A Search for Conjunctions at a Time of Direction-setting Review and Synthesis
- Authors: O'Donoghue, Rob
- Date: 2011
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/387134 , vital:68209 , xlink:href="https://www.ajol.info/index.php/sajee/article/view/122240"
- Description: This journal reflects a diversity of environment and sustainability education research and viewpoints alongside two synthesis papers. Read as a whole and within a widely held ideal that diversity reflects resilience, the environment and education for sustainable development landscape in Africa might be said to be healthy and proliferating. But read against the pressure to produce tangible evidence of change on an African landscape of persistent climate variation and poverty, along with a widening gap between rich and poor, the picture remains challenging. These contrasting readings are notable at a time when we are looking towards the Association for the Development of Education in Africa (ADEA) Triennial in February, 2012, the Rio+20 Earth Summit in June 2012 and our own EEASA +30 conference in September 2012. The UN Decade of Education for Sustainable Development is characterised by a proliferation of education imperatives. These emerged as modern education in response to the issues of the day and now a modernity in deepening crisis.
- Full Text:
- Authors: O'Donoghue, Rob
- Date: 2011
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/387134 , vital:68209 , xlink:href="https://www.ajol.info/index.php/sajee/article/view/122240"
- Description: This journal reflects a diversity of environment and sustainability education research and viewpoints alongside two synthesis papers. Read as a whole and within a widely held ideal that diversity reflects resilience, the environment and education for sustainable development landscape in Africa might be said to be healthy and proliferating. But read against the pressure to produce tangible evidence of change on an African landscape of persistent climate variation and poverty, along with a widening gap between rich and poor, the picture remains challenging. These contrasting readings are notable at a time when we are looking towards the Association for the Development of Education in Africa (ADEA) Triennial in February, 2012, the Rio+20 Earth Summit in June 2012 and our own EEASA +30 conference in September 2012. The UN Decade of Education for Sustainable Development is characterised by a proliferation of education imperatives. These emerged as modern education in response to the issues of the day and now a modernity in deepening crisis.
- Full Text:
A series of systematic case studies on the treatment of rape-related PTSD in the South African context implications for practice and policy
- Authors: Padmanabhanunni, Anita
- Date: 2011
- Subjects: Post-traumatic stress disorder -- South Africa -- Treatment Post-traumatic stress disorder -- Patients Case studies Rape victims -- Counseling of -- South Africa Psychic trauma -- Treatment Rape victims -- Counseling of Case studies Cognitive therapy
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:3035 , http://hdl.handle.net/10962/d1002544
- Description: In 2009, South African police statistics revealed that more than 68 332 women were raped in the country. The evidence from independent researchers has shown that SAPS statistics are highly susceptible to under-reporting and the actual figure is more than double this amount. One pervasive feature of the phenomenology of rape is post-traumatic stress disorder (PTSD). PTSD is a highly debilitating condition with severe individual and societal costs. The condition takes a critical toll on occupational functioning, schooling and personal relationships and is associated with depression, suicide risk, self-harming behaviours and alcohol-abuse problems. The Ehlers and Clark (2000) cognitive model represents the most efficacious treatment for PTSD but the approach is severely under-utilised by South African practitioners working with sexual trauma. The reasons for such under-utilisation relate to a lack of exposure and training surrounding the model and concerns about the transportability of the treatment to a multi-cultural context. One method of addressing these barriers to treatment delivery is through systematic case-based research. Systematic case-based research offers a complementary means of refining theory and developing evidence-based practice in the context of a developing country. The method offers an intensive analysis and description of the particular phenomena under study within its real-life context. It allows the researcher to intensively examine and identify the specific aspects of the therapist’s responses and client’s reactions that contributed to significant change. Unlike efficacy studies, generalisability in case-study research is based on replication on a case-by-case basis and the creation of case law. This research study uses a systematic-case study approach to investigate the applicability of the Ehlers and Clark (2000) model in the treatment of rape-related PTSD in South Africa. The study aims to demonstrate the transportability of the model and develop a needed evidence base for service providers in the country. Seven women participated in the project and lent their treatment process to the research. The participants varied in terms of age, race, culture, socio-economic status and the nature of their sexual trauma. Through synoptic thematic analysis of their therapy process specific client-related personal aspects, client-related contextual factors and state-level factors were found to impede treatment delivery and implementation. The implications of these aspects for clinical practice and social policy are comprehensively discussed.
- Full Text:
- Authors: Padmanabhanunni, Anita
- Date: 2011
- Subjects: Post-traumatic stress disorder -- South Africa -- Treatment Post-traumatic stress disorder -- Patients Case studies Rape victims -- Counseling of -- South Africa Psychic trauma -- Treatment Rape victims -- Counseling of Case studies Cognitive therapy
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:3035 , http://hdl.handle.net/10962/d1002544
- Description: In 2009, South African police statistics revealed that more than 68 332 women were raped in the country. The evidence from independent researchers has shown that SAPS statistics are highly susceptible to under-reporting and the actual figure is more than double this amount. One pervasive feature of the phenomenology of rape is post-traumatic stress disorder (PTSD). PTSD is a highly debilitating condition with severe individual and societal costs. The condition takes a critical toll on occupational functioning, schooling and personal relationships and is associated with depression, suicide risk, self-harming behaviours and alcohol-abuse problems. The Ehlers and Clark (2000) cognitive model represents the most efficacious treatment for PTSD but the approach is severely under-utilised by South African practitioners working with sexual trauma. The reasons for such under-utilisation relate to a lack of exposure and training surrounding the model and concerns about the transportability of the treatment to a multi-cultural context. One method of addressing these barriers to treatment delivery is through systematic case-based research. Systematic case-based research offers a complementary means of refining theory and developing evidence-based practice in the context of a developing country. The method offers an intensive analysis and description of the particular phenomena under study within its real-life context. It allows the researcher to intensively examine and identify the specific aspects of the therapist’s responses and client’s reactions that contributed to significant change. Unlike efficacy studies, generalisability in case-study research is based on replication on a case-by-case basis and the creation of case law. This research study uses a systematic-case study approach to investigate the applicability of the Ehlers and Clark (2000) model in the treatment of rape-related PTSD in South Africa. The study aims to demonstrate the transportability of the model and develop a needed evidence base for service providers in the country. Seven women participated in the project and lent their treatment process to the research. The participants varied in terms of age, race, culture, socio-economic status and the nature of their sexual trauma. Through synoptic thematic analysis of their therapy process specific client-related personal aspects, client-related contextual factors and state-level factors were found to impede treatment delivery and implementation. The implications of these aspects for clinical practice and social policy are comprehensively discussed.
- Full Text:
A short composition portfolio
- Buitendag, Kingsley Alexander
- Authors: Buitendag, Kingsley Alexander
- Date: 2011
- Subjects: Music -- South Africa Composition (Music)
- Language: English
- Type: text , Thesis , Masters , MMus
- Identifier: vital:2632 , http://hdl.handle.net/10962/d1002297
- Full Text:
- Authors: Buitendag, Kingsley Alexander
- Date: 2011
- Subjects: Music -- South Africa Composition (Music)
- Language: English
- Type: text , Thesis , Masters , MMus
- Identifier: vital:2632 , http://hdl.handle.net/10962/d1002297
- Full Text:
A strange counterpoint : classical music performance and identities in Grahamstown, South Africa
- Marais, Terence Wilmot Eugene
- Authors: Marais, Terence Wilmot Eugene
- Date: 2011
- Subjects: Music -- Western influences Music -- Performance -- Psychological aspects Music appreciation -- South Africa -- Grahamstown Music -- South Africa -- Grahamstown
- Language: English
- Type: Thesis , Masters , MMus
- Identifier: vital:2677 , http://hdl.handle.net/10962/d1007491
- Description: This study investigates the perceptions of South African practitioners of Western European Art Music (WEAM), specifically as they relate to the value of WEAM in contemporary South African society. In exploring some of the connections between musical identity and national identity, it sets out to discover what value WEAM holds for a certain group of student pianists. Qualitative empirical data was collected in the form of in-depth, semi-structured interviews and questionnaire responses, and the findings point to numerous, nuanced expressions of self and varied intersections of the nation with musical identity in the life of the individual. Further, WEAM appears to represent a crucial point of identification for these individuals, in each case generating positive affirmations of the self.
