Selection of DNA aptamers against Cancer-Targeting Murine Antibodies
- Authors: Nisbet, Laura Jade
- Date: 2023-03-29
- Subjects: Uncatalogued
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/422426 , vital:71941
- Description: Access restricted. Access embargoed until 2025. , Thesis (MSc) -- Faculty of Science, Biotechnology Innovation Centre, 2023
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- Date Issued: 2023-03-29
Semantic segmentation of astronomical radio images: a computer vision approach
- Authors: Kupa, Ramadimetse Sydil
- Date: 2023-03-29
- Subjects: Uncatalogued
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/422378 , vital:71937
- Description: The new generation of radio telescopes, such as the MeerKAT, ASKAP (Australian Square Kilometre Array Pathfinder) and the future Square Kilometre Array (SKA), are expected to produce vast amounts of data and images in the petabyte region. Therefore, the amount of incoming data at a specific point in time will overwhelm any current traditional data analysis method being deployed. Deep learning architectures have been applied in many fields, such as, in computer vision, machine vision, natural language processing, social network filtering, speech recognition, machine translation, bioinformatics, medical image analysis, and board game programs. They have produced results which are comparable to human expert performance. Hence, it is appealing to apply it to radio astronomy data. Image segmentation is one such area where deep learning techniques are prominent. The images from the new generation of telescopes have a high density of radio sources, making it difficult to classify the sources in the image. Identifying and segmenting sources from radio images is a pre-processing step that occurs before sources are put into different classes. There is thus a need for automatic segmentation of the sources from the images before they can be classified. This work uses the Unet architecture (originally developed for biomedical image segmentation) to segment radio sources from radio astronomical images with 99.8% accuracy. After segmenting the sources we use OpenCV tools to detect the sources on the mask images, then the detection is translated to the original image where borders are drawn around each detected source. This process automates and simplifies the pre-processing of images for classification tools and any other post-processing tool that requires a specific source as an input. , Thesis (MSc) -- Faculty of Science, Physics and Electronics, 2023
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- Date Issued: 2023-03-29
Source of introduced populations of Hemidactylus mabouia (Moreau de Jonnès, 1818) into the Eastern Cape Province and the potential spread to other South African regions
- Authors: Jeme, Alungile
- Date: 2023-03-29
- Subjects: Uncatalogued
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/422334 , vital:71933
- Description: Human movements globally have resulted in dispersal and introduction of terrestrial and marine organisms into areas outside of their native range. Species that have been introduced to new habitats can either be alien (not causing any harm to the new environment) or invasive alien species (destroying or competing with the indigenous species for resources). Investigating the source of these introductions is important as it provides baseline information about their biology and evolution. It also allows for better prevention measures for future invasions and for effective conservation strategies. In this study, I investigate the source of the introduced populations of tropical house geckos Hemidactylus mabouia in the Eastern Cape Province using two mitochondrial gene regions, ribosomal 16S and NADH dehydrogenase subunit 4 (ND4). We also look at the potential spread of these species using species distribution models (SDMs). The phylogeny showed that the introduced populations into the Eastern Cape were genetically similar to both H. mabouia lineages found in Central & Southern Africa. The phylogeny produced two clades from which the majority of the introduced samples were grouped in a clade with samples from Angola, DRC, and Mozambique, and only a few nested within the second clade with the South African native population. Haplotype networks from both genes also showed two clades, matching those found in the phylogeny. The introduced samples were associated with samples from Angola and those from South Africa (native) as these localities had a number of shared haplotypes. SDMs showed less evidence that these individuals could naturally move west down the coast as the probability of occurrence was below 0.4 from the Eastern Cape to the Western Cape. Our conclusion was that the introductions may be due to multiple avenues like species moving down the east coast or human translocation including trade routes. From this we can conclude that geckos are largely translocated through human movement as they are known for their opportunistic behaviours as they are commensal with humans. , Thesis (MSc) -- Faculty of Science, Zoology and Entomology, 2023
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- Date Issued: 2023-03-29
The development of a low-cost real- time bacterial plate culture monitoring system
