Synthesis, characterisation and evaluation of benzoxaborole-based hybrids as antiplasmodial agents
- Authors: Gumbo, Maureen
- Date: 2017
- Subjects: Malaria Chemotherapy , Antimalarials , Boron compounds , Drug resistance , Plasmodium falciparum , Drug development
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/59193 , vital:27456
- Description: Malaria is a mosquito-borne disease, which continues to pose a threat to the entire humanity. About 40% of the world population is estimated to be at risk of infections by malaria. Despite efforts undertaken by scientific community, government entities and international organizations, malaria is still rampant. The major problem is drug resistance, where the Plasmodium spp have over the past decades developed drug resistance against available drugs. In order to counter this problem, novel antimalarial drugs that are efficacious and with novel mode of action are of great necessity. Benzoxaborole derivatives have been shown to exhibit promising antimalarial activity against Plasmodium falciparum strains. Previous studies reported on the compounds such as 6-(2- (alkoxycarbonyl)pyrazinyl-5-oxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles, which showed good antimalarial activity against both W7 and 3D7 strains without significant toxicity. On the other hand, chloroquine (CQ) and cinnamic acids have a wide variety of biological activity including antimalarial activity. Herein, a hybridisation strategy was employed to synthesise new CQ-benzoxaborole and cinnamoyl-benzoxaborole hybrids. CQ-Benzoxaborole 2.12a-c and cinnamoylbenzoxaborole 2.11a-g hydrid molecules were synthesised in low to good yields. Their structural identities were confirmed using conventional spectroscopic techniques (1H and 13C NMR, and mass spectrometry). CQ-benzoxaborole compounds, however, showed instability, and only 2.12b was used for in vitro biological assay and showed activity comparable to CQ. Furthermore, in vitro biological assay revealed that compounds 2.11a-g poorly inhibited the growth of P. falciparum parasites. Interestingly, these compounds, however, exhibited satisfactory activity against Trypanosoma brucei with IC50 = 0.052 μM for compound 2.11g. The cell cytotoxicity assay of all final compounds confirmed that all CQ-benzoxaborole 2.12b and cinnamoyl-benzoxaborole 2.11a-g hybrids were non-toxic against HeLa cell lines. However, efforts to further expand the structure-activity relationship (SAR) of CQbenzoxaborole by increasing the length of the linker with one extra carbon (Scheme 2.10) were not possible as an important precursor 6-formylbenzoxaborole 2.29 could not be synthesized in sufficient yields. , Thesis (MSc) -- Faculty of Faculty of Science, Chemistry, 2017
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- Date Issued: 2017
An analysis of grade 12 students' attitudes towards agriculture as a career choice in Nkonkobe municipality, Eastern Cape
- Authors: Ndema, Tenjiwe N
- Date: 2016
- Subjects: Career development -- South Africa , Agriculture -- Study and teaching -- South Africa -- Eastern Cape
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10353/26592 , vital:65661
- Description: In South Africa there is a perception that the youth, particularly black youth, lack interest in agriculture as a career. The youth are perceived to be more drawn to white collar jobs, because they believe that these jobs are more pleasant and better paying. The literature moreover suggests that the youth perceive agriculture as dirty work which is more appropriate for uneducated or illiterate people. The main aim of the research was to analyse Grade12 students’ attitudes towards agriculture as a career choice in Nkonkobe Municipality. Students from four high schools were interviewed using a structured questionnaire, and the total sample size was 100. Based on the results, about one third of students have a favorable perception of agriculture as a career choice, which is more than what had been expected based on the literature reviewed. Both students from non-agricultural schools and agricultural schools possess a positive attitude towards agriculture. They indicated that agriculture offers a lot of financial gain, is not necessarily associated with poverty, nor is agriculture widely regarded as a last resort for those who have failed in other careers. Moreover, they believe that agriculture is as important as other sectors. However, of those learners who indicated an intention to pursue agriculture as a career, only 1 % specifically wished to become a farmer. The others rather wanted professional careers within the agricultural sector, such as veterinarians, agricultural economists, and so forth. Their interest in agriculture as a career related in large measure to a desire to live in a rural area and work with their hands; however this did not extend to actual farming. , Thesis (M Agric) -- Faculty of Science and Agriculture, 2016
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- Date Issued: 2016
An assessment of public support given to land reform commonage farmers by local and provincial government and their perfomance: A case study of Makana Local Municipality in Eastern Cape
- Authors: Gqweta, N V P
- Date: 2016
- Subjects: Land reform -- South Africa , Land use
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10353/23991 , vital:62238