- Full Text:
- Authors: Marais, Terence Wilmot Eugene
- Date: 2011
- Subjects: Music -- Western influences Music -- Performance -- Psychological aspects Music appreciation -- South Africa -- Grahamstown Music -- South Africa -- Grahamstown
- Language: English
- Type: Thesis , Masters , MMus
- Identifier: vital:2677 , http://hdl.handle.net/10962/d1007491
- Description: This study investigates the perceptions of South African practitioners of Western European Art Music (WEAM), specifically as they relate to the value of WEAM in contemporary South African society. In exploring some of the connections between musical identity and national identity, it sets out to discover what value WEAM holds for a certain group of student pianists. Qualitative empirical data was collected in the form of in-depth, semi-structured interviews and questionnaire responses, and the findings point to numerous, nuanced expressions of self and varied intersections of the nation with musical identity in the life of the individual. Further, WEAM appears to represent a crucial point of identification for these individuals, in each case generating positive affirmations of the self.
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A study of a class of invariant optimal control problems on the Euclidean group SE(2)
- Authors: Adams, Ross Montague
- Date: 2011
- Subjects: Matrix groups Lie groups Extremal problems (Mathematics) Maximum principles (Mathematics) Hamilton-Jacobi equations Lyapunov stability
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:5420 , http://hdl.handle.net/10962/d1006060
- Description: The aim of this thesis is to study a class of left-invariant optimal control problems on the matrix Lie group SE(2). We classify, under detached feedback equivalence, all controllable (left-invariant) control affine systems on SE(2). This result produces six types of control affine systems on SE(2). Hence, we study six associated left-invariant optimal control problems on SE(2). A left-invariant optimal control problem consists of minimizing a cost functional over the trajectory-control pairs of a left-invariant control system subject to appropriate boundary conditions. Each control problem is lifted from SE(2) to T*SE(2) ≅ SE(2) x se (2)*and then reduced to a problem on se (2)*. The maximum principle is used to obtain the optimal control and Hamiltonian corresponding to the normal extremals. Then we derive the (reduced) extremal equations on se (2)*. These equations are explicitly integrated by trigonometric and Jacobi elliptic functions. Finally, we fully classify, under Lyapunov stability, the equilibrium states of the normal extremal equations for each of the six types under consideration.
- Full Text:
- Authors: Adams, Ross Montague
- Date: 2011
- Subjects: Matrix groups Lie groups Extremal problems (Mathematics) Maximum principles (Mathematics) Hamilton-Jacobi equations Lyapunov stability
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:5420 , http://hdl.handle.net/10962/d1006060
- Description: The aim of this thesis is to study a class of left-invariant optimal control problems on the matrix Lie group SE(2). We classify, under detached feedback equivalence, all controllable (left-invariant) control affine systems on SE(2). This result produces six types of control affine systems on SE(2). Hence, we study six associated left-invariant optimal control problems on SE(2). A left-invariant optimal control problem consists of minimizing a cost functional over the trajectory-control pairs of a left-invariant control system subject to appropriate boundary conditions. Each control problem is lifted from SE(2) to T*SE(2) ≅ SE(2) x se (2)*and then reduced to a problem on se (2)*. The maximum principle is used to obtain the optimal control and Hamiltonian corresponding to the normal extremals. Then we derive the (reduced) extremal equations on se (2)*. These equations are explicitly integrated by trigonometric and Jacobi elliptic functions. Finally, we fully classify, under Lyapunov stability, the equilibrium states of the normal extremal equations for each of the six types under consideration.
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A white man in exile
- Authors: Krueger, Anton
- Date: 2011
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/229459 , vital:49677 , xlink:href="https://doi.org/10.1080/10137548.2011.636974"
- Description: This article explores intersections between understandings of masculinity and nationalism. Etymologically, ‘patriotism’ refers to a love for a fatherland and a patriarchal order; it includes notions of loyalty, honour and a range of qualities often associated with conceptions of masculinity. But if gender remains fixed to these normative constructions, what happens to one’s sense of masculine identity when the national state changes? My interest lies in exploring how white South African men have been repositioned in terms of a shift in their gendered identification, with a reflection on the possibly tragic consequences of maintaining an overly rigid gender role identification. As long as masculinity is embedded within nationalism, it will be caught up within a defensive reactive mode which can turn self-destructive. In order to explore these ideas the article employs as its central metaphor the character of Dawid Olivier, who is the protagonist of Athol Fugard’s Sorrows and Rejoicings (2002).
- Full Text:
- Authors: Krueger, Anton
- Date: 2011
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/229459 , vital:49677 , xlink:href="https://doi.org/10.1080/10137548.2011.636974"
- Description: This article explores intersections between understandings of masculinity and nationalism. Etymologically, ‘patriotism’ refers to a love for a fatherland and a patriarchal order; it includes notions of loyalty, honour and a range of qualities often associated with conceptions of masculinity. But if gender remains fixed to these normative constructions, what happens to one’s sense of masculine identity when the national state changes? My interest lies in exploring how white South African men have been repositioned in terms of a shift in their gendered identification, with a reflection on the possibly tragic consequences of maintaining an overly rigid gender role identification. As long as masculinity is embedded within nationalism, it will be caught up within a defensive reactive mode which can turn self-destructive. In order to explore these ideas the article employs as its central metaphor the character of Dawid Olivier, who is the protagonist of Athol Fugard’s Sorrows and Rejoicings (2002).
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A “place in which to cry”: the place for race and a home for shame in Zoë Wicomb's Playing in the Light
- Authors: Dass, Minesh
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/142588 , vital:38093 , DOI: 10.1080/1013929X.2011.602910
- Description: In Zoë Wicomb's Playing in the Light, the main character's troubled sense of identity (brought about by her parents' shameful decision to ‘play white’) is viscerally symbolised by her discomfort in her own and others' homes. In her Cape Town apartment she has nightmares about other houses. Her visits to her family home, where her elderly father lives alone, are similarly burdened by presences and memories she finds unwelcoming. And, her extended vacation to the UK, once she has discovered her family's secret, is a choice of “a place in which to cry” (Wicomb 2006: 191).
- Full Text:
- Authors: Dass, Minesh
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/142588 , vital:38093 , DOI: 10.1080/1013929X.2011.602910
- Description: In Zoë Wicomb's Playing in the Light, the main character's troubled sense of identity (brought about by her parents' shameful decision to ‘play white’) is viscerally symbolised by her discomfort in her own and others' homes. In her Cape Town apartment she has nightmares about other houses. Her visits to her family home, where her elderly father lives alone, are similarly burdened by presences and memories she finds unwelcoming. And, her extended vacation to the UK, once she has discovered her family's secret, is a choice of “a place in which to cry” (Wicomb 2006: 191).
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Abortion as disruption: discourses surrounding abortion in the talk of men
- Authors: Hansjee, Jateen
- Date: 2011
- Subjects: Abortion -- Psychological aspects Abortion -- Social aspects Men -- South Africa -- Language Men -- South Africa -- Attitudes Health attitudes -- South Africa Discourse analysis -- Psychological aspects Discourse analysis -- Social aspects
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:2984 , http://hdl.handle.net/10962/d1002493
- Description: This research examines men’s talk around abortion using critical discourse analysis. Current literature indicates a dearth of studies addressing the topic of men and abortion in various domains. An understanding of men’s relationship to abortion, however, is crucial to understanding abortion as a social phenomenon. This study utilises the work of Foucault around discourse and power, as well as Butler’s work on gender to create a theoretical framework to approach data. Data were collected in the form of interview groups made up of men, as well as newspaper articles and on-line forum discussions that featured men as the author. What emerged from theses texts was a ‘Familial Discourse’ which posits the nuclear, heterosexual family as a long term relationship between a mother and father, which forms the ideal site to raise children. Discourses that support the family are a discourse of ‘Equal Partnership’ which establishes the man and the woman as being in a heterosexual relationship where each partner is seen to have equal power, and a discourse of ‘Foetal Personhood’ which constructs the foetus as a child in need of a family. Related to the heterosexual matrix, the formation of a family unit comes to be constructed as ‘natural’. Abortion acts as a disruptor to these discourses. By disrupting the formation of the family unit, abortion negatively affects the individuals involved. A relationship where a formation of a family unit was disrupted cannot survive. If the female partner has an abortion without her partner, it is seen as disrupting the equal partnership between the man and the woman. Men in this case see themselves as ‘powerless’ compared to women. From this point a ‘New Man’ discourse emerges, where men position themselves as loving and responsible in the context of a nuclear, heterosexual family unit. Abortion disrupts ‘Foetal Personhood’ and is constructed as murder. In the case of rape the ‘Familial Discourse’ can be invoked either to justify abortion or resist abortion, based on whether or not a family unit can be formed. These discourses reproduce patriarchy.