- Authors: Songcata, Ntobeko
- Date: 2023-03-29
- Subjects: Uncatalogued
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/422437 , vital:71942
- Description: Access restricted. Access embargoed until 2025. , Thesis (MSc) -- Faculty of Science, Biotechnology Innovation Centre, 2023
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- Date Issued: 2023-03-29
The influence of immuno-contraception on the ecology of African savanna elephants (Loxodonta africana) in a small game reserve in the Eastern Cape, South Africa
- Authors: Fowler, Natalie
- Date: 2023-03-29
- Subjects: Uncatalogued
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/422269 , vital:71926
- Description: African savanna elephants (Loxodonta africana) can alter the vegetation structure on a landscape which has both positive and negative consequences for biodiversity. This ecological role can be dependent on the density of elephants in a given area and how the area is transformed. Elephants are currently listed as an endangered species on the International Union for Conservation of Nature (IUCN) global red list. Despite this endangered status, strong conservation efforts in southern Africa have increased elephant numbers in protected areas. In South Africa, many of these protected areas are small (<1000 km2) and fenced. Thus, without the freedom to roam over large areas, elephant impacts on vegetation and other ecosystem processes may be exacerbated. Increased growth rates and higher population densities, have prompted wildlife managers to explore several population-level management techniques to slow elephant growth rates in small, protected areas. One such technique is the use of immuno-contraception. My study focused on three datasets (Pre, During and Post porcine zona pellucida (PZP) treatments) of one elephant population over an 18-year period in a small game reserve in the Eastern Cape, South Africa. The first aim of my study was to compare the female demography and reproductive parameters of treated (with PZP) and non-treated females (no PZP). I predicted that the population growth would decrease as more elephant cows were contracepted as well as them having longer inter-calving intervals than non-treated cows. Further, I predicted that there would be a skewed sex ratio of male calves born to treated cows. Lastly, I predicted that fertility rates would be lower in treated cows than in non-treated cows. I calculated the annual population growth rates, inter-calving intervals, sex ratios, age at first calving, fecundity rates and fertility rates of all breeding cows. Population growth rates were similar to other managed populations although, compared to a relatively untouched elephant population, annual growth rates in my study site were high. The inter-calving intervals and age at first birth were low compared to other African protected areas which were most likely influenced by the use of PZP, rainfall and a lack of density dependence. Treated cows did not have longer inter-calving intervals compared to non-treated cows nor was there a male biased sex ratio of the offspring of treated cows. The second aim was to assess the spatial ecology of this elephant population and how it may be influenced by immuno-contraception. I predicted that the use of PZP would increase the elephant herd’s core range as there were fewer reproducing cows. I also predicted that PZP would alter the elephant’s habitat use making them less selective in terms of the vegetation types they selected. I compared the home ranges of the elephant population among the three treatments (Pre PZP, During PZP and Post PZP treatment). Home ranges were larger when elephants were treated with PZP compared to the Pre and Post treatments. The herd utilized most of the reserve during the use of PZP whereas prior to contraception, their space use was mostly concentrated on the eastern side of the reserve. Additionally, the vegetation utilization was inconsistent across the differing timeframes, specifically between pre PZP and during PZP. Prior to the use of PZP, the elephant herd utilized the old lands and riverine thicket the most whereas during the use of PZP, the grasslands and karroid habitats were used the most. The most likely influence of the changes in home ranges and vegetation utilization were rainfall, the use of PZP and resource availability. My results suggest that the use of PZP is essential for controlling elephant population numbers. However, there may be some long-term effects (e.g., behavioural changes) of the use of PZP in elephant populations in small game reserves. Thus, I recommend continued monitoring of all aspects of elephant ecology on reserves where PZP is used as a contraceptive technique. , Thesis (MSc) -- Faculty of Science, Zoology and Entomology, 2023
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- Date Issued: 2023-03-29
The proprietary consequences of foreign marriages for the purposes of estate planning and succession in South Africa
- Authors: Thorne, Aimee Liza
- Date: 2023-03-29
- Subjects: Uncatalogued
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/420725 , vital:71773