- Description: Access to land is very important for previously disadvantage people from the countries where agriculture is one of the main sources for employment in order to improve their livelihoods. Worldwide, Land Reform arose mainly because of inequalities of resources. In South Africa the Land Reform started in as early as 1658 where blacks were not afforded equal opportunities as white people and therefore off farm land and properties. When South Africa’s first democratic government came into power in 1994, one of its goals was to redress the injustice of the past and give back land to the previously disadvantaged people through various land reform programmes. One of the components of the land reform programme was the provision of commonages lands to urban municipalities for use by the urban poor. The Department of Rural Development and Land Reform acquired commonages land for the municipalities for the purpose of agricultural production. The study focused on the Municipal Commonage Programme and this has been done by assessing the public support given to land reform commonage farmers by local and provincial government and their performance in Makana Local Municipality in Eastern Cape. The study showed that land reform commonage emerging farmers are confronted by numerous challenges such as poor infrastructure, access to markets, mentorship, credit, transport by beneficiaries, lack of support from government departments and lack of co-ordination between government departments. These and other challenges ultimately hamper beneficiaries from making effective use of land. The study was done on eight commonages in Makana Municipality. The data was analyzed using Statistical Package for the Social Science (SPSS) and Microsoft Excel. Data collection entailed questionnaire, interviews and focus group discussions. In view of the challenges for commonage farmers, this study provides recommendation for improving the commonage land reform redistribution projects. Current management attempts are not ensuring the efficient equitable and sustainable use of these commonages. Municipal Commonage should be better integrated into agrarian reform through leases and an efficient Commonage Farmers Support Programmes. , Thesis (MSc) -- Faculty of Science and Agriculture, 2016
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- Date Issued: 2016
An empirical investigation of the demand for money in South Africa within the inflation-targeting era
- Authors: Duah, Rachel
- Date: 2016
- Subjects: South Africa--Economic conditions http://id.loc.gov/authorities/subjects/sh85125465 , Inflation targeting--South Africa , Monetary policy--South Africa
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10353/19465 , vital:43127
- Description: The aim of the study is to empirically test the demand for money function in South Africa’s inflation-targeting era. This came from the fact that there have been a number of structural changes in the South African economy that have appeared to alter the relation between M3 and GDP and other macroeconomic variables. The study employed co-integration tests that showed one co-integrating equation which led to the application of the Vector-Error Correction Model (VECM) using the quarterly time series data covering the period from 2000-2015. The demand for money is investigated by estimating the real money balances as a function of Treasury Bills rate, income and total credit. Results showed that there is a negative relationship among Treasury Bills rate, income and real money balances. However, there is a positive relationship between real money balances and the total credit provided by the banking sector. The CUSUM and CUSUMQ tests are applied to examine the possibility of structural breaks in money demand functions, as well as parameter stability. The results of the study indicated that the estimated parameters for the short and long run dynamics of the real money demand function are stable. It was evident that Treasury bill rate, income and total credit can explain money balances and therefore can influence demand for money. The study recommends that the government ensures that there are economic activities such as employment creation which can then boost income levels so as to get a positive relationship between money balances and income. Through employment creation, there can be a reduction in borrowing. Treasury bill rates, being an effective monetary policy tool, can be used to direct monetary policy and also promote price stability. The study recommends that the South African Reserve Bank continue to improve the conditions in the financial sector. In this regard, the SARB and the government should strive to enact flexible policies that will boost financial credit and uplift business confidence. , Thesis (MCom)(Economics) -- University of Fort Hare, 2016
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- Date Issued: 2016
An unsung dialogue: music, society and the history of The Flames
- Authors: Park, Duncan Keith
- Date: 2016
- Subjects: Uncatalogued
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/193645 , vital:45376
- Description: This research aims to examine the relationship between music and social conditions within the context of apartheid. The focus area is the city of Durban, specifically 1960-1970. A case study of the multi-racial Durban-based band, The Flames (1963 – 1972) will be used to rigorously assess the extent to which social conditions and music can affect each other in both directions. This will also be the first coherent and historical narrative of the band, The Flames. As such, the thesis aims to make an original contribution to this field of music history, while it will provide the very first academic discussion of The Flames. , Thesis (MA) -- Faculty of Humanities, History, 2016