- Full Text:
- Authors: Hansjee, Jateen
- Date: 2011
- Subjects: Abortion -- Psychological aspects Abortion -- Social aspects Men -- South Africa -- Language Men -- South Africa -- Attitudes Health attitudes -- South Africa Discourse analysis -- Psychological aspects Discourse analysis -- Social aspects
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:2984 , http://hdl.handle.net/10962/d1002493
- Description: This research examines men’s talk around abortion using critical discourse analysis. Current literature indicates a dearth of studies addressing the topic of men and abortion in various domains. An understanding of men’s relationship to abortion, however, is crucial to understanding abortion as a social phenomenon. This study utilises the work of Foucault around discourse and power, as well as Butler’s work on gender to create a theoretical framework to approach data. Data were collected in the form of interview groups made up of men, as well as newspaper articles and on-line forum discussions that featured men as the author. What emerged from theses texts was a ‘Familial Discourse’ which posits the nuclear, heterosexual family as a long term relationship between a mother and father, which forms the ideal site to raise children. Discourses that support the family are a discourse of ‘Equal Partnership’ which establishes the man and the woman as being in a heterosexual relationship where each partner is seen to have equal power, and a discourse of ‘Foetal Personhood’ which constructs the foetus as a child in need of a family. Related to the heterosexual matrix, the formation of a family unit comes to be constructed as ‘natural’. Abortion acts as a disruptor to these discourses. By disrupting the formation of the family unit, abortion negatively affects the individuals involved. A relationship where a formation of a family unit was disrupted cannot survive. If the female partner has an abortion without her partner, it is seen as disrupting the equal partnership between the man and the woman. Men in this case see themselves as ‘powerless’ compared to women. From this point a ‘New Man’ discourse emerges, where men position themselves as loving and responsible in the context of a nuclear, heterosexual family unit. Abortion disrupts ‘Foetal Personhood’ and is constructed as murder. In the case of rape the ‘Familial Discourse’ can be invoked either to justify abortion or resist abortion, based on whether or not a family unit can be formed. These discourses reproduce patriarchy.
- Full Text:
Above ground woody community attributes, biomass and carbon stocks along a rainfall gradient in the savannas of the central lowveld, South Africa
- Shackleton, Charlie M, Scholes, Robert J
- Authors: Shackleton, Charlie M , Scholes, Robert J
- Date: 2011
- Language: English
- Type: Article
- Identifier: vital:6658 , http://hdl.handle.net/10962/d1007079
- Description: Enumeration of carbon stocks at benchmark sites is a necessary activity in assessing the potential carbon sequestration and possible generation of credits through restoration of intensively impacted sites. However, there is a lack of empirical studies throughout much of the savannas of sub-Saharan Africa, including South Africa. We report an estimation of species specific and site biomass and carbon stocks, and general vegetation structural attributes from three protected areas along a rainfall gradient in the central lowveld, South Africa. Estimates of biomass and carbon stocks were effected through destructive sampling to establish locally derived allometric equations. There was a gradient of increasing woody density, height of the canopy, number of species, density of regenerative stems and a greater proportion of stems in small size classes from the arid locality to the mesic locality, with the semi-arid locality being intermediate. The proportion of spinescent species decreased with increasing rainfall. The mesic locality was significantly more woody than either the arid or semi-arid sites, having double the biomass, four times the density and 40% higher basal area. Above ground carbon pools were also higher; carbon stocks were approximately 9 t/ha for the arid and semi-arid sites and 18 t/ha for the mesic site.
- Full Text:
- Authors: Shackleton, Charlie M , Scholes, Robert J
- Date: 2011
- Language: English
- Type: Article
- Identifier: vital:6658 , http://hdl.handle.net/10962/d1007079
- Description: Enumeration of carbon stocks at benchmark sites is a necessary activity in assessing the potential carbon sequestration and possible generation of credits through restoration of intensively impacted sites. However, there is a lack of empirical studies throughout much of the savannas of sub-Saharan Africa, including South Africa. We report an estimation of species specific and site biomass and carbon stocks, and general vegetation structural attributes from three protected areas along a rainfall gradient in the central lowveld, South Africa. Estimates of biomass and carbon stocks were effected through destructive sampling to establish locally derived allometric equations. There was a gradient of increasing woody density, height of the canopy, number of species, density of regenerative stems and a greater proportion of stems in small size classes from the arid locality to the mesic locality, with the semi-arid locality being intermediate. The proportion of spinescent species decreased with increasing rainfall. The mesic locality was significantly more woody than either the arid or semi-arid sites, having double the biomass, four times the density and 40% higher basal area. Above ground carbon pools were also higher; carbon stocks were approximately 9 t/ha for the arid and semi-arid sites and 18 t/ha for the mesic site.
- Full Text:
Action competence and waste management: a case study of learner agency in two Grahamstown eco-schools
- Chiphwanya, Nellie Chimwemwe
- Authors: Chiphwanya, Nellie Chimwemwe
- Date: 2011
- Subjects: Environmental education -- South Africa -- Grahamstown -- Case studies Environmental education -- Study and teaching (Primary) -- South Africa -- Grahamstown -- Case studies Student-centered learning -- South Africa -- Grahamstown -- Case studies Refuse and refuse disposal -- Environmental aspects -- South Africa -- Grahamstown -- Case studies Recycling (Waste, etc) -- South Africa -- Grahamstown -- Case studies Active learning -- South Africa -- Grahamstown -- Case studies Competency based education -- South Africa -- Grahamstown -- Case studies
- Language: English
- Type: Thesis , Masters , MEd
- Identifier: vital:1956 , http://hdl.handle.net/10962/d1008308
- Description: There has been a growing need in environmental education to develop students' ability and will to take part in democratic processes that enable them take environmental action in their local environment. This study examined learner action competence in waste management practices in two primary school contexts in the Eastern Cape, South Africa. An interpretive case study design is used to probe how learner participation in Eco-School waste management practices enabled the acquisition of knowledge in purposeful learning and action experiences that developed the vision and agency of informed action. The research was centred on two guiding questions: 1. How informed, purposeful and action-orientated is learner participation in Eco-School waste management activities? 2. What Eco-School waste management activities are fostering active participation towards a learner-led agency? Educators in the two schools were interviewed and Eco-School portfolios were examined for evidence of the learning activities and learner achievement. This provided the contextual data for reviewing focus group interviews to probe what was significant to learners, what they came to know and how they had contributed to the process of developing better waste management in the Eco-School context. The evidence generated in the study was used to identify the roles of the various players, the significant activities and processes that enabled and constrained the emergence of learner-led agency. The main findings in the study were that teacher intentionality and school management ethos were significant in engaging learners in meaningful waste management activities in both cases. The study also revealed that although most of the waste management activities in both cases were teacher-initiated, there were spaces open for learner initiatives. However, it appeared that the activity based waste management practices mostly allowed learners to learn how to do waste management more than allowing them to find out more about the scope and nature of ii the problem of waste. This then resulted in learners talking more about what they were doing with waste than talking about what they knew about waste. There were differences in the way in which learners approached waste in the two cases. In the one case, Kingswood Junior School learners used waste artistically and carried out activities that allowed for better use of waste resources like paper while in the other School, Grahamstown SDA School, learners approached waste as a resource for making money. However, in both cases, learners appeared to enjoy the positive experiences of doing things that contributed to a cleaner environment and were of benefit to others and this gave them a sense of pride to share their experiences with others. This study was significant as it allowed me to probe learner participation and examine the development of their action competence through listening to the voices of the learners themselves and understanding what was important to them about the knowledge they gained and their vision of better waste management.