- Description: This thesis is intended to provide clarity regarding the proprietary consequences of foreign marriages in the context of estate planning and succession in South Africa. It includes an exploration into the impact of specific legislation on foreign marriages, the implications of matrimonial property regimes on a deceased estate in South Africa, private international law principles affecting matrimonial property and succession claims, the scope of antenuptial contracts and postnuptial contracts as existing remedies for foreign remedies, and the harmonisation of succession and matrimonial property law in the European Union (EU). It furthermore suggests potential reforms for the overhaul of the lex domicilii matrimonii principle and associated issues arising therefrom. Various specific issues discussed include the waiver of accrual claims, maintenance claims by surviving spouses of a foreign marriage, choice-of-law rules for matrimonial property rights and succession rights, the registration of a domestic or foreign antenuptial contract for foreign marriages, the formal validity and proper law of antenuptial contracts, the operation of the immutability principle on a domestic and international level, and the common-law approach to the recognition of postnuptial contracts and spousal donations. , Thesis (LLM) -- Faculty of Law, Law, 2023
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- Date Issued: 2023-03-29
An appraisal analysis of a selection of Zapiro’s political cartoons
- Authors: Hussey, Thomas Davey
- Date: 2022-10-14
- Subjects: Uncatalogued
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/406725 , vital:70302
- Description: Thesis embargoed. To be released in 2025. , Thesis (MA) -- Faculty of Humanities, Linguistics and Applied Language Studies, 2022
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- Date Issued: 2022-10-14
An Investigation into Speaker and Headphone-Based Immersive Audio for VR and Digital Gaming Applications
- Authors: Marais, Kyle Donald
- Date: 2022-10-14
- Subjects: Uncatalogued
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/365246 , vital:65720
- Description: Thesis embargoed. Possible release date set for early 2024. , Thesis (MSc) -- Faculty of Science, Computer Science, 2022
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- Date Issued: 2022-10-14
Bioactivity evaluation of manno-oligosaccharides produced from spent coffee grounds using a Bacillus sp. derived endo-1,4-β-mannanase
- Authors: Magengelele, Mihle
- Date: 2022-10-14
- Subjects: Uncatalogued
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/365233 , vital:65719
- Description: Thesis embargoed. Possible release date set for early 2024. , Thesis (MSc) -- Faculty of Science, Biochemistry and Microbiology, 2022
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- Date Issued: 2022-10-14
Characterisation of two novel ferrocenyl benzoxazines as in vitro triple-negative breast cancer inhibitors
- Authors: Mhlanga, Richwell
- Date: 2022-10-14
- Subjects: Uncatalogued
- Language: English
- Type: Academic theses , Doctoral theses , text
- Identifier: http://hdl.handle.net/10962/365689 , vital:65776
- Description: Thesis access embargoed. Expected released date early 2025. , Thesis (PhD) -- Faculty of Science, Biochemistry and Microbiology, 2022
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- Date Issued: 2022-10-14
Contextualising job satisfaction amongst lowest paid support staff in a Higher Education institution
- Authors: Madito, Gotlannamang Moloiesi Boipelo
- Date: 2022-10-14
- Subjects: Uncatalogued
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/405984 , vital:70225
- Description: Thesis embargoed. To be relased in 2024. , Thesis (MA) -- Faculty of Humanities, Psychology, 2022
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- Date Issued: 2022-10-14
Country risk and stock market volatility in Africa: Measuring the contribution of political and economic risk factors
- Authors: Hoveni, Jamela Basani
- Date: 2022-10-14
- Subjects: Uncatalogued
- Language: English
- Type: Academic theses , Doctoral theses , text
- Identifier: http://hdl.handle.net/10962/405445 , vital:70172
- Description: Thesis embargoed. To be released in 2025. , Thesis (PhD) -- Faculty of Commerce, Economics and economic History, 2022
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- Date Issued: 2022-10-14
Development of biosensor systems for the detection of anti-cancer drugs and prostate cancer
- Authors: Mwanza, Daniel
- Date: 2022-10-14
- Subjects: Uncatalogued
- Language: English
- Type: Academic theses , Doctoral theses , text
- Identifier: http://hdl.handle.net/10962/365929 , vital:65803
- Description: Thesis embargoed. Expected release date early 2025. , Thesis (PhD) -- Faculty of Science, Chemistry, 2022
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- Date Issued: 2022-10-14
Evaluating the role of Stress Induced Phosphoprotein 1 isoforms in Kaposi's Sarcoma-Associated Herpesvirus biology
- Authors: Ruck, Duncan Kyle
- Date: 2022-10-14
- Subjects: Uncatalogued
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/365280 , vital:65723
- Description: Thesis embargoed. Possible release date set for early 2025. , Thesis (MSc) -- Faculty of Science, Biochemistry and Microbiology, 2022
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- Date Issued: 2022-10-14
Exploration of remote work and wellbeing of academics in a South African tertiary institution
- Authors: Chikutu, Michelle
- Date: 2022-10-14
- Subjects: Uncatalogued
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/405963 , vital:70223
- Description: Thesis embargoed. To be released in 2024. , Thesis (MA) -- Faculty of Humanities, Psychology, 2022
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- Date Issued: 2022-10-14
Exploring integration for the topic of stoichiometry in South African natural sciences and physical sciences school curricula
- Authors: Mgolozeli, Kwanele
- Date: 2022-10-14
- Subjects: Uncatalogued
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/405330 , vital:70162
- Description: Many developing countries, including South Africa, have identified the provision and implementation of strong science curricula as central to their developmental needs. Stoichiometry is a fundamental chemistry topic because the concepts involved form the basis of later topics such as chemical equilibrium, rates of reactions, redox reactions, and acid-base reactions. School students consistently demonstrate lack of understanding of stoichiometry-related concepts and skills such as the particulate nature of matter and related mathematical problem-solving. The poor performance of high school students in central science topics such as stoichiometry is problematic for their further study of chemistry and for the country meeting its need for science graduates. Successive examiner reports pointed to the lack of integration of stoichiometry concepts across the grades being the main problem. However, no study could be found which explores how stoichiometry is integrated in the South African Natural Sciences and Physical Sciences curriculum across the grades. This provided the rationale for the current study. The case study reported in this thesis thus aimed to explore integration of stoichiometry concepts in South African Natural Sciences and Physical Sciences school curricula. It involved document analysis as the method of collecting data. The research adopted the social realist paradigm, with its realist ontology and relativist epistemology. Legitimation Code Theory provided the theoretical framing. Chemistry concepts that are foundational to the understanding of stoichiometry according to literature, were chosen as root concepts for the concept mapping undertaken to identify types of integration. The concept maps revealed four stoichiometry integration themes: integration of stoichiometry concepts with symbols, integration of stoichiometry concepts with explanations, integration with applications in a chemistry context, and integration with an everyday context. These themes provided integration categories. A semantic gravity translation device was then developed for characterising the types of integration in terms of the degree of contextualisation. The results of this study show that stoichiometry integration of weaker semantic gravity is legitimated more strongly over other semantic gravity codes in the Natural Sciences and Physical Sciences curricula across all grade levels. While this has advantages in terms of knowledge-building potential, the consequence is that the integration occurs at very abstract levels that are far removed from learners’ everyday lives. The practical implication for curriculum developers involves increasing the instances of integration of stoichiometry concepts at stronger levels of semantic gravity, for a more even semantic gravity range of integration types. Natural Sciences and Physical Sciences teachers also need to source and include real-life examples for explanations and applications of stoichiometry concepts when teaching, in light of current curriculum documents focusing more on abstract forms of integration. Methodologically, this study contributes to the increased utility of semantic gravity through its exploration of integration in relation to knowledge-building potential of curriculum for hierarchical knowledge structures such as chemistry. , Thesis (MEd) -- Faculty of Education, Education, 2022
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- Date Issued: 2022-10-14
Exploring primary school mathematics teachers use of gamification in formative assessment: a case study
- Authors: Simelane, Thando
- Date: 2022-10-14
- Subjects: Uncatalogued
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/405412 , vital:70169
- Description: Technology integration has gained much influence with the emergence of technological tools in educational areas. The vast resources and opportunities that technologies and the Internet have brought new approaches, strategies, and tools to assess learners' performance in many subject areas. Teachers have many computer/mobile device applications and learning management systems. Most teachers are trying new ways of integrating technology into the mathematics classroom to increase the quality of teaching and learning. Thus, this study explored how primary school mathematics teachers use Kahoot as a formative assessment tool. The study adopted an exploratory case study underpinned by the interpretive paradigm. It was conducted in a primary school in the Shiselweni Region in Swaziland. The participants were ten mathematics teachers teaching different grades at the school. Data was generated using observations, workshops, structured questionnaires, journal reflections and focus group interviews. The theoretical and analytical framework that underpinned this study was a combination of Davis' (1989) Technology Acceptance Model (TAM) and Mishra & Koehler's (2006) Technological Pedagogical Content Knowledge (TPACK) framework. The study results showed that the perceptions and attitudes of primary school mathematics teachers towards using Kahoot generally appear to be positive. The study also revealed that all the participants found Kahoot helpful and perceived it as easy to use. The study found that the provision of technical support for teachers; and financial support for schools to implement technology use in the classroom were enabling factors for using Kahoot as a formative assessment technology. Constraining factors were lack of high-speed internet connectivity; and lack of basic technological knowledge for using Kahoot in formative assessment. The study concluded that Kahoot increases learner motivation, engagement, attention, enjoyment, and knowledge retention. This study recommended the integration of Kahoot gamification into the mathematics curriculum.The study recommends that there is a need for schools to initiate the presence of technologies in mathematics classrooms and encourage teachers to integrate technologies assessment and teaching. The study suggest future research to explore use of Kahoot as a formative assessment technology in resource-constrained schooling contexts using multiple cases. , Thesis (MEd) -- Faculty of Education, Education, 2022
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- Date Issued: 2022-10-14
Exploring the influence of student protests on organisational citizenship behaviour of academics and support mechanisms in higher learning institutions
- Authors: Mayekiso, Sinovuyo
- Date: 2022-10-14
- Subjects: Uncatalogued
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/406198 , vital:70248
- Description: Embargoed. To be released in 2024. , Thesis (MA) -- Faculty of Humanities, Psychology, 2022
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- Date Issued: 2022-10-14
Identification and characterisation of microbial communities and their metabolic potential in meltwater ponds, Western Dronning Mau Land, Antarctica
- Authors: Van Aswegen, Sunet
- Date: 2022-10-14
- Subjects: Uncatalogued
- Language: English
- Type: Academic theses , Doctoral theses , text
- Identifier: http://hdl.handle.net/10962/365723 , vital:65779
- Description: Thesis embargoed. Expected release date early 2024. , Thesis (PhD) -- Faculty of Science, Biochemistry and Microbiology, 2022
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- Date Issued: 2022-10-14
Inadequate menstrual health management and human rights
- Authors: Hartley, Gemma-Maé
- Date: 2022-10-14
- Subjects: Uncatalogued
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/422506 , vital:71953
- Description: Various human rights bodies have suggested that Inadequate Menstrual Health Management (MHM) could contribute to violations of human rights or, at the very least, is connected to the fulfilment of human rights. Despite recognition of this, there has not been thorough analysis of whether inadequate MHM is a violation of human rights, particularly in political discussions on the philosophy of human rights. Using a liberal cosmopolitan framework, this thesis attempts to bridge this gap and, ultimately, to argue that inadequate MHM constitutes a violation of human rights. This assertion brings with it various complications due to the heavily contested nature of human rights, their correlative duties, and the requirements for a lack of fulfilment to be considered a violation. I address each complication in turn. I argue that the traditional approach to human rights violations fails to consider the various ways that human rights are violated in our contemporary, globalised world. I suggest that structural violations of human rights should not be ruled out, particularly when we consider severe poverty and its by-products. Ultimately, the question of inadequate MHM is concerned with the content of human rights. If inadequate MHM were a violation, it would be a violation of women’s socio-economic rights. However, both group rights and socio-economic rights are contested. This thesis therefore justifies these rights. Group-differentiated rights are argued to be necessary for substantive equality. This is particularly the case when we consider the various risks women face simply because they are women. Women therefore need special protections and provisions for their human rights to be fulfilled. Socio-economic rights are necessary for the well-being and dignity of individuals everywhere. We can justify them even if they are costly, vague, and demanding on states, as critics argue they are. Therefore, if we can accept socio-economic rights and women’s rights, we can argue that inadequate MHM is a structural violation of human rights. Thinking about inadequate MHM in this way means we can respond to it with a level of urgency. This has the potential to improve the well-being, development, and dignity of women. , Thesis (MA) -- Faculty of Humanities, Political and International Studies, 2023
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- Date Issued: 2022-10-14