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- Date Issued: 2016
Investigating the role of the South African Schools Choral Eisteddfod in introducing learners to music career
- Authors: Sibene, Vuyelwa
- Date: 2016
- Subjects: Choral music -- South Africa , Choral singing -- Instruction and study -- South Africa
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10353/26382 , vital:65298
- Description: This research investigates the role of South African Schools Choral Eisteddfod (SASCE) in introducing learners in high schools to music career. It attempts to identify learners in grade 12 who want to study music at university and students who were involved in SASCE and are now in university. These learners and students have limited music background and are/were involved in the South African Schools Choral Eisteddfod (SASCE) program. Within the study, I felt to also include a graduated music student to validate the study. The study proceeds with the investigation by exploring numerous areas such as SASCE as a music program, music education, music careers, national curriculum, music literacy etc. Also, I write about the background to the study in which I share my motivation and experiences about the SASCE programme and how it influenced me and other former SASCE participants’ decisions about musical careers. Data collection is executed through the involvement of the sampled learner and students through participating in semi-structured interview, document analysis and personal observations. Four interviews which were in qualitative method were conducted with 4 participants, one interview each participant was in a semi-structure form. Interviews were aimed in recognizing the current status of the learner/students in music literacy and are they coping in their respected places of study. The data is analyzed using a qualitative analyses technique. Further, the study outlines problems and one research question of the investigation, 'To which extent do University music students with limited music background succeed or fail to obtain their music degrees?’. , Thesis (BMUS) -- Faculty of Humanities, 2016
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- Date Issued: 2016
Islamic compliant short term insurance: an exploratory study to develop an Islamic compliant insurance model within a South African context
- Authors: Jeeva, Shakir
- Date: 2016
- Subjects: Uncatalogued
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/193633 , vital:45375
- Description: In a world where there is ever increasing risks to be mitigated, either by choice or due to the law of the country, an insurance instrument is the most popular risk mitigation tool. However, from an Islamic perspective, Muslims have certain parameters to adhere to due to the laws and boundaries as set out in the Quraan, as well as the teachings of the final prophet, Prophet Muhammed (Peace Be Upon Him). This has relevance in this context as, according to Islam, the conventional insurance models are in contravention of certain Islamic laws as they contain elements which are not acceptable in the Muslim faith. Therefore, the Islamic insurance models, or Takaful models, have removed the impermissible elements of usury, speculation, and uncertainty, which are all contained in the current conventional insurance models. By removing these impermissible elements from the insurance model, the Takaful model is acceptable for Muslims to use as a risk mitigation tool. The primary aim of the study sought to propose a short term Islamic compliant insurance model within a South African framework. The secondary aims were to ascertain the Islamic requirements for an Islamic insurance model, how these requirements fit into an insurance model, to then compare and contrast the differences between conventional insurance and Islamic insurance and, lastly, to explore awareness and attitudes towards Islamic insurance. Therefore, from the above, a proposed short term Islamic insurance model was developed within a South African context which conforms to the laws and boundaries of Islam, making this insurance model permissible to use as a Takaful tool. Additionally, semi structured interviews were conducted with certain research participants, using purposive sampling, to examine the attitudes and knowledge of the Muslim community towards the Takaful model within a South African context. It was concluded that while the majority of the research participants understand the Takaful model and the significance of this, they have chosen to use the conventional insurance offerings due to the fact that they were unaware of other Takaful alternatives, or due to the fact that the Takaful alternative was out-priced when compared to the conventional insurance offerings. It was therefore concluded that while there is a need for Takaful offerings within South Africa, this must be done in conjunction with additional marketing, education and competitive pricing for potential clients to consider this as an insurance option. , Thesis (MCom) -- Faculty of Commerce, Accounting, 2016
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- Date Issued: 2016