- Full Text:
- Authors: Chiphwanya, Nellie Chimwemwe
- Date: 2011
- Subjects: Environmental education -- South Africa -- Grahamstown -- Case studies Environmental education -- Study and teaching (Primary) -- South Africa -- Grahamstown -- Case studies Student-centered learning -- South Africa -- Grahamstown -- Case studies Refuse and refuse disposal -- Environmental aspects -- South Africa -- Grahamstown -- Case studies Recycling (Waste, etc) -- South Africa -- Grahamstown -- Case studies Active learning -- South Africa -- Grahamstown -- Case studies Competency based education -- South Africa -- Grahamstown -- Case studies
- Language: English
- Type: Thesis , Masters , MEd
- Identifier: vital:1956 , http://hdl.handle.net/10962/d1008308
- Description: There has been a growing need in environmental education to develop students' ability and will to take part in democratic processes that enable them take environmental action in their local environment. This study examined learner action competence in waste management practices in two primary school contexts in the Eastern Cape, South Africa. An interpretive case study design is used to probe how learner participation in Eco-School waste management practices enabled the acquisition of knowledge in purposeful learning and action experiences that developed the vision and agency of informed action. The research was centred on two guiding questions: 1. How informed, purposeful and action-orientated is learner participation in Eco-School waste management activities? 2. What Eco-School waste management activities are fostering active participation towards a learner-led agency? Educators in the two schools were interviewed and Eco-School portfolios were examined for evidence of the learning activities and learner achievement. This provided the contextual data for reviewing focus group interviews to probe what was significant to learners, what they came to know and how they had contributed to the process of developing better waste management in the Eco-School context. The evidence generated in the study was used to identify the roles of the various players, the significant activities and processes that enabled and constrained the emergence of learner-led agency. The main findings in the study were that teacher intentionality and school management ethos were significant in engaging learners in meaningful waste management activities in both cases. The study also revealed that although most of the waste management activities in both cases were teacher-initiated, there were spaces open for learner initiatives. However, it appeared that the activity based waste management practices mostly allowed learners to learn how to do waste management more than allowing them to find out more about the scope and nature of ii the problem of waste. This then resulted in learners talking more about what they were doing with waste than talking about what they knew about waste. There were differences in the way in which learners approached waste in the two cases. In the one case, Kingswood Junior School learners used waste artistically and carried out activities that allowed for better use of waste resources like paper while in the other School, Grahamstown SDA School, learners approached waste as a resource for making money. However, in both cases, learners appeared to enjoy the positive experiences of doing things that contributed to a cleaner environment and were of benefit to others and this gave them a sense of pride to share their experiences with others. This study was significant as it allowed me to probe learner participation and examine the development of their action competence through listening to the voices of the learners themselves and understanding what was important to them about the knowledge they gained and their vision of better waste management.
- Full Text:
Adjustment of commercial banks' interest rates and the effectiveness of monetary policy: evidence from Anglophone West Africa
- Authors: Bangura, Lamin
- Date: 2011
- Subjects: Monetary policy -- Africa, West , Banks and banking -- Africa, West , Interest rates -- Africa, West
- Language: English
- Type: Thesis , Masters , MCom
- Identifier: vital:951 , http://hdl.handle.net/10962/d1002685 , Monetary policy -- Africa, West , Banks and banking -- Africa, West , Interest rates -- Africa, West
- Description: Most central banks use short-term interest rates as their main instrument of monetary policy. It is assumed that a change in policy rate will influence interest rates set by commercial banks, but this is not usually the case. Commercial banks adjust their interest rates in response to changes in policy rate with lags, which make their interest rates sticky. Stickiness in commercial banks interest rates have been seen as an obstacle to the smooth transmission of monetary policy decisions. Despite the importance of the transmission process, little attention has been given to a systematic measurement of the degree of response of commercial banks‟ interest rates to changes in monetary policy stance in the Anglophone West African countries, specifically within the West African Monetary Zone (WAMZ) economies. Against this backdrop, this study explores the interest rate adjustment dynamics using monthly interest rate series on discount rate, treasury bill rate, commercial banks‟ deposit and lending rates from 1989 to 2009 (for Gambia, Nigeria and Sierra Leone) and from 2000 to 2009 (for Ghana). Specifically, the study set out to examine how lending and deposit rates respond to changes in the official rates and to see whether there is a convergence among the rates over time. Also, to examine the relative adjustment of commercial bank lending rates to changes in the official rate when there is disequilibrium. The analyses were twofold: a full sample period and a rolling window analysis. Following Cottarelli and Kourelis (1994), the study employed cointegration technique and an asymmetric error correction model to obtain the short-run and long-run parameters from which the error correction coefficients, mean adjustment lags and asymmetric mean adjustment lags were estimated. The results for the entire sample period revealed that the long-run pass-through in Nigeria was 81% and 67% for lending rates and deposit rates respectively. In Ghana, it was 66% and 69% for lending and deposit rates respectively. While in Sierra Leone, long-run pass-through was 62% and 72% for lending and deposit rates respectively. In Gambia, it was 50% and 40% for lending and deposit rates respectively. On the other hand, the short-run pass-through was found to be lower compared to the long-run pass-through: in Nigeria it was 66% and 47%; in Gambia, 26% and 29%; in Sierra Leone, 30% and 13%; and in Ghana, -6% and 35% for lending and deposit rates respectively in each country. The pass-through estimates for the rolling windows were mixed for short-run and long-run pass-through. The mean adjustment lags suggest that the speed of adjustment of Lending rates for full sample period were two, two, seven and twelve months in Nigeria, Ghana, Sierra Leone and Gambia respectively. While for deposit rates they were five, six, seven and eighteen for Ghana, Nigeria, Gambia and Sierra Leone respectively. The average speeds of adjustment for the rolling windows were four and five months for lending and deposit rates respectively. Weak evidence of convergence was found in lending and deposit rates in the short-run and long-run pass-through among the countries. However, the results suggest that the magnitude and speed of the pass-through amongst the countries on average were high compared to emerging Asian countries. Significant asymmetric adjustments were found in the lending rates for Gambia and Sierra Leone, while in Gambia and Nigeria there were asymmetries in deposit rates. Based on the evidence provided, interest rate pass-through is high in Nigeria and Ghana compared to Gambia and Sierra Leone and this calls for the harmonization of financial policies on the part of the financial authorities in the WAMZ. Viewed solely from an interest rate pass-through, the lack of convergence among the countries suggests that WAMZ is far from ready for a monetary union. The relatively low pass-through in some of the countries suggests rigidity in the banking system which may be due to underdevelopment of the system. Thus efforts geared toward strengthening the banking system and the financial system as whole would further enhance the prospect of a monetary union among them.
- Full Text:
- Authors: Bangura, Lamin
- Date: 2011
- Subjects: Monetary policy -- Africa, West , Banks and banking -- Africa, West , Interest rates -- Africa, West
- Language: English
- Type: Thesis , Masters , MCom
- Identifier: vital:951 , http://hdl.handle.net/10962/d1002685 , Monetary policy -- Africa, West , Banks and banking -- Africa, West , Interest rates -- Africa, West
- Description: Most central banks use short-term interest rates as their main instrument of monetary policy. It is assumed that a change in policy rate will influence interest rates set by commercial banks, but this is not usually the case. Commercial banks adjust their interest rates in response to changes in policy rate with lags, which make their interest rates sticky. Stickiness in commercial banks interest rates have been seen as an obstacle to the smooth transmission of monetary policy decisions. Despite the importance of the transmission process, little attention has been given to a systematic measurement of the degree of response of commercial banks‟ interest rates to changes in monetary policy stance in the Anglophone West African countries, specifically within the West African Monetary Zone (WAMZ) economies. Against this backdrop, this study explores the interest rate adjustment dynamics using monthly interest rate series on discount rate, treasury bill rate, commercial banks‟ deposit and lending rates from 1989 to 2009 (for Gambia, Nigeria and Sierra Leone) and from 2000 to 2009 (for Ghana). Specifically, the study set out to examine how lending and deposit rates respond to changes in the official rates and to see whether there is a convergence among the rates over time. Also, to examine the relative adjustment of commercial bank lending rates to changes in the official rate when there is disequilibrium. The analyses were twofold: a full sample period and a rolling window analysis. Following Cottarelli and Kourelis (1994), the study employed cointegration technique and an asymmetric error correction model to obtain the short-run and long-run parameters from which the error correction coefficients, mean adjustment lags and asymmetric mean adjustment lags were estimated. The results for the entire sample period revealed that the long-run pass-through in Nigeria was 81% and 67% for lending rates and deposit rates respectively. In Ghana, it was 66% and 69% for lending and deposit rates respectively. While in Sierra Leone, long-run pass-through was 62% and 72% for lending and deposit rates respectively. In Gambia, it was 50% and 40% for lending and deposit rates respectively. On the other hand, the short-run pass-through was found to be lower compared to the long-run pass-through: in Nigeria it was 66% and 47%; in Gambia, 26% and 29%; in Sierra Leone, 30% and 13%; and in Ghana, -6% and 35% for lending and deposit rates respectively in each country. The pass-through estimates for the rolling windows were mixed for short-run and long-run pass-through. The mean adjustment lags suggest that the speed of adjustment of Lending rates for full sample period were two, two, seven and twelve months in Nigeria, Ghana, Sierra Leone and Gambia respectively. While for deposit rates they were five, six, seven and eighteen for Ghana, Nigeria, Gambia and Sierra Leone respectively. The average speeds of adjustment for the rolling windows were four and five months for lending and deposit rates respectively. Weak evidence of convergence was found in lending and deposit rates in the short-run and long-run pass-through among the countries. However, the results suggest that the magnitude and speed of the pass-through amongst the countries on average were high compared to emerging Asian countries. Significant asymmetric adjustments were found in the lending rates for Gambia and Sierra Leone, while in Gambia and Nigeria there were asymmetries in deposit rates. Based on the evidence provided, interest rate pass-through is high in Nigeria and Ghana compared to Gambia and Sierra Leone and this calls for the harmonization of financial policies on the part of the financial authorities in the WAMZ. Viewed solely from an interest rate pass-through, the lack of convergence among the countries suggests that WAMZ is far from ready for a monetary union. The relatively low pass-through in some of the countries suggests rigidity in the banking system which may be due to underdevelopment of the system. Thus efforts geared toward strengthening the banking system and the financial system as whole would further enhance the prospect of a monetary union among them.
- Full Text:
Adoption, use and perception of Australian acacias around the world
- Kull, Christian A, Shackleton, Charlie M, Cunningham, Peter J, Ducatillon, Catherine, Dufour-Dror, Jean-Mark, Esler, Karen J, Friday, James B, Gouveia, António C, Griffin, A R, Marchante, Elizabete, Midgley, Steven J, Pauchard, Aníbal, Rangan, Haripriya, Richardson, David M, Rinaudo, Tony, Tassin, Jacques, Urgenson, Lauren S, van Maltitz, Graham P, Zenni, Rafael D, Zylstra, Matthew J
- Authors: Kull, Christian A , Shackleton, Charlie M , Cunningham, Peter J , Ducatillon, Catherine , Dufour-Dror, Jean-Mark , Esler, Karen J , Friday, James B , Gouveia, António C , Griffin, A R , Marchante, Elizabete , Midgley, Steven J , Pauchard, Aníbal , Rangan, Haripriya , Richardson, David M , Rinaudo, Tony , Tassin, Jacques , Urgenson, Lauren S , van Maltitz, Graham P , Zenni, Rafael D , Zylstra, Matthew J
- Date: 2011
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/182149 , vital:43804 , xlink:href="https://doi.org/10.1111/j.1472-4642.2011.00783.x"
- Description: To examine the different uses and perceptions of introduced Australian acacias (wattles; Acacia subgenus Phyllodineae) by rural households and communities. Eighteen landscape-scale case studies around the world, in Vietnam, India, Réunion, Madagascar, South Africa, Congo, Niger, Ethiopia, Israel, France, Portugal, Brazil, Chile, Dominican Republic and Hawai‘i. Qualitative comparison of case studies, based on questionnaire sent to network of acacia researchers. Information based on individual knowledge of local experts, published and unpublished sources. We propose a conceptual model to explain current uses and perceptions of introduced acacias. It highlights historically and geographically contingent processes, including economic development, environmental discourses, political context, and local or regional needs. Four main groupings of case studies were united by similar patterns: (1) poor communities benefiting from targeted agroforestry projects; (2) places where residents, generally poor, take advantage of a valuable resource already present in their landscape via plantation and/or invasion; (3) regions of small and mid-scale tree farmers participating in the forestry industry; and (4) a number of high-income communities dealing with the legacies of former or niche use of introduced acacia in a context of increased concern over biodiversity and ecosystem services. Economic conditions play a key role shaping acacia use. Poorer communities rely strongly on acacias (often in, or escaped from, formal plantations) for household needs and, sometimes, for income. Middle-income regions more typically host private farm investments in acacia woodlots for commercialization. Efforts at control of invasive acacias must take care to not adversely impact poor dependent communities.
- Full Text:
- Authors: Kull, Christian A , Shackleton, Charlie M , Cunningham, Peter J , Ducatillon, Catherine , Dufour-Dror, Jean-Mark , Esler, Karen J , Friday, James B , Gouveia, António C , Griffin, A R , Marchante, Elizabete , Midgley, Steven J , Pauchard, Aníbal , Rangan, Haripriya , Richardson, David M , Rinaudo, Tony , Tassin, Jacques , Urgenson, Lauren S , van Maltitz, Graham P , Zenni, Rafael D , Zylstra, Matthew J
- Date: 2011
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/182149 , vital:43804 , xlink:href="https://doi.org/10.1111/j.1472-4642.2011.00783.x"
- Description: To examine the different uses and perceptions of introduced Australian acacias (wattles; Acacia subgenus Phyllodineae) by rural households and communities. Eighteen landscape-scale case studies around the world, in Vietnam, India, Réunion, Madagascar, South Africa, Congo, Niger, Ethiopia, Israel, France, Portugal, Brazil, Chile, Dominican Republic and Hawai‘i. Qualitative comparison of case studies, based on questionnaire sent to network of acacia researchers. Information based on individual knowledge of local experts, published and unpublished sources. We propose a conceptual model to explain current uses and perceptions of introduced acacias. It highlights historically and geographically contingent processes, including economic development, environmental discourses, political context, and local or regional needs. Four main groupings of case studies were united by similar patterns: (1) poor communities benefiting from targeted agroforestry projects; (2) places where residents, generally poor, take advantage of a valuable resource already present in their landscape via plantation and/or invasion; (3) regions of small and mid-scale tree farmers participating in the forestry industry; and (4) a number of high-income communities dealing with the legacies of former or niche use of introduced acacia in a context of increased concern over biodiversity and ecosystem services. Economic conditions play a key role shaping acacia use. Poorer communities rely strongly on acacias (often in, or escaped from, formal plantations) for household needs and, sometimes, for income. Middle-income regions more typically host private farm investments in acacia woodlots for commercialization. Efforts at control of invasive acacias must take care to not adversely impact poor dependent communities.
- Full Text:
Adventures with abalone : aquaculture, poaching, and fishery restoration
- Authors: Britz, Peter Jacobus, 1959-
- Date: 2011
- Language: English
- Type: Text
- Identifier: vital:583 , http://hdl.handle.net/10962/d1018943
- Description: [From the text] Tonight I am going to tell you about my research on a another mollusc, the humble abalone. - In contrast with the highly evolved squid, this marine snail belonging to the ancient archeogastrod lineage which has a much simpler anatomy and lifestyle. It doesn’t posses a proper brain mass, only having 4 ganglia or nerves knots at the front end. Its two simple eye spots which detect light and dark, a tough shell and a large and extremely powerful foot muscle to adhere to rocks. This simple configuration has served well for over 100 million years.
- Full Text:
- Authors: Britz, Peter Jacobus, 1959-
- Date: 2011
- Language: English
- Type: Text
- Identifier: vital:583 , http://hdl.handle.net/10962/d1018943
- Description: [From the text] Tonight I am going to tell you about my research on a another mollusc, the humble abalone. - In contrast with the highly evolved squid, this marine snail belonging to the ancient archeogastrod lineage which has a much simpler anatomy and lifestyle. It doesn’t posses a proper brain mass, only having 4 ganglia or nerves knots at the front end. Its two simple eye spots which detect light and dark, a tough shell and a large and extremely powerful foot muscle to adhere to rocks. This simple configuration has served well for over 100 million years.
- Full Text:
Africa: unity, sovereignty and sorrow A book review
- Authors: Matthews, Sally
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/142387 , vital:38075 , DOI: 10.1080/02589001.2011.562007
- Description: This ambitious book begins with the statement ‘By and large, the states of sub-Saharan Africa are failures’ (p. 1) and then sets out to explain state failure in Africa and to provide some ‘rational policy fantasies’ in response to this failure. The book builds on the work of scholars like Robert Jackson, William Reno and Jeffrey Herbst, with the particular focus of Englebert's book being on the domestic implications of the unconditional recognition of the sovereignty of African states. African states are internationally recognised despite lacking the features and not being able to perform the functions typically associated with statehood. Englebert's interest is to examine some of the domestic effects of this unconditional international recognition.
- Full Text:
- Authors: Matthews, Sally
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/142387 , vital:38075 , DOI: 10.1080/02589001.2011.562007
- Description: This ambitious book begins with the statement ‘By and large, the states of sub-Saharan Africa are failures’ (p. 1) and then sets out to explain state failure in Africa and to provide some ‘rational policy fantasies’ in response to this failure. The book builds on the work of scholars like Robert Jackson, William Reno and Jeffrey Herbst, with the particular focus of Englebert's book being on the domestic implications of the unconditional recognition of the sovereignty of African states. African states are internationally recognised despite lacking the features and not being able to perform the functions typically associated with statehood. Englebert's interest is to examine some of the domestic effects of this unconditional international recognition.
- Full Text:
African Languages And ICT Education
- Dalvit, Lorenzo, Murray, Sarah, Terzoli, Alfredo
- Authors: Dalvit, Lorenzo , Murray, Sarah , Terzoli, Alfredo
- Date: 2011
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/431166 , vital:72750 , https://www.scitepress.org/Papers/2011/33507/33507.pdf
- Description: In South Africa, English plays a dominant role compared to African lan-guages in empowering domain. Better access to Education through the use of African languages is an object of heated debate. This paper shows that an intervention involving the use of an African language in the domain of ICT Education can change the attitudes of Black universi-ty students. The methodology used included a survey with preliminary and follow-up questionnaires and interviews and an intervention involv-ing the use of localised software and of an on-line glossary of computer terms translated, explained and exemplified in an African language (isiXhosa). This experience increased the support for the use of African languages as additional LoLT, even in the English-dominated field of study of Computer Science. This is an initial step towards promoting linguistic equality between English and African languages and social equality between their speakers.
- Full Text:
- Authors: Dalvit, Lorenzo , Murray, Sarah , Terzoli, Alfredo
- Date: 2011
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/431166 , vital:72750 , https://www.scitepress.org/Papers/2011/33507/33507.pdf
- Description: In South Africa, English plays a dominant role compared to African lan-guages in empowering domain. Better access to Education through the use of African languages is an object of heated debate. This paper shows that an intervention involving the use of an African language in the domain of ICT Education can change the attitudes of Black universi-ty students. The methodology used included a survey with preliminary and follow-up questionnaires and interviews and an intervention involv-ing the use of localised software and of an on-line glossary of computer terms translated, explained and exemplified in an African language (isiXhosa). This experience increased the support for the use of African languages as additional LoLT, even in the English-dominated field of study of Computer Science. This is an initial step towards promoting linguistic equality between English and African languages and social equality between their speakers.
- Full Text:
African traditional medicine-antiretroviral interactions : effects of Sutherlandia frutescens on the pharmacokinetics of Atazanavir
- Authors: Müller, Adrienne Carmel
- Date: 2011 , 2011-03-28
- Subjects: Antiretroviral agents , Medicinal plants , Traditional medicine , AIDS (Disease) -- Treatment , HIV infections -- Drug therapy , Drug interactions , Pharmacokinetics
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:3859 , http://hdl.handle.net/10962/d1013373
- Description: In response to the urgent call for investigations into antiretroviral (ARV)-African traditional medicine (ATM) interactions, this research was undertaken to ascertain whether chronic administration of the ATM, Sutherlandia frutescens (SF) may alter the bioavailability of the protease inhibitor (PI), atazanavir (ATV), which may impact on the safety or efficacy of the ARV. Prior to investigating a potential interaction between ATV and SF in vitro and in vivo, a high performance liquid chromatography method with ultraviolet detection (HPLC-UV) was developed and validated for the bioanalysis of ATV in human plasma and liver microsomes. An improved and efficient analytical method with minimal use of solvents and short run time was achieved in comparison to methods published in the literature. In addition, the method was selective, linear, accurate and precise for quantitative analysis of ATV in these studies. Molecular docking studies were conducted to compare the binding modes and affinities of ATV and two major SF constituents, Sutherlandioside B and Sutherlandin C, with the efflux transporter, P-glycoprotein (P-gp) and the CYP450 isoenzyme, CYP3A4 to determine the potential for these phytochemicals to competitively inhibit the binding of ATV to these two proteins, which are mediators of absorption and metabolism. These studies revealed that modulation of P-gp transport of ATV by Sutherlandioside B and Sutherlandin C was not likely to occur via competitive inhibition. The results further indicated that weak competitive inhibition of CYP3A4 may possibly occur in the presence of either of these two SF constituents. The Caco-2 cell line was used as an in vitro model of human intestinal absorption. Accumulation studies in these cells were conducted to ascertain whether extracts and constituents of SF have the ability to alter the absorption of ATV. The results showed that the aqueous extract of SF significantly reduced ATV accumulation, suggesting decreased ATV absorption, whilst a triterpenoid glycoside fraction isolated from SF exhibited an opposing effect. Analogous responses were elicited by the aqueous extract and a triterpenoid glycoside fraction in similar accumulation studies in P-gp overexpressing Madin–Darby Canine Kidney Strain II cells (MDCKII-MDR1), which signified that the effects of this extract and component on ATV transport in the Caco-2 cells were P-gp-mediated. The quantitative analysis of ATV in human liver microsomes after co-incubation with extracts and components of SF was conducted to determine the effects of SF on the metabolism of ATV. The aqueous and methanolic extracts of SF inhibited ATV metabolism, whilst the triterpenoid glycoside fraction had a converse effect. Analogous effects by the extracts were demonstrated in experiments conducted in CYP3A4-transfected microsomes, suggesting that the inhibition of ATV metabolism in the liver microsomes by these SF extracts was CYP3A4-mediated. A combination of Sutherlandiosides C and D also inhibited CYP3A4-mediated ATV metabolism, which was in contrast to the response elicited by the triterpenoid fraction in the liver microsomes, where other unidentified compounds, shown to be present therein, may have contributed to the activation of ATV metabolism. The in vitro studies revealed the potential for SF to alter the bioavailability of ATV, therefore a clinical study in which the effect of a multiple dose regimen of SF on the pharmacokinetics (PK) of a single dose of ATV was conducted in healthy male volunteers. The statistical analysis showed that the 90 % confidence intervals around the geometric mean ratios (ATV + SF/ATV alone) for both Cmax and AUC0-24 hours, fell well below the lower limit of the "no-effect" boundary of 0.8 – 1.25, implying that the bioavailability of ATV was significantly reduced in this cohort of subjects. It may thus be concluded that if the reduction in bioavailability observed in this clinical study is found to be clinically relevant, co-administration of SF commercial dosage forms and ATV in HIV/AIDS patients may potentially result in subtherapeutic ATV levels, which may in turn contribute to ATV resistance and/or treatment failure. This research has therefore highlighted the potential risk for toxicity or lack of efficacy of ARV regimens which may result when ATMs and PIs are used concurrently and that patients and health care practitioners alike should be aware of these perils.
- Full Text:
- Authors: Müller, Adrienne Carmel
- Date: 2011 , 2011-03-28
- Subjects: Antiretroviral agents , Medicinal plants , Traditional medicine , AIDS (Disease) -- Treatment , HIV infections -- Drug therapy , Drug interactions , Pharmacokinetics
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:3859 , http://hdl.handle.net/10962/d1013373
- Description: In response to the urgent call for investigations into antiretroviral (ARV)-African traditional medicine (ATM) interactions, this research was undertaken to ascertain whether chronic administration of the ATM, Sutherlandia frutescens (SF) may alter the bioavailability of the protease inhibitor (PI), atazanavir (ATV), which may impact on the safety or efficacy of the ARV. Prior to investigating a potential interaction between ATV and SF in vitro and in vivo, a high performance liquid chromatography method with ultraviolet detection (HPLC-UV) was developed and validated for the bioanalysis of ATV in human plasma and liver microsomes. An improved and efficient analytical method with minimal use of solvents and short run time was achieved in comparison to methods published in the literature. In addition, the method was selective, linear, accurate and precise for quantitative analysis of ATV in these studies. Molecular docking studies were conducted to compare the binding modes and affinities of ATV and two major SF constituents, Sutherlandioside B and Sutherlandin C, with the efflux transporter, P-glycoprotein (P-gp) and the CYP450 isoenzyme, CYP3A4 to determine the potential for these phytochemicals to competitively inhibit the binding of ATV to these two proteins, which are mediators of absorption and metabolism. These studies revealed that modulation of P-gp transport of ATV by Sutherlandioside B and Sutherlandin C was not likely to occur via competitive inhibition. The results further indicated that weak competitive inhibition of CYP3A4 may possibly occur in the presence of either of these two SF constituents. The Caco-2 cell line was used as an in vitro model of human intestinal absorption. Accumulation studies in these cells were conducted to ascertain whether extracts and constituents of SF have the ability to alter the absorption of ATV. The results showed that the aqueous extract of SF significantly reduced ATV accumulation, suggesting decreased ATV absorption, whilst a triterpenoid glycoside fraction isolated from SF exhibited an opposing effect. Analogous responses were elicited by the aqueous extract and a triterpenoid glycoside fraction in similar accumulation studies in P-gp overexpressing Madin–Darby Canine Kidney Strain II cells (MDCKII-MDR1), which signified that the effects of this extract and component on ATV transport in the Caco-2 cells were P-gp-mediated. The quantitative analysis of ATV in human liver microsomes after co-incubation with extracts and components of SF was conducted to determine the effects of SF on the metabolism of ATV. The aqueous and methanolic extracts of SF inhibited ATV metabolism, whilst the triterpenoid glycoside fraction had a converse effect. Analogous effects by the extracts were demonstrated in experiments conducted in CYP3A4-transfected microsomes, suggesting that the inhibition of ATV metabolism in the liver microsomes by these SF extracts was CYP3A4-mediated. A combination of Sutherlandiosides C and D also inhibited CYP3A4-mediated ATV metabolism, which was in contrast to the response elicited by the triterpenoid fraction in the liver microsomes, where other unidentified compounds, shown to be present therein, may have contributed to the activation of ATV metabolism. The in vitro studies revealed the potential for SF to alter the bioavailability of ATV, therefore a clinical study in which the effect of a multiple dose regimen of SF on the pharmacokinetics (PK) of a single dose of ATV was conducted in healthy male volunteers. The statistical analysis showed that the 90 % confidence intervals around the geometric mean ratios (ATV + SF/ATV alone) for both Cmax and AUC0-24 hours, fell well below the lower limit of the "no-effect" boundary of 0.8 – 1.25, implying that the bioavailability of ATV was significantly reduced in this cohort of subjects. It may thus be concluded that if the reduction in bioavailability observed in this clinical study is found to be clinically relevant, co-administration of SF commercial dosage forms and ATV in HIV/AIDS patients may potentially result in subtherapeutic ATV levels, which may in turn contribute to ATV resistance and/or treatment failure. This research has therefore highlighted the potential risk for toxicity or lack of efficacy of ARV regimens which may result when ATMs and PIs are used concurrently and that patients and health care practitioners alike should be aware of these perils.
- Full Text:
After Baines
- Walters, John Attwood Vereker
- Authors: Walters, John Attwood Vereker
- Date: 2011
- Subjects: Baines, Thomas, 1820-1875 Baines, Thomas, 1820-1875 -- Biography Painting, South African -- Exhibitions Painters -- South Africa -- Biography
- Language: English
- Type: Thesis , Masters , MFA
- Identifier: vital:2432 , http://hdl.handle.net/10962/d1004368
- Description: By researching the life and work of Thomas Baines (1820 - 1875) in relation to a broader discourse of painting and the lived experience of being a 'white' male in a post-apartheid South Africa, I explore the ways in which this figure from the past has provoked the three series of artworks I have produced for my Master of Fine Art exhibition. This study has been divided into two parts, represented by the two chapters contained herein. Chapter One includes a critical retelling of Baines' biography and a discussion of the primary ways in which I have engaged with both the life and the working practice of this artist. I also address my own personal complicity in the constructions of 'the figure of Baines' as I have framed him both visually and textually during my work for this degree. Chapter Two describes some of the practicalities of my working process as a visual artist, including how I understand the theoretical and conceptual concerns which I raise in Chapter One to be visually manifest in my work. In this chapter, I also discuss my work in relation to the work of the contemporary South African artists William Kentridge and Johannes Phokela. The artistic practice of one artist imitating another artist's work is also explored as a central conceptual thread which could be seen to weave my verbal and visual production together.
- Full Text:
- Authors: Walters, John Attwood Vereker
- Date: 2011
- Subjects: Baines, Thomas, 1820-1875 Baines, Thomas, 1820-1875 -- Biography Painting, South African -- Exhibitions Painters -- South Africa -- Biography
- Language: English
- Type: Thesis , Masters , MFA
- Identifier: vital:2432 , http://hdl.handle.net/10962/d1004368
- Description: By researching the life and work of Thomas Baines (1820 - 1875) in relation to a broader discourse of painting and the lived experience of being a 'white' male in a post-apartheid South Africa, I explore the ways in which this figure from the past has provoked the three series of artworks I have produced for my Master of Fine Art exhibition. This study has been divided into two parts, represented by the two chapters contained herein. Chapter One includes a critical retelling of Baines' biography and a discussion of the primary ways in which I have engaged with both the life and the working practice of this artist. I also address my own personal complicity in the constructions of 'the figure of Baines' as I have framed him both visually and textually during my work for this degree. Chapter Two describes some of the practicalities of my working process as a visual artist, including how I understand the theoretical and conceptual concerns which I raise in Chapter One to be visually manifest in my work. In this chapter, I also discuss my work in relation to the work of the contemporary South African artists William Kentridge and Johannes Phokela. The artistic practice of one artist imitating another artist's work is also explored as a central conceptual thread which could be seen to weave my verbal and visual production together.
- Full Text:
Age validation, growth, mortality, and demographic modeling of spotted gully shark (Triakis megalopterus) from the southeast coast of South Africa
- Booth, Anthony J, Foulis, Alan J, Smale, Malcolm J
- Authors: Booth, Anthony J , Foulis, Alan J , Smale, Malcolm J
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/123630 , vital:35466 , https://spo.nmfs.noaa.gov/sites/default/files/pdf-content/2011/1091/booth.pdf
- Description: This study documents validation of vertebral band-pair formation in spotted gully shark (Triakis megalopterus) with the use of f luorochrome injection and tagging of captive and wild sharks over a 21-year period. Growth and mortality rates of T. megalopterus were also estimated and a demographic analysis of the species was conducted. Of the 23 OTC (oxytetracycline) -marked vertebrae examined (12 from captive and 11 from wild sharks), seven vertebrae (three from captive and four from wild sharks) exhibited chelation of the OTC and f luoresced under ultraviolet light. It was concluded that a single opaque and translucent band pair was deposited annually up to at least 25 years of age, the maximum age recorded. Reader precision was assessed by using an index of average percent error calculated at 5%. No significant differences were found between male and female growth patterns (P>0.05), and von Bertalanffy growth model parameters for combined sexes were estimated to be L∞=1711.07 mm TL, k=0.11/yr and t0= –2.43 yr (n=86). Natural mortality was estimated at 0.17/yr. Age at maturity was estimated at 11 years for males and 15 years for females. Results of the demographic analysis showed that the population, in the absence of fishing mortality, was stable and not significantly different from zero and particularly sensitive to overfishing. At the current age at first capture and natural mortality rate, the fishing mortality rate required to result in negative population growth was low at F>0.004/ yr. Elasticity analysis revealed that juvenile survival was the principal factor in explaining variability in population growth rate.
- Full Text:
- Authors: Booth, Anthony J , Foulis, Alan J , Smale, Malcolm J
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/123630 , vital:35466 , https://spo.nmfs.noaa.gov/sites/default/files/pdf-content/2011/1091/booth.pdf
- Description: This study documents validation of vertebral band-pair formation in spotted gully shark (Triakis megalopterus) with the use of f luorochrome injection and tagging of captive and wild sharks over a 21-year period. Growth and mortality rates of T. megalopterus were also estimated and a demographic analysis of the species was conducted. Of the 23 OTC (oxytetracycline) -marked vertebrae examined (12 from captive and 11 from wild sharks), seven vertebrae (three from captive and four from wild sharks) exhibited chelation of the OTC and f luoresced under ultraviolet light. It was concluded that a single opaque and translucent band pair was deposited annually up to at least 25 years of age, the maximum age recorded. Reader precision was assessed by using an index of average percent error calculated at 5%. No significant differences were found between male and female growth patterns (P>0.05), and von Bertalanffy growth model parameters for combined sexes were estimated to be L∞=1711.07 mm TL, k=0.11/yr and t0= –2.43 yr (n=86). Natural mortality was estimated at 0.17/yr. Age at maturity was estimated at 11 years for males and 15 years for females. Results of the demographic analysis showed that the population, in the absence of fishing mortality, was stable and not significantly different from zero and particularly sensitive to overfishing. At the current age at first capture and natural mortality rate, the fishing mortality rate required to result in negative population growth was low at F>0.004/ yr. Elasticity analysis revealed that juvenile survival was the principal factor in explaining variability in population growth rate.
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Aging, sex, death (and heavy metals)
- Authors: Limson, Janice L
- Date: 2011
- Language: English
- Type: Text
- Identifier: vital:589 , http://hdl.handle.net/10962/d1019732
- Description: Vice Chancellor's Distinguished Research Award Lecture August 2011
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- Authors: Limson, Janice L
- Date: 2011
- Language: English
- Type: Text
- Identifier: vital:589 , http://hdl.handle.net/10962/d1019732
- Description: Vice Chancellor's Distinguished Research Award Lecture August 2011
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An analysis of sources and predictability of geomagnetic storms
- Authors: Uwamahoro, Jean
- Date: 2011
- Subjects: Ionospheric storms Solar flares Interplanetary magnetic fields Magnetospheric substorms Coronal mass ejections Space environment Neural networks (Computer science)
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:5451 , http://hdl.handle.net/10962/d1005236
- Description: Solar transient eruptions are the main cause of interplanetary-magnetospheric disturbances leading to the phenomena known as geomagnetic storms. Eruptive solar events such as coronal mass ejections (CMEs) are currently considered the main cause of geomagnetic storms (GMS). GMS are strong perturbations of the Earth’s magnetic field that can affect space-borne and ground-based technological systems. The solar-terrestrial impact on modern technological systems is commonly known as Space Weather. Part of the research study described in this thesis was to investigate and establish a relationship between GMS (periods with Dst ≤ −50 nT) and their associated solar and interplanetary (IP) properties during solar cycle (SC) 23. Solar and IP geoeffective properties associated with or without CMEs were investigated and used to qualitatively characterise both intense and moderate storms. The results of this analysis specifically provide an estimate of the main sources of GMS during an average 11-year solar activity period. This study indicates that during SC 23, the majority of intense GMS (83%) were associated with CMEs, while the non-associated CME storms were dominant among moderate storms. GMS phenomena are the result of a complex and non-linear chaotic system involving the Sun, the IP medium, the magnetosphere and ionosphere, which make the prediction of these phenomena challenging. This thesis also explored the predictability of both the occurrence and strength of GMS. Due to their nonlinear driving mechanisms, the prediction of GMS was attempted by the use of neural network (NN) techniques, known for their non-linear modelling capabilities. To predict the occurrence of storms, a combination of solar and IP parameters were used as inputs in the NN model that proved to predict the occurrence of GMS with a probability of 87%. Using the solar wind (SW) and IP magnetic field (IMF) parameters, a separate NN-based model was developed to predict the storm-time strength as measured by the global Dst and ap geomagnetic indices, as well as by the locally measured K-index. The performance of the models was tested on data sets which were not part of the NN training process. The results obtained indicate that NN models provide a reliable alternative method for empirically predicting the occurrence and strength of GMS on the basis of solar and IP parameters. The demonstrated ability to predict the geoeffectiveness of solar and IP transient events is a key step in the goal towards improving space weather modelling and prediction.
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- Authors: Uwamahoro, Jean
- Date: 2011
- Subjects: Ionospheric storms Solar flares Interplanetary magnetic fields Magnetospheric substorms Coronal mass ejections Space environment Neural networks (Computer science)
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:5451 , http://hdl.handle.net/10962/d1005236
- Description: Solar transient eruptions are the main cause of interplanetary-magnetospheric disturbances leading to the phenomena known as geomagnetic storms. Eruptive solar events such as coronal mass ejections (CMEs) are currently considered the main cause of geomagnetic storms (GMS). GMS are strong perturbations of the Earth’s magnetic field that can affect space-borne and ground-based technological systems. The solar-terrestrial impact on modern technological systems is commonly known as Space Weather. Part of the research study described in this thesis was to investigate and establish a relationship between GMS (periods with Dst ≤ −50 nT) and their associated solar and interplanetary (IP) properties during solar cycle (SC) 23. Solar and IP geoeffective properties associated with or without CMEs were investigated and used to qualitatively characterise both intense and moderate storms. The results of this analysis specifically provide an estimate of the main sources of GMS during an average 11-year solar activity period. This study indicates that during SC 23, the majority of intense GMS (83%) were associated with CMEs, while the non-associated CME storms were dominant among moderate storms. GMS phenomena are the result of a complex and non-linear chaotic system involving the Sun, the IP medium, the magnetosphere and ionosphere, which make the prediction of these phenomena challenging. This thesis also explored the predictability of both the occurrence and strength of GMS. Due to their nonlinear driving mechanisms, the prediction of GMS was attempted by the use of neural network (NN) techniques, known for their non-linear modelling capabilities. To predict the occurrence of storms, a combination of solar and IP parameters were used as inputs in the NN model that proved to predict the occurrence of GMS with a probability of 87%. Using the solar wind (SW) and IP magnetic field (IMF) parameters, a separate NN-based model was developed to predict the storm-time strength as measured by the global Dst and ap geomagnetic indices, as well as by the locally measured K-index. The performance of the models was tested on data sets which were not part of the NN training process. The results obtained indicate that NN models provide a reliable alternative method for empirically predicting the occurrence and strength of GMS on the basis of solar and IP parameters. The demonstrated ability to predict the geoeffectiveness of solar and IP transient events is a key step in the goal towards improving space weather modelling and prediction.
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