improvements were shown to be significant. The use of the resource led to an increase in the quality and quantity of diagrams drawn by students in subsequent assessments.
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- Authors: Cobbing, Kathleen Margaret
- Date: 2020
- Subjects: Physics -- Study and teaching (Secondary) -- South Africa , Physics -- Examinations, questions, etc. -- South Africa , Motion -- Study and teaching (Secondary) -- South Africa
- Language: English
- Type: text , Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10962/146903 , vital:38575
- Description: Globally, many students show a poor understanding of concepts in high school physics and lack the necessary problem-solving skills that the course demands. The application of Newton’s second law was found to be particularly problematic through document analysis of South African examination feedback reports, as well as from an analysis of the physics examinations at a pair of well-resourced South African independent schools that follow the Independent Examination Board curriculum. Through an action-research approach, a resource for use by students was designed and modified to improve students’ understanding of this concept, while modelling problemsolving methods. The resource consisted of brief revision notes, worked examples and scaffolded exercises. The design of the resource was influenced by the theory of cognitive apprenticeship, cognitive load theory and conceptual change theory. One of the aims of the resource was to encourage students to translate between the different representations of a problem situation: symbolic, abstract, model and concrete. The impact of this resource was evaluated at a pair of schools using a mixed methods approach. This incorporated pre- and post-tests for a quantitative assessment, qualitative student evaluations and the analysis of examination scripts. There was an improvement from pre- to post-test for all four iterations of the intervention and these improvements were shown to be significant. The use of the resource led to an increase in the quality and quantity of diagrams drawn by students in subsequent assessments.
- Full Text: